-
1
-
-
63149139630
-
Post-translational modifications of expanded polyglutamine proteins: Impact on neurotoxicity
-
Pennuto, M., Palazzolo, I., and Poletti, A., Post-translational modifications of expanded polyglutamine proteins: impact on neurotoxicity, Hum Mol Genet, 2009; 18(R1): R40-47.
-
(2009)
Hum Mol Genet
, vol.18
, Issue.R1
, pp. R40-R47
-
-
Pennuto, M.1
Palazzolo, I.2
Poletti, A.3
-
2
-
-
37849030901
-
Polyglutamine diseases: Emerging concepts in pathogenesis and therapy
-
Shao, J., and Diamond, M.I., Polyglutamine diseases: emerging concepts in pathogenesis and therapy, Hum Mol Genet, 2007;16 Spec No. 2: R115-123.
-
(2007)
Hum Mol Genet
, vol.16
, pp. R115-R123
-
-
Shao, J.1
Diamond, M.I.2
-
3
-
-
84874872486
-
Putting huntingtin "aggregation" in view with windows into the cellular milieu
-
Hatters, D.M., Putting huntingtin "aggregation" in view with windows into the cellular milieu, Current topics in medicinal chemistry, 2012; 12(22): 2611-2622.
-
(2012)
Current Topics in Medicinal Chemistry
, vol.12
, Issue.22
, pp. 2611-2622
-
-
Hatters, D.M.1
-
4
-
-
0037059042
-
Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity
-
Sakahira, H., Breuer, P., Hayer-Hartl, M.K., and Hartl, F.U., Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity, Proc Natl Acad Sci U S A, 2002; 99 Suppl 4: 16412-16418.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 16412-16418
-
-
Sakahira, H.1
Breuer, P.2
Hayer-Hartl, M.K.3
Hartl, F.U.4
-
5
-
-
78650811716
-
Formation and toxicity of soluble polyglutamine oligomers in living cells
-
Lajoie, P., and Snapp, E.L., Formation and toxicity of soluble polyglutamine oligomers in living cells, PLoS One, 2010; 5(12): e15245.
-
(2010)
PLoS One
, vol.5
, Issue.12
-
-
Lajoie, P.1
Snapp, E.L.2
-
6
-
-
3042717240
-
Cellular toxicity of polyglutamine expansion proteins: Mechanism of transcription factor deactivation
-
Schaffar, G., Breuer, P., Boteva, R., Behrends, C., Tzvetkov, N., Strippel, N., Sakahira, H., Siegers, K., Hayer-Hartl, M., and Hartl, F.U., Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation, Mol Cell, 2004; 15(1): 95-105.
-
(2004)
Mol Cell
, vol.15
, Issue.1
, pp. 95-105
-
-
Schaffar, G.1
Breuer, P.2
Boteva, R.3
Behrends, C.4
Tzvetkov, N.5
Strippel, N.6
Sakahira, H.7
Siegers, K.8
Hayer-Hartl, M.9
Hartl, F.U.10
-
7
-
-
38349158062
-
Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic
-
Takahashi, T., Kikuchi, S., Katada, S., Nagai, Y., Nishizawa, M., and Onodera, O., Soluble polyglutamine oligomers formed prior to inclusion body formation are cytotoxic, Hum Mol Genet, 2008; 17(3): 345-356.
-
(2008)
Hum Mol Genet
, vol.17
, Issue.3
, pp. 345-356
-
-
Takahashi, T.1
Kikuchi, S.2
Katada, S.3
Nagai, Y.4
Nishizawa, M.5
Onodera, O.6
-
8
-
-
84887792874
-
Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress
-
Leitman, J., Ulrich Hartl, F., and Lederkremer, G.Z., Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress, Nat Commun, 2013; 4: 2753.
-
(2013)
Nat Commun
, vol.4
, pp. 2753
-
-
Leitman, J.1
Ulrich Hartl, F.2
Lederkremer, G.Z.3
-
9
-
-
84912100068
-
Potential function for the Huntingtin protein as a scaffold for selective autophagy
-
Ochaba, J., Lukacsovich, T., Csikos, G., Zheng, S., Margulis, J., Salazar, L., Mao, K., Lau, A.L., Yeung, S.Y., Humbert, S., et al., Potential function for the Huntingtin protein as a scaffold for selective autophagy, Proc Natl Acad Sci U S A, 2014; 111(47): 16889-16894.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, Issue.47
, pp. 16889-16894
-
-
Ochaba, J.1
Lukacsovich, T.2
Csikos, G.3
Zheng, S.4
Margulis, J.5
Salazar, L.6
Mao, K.7
Lau, A.L.8
Yeung, S.Y.9
Humbert, S.10
-
10
-
-
84923789937
-
Huntingtin functions as a scaffold for selective macroautophagy
-
Rui, Y.N., Xu, Z., Patel, B., Chen, Z., Chen, D., Tito, A., David, G., Sun, Y., Stimming, E.F., Bellen, H.J., et al., Huntingtin functions as a scaffold for selective macroautophagy, Nat Cell Biol, 2015; 17(3): 262-275.
-
(2015)
Nat Cell Biol
, vol.17
, Issue.3
, pp. 262-275
-
-
Rui, Y.N.1
Xu, Z.2
Patel, B.3
Chen, Z.4
Chen, D.5
Tito, A.6
David, G.7
Sun, Y.8
Stimming, E.F.9
Bellen, H.J.10
-
11
-
-
84921411838
-
Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes
-
Lee, J.H., Tecedor, L., Chen, Y.H., Monteys, A.M., Sowada, M.J., Thompson, L.M., and Davidson, B.L., Reinstating aberrant mTORC1 activity in Huntington's disease mice improves disease phenotypes, Neuron, 2015; 85(2): 303-315.
-
(2015)
Neuron
, vol.85
, Issue.2
, pp. 303-315
-
-
Lee, J.H.1
Tecedor, L.2
Chen, Y.H.3
Monteys, A.M.4
Sowada, M.J.5
Thompson, L.M.6
Davidson, B.L.7
-
12
-
-
44449131447
-
Huntington's disease: From pathology and genetics to potential therapies
-
Imarisio, S., Carmichael, J., Korolchuk, V., Chen, C.W., Saiki, S., Rose, C., Krishna, G., Davies, J.E., Ttofi, E., Underwood, B.R., et al., Huntington's disease: from pathology and genetics to potential therapies, Biochem J, 2008; 412(2): 191-209.
-
(2008)
Biochem J
, vol.412
, Issue.2
, pp. 191-209
-
-
Imarisio, S.1
Carmichael, J.2
Korolchuk, V.3
Chen, C.W.4
Saiki, S.5
Rose, C.6
Krishna, G.7
Davies, J.E.8
Ttofi, E.9
Underwood, B.R.10
-
13
-
-
84904065460
-
An update on Huntington's disease: From the gene to the clinic
-
Kim, S.D., and Fung, V.S., An update on Huntington's disease: from the gene to the clinic, Current opinion in neurology, 2014; 27(4): 477-483.
-
(2014)
Current Opinion in Neurology
, vol.27
, Issue.4
, pp. 477-483
-
-
Kim, S.D.1
Fung, V.S.2
-
14
-
-
77952135272
-
Dopamine and glutamate in Huntington's disease: A balancing act
-
Andre, V.M., Cepeda, C., and Levine, M.S., Dopamine and glutamate in Huntington's disease: A balancing act, CNS neuroscience & therapeutics, 2010; 16(3): 163-178.
-
(2010)
CNS Neuroscience & Therapeutics
, vol.16
, Issue.3
, pp. 163-178
-
-
Andre, V.M.1
Cepeda, C.2
Levine, M.S.3
-
15
-
-
62149084867
-
Glutamate toxicity in the striatum of the R6/2 Huntington's disease transgenic mice is age-dependent and correlates with decreased levels of glutamate transporters
-
Estrada-Sanchez, A.M., Montiel, T., Segovia, J., and Massieu, L., Glutamate toxicity in the striatum of the R6/2 Huntington's disease transgenic mice is age-dependent and correlates with decreased levels of glutamate transporters, Neurobiology of disease, 2009; 34(1): 78-86.
-
(2009)
Neurobiology of Disease
, vol.34
, Issue.1
, pp. 78-86
-
-
Estrada-Sanchez, A.M.1
Montiel, T.2
Segovia, J.3
Massieu, L.4
-
16
-
-
63849154126
-
In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease
-
Heng, M.Y., Detloff, P.J., Wang, P.L., Tsien, J.Z., and Albin, R.L., In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease, J Neurosci, 2009; 29(10): 3200-3205.
-
(2009)
J Neurosci
, vol.29
, Issue.10
, pp. 3200-3205
-
-
Heng, M.Y.1
Detloff, P.J.2
Wang, P.L.3
Tsien, J.Z.4
Albin, R.L.5
-
17
-
-
56349163764
-
Mutant huntingtin and mitochondrial dysfunction
-
Bossy-Wetzel, E., Petrilli, A., and Knott, A.B., Mutant huntingtin and mitochondrial dysfunction, Trends in neurosciences, 2008; 31(12): 609-616.
-
(2008)
Trends in Neurosciences
, vol.31
, Issue.12
, pp. 609-616
-
-
Bossy-Wetzel, E.1
Petrilli, A.2
Knott, A.B.3
-
18
-
-
70349422148
-
Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease
-
Quintanilla, R.A., and Johnson, G.V., Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease, Brain research bulletin, 2009; 80(4-5): 242-247.
-
(2009)
Brain Research Bulletin
, vol.80
, Issue.4-5
, pp. 242-247
-
-
Quintanilla, R.A.1
Johnson, G.V.2
-
19
-
-
33947675275
-
Oxidative damage in Huntington's disease pathogenesis
-
Browne, S.E., and Beal, M.F., Oxidative damage in Huntington's disease pathogenesis, Antioxidants & redox signaling, 2006; 8(11-12): 2061-2073.
-
(2006)
Antioxidants & Redox Signaling
, vol.8
, Issue.11
-
-
Browne, S.E.1
Beal, M.F.2
-
20
-
-
84975612082
-
Mutant Huntingtin and Elusive Defects in Oxidative Metabolism and Mitochondrial Calcium Handling
-
Brustovetsky, N., Mutant Huntingtin and Elusive Defects in Oxidative Metabolism and Mitochondrial Calcium Handling, Molecular neurobiology, 2015.
-
(2015)
Molecular Neurobiology
-
-
Brustovetsky, N.1
-
21
-
-
84901592715
-
Inhibition of mitochondrial protein import by mutant huntingtin
-
Yano, H., Baranov, S.V., Baranova, O.V., Kim, J., Pan, Y., Yablonska, S., Carlisle, D.L., Ferrante, R.J., Kim, A.H., and Friedlander, R.M., Inhibition of mitochondrial protein import by mutant huntingtin, Nature neuroscience, 2014; 17(6): 822-831.
-
(2014)
Nature Neuroscience
, vol.17
, Issue.6
, pp. 822-831
-
-
Yano, H.1
Baranov, S.V.2
Baranova, O.V.3
Kim, J.4
Pan, Y.5
Yablonska, S.6
Carlisle, D.L.7
Ferrante, R.J.8
Kim, A.H.9
Friedlander, R.M.10
-
22
-
-
84919619341
-
Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane
-
Brandstaetter, H., Kruppa, A.J., and Buss, F., Huntingtin is required for ER-to-Golgi transport and for secretory vesicle fusion at the plasma membrane, Disease models & mechanisms, 2014; 7(12): 1335-1340.
-
(2014)
Disease Models & Mechanisms
, vol.7
, Issue.12
, pp. 1335-1340
-
-
Brandstaetter, H.1
Kruppa, A.J.2
Buss, F.3
-
23
-
-
12144280807
-
Polyglutamine diseases and transport problems: Deadly traffic jams on neuronal highways
-
Gunawardena, S., and Goldstein, L.S., Polyglutamine diseases and transport problems: deadly traffic jams on neuronal highways, Archives of neurology, 2005; 62(1): 46-51.
-
(2005)
Archives of Neurology
, vol.62
, Issue.1
, pp. 46-51
-
-
Gunawardena, S.1
Goldstein, L.S.2
-
24
-
-
4444316194
-
Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro
-
Trushina, E., Dyer, R.B., Badger, J.D., 2nd, Ure, D., Eide, L., Tran, D.D., Vrieze, B.T., Legendre-Guillemin, V., McPherson, P.S., Mandavilli, B.S., et al., Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro, Molecular and cellular biology, 2004; 24(18): 8195-8209.
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.18
, pp. 8195-8209
-
-
Trushina, E.1
Dyer, R.B.2
Badger, J.D.3
Ure, D.4
Eide, L.5
Tran, D.D.6
Vrieze, B.T.7
Legendre-Guillemin, V.8
McPherson, P.S.9
Mandavilli, B.S.10
-
25
-
-
77952316271
-
Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis
-
Becanovic, K., Pouladi, M.A., Lim, R.S., Kuhn, A., Pavlidis, P., Luthi-Carter, R., Hayden, M.R., and Leavitt, B.R., Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis, Hum Mol Genet, 2010; 19(8): 1438-1452.
