-
1
-
-
0142072674
-
Prevention of epilepsy after head trauma: Do we need new drugs or a new approach?
-
Benardo LS,. Prevention of epilepsy after head trauma: do we need new drugs or a new approach? Epilepsia 2003; 44 (suppl 10): 27-33.
-
(2003)
Epilepsia
, vol.44
, Issue.SUPPL. 10
, pp. 27-33
-
-
Benardo, L.S.1
-
2
-
-
79953705357
-
Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma
-
Löscher W, Schmidt D,. Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 2011; 52: 657-678.
-
(2011)
Epilepsia
, vol.52
, pp. 657-678
-
-
Löscher, W.1
Schmidt, D.2
-
3
-
-
0035048478
-
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: Meta-analysis of controlled trials
-
Temkin NR,. Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. Epilepsia 2001; 42: 515-524.
-
(2001)
Epilepsia
, vol.42
, pp. 515-524
-
-
Temkin, N.R.1
-
4
-
-
84863715734
-
Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects
-
Jimenez-Mateos EM, Engel T, Merino-Serrais P, et al. Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects. Nat Med 2012; 18: 1087-1094.
-
(2012)
Nat Med
, vol.18
, pp. 1087-1094
-
-
Jimenez-Mateos, E.M.1
Engel, T.2
Merino-Serrais, P.3
-
5
-
-
80052587330
-
Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy
-
McClelland S, Flynn C, Dubé C, et al. Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy. Ann Neurol 2011; 70: 454-464.
-
(2011)
Ann Neurol
, vol.70
, pp. 454-464
-
-
McClelland, S.1
Flynn, C.2
Dubé, C.3
-
6
-
-
79960108626
-
The methylation hypothesis: Do epigenetic chromatin modifications play a role in epileptogenesis?
-
Kobow K, Blümcke I,. The methylation hypothesis: do epigenetic chromatin modifications play a role in epileptogenesis? Epilepsia 2011; 52 (suppl 4): 15-19.
-
(2011)
Epilepsia
, vol.52
, Issue.SUPPL. 4
, pp. 15-19
-
-
Kobow, K.1
Blümcke, I.2
-
8
-
-
2342514015
-
An important role of Nrf2-ARE pathway in the cellular defense mechanism
-
Lee JM, Johnson JA,. An important role of Nrf2-ARE pathway in the cellular defense mechanism. J Biochem Mol Biol 2004; 37: 139-143.
-
(2004)
J Biochem Mol Biol
, vol.37
, pp. 139-143
-
-
Lee, J.M.1
Johnson, J.A.2
-
9
-
-
0037763721
-
Regulatory mechanisms controlling gene expression mediated by the antioxidant response element
-
Nguyen T, Sherratt PJ, Pickett CB,. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu Rev Pharmacol Toxicol 2003; 43: 233-260.
-
(2003)
Annu Rev Pharmacol Toxicol
, vol.43
, pp. 233-260
-
-
Nguyen, T.1
Sherratt, P.J.2
Pickett, C.B.3
-
10
-
-
81855204961
-
Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation
-
Hybertson BM, Gao B, Bose SK, et al. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med 2011; 32: 234-246.
-
(2011)
Mol Aspects Med
, vol.32
, pp. 234-246
-
-
Hybertson, B.M.1
Gao, B.2
Bose, S.K.3
-
11
-
-
77749339881
-
Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease
-
Rojo AI, Innamorato NG, Martin-Moreno AM, et al. Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease. Glia 2010; 58: 588-598.
-
(2010)
Glia
, vol.58
, pp. 588-598
-
-
Rojo, A.I.1
Innamorato, N.G.2
Martin-Moreno, A.M.3
-
12
-
-
77955608828
-
Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1
-
Innamorato NG, Jazwa A, Rojo AI, et al. Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1. PLoS One 2010; 5: e11838.
