Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 29, 2005, Pages 10070-10075

  Eggler, Aimee L ^a   Liu, Guowen ^a   Pezzuto, John M ^b   Van Breemen, Richard B ^a   Mesecar, Andrew D ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

15 deoxy 12,14 prostaglandin J2; Antioxidant response element; Oxidative stress; Sulforaphane; Ubiquitination

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 15 DEOXY DELTA12,14 PROSTAGLANDIN J2; CELL PROTEIN; CYSTEINE; IODOACETAMIDE; ISOLIQUIRITIGENIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MENADIONE; NEH2 PROTEIN; REACTIVE OXYGEN METABOLITE; SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BINDING SITE; BIOACCUMULATION; CANCER RISK; CELL NUCLEUS; CHEMICAL REACTION; COMPLEX FORMATION; DEGENERATIVE DISEASE; DISSOCIATION; ENZYME ACTIVATION; ENZYME INDUCTION; GENE ACTIVATION; ISOTHERMAL TITRATION CALORIMETRY; MASS SPECTROMETRY; MOLECULAR MODEL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STOICHIOMETRY;

ANIMALS; BIOLOGICAL RESPONSE MODIFIERS; CALORIMETRY; CHALCONE; CHALCONES; CLONING, MOLECULAR; CYSTEINE; DINITROBENZENES; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INDUCTION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; IODOACETAMIDE; MODELS, MOLECULAR; MULTIPROTEIN COMPLEXES; NF-E2-RELATED FACTOR 2; PROSTAGLANDIN D2; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEINS; THIOCYANATES; TRANS-ACTIVATORS; VITAMIN K 3;

EID: 22544464124     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0502402102     Document Type: Article

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