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Volumn , Issue , 2016, Pages 107-137

Mitochondrial signaling and neurodegeneration

Author keywords

Epigenetics; Inflammation; Microglia; Mitochondrial damage associated molecular patterns (mtDAMPs); Mitochondrial signaling; Mitochondrial signals of stress (SOS); Neuroendocrine regulation; Protein aggregates; Retrograde signaling; Transcriptional regulation

Indexed keywords


EID: 84979559195     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-319-28637-2_5     Document Type: Chapter
Times cited : (6)

References (223)
  • 1
    • 0022417192 scopus 로고
    • Symbiosis as a mechanism of evolution: Status of cell symbiosis theory
    • Margulis L, Bermudes D. Symbiosis as a mechanism of evolution: status of cell symbiosis theory. Symbiosis. 1985;1:101-24.
    • (1985) Symbiosis. , vol.1 , pp. 101-124
    • Margulis, L.1    Bermudes, D.2
  • 2
    • 84988044805 scopus 로고    scopus 로고
    • The energetics of genome complexity
    • Lane N, Martin W. The energetics of genome complexity. Nature. 2010;467(7318):929-34.
    • (2010) Nature. , vol.467 , Issue.7318 , pp. 929-934
    • Lane, N.1    Martin, W.2
  • 3
    • 77952415166 scopus 로고    scopus 로고
    • Bioenergetics, the origins of complexity, and the ascent of man
    • Wallace DC. Bioenergetics, the origins of complexity, and the ascent of man. Proc Natl Acad Sci U S A. 2010;107 Suppl 2:8947-53.
    • (2010) Proc Natl Acad Sci U S A. , vol.107 , pp. 8947-8953
    • Wallace, D.C.1
  • 4
    • 84859560882 scopus 로고    scopus 로고
    • Role of mitochondrial ca(2+) in the regulation of cellular energetics
    • Glancy B, Balaban RS. Role of mitochondrial ca(2+) in the regulation of cellular energetics. Biochemistry. 2012;51(14):2959-73.
    • (2012) Biochemistry. , vol.51 , Issue.14 , pp. 2959-2973
    • Glancy, B.1    Balaban, R.S.2
  • 5
    • 84957015038 scopus 로고    scopus 로고
    • Mitochondrial calcium uptake modulates synaptic vesicle endocytosis in central nerve terminals
    • Marland JR, Hasel P, Bonnycastle K, Cousin MA. Mitochondrial calcium uptake modulates synaptic vesicle endocytosis in central nerve terminals. J Biol Chem. 2016;291(5):2080-6.
    • (2016) J Biol Chem. , vol.291 , Issue.5 , pp. 2080-2086
    • Marland, J.R.1    Hasel, P.2    Bonnycastle, K.3    Cousin, M.A.4
  • 7
    • 70349769764 scopus 로고    scopus 로고
    • Reactive oxygen species production by mitochondria
    • Lambert AJ, Brand MD. Reactive oxygen species production by mitochondria. Methods Mol Biol. 2009;554:165-81.
    • (2009) Methods Mol Biol. , vol.554 , pp. 165-181
    • Lambert, A.J.1    Brand, M.D.2
  • 8
    • 13944278132 scopus 로고    scopus 로고
    • Mitochondria, oxidants, and aging
    • Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005;120(4):483-95.
    • (2005) Cell. , vol.120 , Issue.4 , pp. 483-495
    • Balaban, R.S.1    Nemoto, S.2    Finkel, T.3
  • 10
    • 84923685347 scopus 로고    scopus 로고
    • Mitochondria: From cell death executioners to regulators of cell differentiation
    • Kasahara A, Scorrano L. Mitochondria: from cell death executioners to regulators of cell differentiation. Trends Cell Biol. 2014;24(12):761-70.
    • (2014) Trends Cell Biol. , vol.24 , Issue.12 , pp. 761-770
    • Kasahara, A.1    Scorrano, L.2
  • 11
    • 27944442272 scopus 로고    scopus 로고
    • Quorum sensing: Cell-to-cell communication in bacteria
    • Waters CM, Bassler BL. Quorum sensing: cell-to-cell communication in bacteria. Annu Rev Cell Dev Biol. 2005;21:319-46.
    • (2005) Annu Rev Cell Dev Biol. , vol.21 , pp. 319-346
    • Waters, C.M.1    Bassler, B.L.2
  • 13
    • 77958197158 scopus 로고    scopus 로고
    • Mitochondria and the culture of the Borg: Understanding the integration of mitochondrial function within the reticulum, the cell, and the organism
    • Braschi E, McBride HM. Mitochondria and the culture of the Borg: understanding the integration of mitochondrial function within the reticulum, the cell, and the organism. Bioessays. 2010;32(11):958-66.
    • (2010) Bioessays. , vol.32 , Issue.11 , pp. 958-966
    • Braschi, E.1    McBride, H.M.2
  • 14
    • 84858282142 scopus 로고    scopus 로고
    • Mitochondria: Starving to reach quorum?: Insight into the physiological purpose of mitochondrial fusion
    • Picard M, Burelle Y. Mitochondria: starving to reach quorum?: insight into the physiological purpose of mitochondrial fusion. Bioessays. 2012;34(4):272-4.
    • (2012) Bioessays. , vol.34 , Issue.4 , pp. 272-274
    • Picard, M.1    Burelle, Y.2
  • 15
  • 16
    • 0035421320 scopus 로고    scopus 로고
    • Propagation of the apoptotic signal by mitochondrial waves
    • Pacher P, Hajnoczky G. Propagation of the apoptotic signal by mitochondrial waves. EMBO J. 2001;20(15):4107-21.
    • (2001) EMBO J. , vol.20 , Issue.15 , pp. 4107-4121
    • Pacher, P.1    Hajnoczky, G.2
  • 17
    • 0034596947 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS)-induced ROS release: A new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes
    • Zorov DB, Filburn CR, Klotz LO, Zweier JL, Sollott SJ. Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J Exp Med. 2000;192(7):1001-14.
    • (2000) J Exp Med. , vol.192 , Issue.7 , pp. 1001-1014
    • Zorov, D.B.1    Filburn, C.R.2    Klotz, L.O.3    Zweier, J.L.4    Sollott, S.J.5
  • 18
    • 84958673479 scopus 로고    scopus 로고
    • Mito-morphosis: Mitochondrial fusion, fission, and cristae remodeling as key mediators of cellular function
    • Pernas L, Scorrano L. Mito-morphosis: mitochondrial fusion, fission, and cristae remodeling as key mediators of cellular function. Annu Rev Physiol. 2015;78:505-31.
    • (2015) Annu Rev Physiol. , vol.78 , pp. 505-531
    • Pernas, L.1    Scorrano, L.2
  • 19
    • 84877105774 scopus 로고    scopus 로고
    • Mitochondrial morphology transitions and functions: Implications for retrograde signaling?
    • Picard M, Shirihai OS, Gentil BJ, Burelle Y. Mitochondrial morphology transitions and functions:implications for retrograde signaling? Am J Physiol Regul Integr Comp Physiol. 2013;304(6):R393-406.
    • (2013) Am J Physiol Regul Integr Comp Physiol. , vol.304 , Issue.6 , pp. R393-R406
    • Picard, M.1    Shirihai, O.S.2    Gentil, B.J.3    Burelle, Y.4
  • 20
    • 79955623510 scopus 로고    scopus 로고
    • During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
    • Gomes LC, Di Benedetto G, Scorrano L. During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol. 2011;13(5):589-98.