-
(2010)
Hum Mol Genet
, vol.19
, Issue.8
, pp. 1438-1452
-
-
Becanovic, K.1
Pouladi, M.A.2
Lim, R.S.3
Kuhn, A.4
Pavlidis, P.5
Luthi-Carter, R.6
Hayden, M.R.7
Leavitt, B.R.8
-
26
-
-
77952888250
-
The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease
-
Buckley, N.J., Johnson, R., Zuccato, C., Bithell, A., and Cattaneo, E., The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease, Neurobiology of disease, 2010; 39(1): 28-39.
-
(2010)
Neurobiology of Disease
, vol.39
, Issue.1
, pp. 28-39
-
-
Buckley, N.J.1
Johnson, R.2
Zuccato, C.3
Bithell, A.4
Cattaneo, E.5
-
27
-
-
43449129732
-
The ubiquitin-proteasome pathway in Huntington's disease
-
Finkbeiner, S., and Mitra, S., The ubiquitin-proteasome pathway in Huntington's disease, ScientificWorldJournal, 2008; 8: 421-433.
-
(2008)
ScientificWorldJournal
, vol.8
, pp. 421-433
-
-
Finkbeiner, S.1
Mitra, S.2
-
28
-
-
34548331451
-
Is the ubiquitin-proteasome system impaired in Huntington's disease?
-
Ortega, Z., Diaz-Hernandez, M., and Lucas, J.J., Is the ubiquitin-proteasome system impaired in Huntington's disease?, Cell Mol Life Sci, 2007; 64(17): 2245-2257.
-
(2007)
Cell Mol Life Sci
, vol.64
, Issue.17
, pp. 2245-2257
-
-
Ortega, Z.1
Diaz-Hernandez, M.2
Lucas, J.J.3
-
29
-
-
34547807613
-
Global changes to the ubiquitin system in Huntington's disease
-
Bennett, E.J., Shaler, T.A., Woodman, B., Ryu, K.Y., Zaitseva, T.S., Becker, C.H., Bates, G.P., Schulman, H., and Kopito, R.R., Global changes to the ubiquitin system in Huntington's disease, Nature, 2007; 448(7154): 704-708.
-
(2007)
Nature
, vol.448
, Issue.7154
, pp. 704-708
-
-
Bennett, E.J.1
Shaler, T.A.2
Woodman, B.3
Ryu, K.Y.4
Zaitseva, T.S.5
Becker, C.H.6
Bates, G.P.7
Schulman, H.8
Kopito, R.R.9
-
30
-
-
84859983420
-
Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease
-
Hipp, M.S., Patel, C.N., Bersuker, K., Riley, B.E., Kaiser, S.E., Shaler, T.A., Brandeis, M., and Kopito, R.R., Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease, J Cell Biol, 2012; 196(5): 573-587.
-
(2012)
J Cell Biol
, vol.196
, Issue.5
, pp. 573-587
-
-
Hipp, M.S.1
Patel, C.N.2
Bersuker, K.3
Riley, B.E.4
Kaiser, S.E.5
Shaler, T.A.6
Brandeis, M.7
Kopito, R.R.8
-
31
-
-
84883204078
-
Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
-
Tsvetkov, A.S., Arrasate, M., Barmada, S., Ando, D.M., Sharma, P., Shaby, B.A., and Finkbeiner, S., Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration, Nature chemical biology, 2013; 9(9): 586-592.
-
(2013)
Nature Chemical Biology
, vol.9
, Issue.9
, pp. 586-592
-
-
Tsvetkov, A.S.1
Arrasate, M.2
Barmada, S.3
Ando, D.M.4
Sharma, P.5
Shaby, B.A.6
Finkbeiner, S.7
-
32
-
-
57749116408
-
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity
-
Duennwald, M.L., and Lindquist, S., Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity, Genes Dev, 2008; 22(23): 3308-3319.
-
(2008)
Genes Dev
, vol.22
, Issue.23
, pp. 3308-3319
-
-
Duennwald, M.L.1
Lindquist, S.2
-
33
-
-
77749270634
-
Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP
-
Yang, H., Liu, C., Zhong, Y., Luo, S., Monteiro, M.J., and Fang, S., Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP, PLoS One, 2010; 5(1): e8905.
-
(2010)
PLoS One
, vol.5
, Issue.1
-
-
Yang, H.1
Liu, C.2
Zhong, Y.3
Luo, S.4
Monteiro, M.J.5
Fang, S.6
-
34
-
-
80855139444
-
Protein quality control, retention, and degradation at the endoplasmic reticulum
-
Benyair, R., Ron, E., and Lederkremer, G.Z., Protein quality control, retention, and degradation at the endoplasmic reticulum, Int Rev Cell Mol Biol, 2011; 292: 197-280.
-
(2011)
Int Rev Cell Mol Biol
, vol.292
, pp. 197-280
-
-
Benyair, R.1
Ron, E.2
Lederkremer, G.Z.3
-
35
-
-
82255161944
-
Road to ruin: Targeting proteins for degradation in the endoplasmic reticulum
-
Smith, M.H., Ploegh, H.L., and Weissman, J.S., Road to ruin: targeting proteins for degradation in the endoplasmic reticulum, Science, 2011; 334(6059): 1086-1090.
-
(2011)
Science
, vol.334
, Issue.6059
, pp. 1086-1090
-
-
Smith, M.H.1
Ploegh, H.L.2
Weissman, J.S.3
-
36
-
-
67650566385
-
Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease
-
Carnemolla, A., Fossale, E., Agostoni, E., Michelazzi, S., Calligaris, R., De Maso, L., Del Sal, G., MacDonald, M.E., and Persichetti, F., Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease, J Biol Chem, 2009; 284(27): 18167-18173.
-
(2009)
J Biol Chem
, vol.284
, Issue.27
, pp. 18167-18173
-
-
Carnemolla, A.1
Fossale, E.2
Agostoni, E.3
Michelazzi, S.4
Calligaris, R.5
De Maso, L.6
Del Sal, G.7
MacDonald, M.E.8
Persichetti, F.9
-
37
-
-
39649114320
-
Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins
-
Reijonen, S., Putkonen, N., Norremolle, A., Lindholm, D., and Korhonen, L., Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins, Exp Cell Res, 2008; 314(5): 950-960.
-
(2008)
Exp Cell Res
, vol.314
, Issue.5
, pp. 950-960
-
-
Reijonen, S.1
Putkonen, N.2
Norremolle, A.3
Lindholm, D.4
Korhonen, L.5
-
38
-
-
84870838478
-
Endoplasmic reticulum dysfunction in neurological disease
-
Roussel, B.D., Kruppa, A.J., Miranda, E., Crowther, D.C., Lomas, D.A., and Marciniak, S.J., Endoplasmic reticulum dysfunction in neurological disease, Lancet Neurol, 2013; 12(1): 105-118.
-
(2013)
Lancet Neurol
, vol.12
, Issue.1
, pp. 105-118
-
-
Roussel, B.D.1
Kruppa, A.J.2
Miranda, E.3
Crowther, D.C.4
Lomas, D.A.5
Marciniak, S.J.6
-
39
-
-
78650827764
-
Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease
-
Vidal, R., Caballero, B., Couve, A., and Hetz, C., Converging pathways in the occurrence of endoplasmic reticulum (ER) stress in Huntington's disease, Curr Mol Med, 2011; 11(1): 1-12.
-
(2011)
Curr Mol Med
, vol.11
, Issue.1
, pp. 1-12
-
-
Vidal, R.1
Caballero, B.2
Couve, A.3
Hetz, C.4
-
40
-
-
0001589776
-
Differential loss of striatal projection neurons in Huntington disease
-
Reiner, A., Albin, R.L., Anderson, K.D., D'Amato, C.J., Penney, J.B., and Young, A.B., Differential loss of striatal projection neurons in Huntington disease, Proc Natl Acad Sci U S A, 1988; 85(15): 5733-5737.
-
(1988)
Proc Natl Acad Sci U S A
, vol.85
, Issue.15
, pp. 5733-5737
-
-
Reiner, A.1
Albin, R.L.2
Anderson, K.D.3
D'Amato, C.J.4
Penney, J.B.5
Young, A.B.6
-
41
-
-
84863008363
-
Huntington's Disease and Striatal Signaling
-
Roze, E., Cahill, E., Martin, E., Bonnet, C., Vanhoutte, P., Betuing, S., and Caboche, J., Huntington's Disease and Striatal Signaling, Front Neuroanat, 2011; 5: 55.
-
(2011)
Front Neuroanat
, vol.5
, pp. 55
-
-
Roze, E.1
Cahill, E.2
Martin, E.3
Bonnet, C.4
Vanhoutte, P.5
Betuing, S.6
Caboche, J.7
-
42
-
-
66749167799
-
Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity
-
Subramaniam, S., Sixt, K.M., Barrow, R., and Snyder, S.H., Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity, Science, 2009; 324(5932): 1327-1330.
-
(2009)
Science
, vol.324
, Issue.5932
, pp. 1327-1330
-
-
Subramaniam, S.1
Sixt, K.M.2
Barrow, R.3
Snyder, S.H.4
-
43
-
-
84923568472
-
The striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo
-
Francelle, L., Galvan, L., Gaillard, M.C., Petit, F., Bernay, B., Guillermier, M., Bonvento, G., Dufour, N., Elalouf, J.M., Hantraye, P., et al., The striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo, Neurobiology of aging, 2015; 36(3): 1601.e1607-1616.
-
(2015)
Neurobiology of Aging
, vol.36
, Issue.3
, pp. 1601.e1607-1616.e1607
-
-
Francelle, L.1
Galvan, L.2
Gaillard, M.C.3
Petit, F.4
Bernay, B.5
Guillermier, M.6
Bonvento, G.7
Dufour, N.8
Elalouf, J.M.9
Hantraye, P.10
-
44
-
-
84897002606
-
ER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtin
-
Leitman, J., Barak, B., Benyair, R., Shenkman, M., Ashery, U., Hartl, F.U., and Lederkremer, G.Z., ER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtin, PLoS One, 2014; 9(3): e90803.
-
(2014)
PLoS One
, vol.9
, Issue.3
-
-
Leitman, J.1
Barak, B.2
Benyair, R.3
Shenkman, M.4
Ashery, U.5
Hartl, F.U.6
Lederkremer, G.Z.7
-
45
-
-
24944446266
-
Endoplasmic reticulum-associated degradation
-
Romisch, K., Endoplasmic reticulum-associated degradation, Annu Rev Cell Dev Biol, 2005; 21: 435-456.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 435-456
-
-
Romisch, K.1
-
46
-
-
63649161943
-
The ubiquitylation machinery of the endoplasmic reticulum
-
Hirsch, C., Gauss, R., Horn, S.C., Neuber, O., and Sommer, T., The ubiquitylation machinery of the endoplasmic reticulum, Nature, 2009; 458(7237): 453-460.
-
(2009)
Nature
, vol.458
, Issue.7237
, pp. 453-460
-
-
Hirsch, C.1
Gauss, R.2
Horn, S.C.3
Neuber, O.4
Sommer, T.5
-
47
-
-
84870907436
-
Cleaning Up: ER-Associated Degradation to the Rescue
-
Brodsky, J.L., Cleaning Up: ER-Associated Degradation to the Rescue, Cell, 2012; 151(6): 1163-1167.
-
(2012)
Cell
, vol.151
, Issue.6
, pp. 1163-1167
-
-
Brodsky, J.L.1
-
48
-
-
84890239048
-
The ubiquitin-proteasome-system
-
Sommer, T., and Wolf, D.H., The ubiquitin-proteasome-system, Biochim Biophys Acta, 2014; 1843(1): 1.
-
(2014)
Biochim Biophys Acta
, vol.1843
, Issue.1
, pp. 1
-
-
Sommer, T.1
Wolf, D.H.2
-
49
-
-
70349855203
-
Glycoprotein folding, quality control and ER-associated degradation
-
Lederkremer, G.Z., Glycoprotein folding, quality control and ER-associated degradation, Curr Opin Struct Biol, 2009; 19(5): 515-523.
-
(2009)
Curr Opin Struct Biol
, vol.19
, Issue.5
, pp. 515-523
-
-
Lederkremer, G.Z.1
-
50
-
-
36249022750
-
Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp
-
Okuda-Shimizu, Y., and Hendershot, L.M., Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp, Mol Cell, 2007; 28(4): 544-554.
-
(2007)
Mol Cell
, vol.28
, Issue.4
, pp. 544-554
-
-
Okuda-Shimizu, Y.1
Hendershot, L.M.2
-
51
-
-
33745265260
-
Protein disulfide isomerase-like proteins play opposing roles during retrotranslocation
-
Forster, M.L., Sivick, K., Park, Y.N., Arvan, P., Lencer, W.I., and Tsai, B., Protein disulfide isomerase-like proteins play opposing roles during retrotranslocation, J Cell Biol, 2006; 173(6): 853-859.
