-
2
-
-
0027212062
-
Chronic intrastriatal dialytic administration of quinolinic acid produces selective neural degeneration
-
Bazzett TJ, Becker JB, Kaatz KW, Albin RL (1993) Chronic intrastriatal dialytic administration of quinolinic acid produces selective neural degeneration. Exp Neurol 120:177-185.
-
(1993)
Exp Neurol
, vol.120
, pp. 177-185
-
-
Bazzett, T.J.1
Becker, J.B.2
Kaatz, K.W.3
Albin, R.L.4
-
3
-
-
0022446150
-
Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid
-
Beal MF, Kowall NW, Ellison DW, Mazurek MF, Swartz KJ, Martin JB (1986) Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid. Nature 321:168-171.
-
(1986)
Nature
, vol.321
, pp. 168-171
-
-
Beal, M.F.1
Kowall, N.W.2
Ellison, D.W.3
Mazurek, M.F.4
Swartz, K.J.5
Martin, J.B.6
-
4
-
-
4444302167
-
Deranged neuronal calcium signaling and Huntington disease
-
Bezprozvanny I, Hayden MR (2004) Deranged neuronal calcium signaling and Huntington disease. Biochem Biophys Res Commun 322:1310-1317.
-
(2004)
Biochem Biophys Res Commun
, vol.322
, pp. 1310-1317
-
-
Bezprozvanny, I.1
Hayden, M.R.2
-
5
-
-
0029118136
-
Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform
-
Brouillet E, Hantraye P, Ferrante RJ, Dolan R, Leroy-Willig A, Kowall NW, Beal MF (1995) Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform. Proc Natl Acad Sci U S A 92:7105-7109.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 7105-7109
-
-
Brouillet, E.1
Hantraye, P.2
Ferrante, R.J.3
Dolan, R.4
Leroy-Willig, A.5
Kowall, N.W.6
Beal, M.F.7
-
6
-
-
34047250333
-
Maintenance of superior learning and memory function in NR2B transgenic mice during aging
-
Cao X, Cui Z, Feng R, Tang YP, Qin Z, Mei B, Tsien JZ (2007) Maintenance of superior learning and memory function in NR2B transgenic mice during aging. Eur J Neurosci 25:1815-1822.
-
(2007)
Eur J Neurosci
, vol.25
, pp. 1815-1822
-
-
Cao, X.1
Cui, Z.2
Feng, R.3
Tang, Y.P.4
Qin, Z.5
Mei, B.6
Tsien, J.Z.7
-
7
-
-
0035889535
-
NMDA receptor function in mouse models of Huntington disease
-
Cepeda C, Ariano MA, Calvert CR, Flores-Hernández J, Chandler SH, Leavitt BR, Hayden MR, Levine MS (2001) NMDA receptor function in mouse models of Huntington disease. J Neurosci Res 66:525-539.
-
(2001)
J Neurosci Res
, vol.66
, pp. 525-539
-
-
Cepeda, C.1
Ariano, M.A.2
Calvert, C.R.3
Flores-Hernández, J.4
Chandler, S.H.5
Leavitt, B.R.6
Hayden, M.R.7
Levine, M.S.8
-
8
-
-
0032971311
-
Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin
-
Chen N, Luo T, Wellington C, Metzler M, McCutcheon K, Hayden MR, Raymond LA (1999) Subtype-specific enhancement of NMDA receptor currents by mutant huntingtin. J Neurochem 72:1890-1898.
-
(1999)
J Neurochem
, vol.72
, pp. 1890-1898
-
-
Chen, N.1
Luo, T.2
Wellington, C.3
Metzler, M.4
McCutcheon, K.5
Hayden, M.R.6
Raymond, L.A.7
-
9
-
-
0017167057
-
Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea
-
Coyle JT, Schwarcz R (1976) Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea. Nature 263:244-246.
-
(1976)
Nature
, vol.263
, pp. 244-246
-
-
Coyle, J.T.1
Schwarcz, R.2
-
10
-
-
0035369112
-
NMDA receptor subunits: Diversity, development and disease
-
Cull-Candy S, Brickley S, Farrant M (2001) NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 11:327-335.
-
(2001)
Curr Opin Neurobiol
, vol.11
, pp. 327-335
-
-
Cull-Candy, S.1
Brickley, S.2
Farrant, M.3
-
12
-
-
34047100940
-
N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease
-
Fan MM, Raymond LA (2007) N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease. Prog Neurobiol 81:272-293.