    • (2011) Nat Cell Biol. , vol.13 , Issue.5 , pp. 589-598
    • Gomes, L.C.1    Di Benedetto, G.2    Scorrano, L.3
  • 21
    • 84884909413 scopus 로고    scopus 로고
    • Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency
    • Cogliati S, Frezza C, Soriano ME, Varanita T, Quintana-Cabrera R, Corrado M, et al. Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell. 2013;155(1):160-71.
    • (2013) Cell. , vol.155 , Issue.1 , pp. 160-171
    • Cogliati, S.1    Frezza, C.2    Soriano, M.E.3    Varanita, T.4    Quintana-Cabrera, R.5    Corrado, M.6
  • 22
    • 34547601410 scopus 로고    scopus 로고
    • Mitochondrial fusion protects against neurodegeneration in the cerebellum
    • Chen H, McCaffery JM, Chan DC. Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell. 2007;130(3):548-62.
    • (2007) Cell. , vol.130 , Issue.3 , pp. 548-562
    • Chen, H.1    McCaffery, J.M.2    Chan, D.C.3
  • 23
    • 84949533347 scopus 로고    scopus 로고
    • Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons
    • Oettinghaus B, Schulz JM, Restelli LM, Licci M, Savoia C, Schmidt A, et al. Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons. Cell Death Differ. 2016;23(1):18-28.
    • (2016) Cell Death Differ. , vol.23 , Issue.1 , pp. 18-28
    • Oettinghaus, B.1    Schulz, J.M.2    Restelli, L.M.3    Licci, M.4    Savoia, C.5    Schmidt, A.6
  • 24
    • 77951737783 scopus 로고    scopus 로고
    • Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations
    • Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, et al. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell. 2010;141(2):280-9.
    • (2010) Cell. , vol.141 , Issue.2 , pp. 280-289
    • Chen, H.1    Vermulst, M.2    Wang, Y.E.3    Chomyn, A.4    Prolla, T.A.5    McCaffery, J.M.6
  • 25
    • 84899813575 scopus 로고    scopus 로고
    • Quantitative proteomics of synaptic and nonsynaptic mitochondria: Insights for synaptic mitochondrial vulnerability
    • Stauch KL, Purnell PR, Fox HS. Quantitative proteomics of synaptic and nonsynaptic mitochondria:insights for synaptic mitochondrial vulnerability. J Proteome Res. 2014;13(5):2620-36.
    • (2014) J Proteome Res. , vol.13 , Issue.5 , pp. 2620-2636
    • Stauch, K.L.1    Purnell, P.R.2    Fox, H.S.3
  • 26
    • 84897567836 scopus 로고    scopus 로고
    • Mitochondrial trafficking and anchoring in neurons: New insight and implications
    • Sheng ZH. Mitochondrial trafficking and anchoring in neurons: new insight and implications. J Cell Biol. 2014;204(7):1087-98.
    • (2014) J Cell Biol. , vol.204 , Issue.7 , pp. 1087-1098
    • Sheng, Z.H.1
  • 27
    • 0034938453 scopus 로고    scopus 로고
    • Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria
    • Ono T, Isobe K, Nakada K, Hayashi JI. Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria. Nat Genet. 2001;28(3):272-5.
    • (2001) Nat Genet. , vol.28 , Issue.3 , pp. 272-275
    • Ono, T.1    Isobe, K.2    Nakada, K.3    Hayashi, J.I.4
  • 28
    • 84930536720 scopus 로고    scopus 로고
    • Mitochondrial fusion provides an 'initial metabolic complementation' controlled by mtDNA
    • Yang L, Long Q, Liu J, Tang H, Li Y, Bao F, et al. Mitochondrial fusion provides an 'initial metabolic complementation' controlled by mtDNA. Cell Mol Life Sci. 2015;72(13):2585-98.
    • (2015) Cell Mol Life Sci. , vol.72 , Issue.13 , pp. 2585-2598
    • Yang, L.1    Long, Q.2    Liu, J.3    Tang, H.4    Li, Y.5    Bao, F.6
  • 29
    • 84889242417 scopus 로고    scopus 로고
    • Mitochondrial dynamics-mitochondrial fission and fusion in human diseases
    • Archer SL. Mitochondrial dynamics-mitochondrial fission and fusion in human diseases. N Engl J Med. 2013;369(23):2236-51.
    • (2013) N Engl J Med. , vol.369 , Issue.23 , pp. 2236-2251
    • Archer, S.L.1
  • 30
    • 84880213863 scopus 로고    scopus 로고
    • OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange
    • Santo-Domingo J, Giacomello M, Poburko D, Scorrano L, Demaurex N. OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange. EMBO J. 2013;32(13):1927-40.
    • (2013) EMBO J. , vol.32 , Issue.13 , pp. 1927-1940
    • Santo-Domingo, J.1    Giacomello, M.2    Poburko, D.3    Scorrano, L.4    Demaurex, N.5
  • 31
    • 0023718495 scopus 로고
    • Coupling membranes as energy-transmitting cables. I. Filamentous mitochondria in fibroblasts and mitochondrial clusters in cardiomyocytes
    • Amchenkova AA, Bakeeva LE, Chentsov YS, Skulachev VP, Zorov DB. Coupling membranes as energy-transmitting cables. I. Filamentous mitochondria in fibroblasts and mitochondrial clusters in cardiomyocytes. J Cell Biol. 1988;107(2):481-95.
    • (1988) J Cell Biol. , vol.107 , Issue.2 , pp. 481-495
    • Amchenkova, A.A.1    Bakeeva, L.E.2    Chentsov, Y.S.3    Skulachev, V.P.4    Zorov, D.B.5
  • 32
    • 84938406146 scopus 로고    scopus 로고
    • Mitochondrial reticulum for cellular energy distribution in muscle
    • Glancy B, Hartnell LM, Malide D, Yu ZX, Combs CA, Connelly PS, et al. Mitochondrial reticulum for cellular energy distribution in muscle. Nature. 2015;523(7562):617-20.
    • (2015) Nature. , vol.523 , Issue.7562 , pp. 617-620
    • Glancy, B.1    Hartnell, L.M.2    Malide, D.3    Yu, Z.X.4    Combs, C.A.5    Connelly, P.S.6
  • 33
    • 10944269186 scopus 로고    scopus 로고
    • The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
    • Li Z, Okamoto K, Hayashi Y, Sheng M. The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell. 2004;119(6):873-87.
    • (2004) Cell. , vol.119 , Issue.6 , pp. 873-887
    • Li, Z.1    Okamoto, K.2    Hayashi, Y.3    Sheng, M.4
  • 34
    • 25444439492 scopus 로고    scopus 로고
    • Mitochondria form a filamentous reticular network in hippocampal dendrites but are present as discrete bodies in axons: A threedimensional ultrastructural study
    • Popov V, Medvedev NI, Davies HA, Stewart MG. Mitochondria form a filamentous reticular network in hippocampal dendrites but are present as discrete bodies in axons: a threedimensional ultrastructural study. J Comp Neurol. 2005;492(1):50-65.
    • (2005) J Comp Neurol. , vol.492 , Issue.1 , pp. 50-65
    • Popov, V.1    Medvedev, N.I.2    Davies, H.A.3    Stewart, M.G.4
  • 35
    • 0035146891 scopus 로고    scopus 로고
    • Mitochondrial filaments and clusters as intracellular power-transmitting cables
    • Skulachev VP. Mitochondrial filaments and clusters as intracellular power-transmitting cables. Trends Biochem Sci. 2001;26(1):23-9.