-
(2006)
J Cell Biol
, vol.173
, Issue.6
, pp. 853-859
-
-
Forster, M.L.1
Sivick, K.2
Park, Y.N.3
Arvan, P.4
Lencer, W.I.5
Tsai, B.6
-
52
-
-
43149096666
-
The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulum
-
Nakatsukasa, K., and Brodsky, J.L., The recognition and retrotranslocation of misfolded proteins from the endoplasmic reticulum, Traffic, 2008; 9(6): 861-870.
-
(2008)
Traffic
, vol.9
, Issue.6
, pp. 861-870
-
-
Nakatsukasa, K.1
Brodsky, J.L.2
-
53
-
-
0035162691
-
A novel quality control compartment derived from the endoplasmic reticulum
-
Kamhi-Nesher, S., Shenkman, M., Tolchinsky, S., Fromm, S.V., Ehrlich, R., and Lederkremer, G.Z., A novel quality control compartment derived from the endoplasmic reticulum, Mol Biol Cell, 2001; 12(6): 1711-1723.
-
(2001)
Mol Biol Cell
, vol.12
, Issue.6
, pp. 1711-1723
-
-
Kamhi-Nesher, S.1
Shenkman, M.2
Tolchinsky, S.3
Fromm, S.V.4
Ehrlich, R.5
Lederkremer, G.Z.6
-
54
-
-
78651394090
-
Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulumassociated degradation steps
-
Groisman, B., Shenkman, M., Ron, E., and Lederkremer, G.Z., Mannose trimming is required for delivery of a glycoprotein from EDEM1 to XTP3-B and to late endoplasmic reticulumassociated degradation steps, J Biol Chem, 2011; 286(2): 1292-1300.
-
(2011)
J Biol Chem
, vol.286
, Issue.2
, pp. 1292-1300
-
-
Groisman, B.1
Shenkman, M.2
Ron, E.3
Lederkremer, G.Z.4
-
55
-
-
34548651757
-
PERK-dependent compartmentalization of ERAD and unfolded protein response machineries during ER stress
-
Kondratyev, M., Avezov, E., Shenkman, M., Groisman, B., and Lederkremer, G.Z., PERK-dependent compartmentalization of ERAD and unfolded protein response machineries during ER stress, Exp Cell Res, 2007; 313(16): 3395-3407.
-
(2007)
Exp Cell Res
, vol.313
, Issue.16
, pp. 3395-3407
-
-
Kondratyev, M.1
Avezov, E.2
Shenkman, M.3
Groisman, B.4
Lederkremer, G.Z.5
-
56
-
-
85042576947
-
Compartmentalization of Endoplasmic Reticulum Quality Control and ER-Associated Degradation Factors
-
Leitman, J., Ron, E., Ogen-Shtern, N., and Lederkremer, G.Z., Compartmentalization of Endoplasmic Reticulum Quality Control and ER-Associated Degradation Factors, DNA Cell Biol, 2012.
-
(2012)
DNA Cell Biol
-
-
Leitman, J.1
Ron, E.2
Ogen-Shtern, N.3
Lederkremer, G.Z.4
-
57
-
-
0141706616
-
Endoplasmic reticulum-associated degradation of mammalian glycoproteins involves sugar chain trimming to Man6-5GlcNAc2
-
Frenkel, Z., Gregory, W., Kornfeld, S., and Lederkremer, G.Z., Endoplasmic reticulum-associated degradation of mammalian glycoproteins involves sugar chain trimming to Man6-5GlcNAc2, J Biol Chem, 2003; 278(36): 34119-34124.
-
(2003)
J Biol Chem
, vol.278
, Issue.36
, pp. 34119-34124
-
-
Frenkel, Z.1
Gregory, W.2
Kornfeld, S.3
Lederkremer, G.Z.4
-
58
-
-
3943059566
-
Roles of N-linked glycans in the endoplasmic reticulum
-
Helenius, A., and Aebi, M., Roles of N-linked glycans in the endoplasmic reticulum, Annu Rev Biochem, 2004; 73: 1019-1049.
-
(2004)
Annu Rev Biochem
, vol.73
, pp. 1019-1049
-
-
Helenius, A.1
Aebi, M.2
-
59
-
-
38749122389
-
Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation
-
Avezov, E., Frenkel, Z., Ehrlich, M., Herscovics, A., and Lederkremer, G.Z., Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation, Mol Biol Cell, 2008; 19(1): 216-225.
-
(2008)
Mol Biol Cell
, vol.19
, Issue.1
, pp. 216-225
-
-
Avezov, E.1
Frenkel, Z.2
Ehrlich, M.3
Herscovics, A.4
Lederkremer, G.Z.5
-
60
-
-
84920946243
-
Mammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates
-
Benyair, R., Ogen-Shtern, N., Mazkereth, N., Shai, B., Ehrlich, M., and Lederkremer, G.Z., Mammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates, Mol Biol Cell, 2015; 26(2): 172-184.
-
(2015)
Mol Biol Cell
, vol.26
, Issue.2
, pp. 172-184
-
-
Benyair, R.1
Ogen-Shtern, N.2
Mazkereth, N.3
Shai, B.4
Ehrlich, M.5
Lederkremer, G.Z.6
-
61
-
-
84931571933
-
Glycan regulation of ER-associated degradation through compartmentalization
-
Benyair, R., Ogen-Shtern, N., and Lederkremer, G.Z., Glycan regulation of ER-associated degradation through compartmentalization, Seminars in cell & developmental biology, 2015; 41: 99-109.
-
(2015)
Seminars in Cell & Developmental Biology
, vol.41
, pp. 99-109
-
-
Benyair, R.1
Ogen-Shtern, N.2
Lederkremer, G.Z.3
-
62
-
-
77952811195
-
EDEM1 accelerates the trimming of alpha1,2-linked mannose on the C branch of N-glycans
-
Hosokawa, N., Tremblay, L.O., Sleno, B., Kamiya, Y., Wada, I., Nagata, K., Kato, K., and Herscovics, A., EDEM1 accelerates the trimming of alpha1,2-linked mannose on the C branch of N-glycans, Glycobiology, 2010; 20(5): 567-575.
-
(2010)
Glycobiology
, vol.20
, Issue.5
, pp. 567-575
-
-
Hosokawa, N.1
Tremblay, L.O.2
Sleno, B.3
Kamiya, Y.4
Wada, I.5
Nagata, K.6
Kato, K.7
Herscovics, A.8
-
63
-
-
84905987689
-
EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step
-
Ninagawa, S., Okada, T., Sumitomo, Y., Kamiya, Y., Kato, K., Horimoto, S., Ishikawa, T., Takeda, S., Sakuma, T., Yamamoto, T., et al., EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step, J Cell Biol, 2014; 206(3): 347-356.
-
(2014)
J Cell Biol
, vol.206
, Issue.3
, pp. 347-356
-
-
Ninagawa, S.1
Okada, T.2
Sumitomo, Y.3
Kamiya, Y.4
Kato, K.5
Horimoto, S.6
Ishikawa, T.7
Takeda, S.8
Sakuma, T.9
Yamamoto, T.10
-
64
-
-
33748795800
-
EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation
-
Olivari, S., Cali, T., Salo, K.E., Paganetti, P., Ruddock, L.W., and Molinari, M., EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation, Biochemical and biophysical research communications, 2006; 349(4): 1278-1284.
-
(2006)
Biochemical and Biophysical Research Communications
, vol.349
, Issue.4
, pp. 1278-1284
-
-
Olivari, S.1
Cali, T.2
Salo, K.E.3
Paganetti, P.4
Ruddock, L.W.5
Molinari, M.6
-
65
-
-
80655144729
-
Bypass of glycan-dependent glycoprotein delivery to ERAD by up-regulated EDEM1
-
Ron, E., Shenkman, M., Groisman, B., Izenshtein, Y., Leitman, J., and Lederkremer, G.Z., Bypass of glycan-dependent glycoprotein delivery to ERAD by up-regulated EDEM1, Mol Biol Cell, 2011; 22(21): 3945-3954.
-
(2011)
Mol Biol Cell
, vol.22
, Issue.21
, pp. 3945-3954
-
-
Ron, E.1
Shenkman, M.2
Groisman, B.3
Izenshtein, Y.4
Leitman, J.5
Lederkremer, G.Z.6
-
66
-
-
34249042608
-
Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3
-
Wang, X., Herr, R.A., Chua, W.J., Lybarger, L., Wiertz, E.J., and Hansen, T.H., Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3, J Cell Biol, 2007; 177(4): 613-624.
-
(2007)
J Cell Biol
, vol.177
, Issue.4
, pp. 613-624
-
-
Wang, X.1
Herr, R.A.2
Chua, W.J.3
Lybarger, L.4
Wiertz, E.J.5
Hansen, T.H.6
-
67
-
-
0034597161
-
Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p
-
Gardner, R.G., Swarbrick, G.M., Bays, N.W., Cronin, S.R., Wilhovsky, S., Seelig, L., Kim, C., and Hampton, R.Y., Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p, J Cell Biol, 2000; 151(1): 69-82.
-
(2000)
J Cell Biol
, vol.151
, Issue.1
, pp. 69-82
-
-
Gardner, R.G.1
Swarbrick, G.M.2
Bays, N.W.3
Cronin, S.R.4
Wilhovsky, S.5
Seelig, L.6
Kim, C.7
Hampton, R.Y.8
-
68
-
-
0035815754
-
Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation
-
Deak, P.M., and Wolf, D.H., Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation, J Biol Chem, 2001; 276(14): 10663-10669.
-
(2001)
J Biol Chem
, vol.276
, Issue.14
, pp. 10663-10669
-
-
Deak, P.M.1
Wolf, D.H.2
-
69
-
-
9144239817
-
Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum
-
Kikkert, M., Doolman, R., Dai, M., Avner, R., Hassink, G., van Voorden, S., Thanedar, S., Roitelman, J., Chau, V., and Wiertz, E., Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum, J Biol Chem, 2004; 279(5): 3525-3534.
-
(2004)
J Biol Chem
, vol.279
, Issue.5
, pp. 3525-3534
-
-
Kikkert, M.1
Doolman, R.2
Dai, M.3
Avner, R.4
Hassink, G.5
Van Voorden, S.6
Thanedar, S.7
Roitelman, J.8
Chau, V.9
Wiertz, E.10
-
70
-
-
0035807839
-
The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum
-
Fang, S., Ferrone, M., Yang, C., Jensen, J.P., Tiwari, S., and Weissman, A.M., The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum, Proc Natl Acad Sci U S A, 2001; 98(25): 14422-14427.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, Issue.25
, pp. 14422-14427
-
-
Fang, S.1
Ferrone, M.2
Yang, C.3
Jensen, J.P.4
Tiwari, S.5
Weissman, A.M.6
-
71
-
-
33646185061
-
Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI)
-
Kreft, S.G., Wang, L., and Hochstrasser, M., Membrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI), J Biol Chem, 2006; 281(8): 4646-4653.
-
(2006)
J Biol Chem
, vol.281
, Issue.8
, pp. 4646-4653
-
-
Kreft, S.G.1
Wang, L.2
Hochstrasser, M.3
-
72
-
-
20544440605
-
TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum
-
Hassink, G., Kikkert, M., van Voorden, S., Lee, S.J., Spaapen, R., van Laar, T., Coleman, C.S., Bartee, E., Fruh, K., Chau, V., et al., TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum, Biochem J, 2005; 388(Pt 2): 647-655.
-
(2005)
Biochem J
, vol.388
, Issue.2
, pp. 647-655
-
-
Hassink, G.1
Kikkert, M.2
Van Voorden, S.3
Lee, S.J.4
Spaapen, R.5
Van Laar, T.6
Coleman, C.S.7
Bartee, E.8
Fruh, K.9
Chau, V.10
-
73
-
-
33750359201
-
SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER
-
Mueller, B., Lilley, B.N., and Ploegh, H.L., SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER, J Cell Biol, 2006; 175(2): 261-270.
-
(2006)
J Cell Biol
, vol.175
, Issue.2
, pp. 261-270
-
-
Mueller, B.1
Lilley, B.N.2
Ploegh, H.L.3
-
74
-
-
3042616595
-
A membrane protein required for dislocation of misfolded proteins from the ER
-
Lilley, B.N., and Ploegh, H.L., A membrane protein required for dislocation of misfolded proteins from the ER, Nature, 2004; 429(6994): 834-840.
-
(2004)
Nature
, vol.429
, Issue.6994
, pp. 834-840
-
-
Lilley, B.N.1
Ploegh, H.L.2
-
75
-
-
80455164551
-
Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant alpha-1 antitrypsin from the endoplasmic reticulum
-
Greenblatt, E.J., Olzmann, J.A., and Kopito, R.R., Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant alpha-1 antitrypsin from the endoplasmic reticulum, Nat Struct Mol Biol, 2011; 18(10): 1147-1152.