-
(2010)
PLoS One
, vol.5
-
-
Innamorato, N.G.1
Jazwa, A.2
Rojo, A.I.3
-
14
-
-
70349482547
-
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
-
Kanninen K, Heikkinen R, Malm T, et al. Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 2009; 106: 16505-16510.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 16505-16510
-
-
Kanninen, K.1
Heikkinen, R.2
Malm, T.3
-
15
-
-
79958818494
-
A systems level, functional genomics analysis of chronic epilepsy
-
Winden KD, Karsten SL, Bragin A, et al. A systems level, functional genomics analysis of chronic epilepsy. PLoS One 2011; 6: e20763.
-
(2011)
PLoS One
, vol.6
-
-
Winden, K.D.1
Karsten, S.L.2
Bragin, A.3
-
16
-
-
33748080476
-
Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element
-
Kraft AD, Lee JM, Johnson DA, et al. Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element. J Neurochem 2006; 98: 1852-1865.
-
(2006)
J Neurochem
, vol.98
, pp. 1852-1865
-
-
Kraft, A.D.1
Lee, J.M.2
Johnson, D.A.3
-
17
-
-
77957237159
-
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
-
Malhotra D, Portales-Casamar E, Singh A, et al. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Res 2010; 38: 5718-5734.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 5718-5734
-
-
Malhotra, D.1
Portales-Casamar, E.2
Singh, A.3
-
18
-
-
58149232358
-
Artificial microRNAs as siRNA shuttles: Improved safety as compared to shRNAs in vitro and in vivo
-
Boudreau RL, Martins I, Davidson BL,. Artificial microRNAs as siRNA shuttles: improved safety as compared to shRNAs in vitro and in vivo. Mol Ther 2009; 17: 169-175.
-
(2009)
Mol Ther
, vol.17
, pp. 169-175
-
-
Boudreau, R.L.1
Martins, I.2
Davidson, B.L.3
-
19
-
-
0036431701
-
Insect cells as a factory to produce adeno-associated virus type 2 vectors
-
Urabe M, Ding C, Kotin RM,. Insect cells as a factory to produce adeno-associated virus type 2 vectors. Hum Gene Ther 2002; 13: 1935-1943.
-
(2002)
Hum Gene Ther
, vol.13
, pp. 1935-1943
-
-
Urabe, M.1
Ding, C.2
Kotin, R.M.3
-
20
-
-
66349121666
-
Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model
-
Paradiso B, Marconi P, Zucchini S, et al. Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model. Proc Natl Acad Sci U S A 2009; 106: 7191-7196.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 7191-7196
-
-
Paradiso, B.1
Marconi, P.2
Zucchini, S.3
-
21
-
-
84866665261
-
Rapid epileptogenesis in the mouse pilocarpine model: Video-EEG, pharmacokinetic and histopathological characterization
-
Mazzuferi M, Kumar G, Rospo C, et al. Rapid epileptogenesis in the mouse pilocarpine model: video-EEG, pharmacokinetic and histopathological characterization. Exp Neurol 2012; 238: 156-167.
-
(2012)
Exp Neurol
, vol.238
, pp. 156-167
-
-
Mazzuferi, M.1
Kumar, G.2
Rospo, C.3
-
22
-
-
0015309163
-
Modification of seizure activity by electrical stimulation. II. Motor seizure
-
Racine RJ,. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 1972; 32: 281-294.
-
(1972)
Electroencephalogr Clin Neurophysiol
, vol.32
, pp. 281-294
-
-
Racine, R.J.1
-
23
-
-
22844446947
-
An integrative genomics approach to infer causal associations between gene expression and disease
-
Schadt EE, Lamb J, Yang X, et al. An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet 2005; 37: 710-717.
-
(2005)
Nat Genet
, vol.37
, pp. 710-717
-
-
Schadt, E.E.1
Lamb, J.2
Yang, X.3
-
24
-
-
4043141580
-
Loss of apolipoprotein e receptor LR11 in Alzheimer disease
-
Scherzer CR, Offe K, Gearing M, et al. Loss of apolipoprotein E receptor LR11 in Alzheimer disease. Arch Neurol 2004; 61: 1200-1205.