    • (2001) Trends Biochem Sci. , vol.26 , Issue.1 , pp. 23-29
    • Skulachev, V.P.1
  • 36
    • 77956291358 scopus 로고    scopus 로고
    • Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters
    • Kurz FT, Aon MA, O'Rourke B, Armoundas AA. Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters. Proc Natl Acad Sci U S A. 2010;107(32):14315-20.
    • (2010) Proc Natl Acad Sci U S A. , vol.107 , Issue.32 , pp. 14315-14320
    • Kurz, F.T.1    Aon, M.A.2    O'Rourke, B.3    Armoundas, A.A.4
  • 39
    • 0033611672 scopus 로고    scopus 로고
    • Presynaptic mitochondria and the temporal pattern of neurotransmitter release
    • Brodin L, Bakeeva L, Shupliakov O. Presynaptic mitochondria and the temporal pattern of neurotransmitter release. Philos Trans R Soc Lond Ser B Biol Sci. 1999;354(1381):365-72.
    • (1999) Philos Trans R Soc Lond Ser B Biol Sci. , vol.354 , Issue.1381 , pp. 365-372
    • Brodin, L.1    Bakeeva, L.2    Shupliakov, O.3
  • 40
    • 84929333887 scopus 로고    scopus 로고
    • Mechanical ventilation triggers abnormal mitochondrial dynamics and morphology in the diaphragm
    • Picard M, Azuelos I, Jung B, Giordano C, Matecki S, Hussain S, et al. Mechanical ventilation triggers abnormal mitochondrial dynamics and morphology in the diaphragm. J Appl Physiol. 2015;118(9):1161-71.
    • (2015) J Appl Physiol. , vol.118 , Issue.9 , pp. 1161-1171
    • Picard, M.1    Azuelos, I.2    Jung, B.3    Giordano, C.4    Matecki, S.5    Hussain, S.6
  • 41
    • 84888342641 scopus 로고    scopus 로고
    • Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle
    • Picard M, Gentil BJ, McManus MJ, White K, St Louis K, Gartside SE, et al. Acute exercise remodels mitochondrial membrane interactions in mouse skeletal muscle. J Appl Physiol. 2013;115(10):1562-71.
    • (2013) J Appl Physiol. , vol.115 , Issue.10 , pp. 1562-1571
    • Picard, M.1    Gentil, B.J.2    McManus, M.J.3    White, K.4    St Louis, K.5    Gartside, S.E.6
  • 43
    • 84900299463 scopus 로고    scopus 로고
    • The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans
    • Yee C, Yang W, Hekimi S. The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. Cell. 2014;157(4):897-909.
    • (2014) Cell. , vol.157 , Issue.4 , pp. 897-909
    • Yee, C.1    Yang, W.2    Hekimi, S.3
  • 45
    • 30444437034 scopus 로고    scopus 로고
    • Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: Current evidence and pharmacological tools
    • McKenna MC, Waagepetersen HS, Schousboe A, Sonnewald U. Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools. Biochem Pharmacol. 2006;71(4):399-407.
    • (2006) Biochem Pharmacol. , vol.71 , Issue.4 , pp. 399-407
    • McKenna, M.C.1    Waagepetersen, H.S.2    Schousboe, A.3    Sonnewald, U.4
  • 46
    • 67649380906 scopus 로고    scopus 로고
    • Effect of transient and permanent permeability transition pore opening on NAD(P)H localization in intact cells
    • Dumas JF, Argaud L, Cottet-Rousselle C, Vial G, Gonzalez C, Detaille D, et al. Effect of transient and permanent permeability transition pore opening on NAD(P)H localization in intact cells. J Biol Chem. 2009;284(22):15117-25.
    • (2009) J Biol Chem. , vol.284 , Issue.22 , pp. 15117-15125
    • Dumas, J.F.1    Argaud, L.2    Cottet-Rousselle, C.3    Vial, G.4    Gonzalez, C.5    Detaille, D.6
  • 47
    • 84877109282 scopus 로고    scopus 로고
    • Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle
    • Gameiro PA, Laviolette LA, Kelleher JK, Iliopoulos O, Stephanopoulos G. Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle. J Biol Chem. 2013;288(18):12967-77.
    • (2013) J Biol Chem. , vol.288 , Issue.18 , pp. 12967-12977
    • Gameiro, P.A.1    Laviolette, L.A.2    Kelleher, J.K.3    Iliopoulos, O.4    Stephanopoulos, G.5
  • 48
    • 84962019445 scopus 로고    scopus 로고
    • Peroxiredoxin 6 is a crucial factor in the initial step of mitochondrial clearance and is upstream of the PINK1-Parkin pathway
    • Ma S, Zhang X, Zheng L, Li Z, Zhao X, Lai W, et al. Peroxiredoxin 6 is a crucial factor in the initial step of mitochondrial clearance and is upstream of the PINK1-Parkin pathway. Antioxid Redox Signal. 2015;24:486-501.
    • (2015) Antioxid Redox Signal. , vol.24 , pp. 486-501
    • Ma, S.1    Zhang, X.2    Zheng, L.3    Li, Z.4    Zhao, X.5    Lai, W.6
  • 49
    • 79956007514 scopus 로고    scopus 로고
    • Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation
    • Meng F, Yao D, Shi Y, Kabakoff J, Wu W, Reicher J, et al. Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation. Mol Neurodegener. 2011;6:34.
    • (2011) Mol Neurodegener. , vol.6 , pp. 34
    • Meng, F.1    Yao, D.2    Shi, Y.3    Kabakoff, J.4    Wu, W.5    Reicher, J.6
  • 50
    • 77949787683 scopus 로고    scopus 로고
    • Levodopa deactivates enzymes that regulate thioldisulfide homeostasis and promotes neuronal cell death: Implications for therapy of Parkinson's disease
    • Sabens EA, Distler AM, Mieyal JJ. Levodopa deactivates enzymes that regulate thioldisulfide homeostasis and promotes neuronal cell death: implications for therapy of Parkinson's disease. Biochemistry. 2010;49(12):2715-24.
    • (2010) Biochemistry. , vol.49 , Issue.12 , pp. 2715-2724
    • Sabens, E.A.1    Distler, A.M.2    Mieyal, J.J.3
  • 51
    • 81255208412 scopus 로고    scopus 로고
    • Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death
    • Angeles DC, Gan BH, Onstead L, Zhao Y, Lim KL, Dachsel J, et al. Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death. Hum Mutat. 2011;32(12):1390-7.
    • (2011) Hum Mutat. , vol.32 , Issue.12 , pp. 1390-1397
    • Angeles, D.C.1    Gan, B.H.2    Onstead, L.3    Zhao, Y.4    Lim, K.L.5    Dachsel, J.6
  • 53
    • 0034694871 scopus 로고    scopus 로고
    • Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: Embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous
    • Dalton TP, Dieter MZ, Yang Y, Shertzer HG, Nebert DW. Knockout of the mouse glutamate cysteine ligase catalytic subunit (Gclc) gene: embryonic lethal when homozygous, and proposed model for moderate glutathione deficiency when heterozygous. Biochem Biophys Res Commun. 2000;279(2):324-9.
    • (2000) Biochem Biophys Res Commun. , vol.279 , Issue.2 , pp. 324-329
    • Dalton, T.P.1    Dieter, M.Z.2    Yang, Y.3    Shertzer, H.G.4    Nebert, D.W.5
  • 54
    • 2042470971 scopus 로고    scopus 로고
    • Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene
    • Matsui M, Oshima M, Oshima H, Takaku K, Maruyama T, Yodoi J, et al. Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene. Dev Biol. 1996;178(1):179-85.
