Sigma 1 receptor stimulation protects against oxidative damage through suppression of the ER stress responses in the human lens

Mechanisms of Ageing and Development

Volumn 133, Issue 11-12, 2012, Pages 665-674

  Wang, Lixin ^a   Eldred, Julie A ^a   Sidaway, Peter ^a   Sanderson, Julie ^a   Smith, Andrew J O ^a   Bowater, Richard P ^a   Reddan, John R ^b   Wormstone, I Michael ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b OAKLAND UNIVERSITY   (United States)

Author keywords

Cataract; ER stress; Human; Lens; Oxidative stress; Sigma 1 receptor

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CASPASE; GLUCOSE REGULATED PROTEIN 78; HYDROGEN PEROXIDE; INITIATION FACTOR 2ALPHA; LACTATE DEHYDROGENASE; PENTAZOCINE; PROCASPASE 12; SIGMA 1 OPIATE RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME RELEASE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; LENS; LONG TERM EXPOSURE; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEINASE INHIBITION;

APOPTOSIS; CALCIUM; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; HEAT-SHOCK PROTEINS; HUMANS; HYDROGEN PEROXIDE; IN SITU NICK-END LABELING; L-LACTATE DEHYDROGENASE; LENS, CRYSTALLINE; OXIDATIVE STRESS; PENTAZOCINE; RECEPTORS, SIGMA;

EID: 84870736640     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2012.09.005     Document Type: Article

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