3-aroylmethylene-2,3,6,7-tetrahydro-1 H -pyrazino[2,1- a ]isoquinolin-4(11b H)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice

Journal of Medicinal Chemistry

Volumn 56, Issue 20, 2013, Pages 7925-7938

  Xi, Mei Yang ^a   Jia, Jian Min ^a   Sun, Hao Peng ^a   Sun, Zhong Ying ^a   Jiang, Jie Wei ^a   Wang, Ya Jing ^a   Zhang, Min Ye ^a   Zhu, Jun Feng ^a   Xu, Li Li ^a   Jiang, Zheng Yu ^a   Xue, Xin ^a   Ye, Ming ^a   Yang, Xi ^a   Gao, Yuan ^a   Tao, Lei ^a   Guo, Xiao Ke ^a   Xu, Xiao Li ^a   Guo, Qing Long ^a   Zhang, Xiao Jin ^a   Hu, Rong ^a   You, Qi Dong ^a   more..

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 OXO 2 PHENYLETHYLIDENE) 10 METHOXY 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 (2 OXO 2 PHENYLETHYLIDENE) 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (2 CHLOROPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (2 FLUOROPHENYL) 2 OXOETHYLIDENE] 10 METHOXY 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (2 FLUOROPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (2 METHOXYPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (2 NITROPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (2,4 DICHLOROPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (3 CHLOROPHENYL) 2 OXOETHYLIDENE] 10 METHOXY 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (3 CHLOROPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (3 FLUOROPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (3 METHOXYPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (3 NITROPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (3,4 DICHLOROPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (3,4 DIFLUOROPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (3,4 DIMETHOXYPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (4 CHLOROPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (4 FLUOROPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (4 METHOXYPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 (4 NITROPHENYL) 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 OXO 2 (4 TOLYL)ETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; 3 [2 [(1,1' BIPHENYL) 4 YL] 2 OXOETHYLIDENE] 2,3,6,7 TETRAHYDRO 1H PYRAZINO[2,1 A]ISOQUINOLIN 4(11BH) ONE; ANTINEOPLASTIC AGENT; HEME OXYGENASE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISOQUINOLINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CANCER CELL; COLORECTAL ADENOMA; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR MODEL;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOMA; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANT RESPONSE ELEMENTS; AZOXYMETHANE; BLOTTING, WESTERN; CELL NUCLEUS; COLORECTAL NEOPLASMS; DEXTRAN SULFATE; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HEME OXYGENASE-1; HEP G2 CELLS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NAD(P)H DEHYDROGENASE (QUINONE); NEOPLASMS; NF-E2-RELATED FACTOR 2;

EID: 84886564402     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm400944k     Document Type: Article

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