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Volumn 7, Issue MAR, 2015, Pages

ER proteostasis disturbances in Parkinson's disease: Novel insights

Author keywords

Dopaminergic neurons; ER stress; Gene therapy; Parkinson disease; Preclinical models; UPR signaling pathways

Indexed keywords

ALPHA SYNUCLEIN; UNCOUPLING PROTEIN;

EID: 84926343690     PISSN: None     EISSN: 16634365     Source Type: Journal    
DOI: 10.3389/fnagi.2015.00039     Document Type: Article
Times cited : (26)

References (32)
  • 1
    • 13644256191 scopus 로고    scopus 로고
    • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
    • Boyce, M., Bryant, K. F., Jousse, C., Long, K., Harding, H. P., Scheuner, D., et al. (2005). A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 307, 935-939. doi: 10.1126/science.1101902
    • (2005) Science , vol.307 , pp. 935-939
    • Boyce, M.1    Bryant, K.F.2    Jousse, C.3    Long, K.4    Harding, H.P.5    Scheuner, D.6
  • 2
    • 84876743936 scopus 로고    scopus 로고
    • Linking membrane dynamics and trafficking to autophagy and the unfolded protein response
    • Chua, C. E., and Tang, B. L. (2013). Linking membrane dynamics and trafficking to autophagy and the unfolded protein response. J. Cell. Physiol. 228, 1638-1640. doi: 10.1002/jcp.24341
    • (2013) J. Cell. Physiol. , vol.228 , pp. 1638-1640
    • Chua, C.E.1    Tang, B.L.2
  • 3
    • 84888070126 scopus 로고    scopus 로고
    • Identification and rescue of alpha-synuclein toxicity in Parkinson patient-derived neurons
    • Chung, C. Y., Khurana, V., Auluck, P. K., Tardiff, D. F., Mazzulli, J. R., Soldner, F., et al. (2013). Identification and rescue of alpha-synuclein toxicity in Parkinson patient-derived neurons. Science 342, 983-987. doi: 10.1126/science.1245296
    • (2013) Science , vol.342 , pp. 983-987
    • Chung, C.Y.1    Khurana, V.2    Auluck, P.K.3    Tardiff, D.F.4    Mazzulli, J.R.5    Soldner, F.6
  • 4
    • 84863230467 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress is important for the manifestations of alpha-synucleinopathy in vivo
    • Colla, E., Coune, P., Liu, Y., Pletnikova, O., Troncoso, J. C., Iwatsubo, T., et al. (2012). Endoplasmic reticulum stress is important for the manifestations of alpha-synucleinopathy in vivo. J. Neurosci. 32, 3306-3320. doi: 10.1523/JNEUROSCI.5367-11.2012
    • (2012) J. Neurosci. , vol.32 , pp. 3306-3320
    • Colla, E.1    Coune, P.2    Liu, Y.3    Pletnikova, O.4    Troncoso, J.C.5    Iwatsubo, T.6
  • 5
    • 33746533924 scopus 로고    scopus 로고
    • Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
    • Cooper, A. A., Gitler, A. D., Cashikar, A., Haynes, C. M., Hill, K. J., Bhullar, B., et al. (2006). Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313, 324-328. doi: 10.1126/science.1129462
    • (2006) Science , vol.313 , pp. 324-328
    • Cooper, A.A.1    Gitler, A.D.2    Cashikar, A.3    Haynes, C.M.4    Hill, K.J.5    Bhullar, B.6
  • 6
    • 84857834456 scopus 로고    scopus 로고
    • Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease
    • Coune, P. G., Bensadoun, J. C., Aebischer, P., and Schneider, B. L. (2011). Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease. J. Parkinsons Dis. 1, 373-387. doi: 10.3233/JPD-2011-11058
    • (2011) J. Parkinsons Dis. , vol.1 , pp. 373-387