    • (1996) Dev Biol. , vol.178 , Issue.1 , pp. 179-185
    • Matsui, M.1    Oshima, M.2    Oshima, H.3    Takaku, K.4    Maruyama, T.5    Yodoi, J.6
  • 55
    • 20044378664 scopus 로고    scopus 로고
    • Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development
    • Jakupoglu C, Przemeck GK, Schneider M, Moreno SG, Mayr N, Hatzopoulos AK, et al. Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development. Mol Cell Biol. 2005;25(5):1980-8.
    • (2005) Mol Cell Biol. , vol.25 , Issue.5 , pp. 1980-1988
    • Jakupoglu, C.1    Przemeck, G.K.2    Schneider, M.3    Moreno, S.G.4    Mayr, N.5    Hatzopoulos, A.K.6
  • 56
    • 84907563036 scopus 로고    scopus 로고
    • Mitochondria-derived reactive oxygen species mediate caspase-dependent and-independent neuronal deaths
    • McManus MJ, Murphy MP, Franklin JL. Mitochondria-derived reactive oxygen species mediate caspase-dependent and-independent neuronal deaths. Mol Cell Neurosci. 2014;63:13-23.
    • (2014) Mol Cell Neurosci. , vol.63 , pp. 13-23
    • McManus, M.J.1    Murphy, M.P.2    Franklin, J.L.3
  • 57
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • Murphy MP. How mitochondria produce reactive oxygen species. Biochem J. 2009;417(1):1-13.
    • (2009) Biochem J. , vol.417 , Issue.1 , pp. 1-13
    • Murphy, M.P.1
  • 58
    • 0027481965 scopus 로고
    • The reaction of no with superoxide
    • Huie RE, Padmaja S. The reaction of no with superoxide. Free Radic Res Commun. 1993;18(4):195-9.
    • (1993) Free Radic Res Commun. , vol.18 , Issue.4 , pp. 195-199
    • Huie, R.E.1    Padmaja, S.2
  • 59
    • 84961212753 scopus 로고    scopus 로고
    • Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI
    • Khan M, Dhammu TS, Matsuda F, Annamalai B, Dhindsa TS, Singh I, et al. Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI. Brain Res. 2015;1630:159-70.
    • (2015) Brain Res. , vol.1630 , pp. 159-170
    • Khan, M.1    Dhammu, T.S.2    Matsuda, F.3    Annamalai, B.4    Dhindsa, T.S.5    Singh, I.6
  • 61
    • 84902322007 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning
    • Kalogeris T, Bao Y, Korthuis RJ. Mitochondrial reactive oxygen species: a double edged sword in ischemia/reperfusion vs preconditioning. Redox Biol. 2014;2:702-14.
    • (2014) Redox Biol. , vol.2 , pp. 702-714
    • Kalogeris, T.1    Bao, Y.2    Korthuis, R.J.3
  • 62
    • 0344012088 scopus 로고    scopus 로고
    • Investigation of the subunit composition and the pharmacology of the mitochondrial ATP-dependent K+ channel in the brain
    • Lacza Z, Snipes JA, Kis B, Szabó C, Grover G, Busija DW. Investigation of the subunit composition and the pharmacology of the mitochondrial ATP-dependent K+ channel in the brain. Brain Res. 2003;994(1):27-36.
    • (2003) Brain Res. , vol.994 , Issue.1 , pp. 27-36
    • Lacza, Z.1    Snipes, J.A.2    Kis, B.3    Szabó, C.4    Grover, G.5    Busija, D.W.6
  • 63
    • 33646534207 scopus 로고    scopus 로고
    • Beta-amyloid mediated nitration of manganese superoxide dismutase: Implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease
    • Anantharaman M, Tangpong J, Keller JN, Murphy MP, Markesbery WR, Kiningham KK, et al. Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease. Am J Pathol. 2006;168(5):1608-18.
    • (2006) Am J Pathol. , vol.168 , Issue.5 , pp. 1608-1618
    • Anantharaman, M.1    Tangpong, J.2    Keller, J.N.3    Murphy, M.P.4    Markesbery, W.R.5    Kiningham, K.K.6
  • 64
    • 0034113502 scopus 로고    scopus 로고
    • Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitritemediated oxidative stress in neurodegenerative diseases
    • Aoyama K, Matsubara K, Fujikawa Y, Nagahiro Y, Shimizu K, Umegae N, et al. Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitritemediated oxidative stress in neurodegenerative diseases. Ann Neurol. 2000;47(4):524-7.
    • (2000) Ann Neurol. , vol.47 , Issue.4 , pp. 524-527
    • Aoyama, K.1    Matsubara, K.2    Fujikawa, Y.3    Nagahiro, Y.4    Shimizu, K.5    Umegae, N.6
  • 65
    • 79960665679 scopus 로고    scopus 로고
    • Permeabilization of the mitochondrial outer membrane by Bax/truncated Bid (tBid) proteins as sensitized by cardiolipin hydroperoxide translocation: Mechanistic implications for the intrinsic pathway of oxidative apoptosis
    • Korytowski W, Basova LV, Pilat A, Kernstock RM, Girotti AW. Permeabilization of the mitochondrial outer membrane by Bax/truncated Bid (tBid) proteins as sensitized by cardiolipin hydroperoxide translocation: mechanistic implications for the intrinsic pathway of oxidative apoptosis. J Biol Chem. 2011;286(30):26334-43.
    • (2011) J Biol Chem. , vol.286 , Issue.30 , pp. 26334-26343
    • Korytowski, W.1    Basova, L.V.2    Pilat, A.3    Kernstock, R.M.4    Girotti, A.W.5
  • 66
    • 33644828424 scopus 로고    scopus 로고
    • Cardiolipin oxidation sets cytochrome c free
    • Orrenius S, Zhivotovsky B. Cardiolipin oxidation sets cytochrome c free. Nat Chem Biol. 2005;1(4):188-9.
    • (2005) Nat Chem Biol. , vol.1 , Issue.4 , pp. 188-189
    • Orrenius, S.1    Zhivotovsky, B.2
  • 67
    • 84932639412 scopus 로고    scopus 로고
    • Disruption of cytochrome c heme coordination is responsible for mitochondrial injury during ischemia
    • Birk AV, Chao WM, Liu S, Soong Y, Szeto HH. Disruption of cytochrome c heme coordination is responsible for mitochondrial injury during ischemia. Biochim Biophys Acta. 2015;1847(10):1075-84.
    • (2015) Biochim Biophys Acta. , vol.1847 , Issue.10 , pp. 1075-1084
    • Birk, A.V.1    Chao, W.M.2    Liu, S.3    Soong, Y.4    Szeto, H.H.5
  • 68
    • 57049132739 scopus 로고    scopus 로고
    • Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c
    • Vaughn AE, Deshmukh M. Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c. Nat Cell Biol. 2008;10(12):1477-83.
    • (2008) Nat Cell Biol. , vol.10 , Issue.12 , pp. 1477-1483
    • Vaughn, A.E.1    Deshmukh, M.2
  • 69
    • 0036703753 scopus 로고    scopus 로고
    • A Bax-induced pro-oxidant state is critical for cytochrome c release during programmed neuronal death
    • Kirkland RA, Windelborn JA, Kasprzak JM, Franklin JL. A Bax-induced pro-oxidant state is critical for cytochrome c release during programmed neuronal death. J Neurosci Off J Soc Neurosci. 2002;22(15):6480-90.
    • (2002) J Neurosci Off J Soc Neurosci. , vol.22 , Issue.15 , pp. 6480-6490
    • Kirkland, R.A.1    Windelborn, J.A.2    Kasprzak, J.M.3    Franklin, J.L.4
  • 70
    • 84904988972 scopus 로고    scopus 로고
    • In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice
    • Logan A, Shabalina IG, Prime TA, Rogatti S, Kalinovich AV, Hartley RC, et al. In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice. Aging Cell. 2014;13(4):765-8.
