Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis

Journal of Computer-Aided Molecular Design

Volumn 28, Issue 12, 2014, Pages 1233-1245

  Jiang, Zheng Yu ^a   Xu, Li Li ^a   Lu, Meng Chen ^a   Pan, Yang ^a   Huang, Hao Ze ^a   Zhang, Xiao Jin ^a   Sun, Hao Peng ^a   You, Qi Dong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

E3 ubiquitin ligase; Keap1; Nrf2; Protein protein interaction

Indexed keywords

BINDING ENERGY; BIOINFORMATICS; ENZYMES; MACHINERY; MOLECULAR DYNAMICS;

BINDING DETERMINANT; E3 LIGASE; E3 UBIQUITIN LIGASES; INTERMOLECULAR RECOGNITION; KELCH-LIKE ECH-ASSOCIATED PROTEIN-1; MULTIPLE SUBSTRATES; NON-POLAR; NRF2; PROTEIN-PROTEIN INTERACTIONS; RECOGNITION MECHANISM;

SUBSTRATES;

CARBOXYL GROUP; HYDROGEN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; OXYGEN; PEPTIDE; SERINE; ANTIOXIDANT; KEAP1 PROTEIN, HUMAN; SIGNAL PEPTIDE; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DECOMPOSITION; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; HYDROGEN BOND; INTERMOLECULAR RECOGNITION; INVESTIGATIVE PROCEDURES; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MOLECULAR RECOGNITION; PRIORITY JOURNAL; QUANTITATIVE STUDY; RECOGNITION; STATIC ELECTRICITY; STEREOSPECIFICITY; STRESS; SURFACE AREA; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYME SPECIFICITY; PROTEIN PROTEIN INTERACTION; PROTEIN TERTIARY STRUCTURE;

ANTIOXIDANTS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR DYNAMICS SIMULATION; PROTEIN INTERACTION MAPS; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 84922080266     PISSN: 0920654X     EISSN: 15734951     Source Type: Journal    
DOI: 10.1007/s10822-014-9799-y     Document Type: Article

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