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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 10, 2013, Pages 3039-3043

Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction

(17) Hu, Longqin a,b Magesh, Sadagopan a Chen, Lin a Wang, Lili c Lewis, Timothy A c Chen, Yu a Khodier, Carol c Inoyama, Daigo a Beamer, Lesa J d Emge, Thomas J e Shen, Jian a Kerrigan, John E b Kong, Ah Ng Tony a,b Dandapani, Sivaraman c Palmer, Michelle c Schreiber, Stuart L c Munoz, Benito c

a RUTGERS UNIVERSITY (United States)

b RUTGERS CANCER INSTITUTE OF NEW JERSEY (United States)

c BROAD INSTITUTE OF MIT AND HARVARD (United States)

d University of Missouri (United States)

e RUTGERS UNIVERSITY (United States)

Author keywords

Keap1 Nrf2 Inhibitors of protein protein interaction Nrf2 activation

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BINDING AFFINITY; CHIRAL CHROMATOGRAPHY; CHIRALITY; CIS ISOMER; FLUORESCENCE POLARIZATION IMMUNOASSAY; GENE TRANSLOCATION; HIGH THROUGHPUT SCREENING; MOLECULAR PROBE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REPORTER GENE; SEPARATION TECHNIQUE; STEREOCHEMISTRY; STEREOISOMERISM; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; FLUORESCENCE POLARIZATION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; MOLECULAR IMAGING; MOLECULAR PROBES; MOLECULAR STRUCTURE; NF-E2-RELATED FACTOR 2; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84876680052 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.03.013 Document Type: Article

Times cited : (169)

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