Applying thermodynamic profiling in lead finding and optimization

Nature Reviews Drug Discovery

Volumn 14, Issue 2, 2015, Pages 95-110

  Klebe, Gerhard ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

THROMBIN INHIBITOR; LIGAND; MOLECULAR LIBRARY; PROTEIN BINDING;

BINDING AFFINITY; BINDING SITE; CHEMICAL STRUCTURE; COMPLEX FORMATION; DESOLVATION; DRUG RECEPTOR BINDING; DRUG RESEARCH; ENTHALPY; ENTROPY; HYDROGEN BOND; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; LIPOPHILICITY; MOLECULAR INTERACTION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; REVIEW; SOLUTION AND SOLUBILITY; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY; CHEMISTRY; DRUG DEVELOPMENT; MEDICINAL CHEMISTRY; MOLECULAR LIBRARY; PHARMACOLOGY; PROCEDURES;

BINDING SITES; CHEMISTRY, PHARMACEUTICAL; DRUG DISCOVERY; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHYSICOCHEMICAL PHENOMENA; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; THERMODYNAMICS;

EID: 84926158682     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4486     Document Type: Review

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