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Volumn 43, Issue , 2015, Pages 639-644

Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism

Author keywords

Cancer; Kelch like ECH associated protein 1 (Keap1); Lipogenesis; Metabolism; Nuclear erythroid factor 2 like 2 (Nrf2); Pentose phosphate pathway

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2; KEAP1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; SIGNAL PEPTIDE;

EID: 84938796685     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20150049     Document Type: Short Survey
Times cited : (67)

References (55)
  • 1
    • 7244253081 scopus 로고    scopus 로고
    • Nrf2-Keap1 defines a physiologically important stress response mechanism
    • CrossRef PubMed
    • Motohashi, H. and Yamamoto, M. (2004) Nrf2-Keap1 defines a physiologically important stress response mechanism. Trends Mol. Med. 10, 549-557 CrossRef PubMed
    • (2004) Trends Mol. Med. , vol.10 , pp. 549-557
    • Motohashi, H.1    Yamamoto, M.2
  • 7
    • 74049120454 scopus 로고    scopus 로고
    • Nrf2: Friend or foe for chemoprevention?
    • CrossRef PubMed
    • Kensler, T.W. and Wakabayashi, N. (2010) Nrf2: friend or foe for chemoprevention? Carcinogenesis 31, 90-99 CrossRef PubMed
    • (2010) Carcinogenesis , vol.31 , pp. 90-99
    • Kensler, T.W.1    Wakabayashi, N.2
  • 8
    • 77649270763 scopus 로고    scopus 로고
    • Targeting NRF2 signaling for cancer chemoprevention
    • CrossRef PubMed
    • Kwak, M.K. and Kensler, T.W. (2010) Targeting NRF2 signaling for cancer chemoprevention. Toxicol. Appl. Pharmacol. 244, 66-76 CrossRef PubMed
    • (2010) Toxicol. Appl. Pharmacol. , vol.244 , pp. 66-76
    • Kwak, M.K.1    Kensler, T.W.2
  • 10
    • 53049105119 scopus 로고    scopus 로고
    • Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
    • CrossRef PubMed
    • Shibata, T., Kokubu, A., Gotoh, M., Ojima, H., Ohta, T., Yamamoto, M. and Hirohashi, S. (2008) Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer. Gastroenterology 135, 1358-1368, 1368 e1351-1354 CrossRef PubMed
    • (2008) Gastroenterology , vol.135
    • Shibata, T.1    Kokubu, A.2    Gotoh, M.3    Ojima, H.4    Ohta, T.5    Yamamoto, M.6    Hirohashi, S.7
  • 13
  • 15
    • 0035853157 scopus 로고    scopus 로고
    • Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
    • CrossRef PubMed
    • Ramos-Gomez, M., Kwak, M.K., Dolan, P.M., Itoh, K., Yamamoto, M., Talalay, P. and Kensler, T.W. (2001) Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 98, 3410-3415 CrossRef PubMed
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 3410-3415
    • Ramos-Gomez, M.1    Kwak, M.K.2    Dolan, P.M.3    Itoh, K.4    Yamamoto, M.5    Talalay, P.6    Kensler, T.W.7
  • 16
    • 34648830424 scopus 로고    scopus 로고
    • Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment
    • CrossRef PubMed
    • Osburn, W.O., Karim, B., Dolan, P.M., Liu, G., Yamamoto, M., Huso, D.L. and Kensler, T.W. (2007) Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. Int. J. Cancer 121, 1883-1891 CrossRef PubMed
    • (2007) Int. J. Cancer , vol.121 , pp. 1883-1891
    • Osburn, W.O.1    Karim, B.2    Dolan, P.M.3    Liu, G.4    Yamamoto, M.5    Huso, D.L.6    Kensler, T.W.7
  • 17
    • 0035875447 scopus 로고    scopus 로고
    • Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust
    • CrossRef PubMed
    • Aoki, Y., Sato, H., Nishimura, N., Takahashi, S., Itoh, K. and Yamamoto, M. (2001) Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust. Toxicol. Appl. Pharmacol. 173, 154-160 CrossRef PubMed