-
(2007)
Prog Neurobiol
, vol.81
, pp. 272-293
-
-
Fan, M.M.1
Raymond, L.A.2
-
13
-
-
0027396021
-
Excitotoxin lesions in primates as a model for Huntington's disease: Histopathologic and neurochemical characterization
-
Ferrante RJ, Kowall NW, Cipolloni PB, Storey E, Beal MF (1993) Excitotoxin lesions in primates as a model for Huntington's disease: histopathologic and neurochemical characterization. Exp Neurol 119:46-71.
-
(1993)
Exp Neurol
, vol.119
, pp. 46-71
-
-
Ferrante, R.J.1
Kowall, N.W.2
Cipolloni, P.B.3
Storey, E.4
Beal, M.F.5
-
14
-
-
0028836272
-
Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate
-
Greene JG, Greenamyre JT (1995) Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate. J Neurochem 64:430-436.
-
(1995)
J Neurochem
, vol.64
, pp. 430-436
-
-
Greene, J.G.1
Greenamyre, J.T.2
-
15
-
-
0036241207
-
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
-
Hardingham GE, Fukunaga Y, Bading H (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat Neurosci 5:405-414.
-
(2002)
Nat Neurosci
, vol.5
, pp. 405-414
-
-
Hardingham, G.E.1
Fukunaga, Y.2
Bading, H.3
-
16
-
-
34548161707
-
Longitudinal evaluation of the Hdh(CAG) 150 knock-in murine model of Huntington's disease
-
Heng MY, Tallaksen-Greene SJ, Detloff PJ, Albin RL (2007) Longitudinal evaluation of the Hdh(CAG) 150 knock-in murine model of Huntington's disease. J Neurosci 27:8989-8998.
-
(2007)
J Neurosci
, vol.27
, pp. 8989-8998
-
-
Heng, M.Y.1
Tallaksen-Greene, S.J.2
Detloff, P.J.3
Albin, R.L.4
-
18
-
-
44449131447
-
Huntington's disease: From pathology and genetics to potential therapies
-
Imarisio S, Carmichael J, Korolchuk V, Chen CW, Saiki S, Rose C, Krishna G, Davies JE, Ttofi E, Underwood BR, Rubinsztein DC (2007) Huntington's disease: from pathology and genetics to potential therapies. Biochem J 412:199-209.
-
(2007)
Biochem J
, vol.412
, pp. 199-209
-
-
Imarisio, S.1
Carmichael, J.2
Korolchuk, V.3
Chen, C.W.4
Saiki, S.5
Rose, C.6
Krishna, G.7
Davies, J.E.8
Ttofi, E.9
Underwood, B.R.10
Rubinsztein, D.C.11
-
19
-
-
57349135887
-
Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors
-
Léveillé F, El Gaamouch F, Gouix E, Lecocq M, Lobner D, Nicole O, Buisson A (2008) Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors. FASEB J 22:4258-4271.
-
(2008)
FASEB J
, vol.22
, pp. 4258-4271
-
-
Léveillé, F.1
El Gaamouch, F.2
Gouix, E.3
Lecocq, M.4
Lobner, D.5
Nicole, O.6
Buisson, A.7
-
20
-
-
0033571743
-
Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease
-
Levine MS, Klapstein GJ, Koppel A, Gruen E, Cepeda C, Vargas ME, Jokel ES, Carpenter EM, Zanjani H, Hurst RS, Efstratiadis A, Zeitlin S, Chesselet MF (1999) Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease. J Neurosci Res 58:515-532.
-
(1999)
J Neurosci Res
, vol.58
, pp. 515-532
-
-
Levine, M.S.1
Klapstein, G.J.2
Koppel, A.3
Gruen, E.4
Cepeda, C.5
Vargas, M.E.6
Jokel, E.S.7
Carpenter, E.M.8
Zanjani, H.9
Hurst, R.S.10
Efstratiadis, A.11
Zeitlin, S.12
Chesselet, M.F.13
-
21
-
-
0344413576
-
Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease
-
Li L, Fan M, Icton CD, Chen N, Leavitt BR, Hayden MR, Murphy TH, Raymond LA (2003) Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease. Neurobiol Aging 24:1113-1121.
-
(2003)
Neurobiol Aging
, vol.24
, pp. 1113-1121
-
-
Li, L.1
Fan, M.2
Icton, C.D.3
Chen, N.4
Leavitt, B.R.5
Hayden, M.R.6
Murphy, T.H.7
Raymond, L.A.8
-
22
-
-
14844314896
-
Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington's disease
-
Li L, Murphy TH, Hayden MR, Raymond LA (2004) Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington's disease. J Neurophysiol 92:2738-2746.
-
(2004)
J Neurophysiol
, vol.92
, pp. 2738-2746
-
-
Li, L.1
Murphy, T.H.2
Hayden, M.R.3
Raymond, L.A.4
-
23
-
-
33947331063
-
NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo
-
Liu Y, Wong TP, Aarts M, Rooyakkers A, Liu L, Lai TW, Wu DC, Lu J, Tymianski M, Craig AM, Wang YT (2007) NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci 27:2846-2857.
