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Volumn 5, Issue 1, 2014, Pages 93-98

Novel protein-protein interaction inhibitor of Nrf2-Keap1 discovered by structure-based virtual screening

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS AFFECTING PROTEIN METABOLISM; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LH 601; PROTEIN INHIBITOR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

EID: 84890849400     PISSN: 20402503     EISSN: 20402511     Source Type: Journal    
DOI: 10.1039/c3md00240c     Document Type: Article
Times cited : (57)

References (28)
  • 1
    • 0034626735 scopus 로고    scopus 로고
    • Oxidants, oxidative stress and the biology of ageing
    • T. Finkel N. J. Holbrook Oxidants, oxidative stress and the biology of ageing Nature 2000 408 6809 239 247
    • (2000) Nature , vol.408 , Issue.6809 , pp. 239-247
    • Finkel, T.1    Holbrook, N.J.2
  • 3
    • 54549093803 scopus 로고    scopus 로고
    • Ageing, oxidative stress and cancer: Paradigms in parallax
    • C. C. Benz C. Yau Ageing, oxidative stress and cancer: paradigms in parallax Nat. Rev. Cancer 2008 8 11 875 879
    • (2008) Nat. Rev. Cancer , vol.8 , Issue.11 , pp. 875-879
    • Benz, C.C.1    Yau, C.2
  • 4
    • 0035005065 scopus 로고    scopus 로고
    • Oxidative stress and antioxidants in exercise
    • C. Leeuwenburgh J. W. Heinecke Oxidative stress and antioxidants in exercise Curr. Med. Chem. 2001 8 7 829 838
    • (2001) Curr. Med. Chem. , vol.8 , Issue.7 , pp. 829-838
    • Leeuwenburgh, C.1    Heinecke, J.W.2
  • 5
    • 79954504166 scopus 로고    scopus 로고
    • Basic principles and emerging concepts in the redox control of transcription factors
    • R. Brigelius-Flohe L. Flohe Basic principles and emerging concepts in the redox control of transcription factors Antioxid. Redox Signaling 2011 15 8 2335 2381
    • (2011) Antioxid. Redox Signaling , vol.15 , Issue.8 , pp. 2335-2381
    • Brigelius-Flohe, R.1    Flohe, L.2
  • 6
    • 0028061444 scopus 로고
    • Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region
    • P. Moi K. Chan I. Asunis A. Cao Y. W. Kan Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region Proc. Natl. Acad. Sci. U. S. A. 1994 91 21 9926 9930
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , Issue.21 , pp. 9926-9930
    • Moi, P.1    Chan, K.2    Asunis, I.3    Cao, A.4    Kan, Y.W.5
  • 7
    • 0029043995 scopus 로고
    • Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins
    • K. Itoh K. Igarashi N. Hayashi M. Nishizawa M. Yamamoto Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins Mol. Cell. Biol. 1995 15 8 4184 4193
    • (1995) Mol. Cell. Biol. , vol.15 , Issue.8 , pp. 4184-4193
    • Itoh, K.1    Igarashi, K.2    Hayashi, N.3    Nishizawa, M.4    Yamamoto, M.5
  • 9
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • T. W. Kensler N. Wakabayashi S. Biswal Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway Annu. Rev. Pharmacol. 2007 47 89 116
    • (2007) Annu. Rev. Pharmacol. , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 10
    • 84863825248 scopus 로고    scopus 로고
    • Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents
    • S. Magesh Y. Chen L. Hu Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents Med. Res. Rev. 2012 32 4 687 726
    • (2012) Med. Res. Rev. , vol.32 , Issue.4 , pp. 687-726
    • Magesh, S.1    Chen, Y.2    Hu, L.3
  • 13
    • 79851512889 scopus 로고    scopus 로고
    • Small molecule modulators of antioxidant response pathway
    • W. Hur N. S. Gray Small molecule modulators of antioxidant response pathway Curr. Opin. Chem. Biol. 2011 15 1 162 173
    • (2011) Curr. Opin. Chem. Biol. , vol.15 , Issue.1 , pp. 162-173
    • Hur, W.1    Gray, N.S.2
  • 16
    • 33747728194 scopus 로고    scopus 로고
    • Dimerization of Substrate Adaptors Can Facilitate Cullin-Mediated Ubiquitylation of Proteins by a Tethering, Mechanism
    • M. McMahon N. Thomas K. Itoh M. Yamamoto J. D. Hayes Dimerization of Substrate Adaptors Can Facilitate Cullin-Mediated Ubiquitylation of Proteins by a Tethering, Mechanism J. Biol. Chem. 2006 281 34 24756
    • (2006) J. Biol. Chem. , vol.281 , Issue.34 , pp. 24756
    • McMahon, M.1    Thomas, N.2    Itoh, K.3    Yamamoto, M.4    Hayes, J.D.5
  • 17
    • 33344463325 scopus 로고    scopus 로고
    • Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model
    • K. I. Tong Y. Katoh H. Kusunoki K. Itoh T. Tanaka M. Yamamoto Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model Mol. Cell. Biol. 2006 26 8 2887 2900
