Endoplasmic reticulum degradation requires lumen to cytosol signaling: Transmembrane control of Hrd1p by Hrd3p

Journal of Cell Biology

Volumn 151, Issue 1, 2000, Pages 69-82

  Gardner, Richard G ^a   Swarbrick, Gwendolyn M ^a   Bays, Nathan W ^a   Cronin, Stephen R ^a   Wilhovsky, Sharon ^a   Seelig, Linda ^a   Kim, Christine ^a   Hampton, Randolph Y ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Endoplasmic reticulum; Proteasome; Topology; Transmembrane signaling; Ubiquitin ligase

Indexed keywords

CYCLOHEXIMIDE; MEMBRANE PROTEIN; PROTEASOME; PROTEIN HRD1P; PROTEIN HRD3P; UNCLASSIFIED DRUG;

ARTICLE; ENDOPLASMIC RETICULUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN PROCESSING; PROTEIN STABILITY; SIGNAL TRANSDUCTION; STOICHIOMETRY;

BINDING SITES; BIOLOGICAL TRANSPORT; CYTOSOL; ENDOPLASMIC RETICULUM; MEMBRANE GLYCOPROTEINS; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASES;

EID: 0034597161     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.151.1.69     Document Type: Article

References (47)

1. Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway
2. Expression of heterologous genes in Saccharomyces cerevisiae from vectors utilizing the glyceraldehyde-3-phosphate dehydrogenase gene promoter
3. A RING-H2 finger motif is essential for the function of Der3/Hrd1 in endoplasmic reticulum associated protein degradation in the yeast Saccharomyces cerevisiae
4. Der3p-Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins
5. The regulated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase requires a short-lived protein and occurs in the endoplasmic reticulum
6. Intracellular retention and degradation of human mutant variant of a alpha 1-antitrypsin in stably transfected Chinese hamster ovary cell lines
7. Cloning and characterization of Sel-1I, a murine homolog of the C. elegans sel-1 gene
8. Mevalonolactone inhibits the rate of synthesis and enhances the rate of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rat hepatocytes
9. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
10. Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast
11. The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70
12. A regulatory link between ER-associated protein degradation and the unfolded-protein response
13. Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism
14. Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein
15. The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8
16. Structure, function, and expression of SEL-1, a negative regulator of LIN-12 and GLP-1 in C. elegans
17. Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast
18. Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase
19. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein
20. In vivo examination of membrane protein localization and degradation with green fluorescent protein
21. ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway
22. Engineering hybrid genes without the use of restriction enzymes: Gene splicing by overlap extension
23. The tyrosine kinase negative regulator c-CBL as a RING-type E2-dependent ubiquitin-protein ligase
24. Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast
25. Degradation from the endoplasmic reticulum: Disposing of newly synthesized proteins
26. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
27. The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene
28. Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme
29. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity
30. Association with cullin partners protects ROC proteins from proteasome-dependent degradation
31. Mutations in PEX10 is the cause of Zellweger peroxisome deficiency syndrome of complementation group B
32. Saccharomyces cerevisiae CNE1 encodes an endoplasmic reticulum (ER) membrane protein with sequence similarity to calnexin and calreticulin and functions as a constituent of the ER quality control apparatus
33. Subunits and substrates of the anaphase-promoting complex
34. Endoplasmic reticulum degradation of a mutated ATP-binding cassette transporter Pdr5 proceeds in a concerted action of Sec61 and the proteasome
35. Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation
36. Identification of SEC12, SED4, truncated SEC16, and EKS1/HRD3 as multicopy suppressors of as mutants of Sar1 GTPase
37. Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34
38. Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1
39. A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole
40. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation
41. Degradation of CFTR by the ubiquitin-proteasome pathway
42. Associations between subunit ectodomains promote T cell antigen receptor assembly and protect against degradation in the ER
43. HRD gene dependence of ER-associated degradation
44. The E2-E3 interaction in the N-end rule pathway: The RING-H2 finger of E3 is required for the synthesis of multi-ubiquitin chain
45. Ubiquitin-proteasome pathway mediates intracellular degradation of apolipoprotein B
46. The engagement of Sec61p in the ER dislocation process
47. Regulated co-translational ubiquitination of apolipoprotein B100. A new paradigm for proteasomal degradation of a secretory protein