    • (2014) Aging Cell. , vol.13 , Issue.4 , pp. 765-768
    • Logan, A.1    Shabalina, I.G.2    Prime, T.A.3    Rogatti, S.4    Kalinovich, A.V.5    Hartley, R.C.6
  • 71
    • 84870769168 scopus 로고    scopus 로고
    • Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
    • Pan-Montojo F, Schwarz M, Winkler C, Arnhold M, O'Sullivan GA, Pal A, et al. Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice. Sci Rep. 2012;2:898.
    • (2012) Sci Rep. , vol.2 , pp. 898
    • Pan-Montojo, F.1    Schwarz, M.2    Winkler, C.3    Arnhold, M.4    O'Sullivan, G.A.5    Pal, A.6
  • 72
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 2006;443(7113):787-95.
    • (2006) Nature. , vol.443 , Issue.7113 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 73
    • 84931069431 scopus 로고    scopus 로고
    • FDG and amyloid PET in cognitively normal individuals at risk for late-onset alzheimer's disease
    • Murray J, Tsui WH, Li Y, McHugh P, Williams S, Cummings M, et al. FDG and amyloid PET in cognitively normal individuals at risk for late-onset alzheimer's disease. Adv Mol Imaging. 2014;4(2):15-26.
    • (2014) Adv Mol Imaging. , vol.4 , Issue.2 , pp. 15-26
    • Murray, J.1    Tsui, W.H.2    Li, Y.3    McHugh, P.4    Williams, S.5    Cummings, M.6
  • 74
    • 57649187117 scopus 로고    scopus 로고
    • Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease
    • Mosconi L, Pupi A, De Leon MJ. Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease. Ann N Y Acad Sci. 2008;1147:180-95.
    • (2008) Ann N Y Acad Sci. , vol.1147 , pp. 180-195
    • Mosconi, L.1    Pupi, A.2    De Leon, M.J.3
  • 75
    • 84944890971 scopus 로고    scopus 로고
    • Neuronal response in Alzheimer's and Parkinson's disease: The effect of toxic proteins on intracellular pathways
    • Majd S, Power JH, Grantham HJ. Neuronal response in Alzheimer's and Parkinson's disease:the effect of toxic proteins on intracellular pathways. BMC Neurosci. 2015;16:69.
    • (2015) BMC Neurosci. , vol.16 , pp. 69
    • Majd, S.1    Power, J.H.2    Grantham, H.J.3
  • 76
    • 84926513913 scopus 로고    scopus 로고
    • Spreading of pathology in neurodegenerative diseases: A focus on human studies
    • Brettschneider J, Del Tredici K, Lee VM, Trojanowski JQ. Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nat Rev Neurosci. 2015;16(2):109-20.
    • (2015) Nat Rev Neurosci. , vol.16 , Issue.2 , pp. 109-120
    • Brettschneider, J.1    Del Tredici, K.2    Lee, V.M.3    Trojanowski, J.Q.4
  • 78
    • 77953507107 scopus 로고    scopus 로고
    • Mitochondrial DNA, mutations in disease and aging
    • Wallace DC. Mitochondrial DNA, mutations in disease and aging. Environ Mol Mutagen. 2010;51(5):440-50.
    • (2010) Environ Mol Mutagen. , vol.51 , Issue.5 , pp. 440-450
    • Wallace, D.C.1
  • 79
    • 77957239234 scopus 로고    scopus 로고
    • Neurotoxic in vivo models of Parkinson's disease recent advances
    • Cannon JR, Greenamyre JT. Neurotoxic in vivo models of Parkinson's disease recent advances. Prog Brain Res. 2010;184:17-33.
    • (2010) Prog Brain Res. , vol.184 , pp. 17-33
    • Cannon, J.R.1    Greenamyre, J.T.2
  • 80
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston JW, Ballard P, Tetrud JW, Irwin I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science. 1983;219(4587):979-80.
    • (1983) Science. , vol.219 , Issue.4587 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 82
    • 80055078025 scopus 로고    scopus 로고
    • Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases
    • Swerdlow RH. Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases. Curr Pharm Des. 2011;17(31):3356-73.
    • (2011) Curr Pharm Des. , vol.17 , Issue.31 , pp. 3356-3373
    • Swerdlow, R.H.1
  • 83
    • 84876265087 scopus 로고    scopus 로고
    • Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein
    • Tan JL, Li QX, Ciccotosto GD, Crouch PJ, Culvenor JG, White AR, et al. Mild oxidative stress induces redistribution of BACE1 in non-apoptotic conditions and promotes the amyloidogenic processing of Alzheimer's disease amyloid precursor protein. PLoS One. 2013;8(4):e61246.
    • (2013) PLoS One. , vol.8 , Issue.4 , pp. e61246
    • Tan, J.L.1    Li, Q.X.2    Ciccotosto, G.D.3    Crouch, P.J.4    Culvenor, J.G.5    White, A.R.6
  • 84
    • 0036403838 scopus 로고    scopus 로고
    • Oxidative stress increases expression and activity of BACE in NT2 neurons
    • Tamagno E, Bardini P, Obbili A, Vitali A, Borghi R, Zaccheo D, et al. Oxidative stress increases expression and activity of BACE in NT2 neurons. Neurobiol Dis. 2002;10(3):279-88.
    • (2002) Neurobiol Dis. , vol.10 , Issue.3 , pp. 279-288
    • Tamagno, E.1    Bardini, P.2    Obbili, A.3    Vitali, A.4    Borghi, R.5    Zaccheo, D.6
  • 85
    • 38049098793 scopus 로고    scopus 로고
    • Oxidative stress activates a positive feedback between the gamma-and beta-secretase cleavages of the beta-amyloid precursor protein
    • Tamagno E, Guglielmotto M, Aragno M, Borghi R, Autelli R, Giliberto L, et al. Oxidative stress activates a positive feedback between the gamma-and beta-secretase cleavages of the beta-amyloid precursor protein. J Neurochem. 2008;104(3):683-95.
    • (2008) J Neurochem. , vol.104 , Issue.3 , pp. 683-695
    • Tamagno, E.1    Guglielmotto, M.2    Aragno, M.3    Borghi, R.4    Autelli, R.5    Giliberto, L.6
  • 86
    • 69349091132 scopus 로고    scopus 로고
    • Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of alpha-, betaand gamma-secretase expression
    • Quiroz-Baez R, Rojas E, Arias C. Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of alpha-, betaand gamma-secretase expression. Neurochem Int. 2009;55(7):662-70.
    • (2009) Neurochem Int. , vol.55 , Issue.7 , pp. 662-670
    • Quiroz-Baez, R.1    Rojas, E.2    Arias, C.3
  • 87
    • 78650662312 scopus 로고    scopus 로고
    • Importance of the caspase cleavage site in amyloid-β protein precursor
    • Bredesen DE, John V, Galvan V. Importance of the caspase cleavage site in amyloid-β protein precursor. J Alzheimers Dis JAD. 2010;22(1):57-63.
    • (2010) J Alzheimers Dis JAD. , vol.22 , Issue.1 , pp. 57-63
    • Bredesen, D.E.1    John, V.2    Galvan, V.3
  • 88
    • 80155148269 scopus 로고    scopus 로고
    • The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease
    • McManus MJ, Murphy MP, Franklin JL. The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease. J Neurosci. 2011;31(44):15703-15.