-
(2004)
Arch Neurol
, vol.61
, pp. 1200-1205
-
-
Scherzer, C.R.1
Offe, K.2
Gearing, M.3
-
25
-
-
58149229504
-
Gene expression meta-analysis identifies chromosomal regions and candidate genes involved in breast cancer metastasis
-
Thomassen M, Tan Q, Kruse TA,. Gene expression meta-analysis identifies chromosomal regions and candidate genes involved in breast cancer metastasis. Breast Cancer Res Treat 2009; 113: 239-249.
-
(2009)
Breast Cancer Res Treat
, vol.113
, pp. 239-249
-
-
Thomassen, M.1
Tan, Q.2
Kruse, T.A.3
-
26
-
-
84870902532
-
Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
-
Zhang M, An C, Gao Y, et al. Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection. Prog Neurobiol 2013; 100: 30-47.
-
(2013)
Prog Neurobiol
, vol.100
, pp. 30-47
-
-
Zhang, M.1
An, C.2
Gao, Y.3
-
27
-
-
77955869480
-
The future of epilepsy treatment: Focus on adeno-associated virus vector gene therapy
-
McCown TJ,. The future of epilepsy treatment: focus on adeno-associated virus vector gene therapy. Drug News Perspect 2010; 23: 281-286.
-
(2010)
Drug News Perspect
, vol.23
, pp. 281-286
-
-
McCown, T.J.1
-
28
-
-
79958191163
-
Adeno-associated virus (AAV) vectors in the CNS
-
McCown TJ,. Adeno-associated virus (AAV) vectors in the CNS. Curr Gene Ther 2011; 11: 181-188.
-
(2011)
Curr Gene Ther
, vol.11
, pp. 181-188
-
-
McCown, T.J.1
-
29
-
-
62449132771
-
Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte
-
Chen PC, Vargas MR, Pani AK, et al. Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: critical role for the astrocyte. Proc Natl Acad Sci U S A 2009; 106: 2933-2938.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 2933-2938
-
-
Chen, P.C.1
Vargas, M.R.2
Pani, A.K.3
-
30
-
-
58149379610
-
Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis
-
Vargas MR, Johnson DA, Sirkis DW, et al. Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis. J Neurosci 2008; 28: 13574-13581.
-
(2008)
J Neurosci
, vol.28
, pp. 13574-13581
-
-
Vargas, M.R.1
Johnson, D.A.2
Sirkis, D.W.3
-
31
-
-
84864425354
-
Beneficial effects of Nrf2 overexpression in a mouse model of Alexander disease
-
LaPash Daniels CM, Austin EV, Rockney DE, et al. Beneficial effects of Nrf2 overexpression in a mouse model of Alexander disease. J Neurosci 2012; 32: 10507-10515.
-
(2012)
J Neurosci
, vol.32
, pp. 10507-10515
-
-
Lapash Daniels, C.M.1
Austin, E.V.2
Rockney, D.E.3
-
32
-
-
84859782754
-
Ketogenic diets: New advances for metabolism-based therapies
-
Kossoff EH, Hartman AL,. Ketogenic diets: new advances for metabolism-based therapies. Curr Opin Neurol 2012; 25: 173-178.
-
(2012)
Curr Opin Neurol
, vol.25
, pp. 173-178
-
-
Kossoff, E.H.1
Hartman, A.L.2
-
33
-
-
77955845526
-
Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet
-
Milder JB, Liang LP, Patel M,. Acute oxidative stress and systemic Nrf2 activation by the ketogenic diet. Neurobiol Dis 2010; 40: 238-244.
