Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity

Science

Volumn 324, Issue 5932, 2009, Pages 1327-1330

  Subramaniam, Srinivasa ^a   Sixt, Katherine M ^a   Barrow, Roxanne ^a   Snyder, Solomon H ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYTOCHROME C; HUNTINGTIN; MUTANT PROTEIN; NUCLEOTIDE BINDING PROTEIN; PROTEIN RHES; UNCLASSIFIED DRUG;

BRAIN; DISEASE; MUTATION; PROTEIN; TOXICITY;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL STRAIN; CELL STRAIN HEK293; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUNTINGTON CHOREA; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; RAT; SUMOYLATION;

ANIMALS; CELL DEATH; CELL LINE; CELL SURVIVAL; CORPUS STRIATUM; GTP-BINDING PROTEINS; HUMANS; MICE; MICE, TRANSGENIC; MUTANT PROTEINS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PC12 CELLS; RATS; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; SUBSTRATE SPECIFICITY; SUMO-1 PROTEIN;

EID: 66749167799     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1172871     Document Type: Article

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32. We thank I. Rao, A. Hayashi, K. Ishizuka and M. Chakraborty for technical support. We thank N. Shahani and R. Mealer for critically reading the manuscript. We thank E. Fossale and M. Macdonald for generously providing striatal cell lines. We thank M. Matunis for providing SUMO-related constructs, H. Zoghbi for ataxin constructs, S. Li and X. J.Li for purified Htt, J. Nathans for use of his cell culture facility and Alessandro Usiello for providing antibody to Rhes. Supported by USPHS grant MH18501 and Research Scientist Award DA00074 (SHS)