    • (2011) J Neurosci. , vol.31 , Issue.44 , pp. 15703-15715
    • McManus, M.J.1    Murphy, M.P.2    Franklin, J.L.3
  • 89
    • 0038644221 scopus 로고    scopus 로고
    • The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide
    • Soucek T, Cumming R, Dargusch R, Maher P, Schubert D. The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide. Neuron. 2003;39(1):43-56.
    • (2003) Neuron. , vol.39 , Issue.1 , pp. 43-56
    • Soucek, T.1    Cumming, R.2    Dargusch, R.3    Maher, P.4    Schubert, D.5
  • 90
    • 0037096251 scopus 로고    scopus 로고
    • A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage
    • Zou K, Gong JS, Yanagisawa K, Michikawa M. A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage. J Neurosci Off J Soc Neurosci. 2002;22(12):4833-41.
    • (2002) J Neurosci Off J Soc Neurosci. , vol.22 , Issue.12 , pp. 4833-4841
    • Zou, K.1    Gong, J.S.2    Yanagisawa, K.3    Michikawa, M.4
  • 91
  • 92
    • 0038045587 scopus 로고    scopus 로고
    • The production of amyloid beta peptide is a critical requirement for the viability of central neurons
    • Plant LD, Boyle JP, Smith IF, Peers C, Pearson HA. The production of amyloid beta peptide is a critical requirement for the viability of central neurons. J Neurosci Off J Soc Neurosci. 2003;23(13):5531-5.
    • (2003) J Neurosci Off J Soc Neurosci. , vol.23 , Issue.13 , pp. 5531-5535
    • Plant, L.D.1    Boyle, J.P.2    Smith, I.F.3    Peers, C.4    Pearson, H.A.5
  • 93
    • 81955164821 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and accumulation of the beta-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice
    • Devi L, Ohno M. Mitochondrial dysfunction and accumulation of the beta-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice. Neurobiol Dis. 2012;45(1):417-24.
    • (2012) Neurobiol Dis. , vol.45 , Issue.1 , pp. 417-424
    • Devi, L.1    Ohno, M.2
  • 94
    • 78649815388 scopus 로고    scopus 로고
    • Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
    • Du H, Guo L, Yan S, Sosunov AA, McKhann GM, Yan SS. Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A. 2010;107(43):18670-5.
    • (2010) Proc Natl Acad Sci U S A. , vol.107 , Issue.43 , pp. 18670-18675
    • Du, H.1    Guo, L.2    Yan, S.3    Sosunov, A.A.4    McKhann, G.M.5    Yan, S.S.6
  • 95
    • 84955346453 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in a transgenic mouse model expressing human amyloid precursor protein (APP) with the Arctic mutation
    • Ronnback A, Pavlov PF, Mansory M, Gonze P, Marliere N, Winblad B, et al. Mitochondrial dysfunction in a transgenic mouse model expressing human amyloid precursor protein (APP) with the Arctic mutation. J Neurochem. 2015;136(3):497-502.
    • (2015) J Neurochem. , vol.136 , Issue.3 , pp. 497-502
    • Ronnback, A.1    Pavlov, P.F.2    Mansory, M.3    Gonze, P.4    Marliere, N.5    Winblad, B.6
  • 96
    • 3543081564 scopus 로고    scopus 로고
    • Amyloid-beta: Phylogenesis of a chameleon
    • Kontush A, Atwood CS. Amyloid-beta: phylogenesis of a chameleon. Brain Res Brain Res Rev. 2004;46(1):118-20.
    • (2004) Brain Res Brain Res Rev. , vol.46 , Issue.1 , pp. 118-120
    • Kontush, A.1    Atwood, C.S.2
  • 98
    • 84892695519 scopus 로고    scopus 로고
    • Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease
    • Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, et al. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N Engl J Med. 2014;370(4):322-33.
    • (2014) N Engl J Med. , vol.370 , Issue.4 , pp. 322-333
    • Salloway, S.1    Sperling, R.2    Fox, N.C.3    Blennow, K.4    Klunk, W.5    Raskind, M.6
  • 100
    • 47149112621 scopus 로고    scopus 로고
    • Long-term effects of Abeta42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebocontrolled phase I trial
    • Holmes C, Boche D, Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, et al. Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebocontrolled phase I trial. Lancet (London, England). 2008;372(9634):216-23.
    • (2008) Lancet (London, England). , vol.372 , Issue.9634 , pp. 216-223
    • Holmes, C.1    Boche, D.2    Wilkinson, D.3    Yadegarfar, G.4    Hopkins, V.5    Bayer, A.6
  • 101
    • 84949092821 scopus 로고    scopus 로고
    • Decreased amyloid-beta and increased neuronal hyperactivity by immunotherapy in Alzheimer's models
    • Busche MA, Grienberger C, Keskin AD, Song B, Neumann U, Staufenbiel M, et al. Decreased amyloid-beta and increased neuronal hyperactivity by immunotherapy in Alzheimer's models. Nat Neurosci. 2015;18(12):1725-7.
    • (2015) Nat Neurosci. , vol.18 , Issue.12 , pp. 1725-1727
    • Busche, M.A.1    Grienberger, C.2    Keskin, A.D.3    Song, B.4    Neumann, U.5    Staufenbiel, M.6
  • 102
    • 84952718632 scopus 로고    scopus 로고
    • Tau and neurodegenerative disease: The story so far
    • Iqbal K, Liu F, Gong CX. Tau and neurodegenerative disease: the story so far. Nat Rev Neurol. 2015;12:15-27.
    • (2015) Nat Rev Neurol. , vol.12 , pp. 15-27
    • Iqbal, K.1    Liu, F.2    Gong, C.X.3
  • 104
    • 84882643371 scopus 로고    scopus 로고
    • Rotenone directly induces BV2 cell activation via the p38 MAPK pathway
    • Gao F, Chen D, Hu Q, Wang G. Rotenone directly induces BV2 cell activation via the p38 MAPK pathway. PLoS One. 2013;8(8):e72046.
    • (2013) PLoS One. , vol.8 , Issue.8 , pp. e72046
    • Gao, F.1    Chen, D.2    Hu, Q.3    Wang, G.4
  • 105
    • 84871186542 scopus 로고    scopus 로고
    • Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3alpha/beta and Bax, leading to permeability transition pore opening and tumor cell death
    • Chiara F, Gambalunga A, Sciacovelli M, Nicolli A, Ronconi L, Fregona D, et al. Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3alpha/beta and Bax, leading to permeability transition pore opening and tumor cell death. Cell Death Dis. 2012;3:e444.
    • (2012) Cell Death Dis. , vol.3 , pp. e444
    • Chiara, F.1    Gambalunga, A.2    Sciacovelli, M.3    Nicolli, A.4    Ronconi, L.5    Fregona, D.6
  • 106
    • 84947998831 scopus 로고    scopus 로고
    • Tau hyperphosphorylation and oxidative stress, a critical vicious circle in neurodegenerative tauopathies?
    • Alavi Naini SM, Soussi-Yanicostas N. Tau hyperphosphorylation and oxidative stress, a critical vicious circle in neurodegenerative tauopathies? Oxidative Med Cell Longev. 2015;2015:151979.
    • (2015) Oxidative Med Cell Longev. , vol.2015 , pp. 151979
    • Alavi Naini, S.M.1    Soussi-Yanicostas, N.2
  • 107
    • 84922347183 scopus 로고    scopus 로고
    • Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease
    • Chen CH, Li W, Sultana R, You MH, Kondo A, Shahpasand K, et al. Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease. Neurobiol Dis. 2015;76:13-23.