    • (2006) Mol. Cell. Biol. , vol.26 , Issue.8 , pp. 2887-2900
    • Tong, K.I.1    Katoh, Y.2    Kusunoki, H.3    Itoh, K.4    Tanaka, T.5    Yamamoto, M.6
  • 18
    • 33750613056 scopus 로고    scopus 로고
    • Two-site substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism
    • K. I. Tong A. Kobayashi F. Katsuoka M. Yamamoto Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism Biol. Chem. 2006 387 10-11 1311 1320
    • (2006) Biol. Chem. , vol.387 , Issue.1011 , pp. 1311-1320
    • Tong, K.I.1    Kobayashi, A.2    Katsuoka, F.3    Yamamoto, M.4
  • 19
    • 35648970026 scopus 로고    scopus 로고
    • Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response
    • K. I. Tong B. Padmanabhan A. Kobayashi C. Shang Y. Hirotsu S. Yokoyama M. Yamamoto Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response Mol. Cell. Biol. 2007 27 21 7511 7521
    • (2007) Mol. Cell. Biol. , vol.27 , Issue.21 , pp. 7511-7521
    • Tong, K.I.1    Padmanabhan, B.2    Kobayashi, A.3    Shang, C.4    Hirotsu, Y.5    Yokoyama, S.6    Yamamoto, M.7
  • 21
    • 33747606306 scopus 로고    scopus 로고
    • Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling
    • S.-C. Lo X. Li M. T. Henzl L. J. Beamer M. Hannink Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling EMBO J. 2006 25 15 3605 3617
    • (2006) EMBO J. , vol.25 , Issue.15 , pp. 3605-3617
    • Lo, S.-C.1    Li, X.2    Henzl, M.T.3    Beamer, L.J.4    Hannink, M.5
  • 23
    • 84861088185 scopus 로고    scopus 로고
    • Anti-Inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2-Keap1 Interaction
    • R. Steel J. Cowan E. Payerne M. A. O'Connell M. Searcey Anti-Inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2-Keap1 Interaction ACS Med. Chem. Lett. 2012 3 5 407 410
    • (2012) ACS Med. Chem. Lett. , vol.3 , Issue.5 , pp. 407-410
    • Steel, R.1    Cowan, J.2    Payerne, E.3    O'Connell, M.A.4    Searcey, M.5
  • 24
    • 84877659801 scopus 로고    scopus 로고
    • Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction with improved binding and cellular activity
    • R. Hancock M. Schaap H. Pfister G. Wells Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction with improved binding and cellular activity Org. Biomol. Chem. 2013 11 21 3553 3557
    • (2013) Org. Biomol. Chem. , vol.11 , Issue.21 , pp. 3553-3557
    • Hancock, R.1    Schaap, M.2    Pfister, H.3    Wells, G.4
  • 25
    • 84884172226 scopus 로고    scopus 로고
    • Insight into the Intermolecular Recognition Mechanism between Keap1 and IKKβ Combining Homology Modelling, Protein-Protein Docking, Molecular Dynamics Simulations and Virtual Alanine Mutation
    • Z.-Y. Jiang H.-X. Chu M.-Y. Xi T.-T. Yang J.-M. Jia J.-J. Huang X.-K. Guo X.-J. Zhang Q.-D. You H.-P. Sun Insight into the Intermolecular Recognition Mechanism between Keap1 and IKKβ Combining Homology Modelling, Protein-Protein Docking, Molecular Dynamics Simulations and Virtual Alanine Mutation PLoS One 2013 8 9 e75076
    • (2013) PLoS One , vol.8 , Issue.9 , pp. 75076
    • Jiang, Z.-Y.1    Chu, H.-X.2    Xi, M.-Y.3    Yang, T.-T.4    Jia, J.-M.5    Huang, J.-J.6    Guo, X.-K.7    Zhang, X.-J.8    You, Q.-D.9    Sun, H.-P.10
  • 26
    • 77249106566 scopus 로고    scopus 로고
    • Three-dimensional pharmacophore methods in drug discovery
    • A. R. Leach V. J. Gillet R. A. Lewis R. Taylor Three-dimensional pharmacophore methods in drug discovery J. Med. Chem. 2010 53 2 539 558
    • (2010) J. Med. Chem. , vol.53 , Issue.2 , pp. 539-558
    • Leach, A.R.1    Gillet, V.J.2    Lewis, R.A.3    Taylor, R.4
  • 27
    • 79957946803 scopus 로고    scopus 로고
    • Pharmacophore Modelling: A Forty Year Old Approach and its Modern Synergies
    • F. Caporuscio A. Tafi Pharmacophore Modelling: A Forty Year Old Approach and its Modern Synergies Curr. Med. Chem. 2011 18 17 2543 2553
    • (2011) Curr. Med. Chem. , vol.18 , Issue.17 , pp. 2543-2553
    • Caporuscio, F.1    Tafi, A.2
  • 28
    • 84858987152 scopus 로고    scopus 로고
    • Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction
    • D. Inoyama Y. Chen X. Huang L. J. Beamer A. N. Kong L. Hu Optimization of fluorescently labeled Nrf2 peptide probes and the development of a fluorescence polarization assay for the discovery of inhibitors of Keap1-Nrf2 interaction J. Biomol. Screening 2012 17 4 435 447
    • (2012) J. Biomol. Screening , vol.17 , Issue.4 , pp. 435-447
    • Inoyama, D.1    Chen, Y.2    Huang, X.3    Beamer, L.J.4    Kong, A.N.5    Hu, L.6


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