-
(2007)
J Neurosci
, vol.27
, pp. 2846-2857
-
-
Liu, Y.1
Wong, T.P.2
Aarts, M.3
Rooyakkers, A.4
Liu, L.5
Lai, T.W.6
Wu, D.C.7
Lu, J.8
Tymianski, M.9
Craig, A.M.10
Wang, Y.T.11
-
24
-
-
0037216407
-
The N-methyl-D-aspartate receptor subunit NR2B: Localization, functional properties, regulation, and clinical implications
-
Loftis JM, Janowsky A (2003) The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation, and clinical implications. Pharmacol Ther 97:55-85.
-
(2003)
Pharmacol Ther
, vol.97
, pp. 55-85
-
-
Loftis, J.M.1
Janowsky, A.2
-
25
-
-
0037186456
-
Age-related changes in the protein expression of subunits of the NMDA receptor
-
Magnusson KR, Nelson SE, Young AB (2002) Age-related changes in the protein expression of subunits of the NMDA receptor. Mol Brain Res 99:40-45.
-
(2002)
Mol Brain Res
, vol.99
, pp. 40-45
-
-
Magnusson, K.R.1
Nelson, S.E.2
Young, A.B.3
-
26
-
-
58149476292
-
In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death
-
Martel MA, Wyllie DJ, Hardingham GE (2009) In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death. Neuroscience 158:334-343.
-
(2009)
Neuroscience
, vol.158
, pp. 334-343
-
-
Martel, M.A.1
Wyllie, D.J.2
Hardingham, G.E.3
-
27
-
-
0017090806
-
Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids
-
McGeer EG, McGeer PL (1976) Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids. Nature 263:517-519.
-
(1976)
Nature
, vol.263
, pp. 517-519
-
-
McGeer, E.G.1
McGeer, P.L.2
-
28
-
-
0026721811
-
Heteromeric NMDA receptors: Molecular and functional distinction of subtypes
-
Monyer H, Sprengel R, Schoepfer R, Herb A, Higuchi M, Lomeli H, Burnashev N, Sakmann B, Seeburg PH (1992) Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256:1217-1221.
-
(1992)
Science
, vol.256
, pp. 1217-1221
-
-
Monyer, H.1
Sprengel, R.2
Schoepfer, R.3
Herb, A.4
Higuchi, M.5
Lomeli, H.6
Burnashev, N.7
Sakmann, B.8
Seeburg, P.H.9
-
29
-
-
35948937549
-
The dichotomy of NMDA receptor signaling
-
Papadia S, Hardingham GE (2007) The dichotomy of NMDA receptor signaling. Neuroscientist 13:572-579.
-
(2007)
Neuroscientist
, vol.13
, pp. 572-579
-
-
Papadia, S.1
Hardingham, G.E.2
-
30
-
-
41149178631
-
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses
-
Papadia S, Soriano FX, Léveillé F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, Hardingham GE (2008) Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci 11:476-487.
-
(2008)
Nat Neurosci
, vol.11
, pp. 476-487
-
-
Papadia, S.1
Soriano, F.X.2
Léveillé, F.3
Martel, M.A.4
Dakin, K.A.5
Hansen, H.H.6
Kaindl, A.7
Sifringer, M.8
Fowler, J.9
Stefovska, V.10
McKenzie, G.11
Craigon, M.12
Corriveau, R.13
Ghazal, P.14
Horsburgh, K.15
Yankner, B.A.16
Wyllie, D.J.17
Ikonomidou, C.18
Hardingham, G.E.19
-
31
-
-
0020702374
-
Quinolinic acid: An endogenous metabolite that produces axon-sparing lesions in rat brain
-
Schwarcz R, Whetsell WO Jr, Mangano RM (1983) Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain. Science 219:316-318.
-
(1983)
Science
, vol.219
, pp. 316-318
-
-
Schwarcz, R.1
Whetsell Jr, W.O.2
Mangano, R.M.3
-
32
-
-
30744437894
-
Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease
-
Shehadeh J, Fernandes HB, Zeron Mullins MM, Graham RK, Leavitt BR, Hayden MR, Raymond LA (2006) Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease. Neurobiol Dis 21:392-403.
-
(2006)
Neurobiol Dis
, vol.21
, pp. 392-403
-
-
Shehadeh, J.1
Fernandes, H.B.2
Zeron Mullins, M.M.3
Graham, R.K.4
Leavitt, B.R.5
Hayden, M.R.6
Raymond, L.A.7
-
33
-
-
36348937388
-
Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice
-
Stack EC, Dedeoglu A, Smith KM, Cormier K, Kubilus JK, Bogdanov M, Matson WR, Yang L, Jenkins BG, Luthi-Carter R, Kowall NW, Hersch SM, Beal MF, Ferrante RJ (2007) Neuroprotective effects of synaptic modulation in Huntington's disease R6/2 mice. J Neurosci 27:12908-12915.