    • (2015) Neurobiol Dis. , vol.76 , pp. 13-23
    • Chen, C.H.1    Li, W.2    Sultana, R.3    You, M.H.4    Kondo, A.5    Shahpasand, K.6
  • 110
    • 33646511135 scopus 로고    scopus 로고
    • Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis
    • Sultana R, Boyd-Kimball D, Poon HF, Cai J, Pierce WM, Klein JB, et al. Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: a redox proteomics analysis. Neurobiol Aging. 2006;27(7):918-25.
    • (2006) Neurobiol Aging. , vol.27 , Issue.7 , pp. 918-925
    • Sultana, R.1    Boyd-Kimball, D.2    Poon, H.F.3    Cai, J.4    Pierce, W.M.5    Klein, J.B.6
  • 111
    • 84865352799 scopus 로고    scopus 로고
    • Tau promotes neurodegeneration via DRP1 mislocalization in vivo
    • DuBoff B, Gotz J, Feany MB. Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron. 2012;75(4):618-32.
    • (2012) Neuron. , vol.75 , Issue.4 , pp. 618-632
    • DuBoff, B.1    Gotz, J.2    Feany, M.B.3
  • 112
    • 0033577159 scopus 로고    scopus 로고
    • Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro
    • Hashimoto M, Hsu LJ, Xia Y, Takeda A, Sisk A, Sundsmo M, et al. Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro. Neuroreport. 1999;10(4):717-21.
    • (1999) Neuroreport. , vol.10 , Issue.4 , pp. 717-721
    • Hashimoto, M.1    Hsu, L.J.2    Xia, Y.3    Takeda, A.4    Sisk, A.5    Sundsmo, M.6
  • 113
    • 0035834655 scopus 로고    scopus 로고
    • Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins
    • Perrin RJ, Woods WS, Clayton DF, George JM. Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins. J Biol Chem. 2001;276(45):41958-62.
    • (2001) J Biol Chem. , vol.276 , Issue.45 , pp. 41958-41962
    • Perrin, R.J.1    Woods, W.S.2    Clayton, D.F.3    George, J.M.4
  • 114
    • 84942878943 scopus 로고    scopus 로고
    • A novel link between the conformations, exposure of specific epitopes, and subcellular localization of alpha-synuclein
    • Nam MK, Han JH, Jang JY, Yun SE, Kim GY, Kang S, et al. A novel link between the conformations, exposure of specific epitopes, and subcellular localization of alpha-synuclein. Biochim Biophys Acta. 2015;1850(12):2497-505.
    • (2015) Biochim Biophys Acta. , vol.1850 , Issue.12 , pp. 2497-2505
    • Nam, M.K.1    Han, J.H.2    Jang, J.Y.3    Yun, S.E.4    Kim, G.Y.5    Kang, S.6
  • 115
    • 31344464179 scopus 로고    scopus 로고
    • The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein
    • Zhou W, Zhu M, Wilson MA, Petsko GA, Fink AL. The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein. J Mol Biol. 2006;356(4):1036-48.
    • (2006) J Mol Biol. , vol.356 , Issue.4 , pp. 1036-1048
    • Zhou, W.1    Zhu, M.2    Wilson, M.A.3    Petsko, G.A.4    Fink, A.L.5
  • 116
    • 77952915653 scopus 로고    scopus 로고
    • Serine 129 phosphorylation reduces the ability of α-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo
    • Lou H, Montoya SE, Alerte TNM, Wang J, Wu J, Peng X, et al. Serine 129 phosphorylation reduces the ability of α-synuclein to regulate tyrosine hydroxylase and protein phosphatase 2A in vitro and in vivo. J Biol Chem. 2010;285(23):17648-61.
    • (2010) J Biol Chem. , vol.285 , Issue.23 , pp. 17648-17661
    • Lou, H.1    Montoya, S.E.2    Alerte, T.N.M.3    Wang, J.4    Wu, J.5    Peng, X.6
  • 117
    • 84861554724 scopus 로고    scopus 로고
    • Alpha-synuclein controls mitochondrial calcium homeostasis by enhancing endoplasmic reticulum-mitochondria interactions
    • Cali T, Ottolini D, Negro A, Brini M. Alpha-synuclein controls mitochondrial calcium homeostasis by enhancing endoplasmic reticulum-mitochondria interactions. J Biol Chem. 2012;287(22):17914-29.
    • (2012) J Biol Chem. , vol.287 , Issue.22 , pp. 17914-17929
    • Cali, T.1    Ottolini, D.2    Negro, A.3    Brini, M.4
  • 119
    • 84855809551 scopus 로고    scopus 로고
    • Transcript expression levels of fulllength alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression
    • McLean JR, Hallett PJ, Cooper O, Stanley M, Isacson O. Transcript expression levels of fulllength alpha-synuclein and its three alternatively spliced variants in Parkinson's disease brain regions and in a transgenic mouse model of alpha-synuclein overexpression. Mol Cell Neurosci. 2012;49(2):230-9.
    • (2012) Mol Cell Neurosci. , vol.49 , Issue.2 , pp. 230-239
    • McLean, J.R.1    Hallett, P.J.2    Cooper, O.3    Stanley, M.4    Isacson, O.5
  • 120
    • 84871414210 scopus 로고    scopus 로고
    • The many faces of alpha-synuclein: From structure and toxicity to therapeutic target
    • Lashuel HA, Overk CR, Oueslati A, Masliah E. The many faces of alpha-synuclein: from structure and toxicity to therapeutic target. Nat Rev Neurosci. 2013;14(1):38-48.
    • (2013) Nat Rev Neurosci. , vol.14 , Issue.1 , pp. 38-48
    • Lashuel, H.A.1    Overk, C.R.2    Oueslati, A.3    Masliah, E.4
  • 121
    • 9144229591 scopus 로고    scopus 로고
    • Functional consequences of alpha-synuclein tyrosine nitration: Diminished binding to lipid vesicles and increased fibril formation
    • Hodara R, Norris EH, Giasson BI, Mishizen-Eberz AJ, Lynch DR, Lee VM, et al. Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation. J Biol Chem. 2004;279(46):47746-53.
    • (2004) J Biol Chem. , vol.279 , Issue.46 , pp. 47746-47753
    • Hodara, R.1    Norris, E.H.2    Giasson, B.I.3    Mishizen-Eberz, A.J.4    Lynch, D.R.5    Lee, V.M.6
  • 123
    • 63449093494 scopus 로고    scopus 로고
    • Alpha-synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity
    • Liu G, Zhang C, Yin J, Li X, Cheng F, Li Y, et al. Alpha-synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity. Neurosci Lett. 2009;454(3):187-92.
    • (2009) Neurosci Lett. , vol.454 , Issue.3 , pp. 187-192
    • Liu, G.1    Zhang, C.2    Yin, J.3    Li, X.4    Cheng, F.5    Li, Y.6
  • 124
    • 0037085288 scopus 로고    scopus 로고
    • Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors
    • Lee HJ, Shin SY, Choi C, Lee YH, Lee SJ. Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors. J Biol Chem. 2002;277(7):5411-7.
    • (2002) J Biol Chem. , vol.277 , Issue.7 , pp. 5411-5417
    • Lee, H.J.1    Shin, S.Y.2    Choi, C.3    Lee, Y.H.4    Lee, S.J.5
  • 125
    • 44049099669 scopus 로고    scopus 로고
    • Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain
    • Devi L, Raghavendran V, Prabhu BM, Avadhani NG, Anandatheerthavarada HK. Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J Biol Chem. 2008;283(14):9089-100.