-
(2010)
Neurobiol Dis
, vol.40
, pp. 238-244
-
-
Milder, J.B.1
Liang, L.P.2
Patel, M.3
-
34
-
-
84872098804
-
Abnormal dentate gyrus network circuitry in temporal lobe epilepsy
-
Noebels J.L. Avoli M. Rogawski M.A. et al, eds. 4th ed. Bethesda, MD: National Center for Biotechnology Information. Accessed June 2013
-
Sloviter RS, Bumanglag AV, Schwarcz R, et al. Abnormal dentate gyrus network circuitry in temporal lobe epilepsy. In:, Noebels JL, Avoli M, Rogawski MA, et al, eds. Jasper's basic mechanisms of the epilepsies. 4th ed. Bethesda, MD: National Center for Biotechnology Information, 2012. Available at: http://www.ncbi.nlm.nih.gov/books/NBK98207/. Accessed June 2013.
-
(2012)
Jasper's Basic Mechanisms of the Epilepsies
-
-
Sloviter, R.S.1
Bumanglag, A.V.2
Schwarcz, R.3
-
35
-
-
0036456444
-
Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy
-
Pitkänen A, Nissinen J, Nairismägi J, et al. Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy. Prog Brain Res 2002; 135: 67-83.
-
(2002)
Prog Brain Res
, vol.135
, pp. 67-83
-
-
Pitkänen, A.1
Nissinen, J.2
Nairismägi, J.3
-
36
-
-
84864590672
-
Neuronal degeneration and gliosis time-course in the mouse hippocampal formation after pilocarpine-induced status epilepticus
-
do Nascimento AL, Dos Santos NF, Campos PF, et al. Neuronal degeneration and gliosis time-course in the mouse hippocampal formation after pilocarpine-induced status epilepticus. Brain Res 2012; 1470: 98-110.
-
(2012)
Brain Res
, vol.1470
, pp. 98-110
-
-
Do Nascimento, A.L.1
Dos Santos, N.F.2
Campos, P.F.3
-
37
-
-
22544441336
-
Progression in temporal lobe epilepsy: Differential atrophy in mesial temporal structures
-
Bernasconi N, Natsume J, Bernasconi A,. Progression in temporal lobe epilepsy: differential atrophy in mesial temporal structures. Neurology 2005; 65: 223-228.
-
(2005)
Neurology
, vol.65
, pp. 223-228
-
-
Bernasconi, N.1
Natsume, J.2
Bernasconi, A.3
-
38
-
-
33644625777
-
Brain inflammation in epilepsy: Experimental and clinical evidence
-
Vezzani A, Granata T,. Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 2005; 46: 1724-1743.
-
(2005)
Epilepsia
, vol.46
, pp. 1724-1743
-
-
Vezzani, A.1
Granata, T.2
-
39
-
-
84873482748
-
Glia-neuronal interactions in ictogenesis and epileptogenesis: Role of inflammatory mediators
-
Noebels J.L. Avoli M. Rogawski M.A. et al, eds. 4th ed. Bethesda, MD: National Center for Biotechnology Information. Accessed June 2013
-
Vezzani A, Auvin S, Ravizza T, et al. Glia-neuronal interactions in ictogenesis and epileptogenesis: role of inflammatory mediators. In:, Noebels JL, Avoli M, Rogawski MA, et al, eds. Jasper's basic mechanisms of the epilepsies. 4th ed. Bethesda, MD: National Center for Biotechnology Information, 2012. Available at: http://www.ncbi.nlm.nih.gov/books/NBK98146/. Accessed June 2013.
-
(2012)
Jasper's Basic Mechanisms of the Epilepsies
-
-
Vezzani, A.1
Auvin, S.2
Ravizza, T.3
-
40
-
-
84874209677
-
Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain
-
Kwon YS, Pineda E, Auvin S, et al. Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain. J Neuroinflammation 2013; 10: 30.
-
(2013)
J Neuroinflammation
, vol.10
, pp. 30
-
-
Kwon, Y.S.1
Pineda, E.2
Auvin, S.3
-
41
-
-
84863769005
-
The Keap1-Nrf2 cell defense pathway - A promising therapeutic target?
-
Copple IM,. The Keap1-Nrf2 cell defense pathway-a promising therapeutic target? Adv Pharmacol 2012; 63: 43-79.
-
(2012)
Adv Pharmacol
, vol.63
, pp. 43-79
-
-
Copple, I.M.1
|