    • Coune, P.G.1    Bensadoun, J.C.2    Aebischer, P.3    Schneider, B.L.4
  • 8
    • 84923871028 scopus 로고    scopus 로고
    • Alpha-synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease
    • Credle, J. J., Forcelli, P. A., Delannoy, M., Oaks, A. W., Permaul, E., Berry, D. L., et al. (2015). Alpha-synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease. Neurobiol. Dis. 76, 112-125. doi: 10.1016/j.nbd.2015.02.005
    • (2015) Neurobiol. Dis. , vol.76 , pp. 112-125
    • Credle, J.J.1    Forcelli, P.A.2    Delannoy, M.3    Oaks, A.W.4    Permaul, E.5    Berry, D.L.6
  • 9
    • 79953148080 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress sensor, ATF6alpha, protects against neurotoxin-induced dopaminergic neuronal death
    • Egawa, N., Yamamoto, K., Inoue, H., Hikawa, R., Nishi, K., Mori, K., et al. (2011). The endoplasmic reticulum stress sensor, ATF6alpha, protects against neurotoxin-induced dopaminergic neuronal death. J. Biol. Chem. 286, 7947-7957. doi: 10.1074/jbc. M110.156430
    • (2011) J. Biol. Chem. , vol.286 , pp. 7947-7957
    • Egawa, N.1    Yamamoto, K.2    Inoue, H.3    Hikawa, R.4    Nishi, K.5    Mori, K.6
  • 10
    • 84862303631 scopus 로고    scopus 로고
    • ER stress inhibits neuronal death by promoting autophagy
    • Fouillet, A., Levet, C., Virgone, A., Robin, M., Dourlen, P., Rieusset, J., et al. (2012). ER stress inhibits neuronal death by promoting autophagy. Autophagy 8, 915-926. doi: 10.4161/auto.19716
    • (2012) Autophagy , vol.8 , pp. 915-926
    • Fouillet, A.1    Levet, C.2    Virgone, A.3    Robin, M.4    Dourlen, P.5    Rieusset, J.6
  • 12
    • 84863498486 scopus 로고    scopus 로고
    • Glucose regulated protein 78 diminishes alpha-synuclein neurotoxicity in a rat model of Parkinson disease
    • Gorbatyuk, M. S., Shabashvili, A., Chen, W., Meyers, C., Sullivan, L. F., Salganik, M., et al. (2012). Glucose regulated protein 78 diminishes alpha-synuclein neurotoxicity in a rat model of Parkinson disease. Mol. Ther. 20, 1327-1337. doi: 10.1038/mt.2012.28
    • (2012) Mol. Ther. , vol.20 , pp. 1327-1337
    • Gorbatyuk, M.S.1    Shabashvili, A.2    Chen, W.3    Meyers, C.4    Sullivan, L.F.5    Salganik, M.6
  • 13
    • 84904497398 scopus 로고    scopus 로고
    • Prions: generation and spread versus neurotoxicity
    • Halliday, M., Radford, H., and Mallucci, G. R. (2014). Prions: generation and spread versus neurotoxicity. J. Biol. Chem. 289, 9862-19868. doi: 10.1074/jbc. R114.568477
    • (2014) J. Biol. Chem. , vol.289
    • Halliday, M.1    Radford, H.2    Mallucci, G.R.3
  • 14
    • 0037353039 scopus 로고    scopus 로고
    • An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
    • Harding, H. P., Zhang, Y., Zeng, H., Novoa, I., Lu, P. D., Calfon, M., et al. (2003). An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol. Cell 11, 619-633. doi: 10.1016/S1097-2765(03)00105-9
    • (2003) Mol. Cell , vol.11 , pp. 619-633
    • Harding, H.P.1    Zhang, Y.2    Zeng, H.3    Novoa, I.4    Lu, P.D.5    Calfon, M.6
  • 15
    • 84856111924 scopus 로고    scopus 로고
    • The unfolded protein response: controlling cell fate decisions under ER stress and beyond
    • Hetz, C. (2012). The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat. Rev. Mol. Cell Biol. 13, 89-102. doi: 10.1038/nrm3270
