The Keap1/Nrf2 pathway in health and disease: From the bench to the clinic

Biochemical Society Transactions

Volumn 43, Issue , 2015, Pages 687-689

  O'Connell, Maria A ^a   Hayes, John D ^b  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Cytoprotection; Kelch like ECH associated protein 1 (Keap1); Nuclear factor erythroid 2 p45 related factor 2 (Nrf2); Redox; Signalling; Stress

Indexed keywords

BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; GLYCOGEN SYNTHASE KINASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRANSCRIPTION FACTOR NRF2; UBIQUITIN PROTEIN LIGASE E3; KEAP1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; SIGNAL PEPTIDE;

AGING; ARTICLE; CHEMOPROPHYLAXIS; DEGENERATIVE DISEASE; DRUG METABOLISM; DRUG RESISTANCE; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; HEALTH; HUMAN; INFLAMMATION; LIPOGENESIS; METABOLISM; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; REDOX STRESS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; HOMEOSTASIS; ORGANIZATION; OXIDATION REDUCTION REACTION;

ANIMALS; CONGRESSES AS TOPIC; HOMEOSTASIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; SIGNAL TRANSDUCTION;

EID: 84938765962     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20150069     Document Type: Article

References (15)

1. Dinkova-Kostova, A., Baird, L., Hölmstrom, K.M., Meyer, C.J. and Abramov, A.Y. (2015) The spatiotemporal regulation of the Keap1/Nrf2 pathway and its importance in cellular bioenergetics. Biochem. Soc. Trans.
2. Hayes, J.D., Chowdhry, S., Dinkova-Kostova, A. and Sutherland, C. (2015) Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3. Biochem. Soc. Trans.
3. Wardyn, J.D., Ponsford, A. and Sanderson, C. (2015) Dissecting molecular crosstalk between Nrf2 and NF-κB response pathways. Biochem. Soc. Trans.
4. Chartoumpekis, D., Wakabayashi, N. and Kensler, T.W. (2015) Nrf2: structure, function and regulation of activity. Biochem. Soc. Trans.
5. Kurinna, S. and Werner, S. (2015) Nrf2 and microRNAs: new but awaited relations. Biochem. Soc. Trans.
6. Harder, B., Jiang, T., Wu, T., Tao, S., De La Vega, M.R., Tian, W., Chapman, E. and Zhang, D.D. (2015) Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention. Biochem. Soc. Trans.
7. Xue, M., Momiji, H., Rabbani, N., Bretschneider, T., Rand, D.A. and Thornalley, P.J. (2015) Frequency modulated translocational oscillations of Nrf2 - a transcription factor functioning like a wireless sensor. Biochem. Soc. Trans.
8. Schmidt, E. (2015) Interplay between cytosolic disulfide reductase systems and the Nrf2/Keap1 pathway. Biochem. Soc. Trans.
9. Madhavan, L. (2015) Redox-based regulation of neural stem cell function and its implications for brain repair. Biochem. Soc. Trans.
10. Soares, M.P. and Ribeiro, A.M. (2015) Nrf2 acts as a master regulator of tissue damage control and Disease tolerance to infection. Biochem. Soc. Trans.
11. Mutter, F.E., Park, B.K. and Copple, I.M. (2015) Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress. Biochem. Soc. Trans.
12. Sandhu, I., Maksim, N.J., Amouzougan, E.A., Gallion, B.W., Raviele, A.L. and Ooi, A. (2015) Sustained Nrf2 activation in hereditary leiomyomatosis and renal cell cancer (HLRCC) and in hereditary tyrosinemia type 1 (HT1). Biochem. Soc. Trans.
13. Leinonen, H., Kansanen, E., Pölönen, P., Heinäniemi, M. and Levonen, A.-L. (2015) Dysregulation of the Keap1-Nrf2 pathway in cancer. Biochem. Soc. Trans.
14. Yates, M.S., Tauchi, M., Katsuoka, F., Flanders, K.C., Liby, K.T., Honda, T., Gribble, G.W., Johnson, D.A., Johnson, J.A., Burton, N.C. et al. (2007) Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Mol. Cancer Ther. 6, 154-162
15. Wells, G. (2015) Peptide and small molecule inhibitors of the Keap1-Nrf2 protein-protein interaction. Biochem. Soc. Trans.