-
(2011)
Nat Struct Mol Biol
, vol.18
, Issue.10
, pp. 1147-1152
-
-
Greenblatt, E.J.1
Olzmann, J.A.2
Kopito, R.R.3
-
76
-
-
0034693217
-
Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress
-
Kokame, K., Agarwala, K.L., Kato, H., and Miyata, T., Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress, J Biol Chem, 2000; 275(42): 32846-32853.
-
(2000)
J Biol Chem
, vol.275
, Issue.42
, pp. 32846-32853
-
-
Kokame, K.1
Agarwala, K.L.2
Kato, H.3
Miyata, T.4
-
77
-
-
28144436887
-
The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway
-
Schulze, A., Standera, S., Buerger, E., Kikkert, M., van Voorden, S., Wiertz, E., Koning, F., Kloetzel, P.M., and Seeger, M., The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway, J Mol Biol, 2005; 354(5): 1021-1027.
-
(2005)
J Mol Biol
, vol.354
, Issue.5
, pp. 1021-1027
-
-
Schulze, A.1
Standera, S.2
Buerger, E.3
Kikkert, M.4
Van Voorden, S.5
Wiertz, E.6
Koning, F.7
Kloetzel, P.M.8
Seeger, M.9
-
78
-
-
84898754350
-
Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD
-
Leitman, J., Shenkman, M., Gofman, Y., Shtern, N.O., Ben-Tal, N., Hendershot, L.M., and Lederkremer, G.Z., Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD, Mol Biol Cell, 2014; 25(7): 1050-1060.
-
(2014)
Mol Biol Cell
, vol.25
, Issue.7
, pp. 1050-1060
-
-
Leitman, J.1
Shenkman, M.2
Gofman, Y.3
Shtern, N.O.4
Ben-Tal, N.5
Hendershot, L.M.6
Lederkremer, G.Z.7
-
79
-
-
0035658442
-
HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins
-
Bays, N.W., Wilhovsky, S.K., Goradia, A., Hodgkiss-Harlow, K., and Hampton, R.Y., HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins, Mol Biol Cell, 2001; 12(12): 4114-4128.
-
(2001)
Mol Biol Cell
, vol.12
, Issue.12
, pp. 4114-4128
-
-
Bays, N.W.1
Wilhovsky, S.K.2
Goradia, A.3
Hodgkiss-Harlow, K.4
Hampton, R.Y.5
-
80
-
-
0035818999
-
ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
-
Ye, Y., Meyer, H.H., and Rapoport, T.A., The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol, Nature, 2001; 414(6864): 652-656.
-
(2001)
Nature
, vol.414
, Issue.6864
, pp. 652-656
-
-
Ye, Y.1
Meyer, H.H.2
Rapoport, T.A.3
The, A.A.A.4
-
81
-
-
0036136901
-
AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation
-
Rabinovich, E., Kerem, A., Frohlich, K.U., Diamant, N., and Bar-Nun, S., AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation, Mol Cell Biol, 2002; 22(2): 626-634.
-
(2002)
Mol Cell Biol
, vol.22
, Issue.2
, pp. 626-634
-
-
Rabinovich, E.1
Kerem, A.2
Frohlich, K.U.3
Diamant, N.4
Bar-Nun, S.5
-
82
-
-
34547419767
-
Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulumassociated degradation
-
Zhao, G., Zhou, X., Wang, L., Li, G., Schindelin, H., and Lennarz, W.J., Studies on peptide:N-glycanase-p97 interaction suggest that p97 phosphorylation modulates endoplasmic reticulumassociated degradation, Proc Natl Acad Sci U S A, 2007; 104(21): 8785-8790.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, Issue.21
, pp. 8785-8790
-
-
Zhao, G.1
Zhou, X.2
Wang, L.3
Li, G.4
Schindelin, H.5
Lennarz, W.J.6
-
83
-
-
77949295782
-
Lectin-like ERAD players in ER and cytosol
-
Yoshida, Y., and Tanaka, K., Lectin-like ERAD players in ER and cytosol, Biochimica et biophysica acta, 2010; 1800(2): 172-180.
-
(2010)
Biochimica et Biophysica Acta
, vol.1800
, Issue.2
, pp. 172-180
-
-
Yoshida, Y.1
Tanaka, K.2
-
84
-
-
84870735655
-
Endoplasmic reticulum stress sensing in the unfolded protein response
-
Gardner, B.M., Pincus, D., Gotthardt, K., Gallagher, C.M., and Walter, P., Endoplasmic reticulum stress sensing in the unfolded protein response, Cold Spring Harbor perspectives in biology, 2013; 5(3): a013169.
-
(2013)
Cold Spring Harbor Perspectives in Biology
, vol.5
, Issue.3
-
-
Gardner, B.M.1
Pincus, D.2
Gotthardt, K.3
Gallagher, C.M.4
Walter, P.5
-
85
-
-
84865245211
-
Unfolded protein response
-
Cao, S.S., and Kaufman, R.J., Unfolded protein response, Curr Biol, 2012; 22(16): R622-626.
-
(2012)
Curr Biol
, vol.22
, Issue.16
, pp. R622-R626
-
-
Cao, S.S.1
Kaufman, R.J.2
-
86
-
-
0033782015
-
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
-
Bertolotti, A., Zhang, Y., Hendershot, L.M., Harding, H.P., and Ron, D., Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response, Nat Cell Biol, 2000; 2(6): 326-332.
-
(2000)
Nat Cell Biol
, vol.2
, Issue.6
, pp. 326-332
-
-
Bertolotti, A.1
Zhang, Y.2
Hendershot, L.M.3
Harding, H.P.4
Ron, D.5
-
87
-
-
30044432596
-
On the mechanism of sensing unfolded protein in the endoplasmic reticulum
-
Credle, J.J., Finer-Moore, J.S., Papa, F.R., Stroud, R.M., and Walter, P., On the mechanism of sensing unfolded protein in the endoplasmic reticulum, Proc Natl Acad Sci U S A, 2005; 102(52): 18773-18784.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, Issue.52
, pp. 18773-18784
-
-
Credle, J.J.1
Finer-Moore, J.S.2
Papa, F.R.3
Stroud, R.M.4
Walter, P.5
-
88
-
-
0030954870
-
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response
-
Sidrauski, C., and Walter, P., The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response, Cell, 1997; 90(6): 1031-1039.
-
(1997)
Cell
, vol.90
, Issue.6
, pp. 1031-1039
-
-
Sidrauski, C.1
Walter, P.2
-
89
-
-
0032525990
-
A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells
-
Tirasophon, W., Welihinda, A.A., and Kaufman, R.J., A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells, Genes & development, 1998; 12(12): 1812-1824.
-
(1998)
Genes & Development
, vol.12
, Issue.12
, pp. 1812-1824
-
-
Tirasophon, W.1
Welihinda, A.A.2
Kaufman, R.J.3
-
90
-
-
84874251933
-
Negative feedback by IRE1beta optimizes mucin production in goblet cells
-
Tsuru, A., Fujimoto, N., Takahashi, S., Saito, M., Nakamura, D., Iwano, M., Iwawaki, T., Kadokura, H., Ron, D., and Kohno, K., Negative feedback by IRE1beta optimizes mucin production in goblet cells, Proceedings of the National Academy of Sciences of the United States of America, 2013; 110(8): 2864-2869.
-
(2013)
Proceedings of the National Academy of Sciences of the United States of America
, vol.110
, Issue.8
, pp. 2864-2869
-
-
Tsuru, A.1
Fujimoto, N.2
Takahashi, S.3
Saito, M.4
Nakamura, D.5
Iwano, M.6
Iwawaki, T.7
Kadokura, H.8
Ron, D.9
Kohno, K.10
-
91
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
Calfon, M., Zeng, H., Urano, F., Till, J.H., Hubbard, S.R., Harding, H.P., Clark, S.G., and Ron, D., IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA, Nature, 2002; 415(6867): 92-96.
-
(2002)
Nature
, vol.415
, Issue.6867
, pp. 92-96
-
-
Calfon, M.1
Zeng, H.2
Urano, F.3
Till, J.H.4
Hubbard, S.R.5
Harding, H.P.6
Clark, S.G.7
Ron, D.8
-
92
-
-
18244405070
-
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
-
Shen, X., Ellis, R.E., Lee, K., Liu, C.Y., Yang, K., Solomon, A., Yoshida, H., Morimoto, R., Kurnit, D.M., Mori, K., et al., Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development, Cell, 2001; 107(7): 893-903.
-
(2001)
Cell
, vol.107
, Issue.7
, pp. 893-903
-
-
Shen, X.1
Ellis, R.E.2
Lee, K.3
Liu, C.Y.4
Yang, K.5
Solomon, A.6
Yoshida, H.7
Morimoto, R.8
Kurnit, D.M.9
Mori, K.10
-
93
-
-
77958016968
-
Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering
-
Li, H., Korennykh, A.V., Behrman, S.L., and Walter, P., Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering, Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(37): 16113-16118.
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, Issue.37
, pp. 16113-16118
-
-
Li, H.1
Korennykh, A.V.2
Behrman, S.L.3
Walter, P.4
-
94
-
-
0142059951
-
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
-
Lee, A.H., Iwakoshi, N.N., and Glimcher, L.H., XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response, Mol Cell Biol, 2003; 23(21): 7448-7459.
-
(2003)
Mol Cell Biol
, vol.23
, Issue.21
, pp. 7448-7459
-
-
Lee, A.H.1
Iwakoshi, N.N.2
Glimcher, L.H.3
-
95
-
-
0033590451
-
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
-
Harding, H.P., Zhang, Y., and Ron, D., Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase, Nature, 1999; 397(6716): 271-274.
-
(1999)
Nature
, vol.397
, Issue.6716
, pp. 271-274
-
-
Harding, H.P.1
Zhang, Y.2
Ron, D.3
-
96
-
-
0032502721
-
Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family
-
Ishihara, H., Shibasaki, Y., Kizuki, N., Wada, T., Yazaki, Y., Asano, T., and Oka, Y., Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family, The Journal of biological chemistry, 1998; 273(15): 8741-8748.
-
(1998)
The Journal of Biological Chemistry
, vol.273
, Issue.15
, pp. 8741-8748
-
-
Ishihara, H.1
Shibasaki, Y.2
Kizuki, N.3
Wada, T.4
Yazaki, Y.5
Asano, T.6
Oka, Y.7
-
97
-
-
0037353039
-
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
-
Harding, H.P., Zhang, Y., Zeng, H., Novoa, I., Lu, P.D., Calfon, M., Sadri, N., Yun, C., Popko, B., Paules, R., et al., An integrated stress response regulates amino acid metabolism and resistance to oxidative stress, Molecular cell, 2003; 11(3): 619-633.
-
(2003)
Molecular Cell
, vol.11
, Issue.3
, pp. 619-633
-
-
Harding, H.P.1
Zhang, Y.2
Zeng, H.3
Novoa, I.4
Lu, P.D.5
Calfon, M.6
Sadri, N.7
Yun, C.8
Popko, B.9
Paules, R.10
-
98
-
-
0037387670
-
All roads lead to ATF4
-
Rutkowski, D.T., and Kaufman, R.J., All roads lead to ATF4, Dev Cell, 2003; 4(4): 442-444.
-
(2003)
Dev Cell
, vol.4
, Issue.4
, pp. 442-444
-
-
Rutkowski, D.T.1
Kaufman, R.J.2
-
99
-
-
0035947778
-
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
-
Novoa, I., Zeng, H., Harding, H.P., and Ron, D., Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha, J Cell Biol, 2001; 153(5): 1011-1022.
-
(2001)
J Cell Biol
, vol.153
, Issue.5
, pp. 1011-1022
-
-
Novoa, I.1
Zeng, H.2
Harding, H.P.3
Ron, D.4
-
100
-
-
0032693671
-
Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress
-
Haze, K., Yoshida, H., Yanagi, H., Yura, T., and Mori, K., Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress, Molecular biology of the cell, 1999; 10(11): 3787-3799.
-
(1999)
Molecular Biology of the Cell
, vol.10
, Issue.11
, pp. 3787-3799
-
-
Haze, K.1
Yoshida, H.2
Yanagi, H.3
Yura, T.4
Mori, K.5
-
101
-
-
0036713724
-
Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response
-
Okada, T., Yoshida, H., Akazawa, R., Negishi, M., and Mori, K., Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response, The Biochemical journal, 2002; 366(Pt 2): 585-594.
-
(2002)
The Biochemical Journal
, vol.366
, Issue.2
, pp. 585-594
-
-
Okada, T.1
Yoshida, H.2
Akazawa, R.3
Negishi, M.4
Mori, K.5
-
102
-
-
33645156429
-
From acute ER stress to physiological roles of the Unfolded Protein Response
-
Wu, J., and Kaufman, R.J., From acute ER stress to physiological roles of the Unfolded Protein Response, Cell death and differentiation, 2006; 13(3): 374-384.
