Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: Involvement of calpastatin and the NF-κB pathway

Cell Death and Disease

Volumn 4, Issue 5, 2013, Pages

  Hyrskyluoto, A ^a,b   Pulli, I ^c   Tornqvist K ^b,c   Huu Ho, T ^b   Korhonen, L ^a,b,d   Lindholm, D ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^c ÅBO AKADEMI UNIVERSITY   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Calpastatin; HD; NF B; Oxidative stress; Sigma 1 receptor

Indexed keywords

1 PHENYLCYCLOHEXANECARBOXYLIC ACID 2 MORPHOLINOETHYL ESTER; CALCIUM; CALPASTATIN; CASPASE 12; CASPASE 3; CHAPERONE; HUNTINGTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA;

AMINO TERMINAL SEQUENCE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL DEGENERATION; CELL STIMULATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUNTINGTON CHOREA; INTRACELLULAR SIGNALING; MITOCHONDRION; NERVE CELL; NERVE CELL CULTURE; NEUROPROTECTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WILD TYPE;

CALCIUM; CALCIUM-BINDING PROTEINS; CASPASES; CELL LINE; CELL SURVIVAL; GENE EXPRESSION REGULATION; HUMANS; MITOCHONDRIA; MORPHOLINES; NERVE TISSUE PROTEINS; NF-KAPPA B; REACTIVE OXYGEN SPECIES; RECEPTORS, SIGMA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA;

EID: 84879392732     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.170     Document Type: Article

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