Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration

Brain

Volumn 138, Issue 4, 2015, Pages 875-890

  Bernard Marissal, Nathalie ^a,b   Médard, Jean Jacques ^a   Azzedine, Hamid ^a,c   Chrast, Roman ^a,d  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b EPFL   (Switzerland)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

MAMs loss; mitochondrial and endoplasmic reticulum dysfunction; motor neuron degeneration; Sigma 1 receptor

Indexed keywords

SIGMA 1 OPIATE RECEPTOR; SIGMA OPIATE RECEPTOR; SIGMA-1 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CELL CULTURE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CELL DEATH; CELL TRANSPORT; DEGENERATIVE DISEASE; EMBRYO; ENDOPLASMIC RETICULUM; IN VITRO STUDY; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; MOLECULAR INTERACTION; MOTOR NEURON DISEASE; MOUSE; MUSCLE WEAKNESS; NERVE FIBER DEGENERATION; NERVE FIBER TRANSPORT; NEUROMUSCULAR DISEASE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CELL CULTURE; GENETICS; KNOCKOUT MOUSE; METABOLISM; NERVE DEGENERATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; ENDOPLASMIC RETICULUM; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MOTOR NEURON DISEASE; NERVE DEGENERATION; RATS; RECEPTOR CROSS-TALK; RECEPTORS, SIGMA;

EID: 84929069085     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awv008     Document Type: Article

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