-
(2006)
Cell Death and Differentiation
, vol.13
, Issue.3
, pp. 374-384
-
-
Wu, J.1
Kaufman, R.J.2
-
103
-
-
84923195554
-
UPR, autophagy, and mitochondria crosstalk underlies the ER stress response
-
Senft, D., and Ronai, Z.A., UPR, autophagy, and mitochondria crosstalk underlies the ER stress response, Trends in biochemical sciences, 2015; 40(3): 141-148.
-
(2015)
Trends in Biochemical Sciences
, vol.40
, Issue.3
, pp. 141-148
-
-
Senft, D.1
Ronai, Z.A.2
-
104
-
-
84859799949
-
Stress management at the ER: Regulators of ER stress-induced apoptosis
-
Gorman, A.M., Healy, S.J., Jager, R., and Samali, A., Stress management at the ER: regulators of ER stress-induced apoptosis, Pharmacology & therapeutics, 2012; 134(3): 306-316.
-
(2012)
Pharmacology & Therapeutics
, vol.134
, Issue.3
, pp. 306-316
-
-
Gorman, A.M.1
Healy, S.J.2
Jager, R.3
Samali, A.4
-
105
-
-
33748789479
-
Mediators of endoplasmic reticulum stress-induced apoptosis
-
Szegezdi, E., Logue, S.E., Gorman, A.M., and Samali, A., Mediators of endoplasmic reticulum stress-induced apoptosis, EMBO reports, 2006; 7(9): 880-885.
-
(2006)
EMBO Reports
, vol.7
, Issue.9
, pp. 880-885
-
-
Szegezdi, E.1
Logue, S.E.2
Gorman, A.M.3
Samali, A.4
-
106
-
-
52049110715
-
Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo
-
Zhang, K., and Kaufman, R.J., Identification and characterization of endoplasmic reticulum stress-induced apoptosis in vivo, Methods in enzymology, 2008; 442: 395-419.
-
(2008)
Methods in Enzymology
, vol.442
, pp. 395-419
-
-
Zhang, K.1
Kaufman, R.J.2
-
107
-
-
10644233167
-
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
-
Marciniak, S.J., Yun, C.Y., Oyadomari, S., Novoa, I., Zhang, Y., Jungreis, R., Nagata, K., Harding, H.P., and Ron, D., CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum, Genes Dev, 2004; 18(24): 3066-3077.
-
(2004)
Genes Dev
, vol.18
, Issue.24
, pp. 3066-3077
-
-
Marciniak, S.J.1
Yun, C.Y.2
Oyadomari, S.3
Novoa, I.4
Zhang, Y.5
Jungreis, R.6
Nagata, K.7
Harding, H.P.8
Ron, D.9
-
108
-
-
17144417669
-
TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death
-
Ohoka, N., Yoshii, S., Hattori, T., Onozaki, K., and Hayashi, H., TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death, The EMBO journal, 2005; 24(6): 1243-1255.
-
(2005)
The EMBO Journal
, vol.24
, Issue.6
, pp. 1243-1255
-
-
Ohoka, N.1
Yoshii, S.2
Hattori, T.3
Onozaki, K.4
Hayashi, H.5
-
109
-
-
0035787914
-
Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum
-
Harding, H.P., Novoa, I., Bertolotti, A., Zeng, H., Zhang, Y., Urano, F., Jousse, C., and Ron, D., Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum, Cold Spring Harb Symp Quant Biol, 2001; 66: 499-508.
-
(2001)
Cold Spring Harb Symp Quant Biol
, vol.66
, pp. 499-508
-
-
Harding, H.P.1
Novoa, I.2
Bertolotti, A.3
Zeng, H.4
Zhang, Y.5
Urano, F.6
Jousse, C.7
Ron, D.8
-
110
-
-
0344825875
-
Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis
-
Boehning, D., Patterson, R.L., Sedaghat, L., Glebova, N.O., Kurosaki, T., and Snyder, S.H., Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis, Nat Cell Biol, 2003; 5(12): 1051-1061.
-
(2003)
Nat Cell Biol
, vol.5
, Issue.12
, pp. 1051-1061
-
-
Boehning, D.1
Patterson, R.L.2
Sedaghat, L.3
Glebova, N.O.4
Kurosaki, T.5
Snyder, S.H.6
-
111
-
-
20144385980
-
PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis
-
Simmen, T., Aslan, J.E., Blagoveshchenskaya, A.D., Thomas, L., Wan, L., Xiang, Y., Feliciangeli, S.F., Hung, C.H., Crump, C.M., and Thomas, G., PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis, EMBO J, 2005; 24(4): 717-729.
-
(2005)
EMBO J
, vol.24
, Issue.4
, pp. 717-729
-
-
Simmen, T.1
Aslan, J.E.2
Blagoveshchenskaya, A.D.3
Thomas, L.4
Wan, L.5
Xiang, Y.6
Feliciangeli, S.F.7
Hung, C.H.8
Crump, C.M.9
Thomas, G.10
-
112
-
-
62149115148
-
Compartmentalized signalling: Ca2+ compartments, microdomains and the many facets of Ca2+ signalling
-
Laude, A.J., and Simpson, A.W., Compartmentalized signalling: Ca2+ compartments, microdomains and the many facets of Ca2+ signalling, FEBS J, 2009; 276(7): 1800-1816.
-
(2009)
FEBS J
, vol.276
, Issue.7
, pp. 1800-1816
-
-
Laude, A.J.1
Simpson, A.W.2
-
113
-
-
33845692166
-
Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels
-
Szabadkai, G., Bianchi, K., Varnai, P., De Stefani, D., Wieckowski, M.R., Cavagna, D., Nagy, A.I., Balla, T., and Rizzuto, R., Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels, Journal of Cell Biology, 2006; 175(6): 901-911.
-
(2006)
Journal of Cell Biology
, vol.175
, Issue.6
, pp. 901-911
-
-
Szabadkai, G.1
Bianchi, K.2
Varnai, P.3
De Stefani, D.4
Wieckowski, M.R.5
Cavagna, D.6
Nagy, A.I.7
Balla, T.8
Rizzuto, R.9
-
114
-
-
51349169022
-
The subcellular distribution of calnexin is mediated by PACS-2
-
Myhill, N., Lynes, E.M., Nanji, J.A., Blagoveshchenskaya, A.D., Fei, H., Carmine Simmen, K., Cooper, T.J., Thomas, G., and Simmen, T., The subcellular distribution of calnexin is mediated by PACS-2, Mol Biol Cell, 2008; 19(7): 2777-2788.
-
(2008)
Mol Biol Cell
, vol.19
, Issue.7
, pp. 2777-2788
-
-
Myhill, N.1
Lynes, E.M.2
Nanji, J.A.3
Blagoveshchenskaya, A.D.4
Fei, H.5
Carmine Simmen, K.6
Cooper, T.J.7
Thomas, G.8
Simmen, T.9
-
115
-
-
59449097391
-
MAM: More than just a housekeeper
-
Hayashi, T., Rizzuto, R., Hajnoczky, G., and Su, T.P., MAM: more than just a housekeeper, Trends Cell Biol, 2009; 19(2): 81-88.
-
(2009)
Trends Cell Biol
, vol.19
, Issue.2
, pp. 81-88
-
-
Hayashi, T.1
Rizzuto, R.2
Hajnoczky, G.3
Su, T.P.4
-
116
-
-
11844269232
-
Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44
-
Higo, T., Hattori, M., Nakamura, T., Natsume, T., Michikawa, T., and Mikoshiba, K., Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44, Cell, 2005; 120(1): 85-98.
-
(2005)
Cell
, vol.120
, Issue.1
, pp. 85-98
-
-
Higo, T.1
Hattori, M.2
Nakamura, T.3
Natsume, T.4
Michikawa, T.5
Mikoshiba, K.6
-
117
-
-
0034640960
-
Cytosolic phosphorylation of calnexin controls intracellular Ca(2+) oscillations via an interaction with SERCA2b
-
Roderick, H.L., Lechleiter, J.D., and Camacho, P., Cytosolic phosphorylation of calnexin controls intracellular Ca(2+) oscillations via an interaction with SERCA2b, Journal of Cell Biology, 2000; 149(6): 1235-1248.
-
(2000)
Journal of Cell Biology
, vol.149
, Issue.6
, pp. 1235-1248
-
-
Roderick, H.L.1
Lechleiter, J.D.2
Camacho, P.3
-
118
-
-
0347753252
-
Ca2+-dependent redox modulation of SERCA 2b by ERp57
-
Li, Y., and Camacho, P., Ca2+-dependent redox modulation of SERCA 2b by ERp57, Journal of Cell Biology, 2004; 164(1): 35-46.
-
(2004)
Journal of Cell Biology
, vol.164
, Issue.1
, pp. 35-46
-
-
Li, Y.1
Camacho, P.2
-
119
-
-
0032563599
-
Differential modulation of SERCA2 isoforms by calreticulin
-
John, L.M., Lechleiter, J.D., and Camacho, P., Differential modulation of SERCA2 isoforms by calreticulin, Journal of Cell Biology, 1998; 142(4): 963-973.
-
(1998)
Journal of Cell Biology
, vol.142
, Issue.4
, pp. 963-973
-
-
John, L.M.1
Lechleiter, J.D.2
Camacho, P.3
-
120
-
-
70349905357
-
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis
-
Li, G., Mongillo, M., Chin, K.T., Harding, H., Ron, D., Marks, A.R., and Tabas, I., Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis, Journal of Cell Biology, 2009; 186(6): 783-792.
-
(2009)
Journal of Cell Biology
, vol.186
, Issue.6
, pp. 783-792
-
-
Li, G.1
Mongillo, M.2
Chin, K.T.3
Harding, H.4
Ron, D.5
Marks, A.R.6
Tabas, I.7
-
121
-
-
77955708533
-
Ero1alpha requires oxidizing and normoxic conditions to localize to the mitochondriaassociated membrane (MAM)
-
Gilady, S.Y., Bui, M., Lynes, E.M., Benson, M.D., Watts, R., Vance, J.E., and Simmen, T., Ero1alpha requires oxidizing and normoxic conditions to localize to the mitochondriaassociated membrane (MAM), Cell Stress Chaperones, 2010; 15(5): 619-629.
-
(2010)
Cell Stress Chaperones
, vol.15
, Issue.5
, pp. 619-629
-
-
Gilady, S.Y.1
Bui, M.2
Lynes, E.M.3
Benson, M.D.4
Watts, R.5
Vance, J.E.6
Simmen, T.7
-
122
-
-
35549006797
-
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival
-
Hayashi, T., and Su, T.P., Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival, Cell, 2007; 131(3): 596-610.
-
(2007)
Cell
, vol.131
, Issue.3
, pp. 596-610
-
-
Hayashi, T.1
Su, T.P.2
-
123
-
-
84870937818
-
Sigma-1 receptor chaperone and brain-derived neurotrophic factor: Emerging links between cardiovascular disease and depression
-
Hashimoto, K., Sigma-1 receptor chaperone and brain-derived neurotrophic factor: emerging links between cardiovascular disease and depression, Progress in neurobiology, 2013; 100: 15-29.
-
(2013)
Progress in Neurobiology
, vol.100
, pp. 15-29
-
-
Hashimoto, K.1
-
124
-
-
84870736640
-
Sigma1 receptor stimulation protects against oxidative damage through suppression of the ER stress responses in the human lens
-
Wang, L., Eldred, J.A., Sidaway, P., Sanderson, J., Smith, A.J., Bowater, R.P., Reddan, J.R., and Wormstone, I.M., Sigma1 receptor stimulation protects against oxidative damage through suppression of the ER stress responses in the human lens, Mechanisms of ageing and development, 2012; 133(11-12): 665-674.
-
(2012)
Mechanisms of Ageing and Development
, vol.133
, Issue.11-12
, pp. 665-674
-
-
Wang, L.1
Eldred, J.A.2
Sidaway, P.3
Sanderson, J.4
Smith, A.J.5
Bowater, R.P.6
Reddan, J.R.7
Wormstone, I.M.8
-
125
-
-
82355190062
-
Sigma-1Rs are upregulated via PERK/eIF2alpha/ATF4 pathway and execute protective function in ER stress
-
Mitsuda, T., Omi, T., Tanimukai, H., Sakagami, Y., Tagami, S., Okochi, M., Kudo, T., and Takeda, M., Sigma-1Rs are upregulated via PERK/eIF2alpha/ATF4 pathway and execute protective function in ER stress, Biochemical and biophysical research communications, 2011; 415(3): 519-525.
-
(2011)
Biochemical and Biophysical Research Communications
, vol.415
, Issue.3
, pp. 519-525
-
-
Mitsuda, T.1
Omi, T.2
Tanimukai, H.3
Sakagami, Y.4
Tagami, S.5
Okochi, M.6
Kudo, T.7
Takeda, M.8
-
126
-
-
79954498271
-
Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders
-
Hayashi, T., Tsai, S.Y., Mori, T., Fujimoto, M., and Su, T.P., Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disorders, Expert opinion on therapeutic targets, 2011; 15(5): 557-577.