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 89-102
    • Hetz, C.1
  • 16
    • 84883387793 scopus 로고    scopus 로고
    • Targeting the unfolded protein response in disease
    • Hetz, C., Chevet, E., and Harding, H. P. (2013). Targeting the unfolded protein response in disease. Nat. Rev. Drug Discov. 12, 703-719. doi: 10.1038/nrd3976
    • (2013) Nat. Rev. Drug Discov. , vol.12 , pp. 703-719
    • Hetz, C.1    Chevet, E.2    Harding, H.P.3
  • 17
    • 84897094564 scopus 로고    scopus 로고
    • Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases
    • Hetz, C., and Mollereau, B. (2014). Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases. Nat. Rev. Neurosci. 15, 233-249. doi: 10.1038/nrn3689
    • (2014) Nat. Rev. Neurosci. , vol.15 , pp. 233-249
    • Hetz, C.1    Mollereau, B.2
  • 18
    • 70349627027 scopus 로고    scopus 로고
    • XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
    • Hetz, C., Thielen, P., Matus, S., Nassif, M., Court, F., Kiffin, R., et al. (2009). XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev. 23, 2294-2306. doi: 10.1101/gad.1830709
    • (2009) Genes Dev. , vol.23 , pp. 2294-2306
    • Hetz, C.1    Thielen, P.2    Matus, S.3    Nassif, M.4    Court, F.5    Kiffin, R.6
  • 20
    • 84861326241 scopus 로고    scopus 로고
    • X-box-binding protein 1-modified neural stem cells for treatment of Parkinson's disease
    • Lihui, S., Tianmin, X., Fengzhang, W., Qun, L., and Manhua, C. (2012). X-box-binding protein 1-modified neural stem cells for treatment of Parkinson's disease. Neural Regen. Res. 7, 736-740. doi: 10.3969/j.issn.1673-5374.2012.10.003
    • (2012) Neural Regen. Res. , vol.7 , pp. 736-740
    • Lihui, S.1    Tianmin, X.2    Fengzhang, W.3    Qun, L.4    Manhua, C.5
  • 21
    • 84918547483 scopus 로고    scopus 로고
    • Control of systemic proteostasis by the nervous system
    • Mardones, P., Martinez, G., and Hetz, C. (2015). Control of systemic proteostasis by the nervous system. Trends Cell Biol. 25, 1-10. doi: 10.1016/j.tcb.2014.08.001
    • (2015) Trends Cell Biol. , vol.25 , pp. 1-10
    • Mardones, P.1    Martinez, G.2    Hetz, C.3
  • 22
    • 84864866226 scopus 로고    scopus 로고
    • Hormesis: protecting neurons against cellular stress in Parkinson disease
    • Matus, S., Castillo, K., and Hetz, C. (2012). Hormesis: protecting neurons against cellular stress in Parkinson disease. Autophagy 8, 997-1001. doi: 10.4161/auto.20748
    • (2012) Autophagy , vol.8 , pp. 997-1001
    • Matus, S.1    Castillo, K.2    Hetz, C.3
  • 23
    • 84875259777 scopus 로고    scopus 로고
    • An ERcentric view of Parkinson's disease
    • Mercado, G., Valdes, P., and Hetz, C. (2013). An ERcentric view of Parkinson's disease. Trends Mol. Med. 19, 165-175. doi: 10.1016/j.molmed.2012.12.005
    • (2013) Trends Mol. Med. , vol.19 , pp. 165-175
    • Mercado, G.1    Valdes, P.2    Hetz, C.3
  • 24
    • 84911939623 scopus 로고    scopus 로고
    • RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway
    • Ray, A., Zhang, S., Rentas, C., Caldwell, K. A., and Caldwell, G. A. (2014). RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway. J. Neurosci. 34, 16076-16085. doi: 10.1523/JNEUROSCI.1945-14.2014
    • (2014) J. Neurosci. , vol.34
    • Ray, A.1    Zhang, S.2    Rentas, C.3    Caldwell, K.A.4    Caldwell, G.A.5