    • (2001) Toxicol. Appl. Pharmacol. , vol.173 , pp. 154-160
    • Aoki, Y.1    Sato, H.2    Nishimura, N.3    Takahashi, S.4    Itoh, K.5    Yamamoto, M.6
  • 18
    • 84874468267 scopus 로고    scopus 로고
    • Roles of Keap1-Nrf2 system in upper aerodigestive tract carcinogenesis
    • CrossRef
    • Ohkoshi, A., Suzuki, T., Ono, M., Kobayashi, T. and Yamamoto, M. (2013) Roles of Keap1-Nrf2 system in upper aerodigestive tract carcinogenesis. Cancer Prev. Res. 6, 149-159 CrossRef
    • (2013) Cancer Prev. Res. , vol.6 , pp. 149-159
    • Ohkoshi, A.1    Suzuki, T.2    Ono, M.3    Kobayashi, T.4    Yamamoto, M.5
  • 22
    • 77950553993 scopus 로고    scopus 로고
    • Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity
    • CrossRef PubMed
    • Pi, J., Leung, L., Xue, P., Wang, W., Hou, Y., Liu, D., Yehuda-Shnaidman, E., Lee, C., Lau, J., Kurtz, T.W. and Chan, J.Y. (2010) Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesity. J. Biol. Chem. 285, 9292-9300 CrossRef PubMed
    • (2010) J. Biol. Chem. , vol.285 , pp. 9292-9300
    • Pi, J.1    Leung, L.2    Xue, P.3    Wang, W.4    Hou, Y.5    Liu, D.6    Yehuda-Shnaidman, E.7    Lee, C.8    Lau, J.9    Kurtz, T.W.10    Chan, J.Y.11
  • 24
    • 66749112860 scopus 로고    scopus 로고
    • Genetic versus chemoprotective activation of Nrf2 signaling: Overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
    • CrossRef PubMed
    • Yates, M.S., Tran, Q.T., Dolan, P.M., Osburn, W.O., Shin, S., McCulloch, C.C., Silkworth, J.B., Taguchi, K., Yamamoto, M., Williams, C.R. et al. (2009) Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis 30, 1024-1031 CrossRef PubMed
    • (2009) Carcinogenesis , vol.30 , pp. 1024-1031
    • Yates, M.S.1    Tran, Q.T.2    Dolan, P.M.3    Osburn, W.O.4    Shin, S.5    McCulloch, C.C.6    Silkworth, J.B.7    Taguchi, K.8    Yamamoto, M.9    Williams, C.R.10
  • 26
    • 77953290236 scopus 로고    scopus 로고
    • Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver
    • CrossRef PubMed
    • Kitteringham, N.R., Abdullah, A., Walsh, J., Randle, L., Jenkins, R.E., Sison, R., Goldring, C.E., Powell, H., Sanderson, C., Williams, S. et al. (2010) Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. J. Proteomics 73, 1612-1631 CrossRef PubMed
    • (2010) J. Proteomics , vol.73 , pp. 1612-1631
    • Kitteringham, N.R.1    Abdullah, A.2    Walsh, J.3    Randle, L.4    Jenkins, R.E.5    Sison, R.6    Goldring, C.E.7    Powell, H.8    Sanderson, C.9    Williams, S.10
  • 27
    • 77953460849 scopus 로고    scopus 로고
    • Genetic analysis of cytoprotective functions supported by graded expression of Keap1
    • CrossRef PubMed
    • Taguchi, K., Maher, J.M., Suzuki, T., Kawatani, Y., Motohashi, H. and Yamamoto, M. (2010) Genetic analysis of cytoprotective functions supported by graded expression of Keap1. Mol. Cell. Biol. 30, 3016-3026 CrossRef PubMed
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 3016-3026
    • Taguchi, K.1    Maher, J.M.2    Suzuki, T.3    Kawatani, Y.4    Motohashi, H.5    Yamamoto, M.6
  • 30
    • 78650355319 scopus 로고    scopus 로고
    • The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice
    • CrossRef PubMed
    • Saha, P.K., Reddy, V.T., Konopleva, M., Andreeff, M. and Chan, L. (2010) The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice. J. Biol. Chem. 285, 40581-40592 CrossRef PubMed
    • (2010) J. Biol. Chem. , vol.285 , pp. 40581-40592
    • Saha, P.K.1    Reddy, V.T.2    Konopleva, M.3    Andreeff, M.4    Chan, L.5
  • 32
    • 77952952816 scopus 로고    scopus 로고
    • Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet
    • CrossRef PubMed
    • Zhang, Y.K., Yeager, R.L., Tanaka, Y. and Klaassen, C.D. (2010) Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Toxicol. Appl. Pharmacol. 245, 326-334 CrossRef PubMed
    • (2010) Toxicol. Appl. Pharmacol. , vol.245 , pp. 326-334
    • Zhang, Y.K.1    Yeager, R.L.2    Tanaka, Y.3    Klaassen, C.D.4
  • 33
    • 84877809314 scopus 로고    scopus 로고
    • New player on an old field; the keap1/Nrf2 pathway as a target for treatment of type 2 diabetes and metabolic syndrome
    • PubMed
    • Chartoumpekis, D.V. and Kensler, T.W. (2013) New player on an old field; the keap1/Nrf2 pathway as a target for treatment of type 2 diabetes and metabolic syndrome. Curr. Diabetes Rev. 9, 137-145 PubMed
    • (2013) Curr. Diabetes Rev. , vol.9 , pp. 137-145
    • Chartoumpekis, D.V.1    Kensler, T.W.2
  • 34
    • 84897421970 scopus 로고    scopus 로고
    • The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
    • CrossRef PubMed
    • Hayes, J.D. and Dinkova-Kostova, A.T. (2014) The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem. Sci. 39, 199-218 CrossRef PubMed
    • (2014) Trends Biochem. Sci. , vol.39 , pp. 199-218
    • Hayes, J.D.1    Dinkova-Kostova, A.T.2
  • 35
    • 84862996501 scopus 로고    scopus 로고
    • Physiology. De-meaning of metabolism
    • Lazar, M.A. and Birnbaum, M.J. (2012) Physiology. De-meaning of metabolism. Science 336, 1651-1652
    • (2012) Science , vol.336 , pp. 1651-1652
    • Lazar, M.A.1    Birnbaum, M.J.2
  • 36
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • PubMed
    • Warburg, O. (1956) On respiratory impairment in cancer cells. Science 124, 269-270 PubMed
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 37
    • 84883497454 scopus 로고    scopus 로고
    • Glutamine and cancer: Cell biology, physiology, and clinical opportunities
    • CrossRef PubMed
    • Hensley, C.T., Wasti, A.T. and DeBerardinis, R.J. (2013) Glutamine and cancer: cell biology, physiology, and clinical opportunities. J. Clin. Invest. 123, 3678-3684 CrossRef PubMed
    • (2013) J. Clin. Invest. , vol.123 , pp. 3678-3684
    • Hensley, C.T.1    Wasti, A.T.2    DeBerardinis, R.J.3
  • 38
    • 84888866083 scopus 로고    scopus 로고
    • Hooked on fat: The role of lipid synthesis in cancer metabolism and tumour development
    • CrossRef
    • Baenke, F., Peck, B., Miess, H. and Schulze, A. (2013) Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development. Dis. Models Mech. 6, 1353-1363 CrossRef
    • (2013) Dis. Models Mech. , vol.6 , pp. 1353-1363
    • Baenke, F.1    Peck, B.2    Miess, H.3    Schulze, A.4
  • 40
    • 70350728803 scopus 로고    scopus 로고
    • MYC-induced cancer cell energy metabolism and therapeutic opportunities
    • CrossRef PubMed
    • Dang, C.V., Le, A. and Gao, P. (2009) MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin. Cancer Res. 15, 6479-6483 CrossRef PubMed
    • (2009) Clin. Cancer Res. , vol.15 , pp. 6479-6483
    • Dang, C.V.1    Le, A.2    Gao, P.3
  • 41
    • 60549083256 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism by hypoxia-inducible factor 1
    • CrossRef PubMed
    • Semenza, G.L. (2009) Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin. Cancer Biol. 19, 12-16 CrossRef PubMed
    • (2009) Semin. Cancer Biol. , vol.19 , pp. 12-16
    • Semenza, G.L.1
  • 42
    • 70349459599 scopus 로고    scopus 로고
    • p53 and metabolism
    • CrossRef PubMed
    • Vousden, K.H. and Ryan, K.M. (2009) p53 and metabolism. Nat. Rev. Cancer 9, 691-700 CrossRef PubMed