-
(2011)
Expert Opinion on Therapeutic Targets
, vol.15
, Issue.5
, pp. 557-577
-
-
Hayashi, T.1
Tsai, S.Y.2
Mori, T.3
Fujimoto, M.4
Su, T.P.5
-
127
-
-
84924047943
-
Role of sigma-1 receptors in neurodegenerative diseases
-
Nguyen, L., Lucke-Wold, B.P., Mookerjee, S.A., Cavendish, J.Z., Robson, M.J., Scandinaro, A.L., and Matsumoto, R.R., Role of sigma-1 receptors in neurodegenerative diseases, Journal of pharmacological sciences, 2015; 127(1): 17-29.
-
(2015)
Journal of Pharmacological Sciences
, vol.127
, Issue.1
, pp. 17-29
-
-
Nguyen, L.1
Lucke-Wold, B.P.2
Mookerjee, S.A.3
Cavendish, J.Z.4
Robson, M.J.5
Scandinaro, A.L.6
Matsumoto, R.R.7
-
128
-
-
66249137770
-
Sigma receptors suppress multiple aspects of microglial activation
-
Hall, A.A., Herrera, Y., Ajmo, C.T., Jr., Cuevas, J., and Pennypacker, K.R., Sigma receptors suppress multiple aspects of microglial activation, Glia, 2009; 57(7): 744-754.
-
(2009)
Glia
, vol.57
, Issue.7
, pp. 744-754
-
-
Hall, A.A.1
Herrera, Y.2
Ajmo, C.T.3
Cuevas, J.4
Pennypacker, K.R.5
-
129
-
-
23044437134
-
Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity
-
Marrazzo, A., Caraci, F., Salinaro, E.T., Su, T.P., Copani, A., and Ronsisvalle, G., Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity, Neuroreport, 2005; 16(11): 1223-1226.
-
(2005)
Neuroreport
, vol.16
, Issue.11
, pp. 1223-1226
-
-
Marrazzo, A.1
Caraci, F.2
Salinaro, E.T.3
Su, T.P.4
Copani, A.5
Ronsisvalle, G.6
-
130
-
-
76749165731
-
Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB
-
Meunier, J., and Hayashi, T., Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor kappaB, The Journal of pharmacology and experimental therapeutics, 2010; 332(2): 388-397.
-
(2010)
The Journal of Pharmacology and Experimental Therapeutics
, vol.332
, Issue.2
, pp. 388-397
-
-
Meunier, J.1
Hayashi, T.2
-
131
-
-
84929121456
-
Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria
-
Natsvlishvili, N., Goguadze, N., Zhuravliova, E., and Mikeladze, D., Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria, BMC biochemistry, 2015; 16(1): 11.
-
(2015)
BMC Biochemistry
, vol.16
, Issue.1
, pp. 11
-
-
Natsvlishvili, N.1
Goguadze, N.2
Zhuravliova, E.3
Mikeladze, D.4
-
132
-
-
24344489466
-
The unfolded protein response is activated in Alzheimer's disease
-
Hoozemans, J.J., Veerhuis, R., Van Haastert, E.S., Rozemuller, J.M., Baas, F., Eikelenboom, P., and Scheper, W., The unfolded protein response is activated in Alzheimer's disease, Acta neuropathologica, 2005; 110(2): 165-172.
-
(2005)
Acta Neuropathologica
, vol.110
, Issue.2
, pp. 165-172
-
-
Hoozemans, J.J.1
Veerhuis, R.2
Van Haastert, E.S.3
Rozemuller, J.M.4
Baas, F.5
Eikelenboom, P.6
Scheper, W.7
-
133
-
-
77953485026
-
Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice
-
Lee, J.H., Won, S.M., Suh, J., Son, S.J., Moon, G.J., Park, U.J., and Gwag, B.J., Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice, Experimental & molecular medicine, 2010; 42(5): 386-394.
-
(2010)
Experimental & Molecular Medicine
, vol.42
, Issue.5
, pp. 386-394
-
-
Lee, J.H.1
Won, S.M.2
Suh, J.3
Son, S.J.4
Moon, G.J.5
Park, U.J.6
Gwag, B.J.7
-
134
-
-
65349093893
-
The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus
-
Hoozemans, J.J., van Haastert, E.S., Nijholt, D.A., Rozemuller, A.J., Eikelenboom, P., and Scheper, W., The unfolded protein response is activated in pretangle neurons in Alzheimer's disease hippocampus, The American journal of pathology, 2009; 174(4): 1241-1251.
-
(2009)
The American Journal of Pathology
, vol.174
, Issue.4
, pp. 1241-1251
-
-
Hoozemans, J.J.1
Van Haastert, E.S.2
Nijholt, D.A.3
Rozemuller, A.J.4
Eikelenboom, P.5
Scheper, W.6
-
135
-
-
0037147666
-
Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease
-
Chang, R.C., Wong, A.K., Ng, H.K., and Hugon, J., Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease, Neuroreport, 2002; 13(18): 2429-2432.
-
(2002)
Neuroreport
, vol.13
, Issue.18
, pp. 2429-2432
-
-
Chang, R.C.1
Wong, A.K.2
Ng, H.K.3
Hugon, J.4
-
136
-
-
42049089609
-
Low density of sigma1 receptors in early Alzheimer's disease
-
Mishina, M., Ohyama, M., Ishii, K., Kitamura, S., Kimura, Y., Oda, K., Kawamura, K., Sasaki, T., Kobayashi, S., Katayama, Y., et al., Low density of sigma1 receptors in early Alzheimer's disease, Annals of nuclear medicine, 2008; 22(3): 151-156.
-
(2008)
Annals of Nuclear Medicine
, vol.22
, Issue.3
, pp. 151-156
-
-
Mishina, M.1
Ohyama, M.2
Ishii, K.3
Kitamura, S.4
Kimura, Y.5
Oda, K.6
Kawamura, K.7
Sasaki, T.8
Kobayashi, S.9
Katayama, Y.10
-
137
-
-
77956288847
-
Activation of PERK signaling attenuates Abeta-mediated ER stress
-
Lee do, Y., Lee, K.S., Lee, H.J., Kim do, H., Noh, Y.H., Yu, K., Jung, H.Y., Lee, S.H., Lee, J.Y., Youn, Y.C., et al., Activation of PERK signaling attenuates Abeta-mediated ER stress, PLoS One, 2010; 5(5): e10489.
-
(2010)
PLoS One
, vol.5
, Issue.5
-
-
Lee Do, Y.1
Lee, K.S.2
Lee, H.J.3
Kim Do, H.4
Noh, Y.H.5
Yu, K.6
Jung, H.Y.7
Lee, S.H.8
Lee, J.Y.9
Youn, Y.C.10
-
138
-
-
33646881921
-
beta-Amyloid and endoplasmic reticulum stress responses in primary neurons: Effects of drugs that interact with the cytoskeleton
-
Seyb, K.I., Ansar, S., Bean, J., and Michaelis, M.L., beta-Amyloid and endoplasmic reticulum stress responses in primary neurons: effects of drugs that interact with the cytoskeleton, J Mol Neurosci, 2006; 28(2): 111-123.
-
(2006)
J Mol Neurosci
, vol.28
, Issue.2
, pp. 111-123
-
-
Seyb, K.I.1
Ansar, S.2
Bean, J.3
Michaelis, M.L.4
-
139
-
-
50249163706
-
E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity
-
Song, S., Lee, H., Kam, T.I., Tai, M.L., Lee, J.Y., Noh, J.Y., Shim, S.M., Seo, S.J., Kong, Y.Y., Nakagawa, T., et al., E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity, J Cell Biol, 2008; 182(4): 675-684.
-
(2008)
J Cell Biol
, vol.182
, Issue.4
, pp. 675-684
-
-
Song, S.1
Lee, H.2
Kam, T.I.3
Tai, M.L.4
Lee, J.Y.5
Noh, J.Y.6
Shim, S.M.7
Seo, S.J.8
Kong, Y.Y.9
Nakagawa, T.10
-
140
-
-
0035910471
-
Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2
-
Sato, N., Imaizumi, K., Manabe, T., Taniguchi, M., Hitomi, J., Katayama, T., Yoneda, T., Morihara, T., Yasuda, Y., Takagi, T., et al., Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2, J Biol Chem, 2001; 276(3): 2108-2114.
-
(2001)
J Biol Chem
, vol.276
, Issue.3
, pp. 2108-2114
-
-
Sato, N.1
Imaizumi, K.2
Manabe, T.3
Taniguchi, M.4
Hitomi, J.5
Katayama, T.6
Yoneda, T.7
Morihara, T.8
Yasuda, Y.9
Takagi, T.10
-
141
-
-
0035900779
-
Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations
-
Katayama, T., Imaizumi, K., Honda, A., Yoneda, T., Kudo, T., Takeda, M., Mori, K., Rozmahel, R., Fraser, P., George-Hyslop, P.S., et al., Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin-1 mutations, J Biol Chem, 2001; 276(46): 43446-43454.
-
(2001)
J Biol Chem
, vol.276
, Issue.46
, pp. 43446-43454
-
-
Katayama, T.1
Imaizumi, K.2
Honda, A.3
Yoneda, T.4
Kudo, T.5
Takeda, M.6
Mori, K.7
Rozmahel, R.8
Fraser, P.9
George-Hyslop, P.S.10
-
142
-
-
0036828371
-
Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations
-
Milhavet, O., Martindale, J.L., Camandola, S., Chan, S.L., Gary, D.S., Cheng, A., Holbrook, N.J., and Mattson, M.P., Involvement of Gadd153 in the pathogenic action of presenilin-1 mutations, Journal of neurochemistry, 2002; 83(3): 673-681.
-
(2002)
Journal of Neurochemistry
, vol.83
, Issue.3
, pp. 673-681
-
-
Milhavet, O.1
Martindale, J.L.2
Camandola, S.3
Chan, S.L.4
Gary, D.S.5
Cheng, A.6
Holbrook, N.J.7
Mattson, M.P.8
-
143
-
-
50249135503
-
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
-
Bezprozvanny, I., and Mattson, M.P., Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease, Trends in neurosciences, 2008; 31(9): 454-463.
-
(2008)
Trends in Neurosciences
, vol.31
, Issue.9
, pp. 454-463
-
-
Bezprozvanny, I.1
Mattson, M.P.2
-
144
-
-
79960672046
-
Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease
-
Stutzmann, G.E., and Mattson, M.P., Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease, Pharmacological reviews, 2011; 63(3): 700-727.
-
(2011)
Pharmacological Reviews
, vol.63
, Issue.3
, pp. 700-727
-
-
Stutzmann, G.E.1
Mattson, M.P.2
-
145
-
-
84878333056
-
Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation
-
Abisambra, J.F., Jinwal, U.K., Blair, L.J., O'Leary, J.C., 3rd, Li, Q., Brady, S., Wang, L., Guidi, C.E., Zhang, B., Nordhues, B.A., et al., Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation, J Neurosci, 2013; 33(22): 9498-9507.
-
(2013)
J Neurosci
, vol.33
, Issue.22
, pp. 9498-9507
-
-
Abisambra, J.F.1
Jinwal, U.K.2
Blair, L.J.3
O'Leary, J.C.4
Li, Q.5
Brady, S.6
Wang, L.7
Guidi, C.E.8
Zhang, B.9
Nordhues, B.A.10
-
146
-
-
84924402061
-
Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation
-
Jung, E.S., Hong, H., Kim, C., and Mook-Jung, I., Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation, Scientific reports, 2015; 5: 8805.
-
(2015)
Scientific Reports
, vol.5
, pp. 8805
-
-
Jung, E.S.1
Hong, H.2
Kim, C.3
Mook-Jung, I.4
-
147
-
-
84926343690
-
ER proteostasis disturbances in Parkinson's disease: Novel insights
-
Mercado, G., Castillo, V., Vidal, R., and Hetz, C., ER proteostasis disturbances in Parkinson's disease: novel insights, Frontiers in aging neuroscience, 2015; 7: 39.
-
(2015)
Frontiers in Aging Neuroscience
, vol.7
, pp. 39
-
-
Mercado, G.1
Castillo, V.2
Vidal, R.3
Hetz, C.4
-
148
-
-
33846605587
-
Activation of the unfolded protein response in Parkinson's disease
-
Hoozemans, J.J., van Haastert, E.S., Eikelenboom, P., de Vos, R.A., Rozemuller, J.M., and Scheper, W., Activation of the unfolded protein response in Parkinson's disease, Biochemical and biophysical research communications, 2007; 354(3): 707-711.