  • 25
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron, D., and Walter, P. (2007). Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8, 519-529. doi: 10.1038/nrm2199
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 26
    • 63349104307 scopus 로고    scopus 로고
    • Protective effect against Parkinson's disease-related insults through the activation of XBP1
    • Sado, M., Yamasaki, Y., Iwanaga, T., Onaka, Y., Ibuki, T., Nishihara, S., et al. (2009). Protective effect against Parkinson's disease-related insults through the activation of XBP1. Brain Res. 1257, 16-24. doi: 10.1016/j.brainres.2008.11.104
    • (2009) Brain Res. , vol.1257 , pp. 16-24
    • Sado, M.1    Yamasaki, Y.2    Iwanaga, T.3    Onaka, Y.4    Ibuki, T.5    Nishihara, S.6
  • 27
    • 28244466782 scopus 로고    scopus 로고
    • CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism
    • Silva, R. M., Ries, V., Oo, T. F., Yarygina, O., Jackson-Lewis, V., Ryu, E. J., et al. (2005). CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism. J. Neurochem. 95, 974-986. doi: 10.1111/j.1471-4159.2005.03428.x
    • (2005) J. Neurochem. , vol.95 , pp. 974-986
    • Silva, R.M.1    Ries, V.2    Oo, T.F.3    Yarygina, O.4    Jackson-Lewis, V.5    Ryu, E.J.6
  • 29
    • 84899844505 scopus 로고    scopus 로고
    • Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1
    • Valdes, P., Mercado, G., Vidal, R. L., Molina, C., Parsons, G., Court, F. A., et al. (2014). Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1. Proc. Natl. Acad. Sci. U.S.A. 111, 6804-6809. doi: 10.1073/pnas.1321845111
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. 6804-6809
    • Valdes, P.1    Mercado, G.2    Vidal, R.L.3    Molina, C.4    Parsons, G.5    Court, F.A.6
  • 30
    • 84857852395 scopus 로고    scopus 로고
    • Activation of the unfolded protein response enhances motor recovery after spinal cord injury
    • Valenzuela, V., Collyer, E., Armentano, D., Parsons, G. B., Court, F. A., and Hetz, C. (2012). Activation of the unfolded protein response enhances motor recovery after spinal cord injury. Cell Death Dis. 3:e272. doi: 10.1038/cddis.2012.8
    • (2012) Cell Death Dis , vol.3
    • Valenzuela, V.1    Collyer, E.2    Armentano, D.3    Parsons, G.B.4    Court, F.A.5    Hetz, C.6
  • 31
    • 84860471873 scopus 로고    scopus 로고
    • Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy
    • Vidal, R. L., Figueroa, A., Court, F. A., Thielen, P., Molina, C., Wirth, C., et al. (2012). Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy. Hum. Mol. Genet. 21, 2245-2262. doi: 10.1093/hmg/dds040
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 2245-2262
    • Vidal, R.L.1    Figueroa, A.2    Court, F.A.3    Thielen, P.4    Molina, C.5    Wirth, C.6
  • 32
    • 80051534540 scopus 로고    scopus 로고
    • A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease
    • Zimprich, A., Benet-Pages, A., Struhal, W., Graf, E., Eck, S. H., Offman, M. N., et al. (2011). A mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson disease. Am. J. Hum. Genet. 89, 168-175. doi: 10.1016/j.ajhg.2011.06.008
    • (2011) Am. J. Hum. Genet. , vol.89 , pp. 168-175
    • Zimprich, A.1    Benet-Pages, A.2    Struhal, W.3    Graf, E.4    Eck, S.H.5    Offman, M.N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.