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 691-700
    • Vousden, K.H.1    Ryan, K.M.2
  • 43
    • 79251517382 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism
    • CrossRef PubMed
    • Cairns, R.A., Harris, I.S. and Mak, T.W. (2011) Regulation of cancer cell metabolism. Nat. Rev. Cancer 11, 85-95 CrossRef PubMed
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 85-95
    • Cairns, R.A.1    Harris, I.S.2    Mak, T.W.3
  • 44
    • 84862908756 scopus 로고    scopus 로고
    • Activation of androgen receptor, lipogenesis, and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells
    • CrossRef PubMed
    • Huang, W.C., Li, X., Liu, J., Lin, J. and Chung, L.W. (2012) Activation of androgen receptor, lipogenesis, and oxidative stress converged by SREBP-1 is responsible for regulating growth and progression of prostate cancer cells. Mol. Cancer Res. 10, 133-142 CrossRef PubMed
    • (2012) Mol. Cancer Res. , vol.10 , pp. 133-142
    • Huang, W.C.1    Li, X.2    Liu, J.3    Lin, J.4    Chung, L.W.5
  • 45
    • 34548814981 scopus 로고    scopus 로고
    • Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells
    • CrossRef PubMed
    • Yoon, S., Lee, M.Y., Park, S.W., Moon, J.S., Koh, Y.K., Ahn, Y.H., Park, B.W. and Kim, K.S. (2007) Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. J. Biol. Chem. 282, 26122-26131 CrossRef PubMed
    • (2007) J. Biol. Chem. , vol.282 , pp. 26122-26131
    • Yoon, S.1    Lee, M.Y.2    Park, S.W.3    Moon, J.S.4    Koh, Y.K.5    Ahn, Y.H.6    Park, B.W.7    Kim, K.S.8
  • 50
    • 80053452983 scopus 로고    scopus 로고
    • Beneficial role of Nrf2 in regulating NADPH generation and consumption
    • CrossRef PubMed
    • Wu, K.C., Cui, J.Y. and Klaassen, C.D. (2011) Beneficial role of Nrf2 in regulating NADPH generation and consumption. Toxicol. Sci. 123, 590-600 CrossRef PubMed
    • (2011) Toxicol. Sci. , vol.123 , pp. 590-600
    • Wu, K.C.1    Cui, J.Y.2    Klaassen, C.D.3
  • 51
    • 0037106099 scopus 로고    scopus 로고
    • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
    • PubMed
    • Thimmulappa, R.K., Mai, K.H., Srisuma, S., Kensler, T.W., Yamamoto, M. and Biswal, S. (2002) Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 62, 5196-5203 PubMed
    • (2002) Cancer Res. , vol.62 , pp. 5196-5203
    • Thimmulappa, R.K.1    Mai, K.H.2    Srisuma, S.3    Kensler, T.W.4    Yamamoto, M.5    Biswal, S.6
  • 54
    • 33746291023 scopus 로고    scopus 로고
    • Increased lipogenesis in cancer cells: New players, novel targets
    • CrossRef PubMed
    • Swinnen, J.V., Brusselmans, K. and Verhoeven, G. (2006) Increased lipogenesis in cancer cells: new players, novel targets. Curr. Opin. Clin. Nutr. Metab. Care 9, 358-365 CrossRef PubMed
    • (2006) Curr. Opin. Clin. Nutr. Metab. Care , vol.9 , pp. 358-365
    • Swinnen, J.V.1    Brusselmans, K.2    Verhoeven, G.3
  • 55
    • 0346003777 scopus 로고    scopus 로고
    • Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression
    • CrossRef PubMed
    • Yu, S., Matsusue, K., Kashireddy, P., Cao, W.Q., Yeldandi, V., Yeldandi, A.V., Rao, M.S., Gonzalez, F.J. and Reddy, J.K. (2003) Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression. J. Biol. Chem. 278, 498-505 CrossRef PubMed
    • (2003) J. Biol. Chem. , vol.278 , pp. 498-505
    • Yu, S.1    Matsusue, K.2    Kashireddy, P.3    Cao, W.Q.4    Yeldandi, V.5    Yeldandi, A.V.6    Rao, M.S.7    Gonzalez, F.J.8    Reddy, J.K.9


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