-
(2007)
Biochemical and Biophysical Research Communications
, vol.354
, Issue.3
, pp. 707-711
-
-
Hoozemans, J.J.1
Van Haastert, E.S.2
Eikelenboom, P.3
De Vos, R.A.4
Rozemuller, J.M.5
Scheper, W.6
-
149
-
-
29644434199
-
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity
-
Smith, W.W., Jiang, H., Pei, Z., Tanaka, Y., Morita, H., Sawa, A., Dawson, V.L., Dawson, T.M., and Ross, C.A., Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity, Hum Mol Genet, 2005; 14(24): 3801-3811.
-
(2005)
Hum Mol Genet
, vol.14
, Issue.24
, pp. 3801-3811
-
-
Smith, W.W.1
Jiang, H.2
Pei, Z.3
Tanaka, Y.4
Morita, H.5
Sawa, A.6
Dawson, V.L.7
Dawson, T.M.8
Ross, C.A.9
-
150
-
-
0033933048
-
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
-
Shimura, H., Hattori, N., Kubo, S., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K., et al., Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase, Nature genetics, 2000; 25(3): 302-305.
-
(2000)
Nature Genetics
, vol.25
, Issue.3
, pp. 302-305
-
-
Shimura, H.1
Hattori, N.2
Kubo, S.3
Mizuno, Y.4
Asakawa, S.5
Minoshima, S.6
Shimizu, N.7
Iwai, K.8
Chiba, T.9
Tanaka, K.10
-
151
-
-
79954417075
-
Parkin is transcriptionally regulated by ATF4: Evidence for an interconnection between mitochondrial stress and ER stress
-
Bouman, L., Schlierf, A., Lutz, A.K., Shan, J., Deinlein, A., Kast, J., Galehdar, Z., Palmisano, V., Patenge, N., Berg, D., et al., Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress, Cell Death Differ, 2011; 18(5): 769-782.
-
(2011)
Cell Death Differ
, vol.18
, Issue.5
, pp. 769-782
-
-
Bouman, L.1
Schlierf, A.2
Lutz, A.K.3
Shan, J.4
Deinlein, A.5
Kast, J.6
Galehdar, Z.7
Palmisano, V.8
Patenge, N.9
Berg, D.10
-
152
-
-
77950853379
-
Endoplasmic reticulum stress in motor neurons of the spinal cord in sporadic amyotrophic lateral sclerosis
-
Sasaki, S., Endoplasmic reticulum stress in motor neurons of the spinal cord in sporadic amyotrophic lateral sclerosis, Journal of neuropathology and experimental neurology, 2010; 69(4): 346-355.
-
(2010)
Journal of Neuropathology and Experimental Neurology
, vol.69
, Issue.4
, pp. 346-355
-
-
Sasaki, S.1
-
153
-
-
44849124411
-
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1
-
Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K., and Ichijo, H., ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1, Genes Dev, 2008; 22(11): 1451-1464.
-
(2008)
Genes Dev
, vol.22
, Issue.11
, pp. 1451-1464
-
-
Nishitoh, H.1
Kadowaki, H.2
Nagai, A.3
Maruyama, T.4
Yokota, T.5
Fukutomi, H.6
Noguchi, T.7
Matsuzawa, A.8
Takeda, K.9
Ichijo, H.10
-
154
-
-
70350701842
-
Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation
-
Ying, Z., Wang, H., Fan, H., Zhu, X., Zhou, J., Fei, E., and Wang, G., Gp78, an ER associated E3, promotes SOD1 and ataxin-3 degradation, Hum Mol Genet, 2009; 18(22): 4268-4281.
-
(2009)
Hum Mol Genet
, vol.18
, Issue.22
, pp. 4268-4281
-
-
Ying, Z.1
Wang, H.2
Fan, H.3
Zhu, X.4
Zhou, J.5
Fei, E.6
Wang, G.7
-
155
-
-
84155163741
-
A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis
-
Al-Saif, A., Al-Mohanna, F., and Bohlega, S., A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis, Annals of neurology, 2011; 70(6): 913-919.
-
(2011)
Annals of Neurology
, vol.70
, Issue.6
, pp. 913-919
-
-
Al-Saif, A.1
Al-Mohanna, F.2
Bohlega, S.3
-
156
-
-
84929069085
-
Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration
-
Bernard-Marissal, N., Medard, J.J., Azzedine, H., and Chrast, R., Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration, Brain : a journal of neurology, 2015; 138(Pt 4): 875-890.
-
(2015)
Brain: A Journal of Neurology
, vol.138
, pp. 875-890
-
-
Bernard-Marissal, N.1
Medard, J.J.2
Azzedine, H.3
Chrast, R.4
-
157
-
-
84924072040
-
The role of SIGMAR1 gene mutation and mitochondrial dysfunction in amyotrophic lateral sclerosis
-
Fukunaga, K., Shinoda, Y., and Tagashira, H., The role of SIGMAR1 gene mutation and mitochondrial dysfunction in amyotrophic lateral sclerosis, Journal of pharmacological sciences, 2015; 127(1): 36-41.
-
(2015)
Journal of Pharmacological Sciences
, vol.127
, Issue.1
, pp. 36-41
-
-
Fukunaga, K.1
Shinoda, Y.2
Tagashira, H.3
-
158
-
-
0142105406
-
Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein
-
Hetz, C., Russelakis-Carneiro, M., Maundrell, K., Castilla, J., and Soto, C., Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein, The EMBO journal, 2003; 22(20): 5435-5445.
-
(2003)
The EMBO Journal
, vol.22
, Issue.20
, pp. 5435-5445
-
-
Hetz, C.1
Russelakis-Carneiro, M.2
Maundrell, K.3
Castilla, J.4
Soto, C.5
-
159
-
-
84861450392
-
Sustained translational repression by eIF2alpha-P mediates prion neurodegeneration
-
Moreno, J.A., Radford, H., Peretti, D., Steinert, J.R., Verity, N., Martin, M.G., Halliday, M., Morgan, J., Dinsdale, D., Ortori, C.A., et al., Sustained translational repression by eIF2alpha-P mediates prion neurodegeneration, Nature, 2012; 485(7399): 507-511.
-
(2012)
Nature
, vol.485
, Issue.7399
, pp. 507-511
-
-
Moreno, J.A.1
Radford, H.2
Peretti, D.3
Steinert, J.R.4
Verity, N.5
Martin, M.G.6
Halliday, M.7
Morgan, J.8
Dinsdale, D.9
Ortori, C.A.10
-
160
-
-
84927619395
-
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
-
Das, I., Krzyzosiak, A., Schneider, K., Wrabetz, L., D'Antonio, M., Barry, N., Sigurdardottir, A., and Bertolotti, A., Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit, Science, 2015; 348(6231): 239-242.
-
(2015)
Science
, vol.348
, Issue.6231
, pp. 239-242
-
-
Das, I.1
Krzyzosiak, A.2
Schneider, K.3
Wrabetz, L.4
D'Antonio, M.5
Barry, N.6
Sigurdardottir, A.7
Bertolotti, A.8
-
161
-
-
79953288480
-
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis
-
Tsaytler, P., Harding, H.P., Ron, D., and Bertolotti, A., Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis, Science, 2011; 332(6025): 91-94.
-
(2011)
Science
, vol.332
, Issue.6025
, pp. 91-94
-
-
Tsaytler, P.1
Harding, H.P.2
Ron, D.3
Bertolotti, A.4
-
162
-
-
84988811921
-
Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity
-
Halliday, M., Radford, H., Sekine, Y., Moreno, J., Verity, N., le Quesne, J., Ortori, C.A., Barrett, D.A., Fromont, C., Fischer, P.M., et al., Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity, Cell Death Dis, 2015; 6: e1672.
-
(2015)
Cell Death Dis
, vol.6
-
-
Halliday, M.1
Radford, H.2
Sekine, Y.3
Moreno, J.4
Verity, N.5
Le Quesne, J.6
Ortori, C.A.7
Barrett, D.A.8
Fromont, C.9
Fischer, P.M.10
-
163
-
-
76249091683
-
Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease
-
Cho, K.J., Lee, B.I., Cheon, S.Y., Kim, H.W., Kim, H.J., and Kim, G.W., Inhibition of apoptosis signal-regulating kinase 1 reduces endoplasmic reticulum stress and nuclear huntingtin fragments in a mouse model of Huntington disease, Neuroscience, 2009; 163(4): 1128-1134.
-
(2009)
Neuroscience
, vol.163
, Issue.4
, pp. 1128-1134
-
-
Cho, K.J.1
Lee, B.I.2
Cheon, S.Y.3
Kim, H.W.4
Kim, H.J.5
Kim, G.W.6
-
164
-
-
66449112462
-
SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition
-
Noh, J.Y., Lee, H., Song, S., Kim, N.S., Im, W., Kim, M., Seo, H., Chung, C.W., Chang, J.W., Ferrante, R.J., et al., SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition, J Biol Chem, 2009; 284(17): 11318-11325.
-
(2009)
J Biol Chem
, vol.284
, Issue.17
, pp. 11318-11325
-
-
Noh, J.Y.1
Lee, H.2
Song, S.3
Kim, N.S.4
Im, W.5
Kim, M.6
Seo, H.7
Chung, C.W.8
Chang, J.W.9
Ferrante, R.J.10
-
165
-
-
84860471873
-
Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy
-
Vidal, R.L., Figueroa, A., Court, F.A., Thielen, P., Molina, C., Wirth, C., Caballero, B., Kiffin, R., Segura-Aguilar, J., Cuervo, A.M., et al., Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy, Hum Mol Genet, 2012; 21(10): 2245-2262.
-
(2012)
Hum Mol Genet
, vol.21
, Issue.10
, pp. 2245-2262
-
-
Vidal, R.L.1
Figueroa, A.2
Court, F.A.3
Thielen, P.4
Molina, C.5
Wirth, C.6
Caballero, B.7
Kiffin, R.8
Segura-Aguilar, J.9
Cuervo, A.M.10
-
166
-
-
35448994487
-
Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity
-
Atwal, R.S., Xia, J., Pinchev, D., Taylor, J., Epand, R.M., and Truant, R., Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity, Hum Mol Genet, 2007; 16(21): 2600-2615.
-
(2007)
Hum Mol Genet
, vol.16
, Issue.21
, pp. 2600-2615
-
-
Atwal, R.S.1
Xia, J.2
Pinchev, D.3
Taylor, J.4
Epand, R.M.5
Truant, R.6
-
167
-
-
84858374665
-
The amyloid state of proteins in human diseases
-
Eisenberg, D., and Jucker, M., The amyloid state of proteins in human diseases, Cell, 2012; 148(6): 1188-1203.
-
(2012)
Cell
, vol.148
, Issue.6
, pp. 1188-1203
-
-
Eisenberg, D.1
Jucker, M.2
-
168
-
-
63249135140
-
Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease
-
Mitra, S., Tsvetkov, A.S., and Finkbeiner, S., Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in huntington disease, J Biol Chem, 2009; 284(7): 4398-4403.
-
(2009)
J Biol Chem
, vol.284
, Issue.7
, pp. 4398-4403
-
-
Mitra, S.1
Tsvetkov, A.S.2
Finkbeiner, S.3
-
169
-
-
77949352928
-
Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation
-
Ortega, Z., Diaz-Hernandez, M., Maynard, C.J., Hernandez, F., Dantuma, N.P., and Lucas, J.J., Acute polyglutamine expression in inducible mouse model unravels ubiquitin/proteasome system impairment and permanent recovery attributable to aggregate formation, J Neurosci, 2010; 30(10): 3675-3688.
-
(2010)
J Neurosci
, vol.30
, Issue.10
, pp. 3675-3688
-
-
Ortega, Z.1
Diaz-Hernandez, M.2
Maynard, C.J.3
Hernandez, F.4
Dantuma, N.P.5
Lucas, J.J.6
-
170
-
-
13244258435
-
Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation
-
Bennett, E.J., Bence, N.F., Jayakumar, R., and Kopito, R.R., Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation, Mol Cell, 2005; 17(3): 351-365.
-
(2005)
Mol Cell
, vol.17
, Issue.3
, pp. 351-365
-
-
Bennett, E.J.1
Bence, N.F.2
Jayakumar, R.3
Kopito, R.R.4
-
171
-
-
34948838383
-
Riluzole in Huntington's disease: A 3-year, randomized controlled study
-
Landwehrmeyer, G.B., Dubois, B., de Yébenes, J.G., Kremer, B., Gaus, W., Kraus, P.H., Przuntek, H., Dib, M., Doble, A., Fischer, W., et al., Riluzole in Huntington's disease: a 3-year, randomized controlled study, Annals of neurology, 2007; 62(3): 262-272.
-
(2007)
Annals of Neurology
, vol.62
, Issue.3
, pp. 262-272
-
-
Landwehrmeyer, G.B.1
Dubois, B.2
De Yébenes, J.G.3
Kremer, B.4
Gaus, W.5
Kraus, P.H.6
Przuntek, H.7
Dib, M.8
Doble, A.9
Fischer, W.10
-
172
-
-
81355160169
-
Identifying polyglutamine protein species in situ that best predict neurodegeneration
-
Miller, J., Arrasate, M., Brooks, E., Libeu, C.P., Legleiter, J., Hatters, D., Curtis, J., Cheung, K., Krishnan, P., Mitra, S., et al., Identifying polyglutamine protein species in situ that best predict neurodegeneration, Nature chemical biology, 2011; 7(12): 925-934.
