Synthesis and bioevaluation of a series of α-pyrone derivatives as potent activators of Nrf2/ARE pathway (part I)

European Journal of Medicinal Chemistry

Volumn 66, Issue , 2013, Pages 364-371

  Xi, Mei Yang ^a   Sun, Zhong Ying ^a   Sun, Hao Peng ^a   Jia, Jian Min ^a   Jiang, Zheng Yu ^a   Tao, Lei ^a   Ye, Ming ^a   Yang, Xi ^a   Wang, Ya Jing ^a   Xue, Xin ^a   Huang, Jing Jie ^a   Gao, Yuan ^a   Guo, Xiao Ke ^a   Zhang, Sheng Lie ^a   Yang, Ying Rui ^a   Guo, Qing Long ^a   Hu, Rong ^a   You, Qi Dong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

ARE; Chemopreventive agents; Keap1; Nrf2; pyrone derivative

Indexed keywords

2 PYRONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRANSCRIPTION FACTOR NRF2; 1 (3 ACETYL 4 HYDROXY 6 METHYL 2 PYRONE) 3 (2 NAPHTHALENE) 2 EN 1 ONE; 1 (3 ACETYL 4 HYDROXY 6 METHYL 2 PYRONE) 3 (2,4 DIFLUOROPHENYL) 2 EN 1 ONE; 1 (3 ACETYL 4 HYDROXY 6 METHYL 2 PYRONE) 3 (3,4 DIFLUOROPHENYL) 2 EN 1 ONE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CONTROLLED STUDY; DATA BASE; DRUG SCREENING; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; REPORTER GENE; STRUCTURE ACTIVITY RELATION; CELL VIABILITY; CHEMOPROPHYLAXIS; CYTOTOXICITY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HYDROGEN BOND; LUCIFERASE ASSAY; OXIDATIVE STRESS; PHYSICAL CHEMISTRY; PROTEIN PHOSPHORYLATION; STEREOSPECIFICITY; UPREGULATION;

EID: 84879822953     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.06.007     Document Type: Article

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