-
(2007)
J Neurosci
, vol.27
, pp. 12908-12915
-
-
Stack, E.C.1
Dedeoglu, A.2
Smith, K.M.3
Cormier, K.4
Kubilus, J.K.5
Bogdanov, M.6
Matson, W.R.7
Yang, L.8
Jenkins, B.G.9
Luthi-Carter, R.10
Kowall, N.W.11
Hersch, S.M.12
Beal, M.F.13
Ferrante, R.J.14
-
35
-
-
0041963057
-
Huntingtin and huntingtin-assodated protein 1 influences neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1
-
Tang TS, Tu H, Chan EY, Maximov A, Wang Z, Wellington CL, Hayden MR, Bezprozvanny I (2003) Huntingtin and huntingtin-assodated protein 1 influences neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron 39:227-239.
-
(2003)
Neuron
, vol.39
, pp. 227-239
-
-
Tang, T.S.1
Tu, H.2
Chan, E.Y.3
Maximov, A.4
Wang, Z.5
Wellington, C.L.6
Hayden, M.R.7
Bezprozvanny, I.8
-
36
-
-
0033517366
-
Genetic enhancement of learning and memory in mice
-
Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu G, Tsien JZ (1999) Genetic enhancement of learning and memory in mice. Nature 401:63-69.
-
(1999)
Nature
, vol.401
, pp. 63-69
-
-
Tang, Y.P.1
Shimizu, E.2
Dube, G.R.3
Rampon, C.4
Kerchner, G.A.5
Zhuo, M.6
Liu, G.7
Tsien, J.Z.8
-
37
-
-
0033562610
-
The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro
-
Tovar KR, Westbrook GL (1999) The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J Neurosci 19:4180-4188.
-
(1999)
J Neurosci
, vol.19
, pp. 4180-4188
-
-
Tovar, K.R.1
Westbrook, G.L.2
-
38
-
-
13544268511
-
N-methyl-D-aspartate receptor subtypes: Multiple roles in excitotoxicity and neurological disease
-
Waxman EA, Lynch DR (2005) N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease. Neuroscientist 11:37-49.
-
(2005)
Neuroscientist
, vol.11
, pp. 37-49
-
-
Waxman, E.A.1
Lynch, D.R.2
-
39
-
-
0029895292
-
Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease
-
Weeks RA, Piccini P, Harding AE, Brooks DJ (1996) Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease. Ann Neurol 40:49-54.
-
(1996)
Ann Neurol
, vol.40
, pp. 49-54
-
-
Weeks, R.A.1
Piccini, P.2
Harding, A.E.3
Brooks, D.J.4
-
40
-
-
0035154912
-
Mutant huntingtin enhances excitotoxic cell death
-
Zeron MM, Chen N, Moshaver A, Lee AT, Wellington CL, Hayden MR, Raymond LA (2001) Mutant huntingtin enhances excitotoxic cell death. Mol Cell Neurosci 17:41-53.
-
(2001)
Mol Cell Neurosci
, vol.17
, pp. 41-53
-
-
Zeron, M.M.1
Chen, N.2
Moshaver, A.3
Lee, A.T.4
Wellington, C.L.5
Hayden, M.R.6
Raymond, L.A.7
-
41
-
-
0037075624
-
Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease
-
Zeron MM, Hansson O, Chen N, Wellington CL, Leavitt BR, Brundin P, Hayden MR, Raymond LA (2002) Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron 33:849-860.
-
(2002)
Neuron
, vol.33
, pp. 849-860
-
-
Zeron, M.M.1
Hansson, O.2
Chen, N.3
Wellington, C.L.4
Leavitt, B.R.5
Brundin, P.6
Hayden, M.R.7
Raymond, L.A.8
-
42
-
-
1642295805
-
Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease
-
Zeron MM, Fernandes HB, Krebs C, Shehadeh J, Wellington CL, Leavitt BR, Baimbridge KG, Hayden MR, Raymond LA (2004) Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease. Mol Cell Neurosci 25:469-479.
-
(2004)
Mol Cell Neurosci
, vol.25
, pp. 469-479
-
-
Zeron, M.M.1
Fernandes, H.B.2
Krebs, C.3
Shehadeh, J.4
Wellington, C.L.5
Leavitt, B.R.6
Baimbridge, K.G.7
Hayden, M.R.8
Raymond, L.A.9
|