Thermodynamic profiling of inhibitors of Nrf2:Keap1 interactions

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 2, 2016, Pages 526-529

  Nasiri, Hamid R ^a   Linge, Sandra ^a   Ullmann, Dirk ^a  

^a EVOTEC AG   (Germany)

Author keywords

Nrf2:Keap1 interactions; Protein protein interaction; Thermodynamic profiling; Tracer displacement assay

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; TRACER; TRANSCRIPTION FACTOR NRF2; MR121 OXAZINE FLUOROPHORE; OXAZINE DERIVATIVE; PROTEIN BINDING; PYRROLIDINE DERIVATIVE; RA839 COMPOUND; SULFONAMIDE;

ARTICLE; BINDING AFFINITY; CHEMICAL PARAMETERS; CLINICAL PROTOCOL; COMPARATIVE STUDY; DISSOCIATION CONSTANT; ENZYME INHIBITION; FOLLOW UP; GENE EXPRESSION; GENE EXPRESSION PROFILING; IC50; MEDICINAL CHEMISTRY; NONHUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PROCESS OPTIMIZATION; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; THERMODYNAMICS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; HIGH THROUGHPUT SCREENING; PROCEDURES; PROTEIN QUATERNARY STRUCTURE; TEMPERATURE;

HIGH-THROUGHPUT SCREENING ASSAYS; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; NF-E2-RELATED FACTOR 2; OXAZINES; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PYRROLIDINES; SULFONAMIDES; TEMPERATURE; THERMODYNAMICS;

EID: 84952990249     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.11.082     Document Type: Article

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