-
(2011)
Nature Chemical Biology
, vol.7
, Issue.12
, pp. 925-934
-
-
Miller, J.1
Arrasate, M.2
Brooks, E.3
Libeu, C.P.4
Legleiter, J.5
Hatters, D.6
Curtis, J.7
Cheung, K.8
Krishnan, P.9
Mitra, S.10
-
173
-
-
0037096823
-
Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation
-
Kouroku, Y., Fujita, E., Jimbo, A., Kikuchi, T., Yamagata, T., Momoi, M.Y., Kominami, E., Kuida, K., Sakamaki, K., Yonehara, S., et al., Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation, Hum Mol Genet, 2002; 11(13): 1505-1515.
-
(2002)
Hum Mol Genet
, vol.11
, Issue.13
, pp. 1505-1515
-
-
Kouroku, Y.1
Fujita, E.2
Jimbo, A.3
Kikuchi, T.4
Yamagata, T.5
Momoi, M.Y.6
Kominami, E.7
Kuida, K.8
Sakamaki, K.9
Yonehara, S.10
-
174
-
-
0036606540
-
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
-
Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A., and Ichijo, H., ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats, Genes Dev, 2002; 16(11): 1345-1355.
-
(2002)
Genes Dev
, vol.16
, Issue.11
, pp. 1345-1355
-
-
Nishitoh, H.1
Matsuzawa, A.2
Tobiume, K.3
Saegusa, K.4
Takeda, K.5
Inoue, K.6
Hori, S.7
Kakizuka, A.8
Ichijo, H.9
-
175
-
-
84893752733
-
Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax
-
Ueda, M., Li, S., Itoh, M., Hayakawa-Yano, Y., Wang, M.X., Hayakawa, M., Hasebe-Matsubara, R., Ohta, K., Ohta, E., Mizuno, A., et al., Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax, Biochemical and biophysical research communications, 2014; 443(4): 1232-1238.
-
(2014)
Biochemical and Biophysical Research Communications
, vol.443
, Issue.4
, pp. 1232-1238
-
-
Ueda, M.1
Li, S.2
Itoh, M.3
Hayakawa-Yano, Y.4
Wang, M.X.5
Hayakawa, M.6
Hasebe-Matsubara, R.7
Ohta, K.8
Ohta, E.9
Mizuno, A.10
-
176
-
-
78649954745
-
Mechanism of ER stress-induced brain damage by IP(3) receptor
-
Higo, T., Hamada, K., Hisatsune, C., Nukina, N., Hashikawa, T., Hattori, M., Nakamura, T., and Mikoshiba, K., Mechanism of ER stress-induced brain damage by IP(3) receptor, Neuron, 2010; 68(5): 865-878.
-
(2010)
Neuron
, vol.68
, Issue.5
, pp. 865-878
-
-
Higo, T.1
Hamada, K.2
Hisatsune, C.3
Nukina, N.4
Hashikawa, T.5
Hattori, M.6
Nakamura, T.7
Mikoshiba, K.8
-
177
-
-
0041963057
-
Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1
-
Tang, T.S., Tu, H., Chan, E.Y., Maximov, A., Wang, Z., Wellington, C.L., Hayden, M.R., and Bezprozvanny, I., Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1, Neuron, 2003; 39(2): 227-239.
-
(2003)
Neuron
, vol.39
, Issue.2
, pp. 227-239
-
-
Tang, T.S.1
Tu, H.2
Chan, E.Y.3
Maximov, A.4
Wang, Z.5
Wellington, C.L.6
Hayden, M.R.7
Bezprozvanny, I.8
-
178
-
-
45049085513
-
Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease
-
Zhang, H., Li, Q., Graham, R.K., Slow, E., Hayden, M.R., and Bezprozvanny, I., Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease, Neurobiology of disease, 2008; 31(1): 80-88.
-
(2008)
Neurobiology of Disease
, vol.31
, Issue.1
, pp. 80-88
-
-
Zhang, H.1
Li, Q.2
Graham, R.K.3
Slow, E.4
Hayden, M.R.5
Bezprozvanny, I.6
-
179
-
-
84875365804
-
Autophagosomes form at ER-mitochondria contact sites
-
Hamasaki, M., Furuta, N., Matsuda, A., Nezu, A., Yamamoto, A., Fujita, N., Oomori, H., Noda, T., Haraguchi, T., Hiraoka, Y., et al., Autophagosomes form at ER-mitochondria contact sites, Nature, 2013; 495(7441): 389-393.
-
(2013)
Nature
, vol.495
, Issue.7441
, pp. 389-393
-
-
Hamasaki, M.1
Furuta, N.2
Matsuda, A.3
Nezu, A.4
Yamamoto, A.5
Fujita, N.6
Oomori, H.7
Noda, T.8
Haraguchi, T.9
Hiraoka, Y.10
-
180
-
-
84911862220
-
Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntington's disease
-
Miki, Y., Tanji, K., Mori, F., and Wakabayashi, K., Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntington's disease, Neurobiology of disease, 2015; 74: 25-31.
-
(2015)
Neurobiology of Disease
, vol.74
, pp. 25-31
-
-
Miki, Y.1
Tanji, K.2
Mori, F.3
Wakabayashi, K.4
-
181
-
-
33947719749
-
eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory
-
Costa-Mattioli, M., Gobert, D., Stern, E., Gamache, K., Colina, R., Cuello, C., Sossin, W., Kaufman, R., Pelletier, J., Rosenblum, K., et al., eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory, Cell, 2007; 129(1): 195-206.
-
(2007)
Cell
, vol.129
, Issue.1
, pp. 195-206
-
-
Costa-Mattioli, M.1
Gobert, D.2
Stern, E.3
Gamache, K.4
Colina, R.5
Cuello, C.6
Sossin, W.7
Kaufman, R.8
Pelletier, J.9
Rosenblum, K.10
-
182
-
-
84881530677
-
Pharmacological brake-release of mRNA translation enhances cognitive memory
-
Sidrauski, C., Acosta-Alvear, D., Khoutorsky, A., Vedantham, P., Hearn, B.R., Li, H., Gamache, K., Gallagher, C.M., Ang, K.K., Wilson, C., et al., Pharmacological brake-release of mRNA translation enhances cognitive memory, Elife, 2013; 2: e00498.
-
(2013)
Elife
, vol.2
-
-
Sidrauski, C.1
Acosta-Alvear, D.2
Khoutorsky, A.3
Vedantham, P.4
Hearn, B.R.5
Li, H.6
Gamache, K.7
Gallagher, C.M.8
Ang, K.K.9
Wilson, C.10
-
183
-
-
84922460332
-
Delivering a disease-modifying treatment for Huntington's disease
-
Godinho, B.M.D.C., Malhotra, M., O'Driscoll, C.M., and Cryan, J.F., Delivering a disease-modifying treatment for Huntington's disease, Drug Discovery Today, 2015; 20(1): 50-64.
-
(2015)
Drug Discovery Today
, vol.20
, Issue.1
, pp. 50-64
-
-
Godinho, B.M.D.C.1
Malhotra, M.2
O'Driscoll, C.M.3
Cryan, J.F.4
-
184
-
-
84941954604
-
A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits
-
Aharony, I., Ehrnhoefer, D.E., Shruster, A., Qiu, X., Franciosi, S., Hayden, M.R., and Offen, D., A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits, Hum Mol Genet, 2015; 24(9): 2604-2614.
-
(2015)
Hum Mol Genet
, vol.24
, Issue.9
, pp. 2604-2614
-
-
Aharony, I.1
Ehrnhoefer, D.E.2
Shruster, A.3
Qiu, X.4
Franciosi, S.5
Hayden, M.R.6
Offen, D.7
-
185
-
-
0142157600
-
Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice
-
Ferrante, R.J., Kubilus, J.K., Lee, J., Ryu, H., Beesen, A., Zucker, B., Smith, K., Kowall, N.W., Ratan, R.R., Luthi-Carter, R., et al., Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice, J Neurosci, 2003; 23(28): 9418-9427.
-
(2003)
J Neurosci
, vol.23
, Issue.28
, pp. 9418-9427
-
-
Ferrante, R.J.1
Kubilus, J.K.2
Lee, J.3
Ryu, H.4
Beesen, A.5
Zucker, B.6
Smith, K.7
Kowall, N.W.8
Ratan, R.R.9
Luthi-Carter, R.10
-
186
-
-
0036677435
-
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease
-
Keene, C.D., Rodrigues, C.M., Eich, T., Chhabra, M.S., Steer, C.J., and Low, W.C., Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease, Proc Natl Acad Sci U S A, 2002; 99(16): 10671-10676.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, Issue.16
, pp. 10671-10676
-
-
Keene, C.D.1
Rodrigues, C.M.2
Eich, T.3
Chhabra, M.S.4
Steer, C.J.5
Low, W.C.6
-
187
-
-
38849146956
-
ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative lysosomal storage disorders and are alleviated by chemical chaperones
-
Wei, H., Kim, S.J., Zhang, Z., Tsai, P.C., Wisniewski, K.E., and Mukherjee, A.B., ER and oxidative stresses are common mediators of apoptosis in both neurodegenerative and non-neurodegenerative lysosomal storage disorders and are alleviated by chemical chaperones, Hum Mol Genet, 2008; 17(4): 469-477.
-
(2008)
Hum Mol Genet
, vol.17
, Issue.4
, pp. 469-477
-
-
Wei, H.1
Kim, S.J.2
Zhang, Z.3
Tsai, P.C.4
Wisniewski, K.E.5
Mukherjee, A.B.6
-
188
-
-
0035660075
-
The interaction between neuroactive steroids and the sigma1 receptor function: Behavioral consequences and therapeutic opportunities
-
Maurice, T., Urani, A., Phan, V.L., and Romieu, P., The interaction between neuroactive steroids and the sigma1 receptor function: behavioral consequences and therapeutic opportunities, Brain research. Brain research reviews, 2001; 37(1-3): 116-132.
-
(2001)
Brain Research. Brain Research Reviews
, vol.37
, Issue.1-3
, pp. 116-132
-
-
Maurice, T.1
Urani, A.2
Phan, V.L.3
Romieu, P.4
-
189
-
-
79952126094
-
The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke
-
Ruscher, K., Shamloo, M., Rickhag, M., Ladunga, I., Soriano, L., Gisselsson, L., Toresson, H., Ruslim-Litrus, L., Oksenberg, D., Urfer, R., et al., The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke, Brain : a journal of neurology, 2011; 134(Pt 3): 732-746.
-
(2011)
Brain: A Journal of Neurology
, vol.134
, pp. 732-746
-
-
Ruscher, K.1
Shamloo, M.2
Rickhag, M.3
Ladunga, I.4
Soriano, L.5
Gisselsson, L.6
Toresson, H.7
Ruslim-Litrus, L.8
Oksenberg, D.9
Urfer, R.10
-
190
-
-
84922479757
-
Phase II trial of the Sigma-1 receptor agonist cutamesine (SA4503) for recovery enhancement after acute ischemic stroke
-
Urfer, R., Moebius, H.J., Skoloudik, D., Santamarina, E., Sato, W., Mita, S., and Muir, K.W., Phase II trial of the Sigma-1 receptor agonist cutamesine (SA4503) for recovery enhancement after acute ischemic stroke, Stroke; a journal of cerebral circulation, 2014; 45(11): 3304-3310.
-
(2014)
Stroke; a Journal of Cerebral Circulation
, vol.45
, Issue.11
, pp. 3304-3310
-
-
Urfer, R.1
Moebius, H.J.2
Skoloudik, D.3
Santamarina, E.4
Sato, W.5
Mita, S.6
Muir, K.W.7
-
191
-
-
84903529679
-
Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism
-
Francardo, V., Bez, F., Wieloch, T., Nissbrandt, H., Ruscher, K., and Cenci, M.A., Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism, Brain : a journal of neurology, 2014; 137(Pt 7): 1998-2014.
-
(2014)
Brain: A Journal of Neurology
, vol.137
, pp. 1998-2014
-
-
Francardo, V.1
Bez, F.2
Wieloch, T.3
Nissbrandt, H.4
Ruscher, K.5
Cenci, M.A.6
-
192
-
-
84879392732
-
Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: Involvement of calpastatin and the NF-kappaB pathway
-
Hyrskyluoto, A., Pulli, I., Tornqvist, K., Ho, T.H., Korhonen, L., and Lindholm, D., Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-kappaB pathway, Cell Death Dis, 2013; 4: e646.
-
(2013)
Cell Death Dis
, vol.4
, pp. e646
-
-
Hyrskyluoto, A.1
Pulli, I.2
Tornqvist, K.3
Ho, T.H.4
Korhonen, L.5
Lindholm, D.6
|