    • (2008) J Biol Chem. , vol.283 , Issue.14 , pp. 9089-9100
    • Devi, L.1    Raghavendran, V.2    Prabhu, B.M.3    Avadhani, N.G.4    Anandatheerthavarada, H.K.5
  • 126
    • 0037229425 scopus 로고    scopus 로고
    • Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
    • Sherer TB, Kim JH, Betarbet R, Greenamyre JT. Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation. Exp Neurol. 2003;179(1):9-16.
    • (2003) Exp Neurol. , vol.179 , Issue.1 , pp. 9-16
    • Sherer, T.B.1    Kim, J.H.2    Betarbet, R.3    Greenamyre, J.T.4
  • 127
    • 84952637945 scopus 로고    scopus 로고
    • Post-translational modification of alpha-synuclein in Parkinson's disease
    • Barrett PJ, Timothy Greenamyre J. Post-translational modification of alpha-synuclein in Parkinson's disease. Brain Res. 2015;1628(Pt B):247-53.
    • (2015) Brain Res. , vol.1628 , Issue.PART. B , pp. 247-253
    • Barrett, P.J.1    Timothy Greenamyre, J.2
  • 128
    • 84901441806 scopus 로고    scopus 로고
    • Shaping the dynamic mitochondrial network
    • Lackner LL. Shaping the dynamic mitochondrial network. BMC Biol. 2014;12:35.
    • (2014) BMC Biol. , vol.12 , pp. 35
    • Lackner, L.L.1
  • 129
    • 84862809187 scopus 로고    scopus 로고
    • Quantitative imaging of energy expenditure in human brain
    • Zhu XH, Qiao H, Du F, Xiong Q, Liu X, Zhang X, et al. Quantitative imaging of energy expenditure in human brain. NeuroImage. 2012;60(4):2107-17.
    • (2012) NeuroImage. , vol.60 , Issue.4 , pp. 2107-2117
    • Zhu, X.H.1    Qiao, H.2    Du, F.3    Xiong, Q.4    Liu, X.5    Zhang, X.6
  • 130
    • 84938545311 scopus 로고    scopus 로고
    • Mitochondrial synapses: Intracellular communication and signal integration
    • Picard M. Mitochondrial synapses: intracellular communication and signal integration. Trends Neurosci. 2015;38(8):468-74.
    • (2015) Trends Neurosci. , vol.38 , Issue.8 , pp. 468-474
    • Picard, M.1
  • 131
    • 84886812954 scopus 로고    scopus 로고
    • The nexus of chromatin regulation and intermediary metabolism
    • Gut P, Verdin E. The nexus of chromatin regulation and intermediary metabolism. Nature. 2013;502(7472):489-98.
    • (2013) Nature. , vol.502 , Issue.7472 , pp. 489-498
    • Gut, P.1    Verdin, E.2
  • 132
    • 84898845550 scopus 로고    scopus 로고
    • Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process
    • Salminen A, Kaarniranta K, Hiltunen M, Kauppinen A. Krebs cycle dysfunction shapes epigenetic landscape of chromatin: novel insights into mitochondrial regulation of aging process. Cell Signal. 2014;26(7):1598-603.
    • (2014) Cell Signal. , vol.26 , Issue.7 , pp. 1598-1603
    • Salminen, A.1    Kaarniranta, K.2    Hiltunen, M.3    Kauppinen, A.4
  • 133
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird A. Perceptions of epigenetics. Nature. 2007;447(7143):396-8.
    • (2007) Nature. , vol.447 , Issue.7143 , pp. 396-398
    • Bird, A.1
  • 134
    • 84938203544 scopus 로고    scopus 로고
    • Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape
    • Salminen A, Haapasalo A, Kauppinen A, Kaarniranta K, Soininen H, Hiltunen M. Impaired mitochondrial energy metabolism in Alzheimer's disease: impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape. Prog Neurobiol. 2015;131:1-20.
    • (2015) Prog Neurobiol. , vol.131 , pp. 1-20
    • Salminen, A.1    Haapasalo, A.2    Kauppinen, A.3    Kaarniranta, K.4    Soininen, H.5    Hiltunen, M.6
  • 135
    • 84919784465 scopus 로고    scopus 로고
    • Alzheimer's disease: Early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci
    • De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, et al. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nat Neurosci. 2014;17(9):1156-63.
    • (2014) Nat Neurosci. , vol.17 , Issue.9 , pp. 1156-1163
    • De Jager, P.L.1    Srivastava, G.2    Lunnon, K.3    Burgess, J.4    Schalkwyk, L.C.5    Yu, L.6
  • 136
    • 84907267817 scopus 로고    scopus 로고
    • Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming
    • Picard M, Zhang J, Hancock S, Derbeneva O, Golhar R, Golik P, et al. Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming. Proc Natl Acad Sci U S A. 2014;111(38):E4033-42.
    • (2014) Proc Natl Acad Sci U S A. , vol.111 , Issue.38 , pp. E4033-E4042
    • Picard, M.1    Zhang, J.2    Hancock, S.3    Derbeneva, O.4    Golhar, R.5    Golik, P.6
  • 137
    • 84863664040 scopus 로고    scopus 로고
    • Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxiainduced transcription
    • Al-Mehdi AB, Pastukh VM, Swiger BM, Reed DJ, Patel MR, Bardwell GC, et al. Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxiainduced transcription. Sci Signal. 2012;5(231):ra47.
    • (2012) Sci Signal. , vol.5 , Issue.231 , pp. ra47
    • Al-Mehdi, A.B.1    Pastukh, V.M.2    Swiger, B.M.3    Reed, D.J.4    Patel, M.R.5    Bardwell, G.C.6
  • 138
    • 34249028642 scopus 로고    scopus 로고
    • Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
    • Passos JF, Saretzki G, Ahmed S, Nelson G, Richter T, Peters H, et al. Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol. 2007;5(5):e110.
    • (2007) PLoS Biol. , vol.5 , Issue.5 , pp. e110
    • Passos, J.F.1    Saretzki, G.2    Ahmed, S.3    Nelson, G.4    Richter, T.5    Peters, H.6
  • 139
    • 84859483420 scopus 로고    scopus 로고
    • Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
    • Velarde MC, Flynn JM, Day NU, Melov S, Campisi J. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging. 2012;4(1):3-12.
    • (2012) Aging. , vol.4 , Issue.1 , pp. 3-12
    • Velarde, M.C.1    Flynn, J.M.2    Day, N.U.3    Melov, S.4    Campisi, J.5
  • 140
    • 51649126499 scopus 로고    scopus 로고
    • Reverse of agedependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice
    • Hayashi Y, Yoshida M, Yamato M, Ide T, Wu Z, Ochi-Shindou M, et al. Reverse of agedependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice. J Neurosci Off J Soc Neurosci. 2008;28(34):8624-34.
    • (2008) J Neurosci Off J Soc Neurosci. , vol.28 , Issue.34 , pp. 8624-8634
    • Hayashi, Y.1    Yoshida, M.2    Yamato, M.3    Ide, T.4    Wu, Z.5    Ochi-Shindou, M.6
  • 141
    • 48149093475 scopus 로고    scopus 로고
    • A functional genomic fingerprint of chronic stress in humans: Blunted glucocorticoid and increased NF-kappaB signaling
    • Miller GE, Chen E, Sze J, Marin T, Arevalo JM, Doll R, et al. A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling. Biol Psychiatry. 2008;64(4):266-72.
    • (2008) Biol Psychiatry. , vol.64 , Issue.4 , pp. 266-272
    • Miller, G.E.1    Chen, E.2    Sze, J.3    Marin, T.4    Arevalo, J.M.5    Doll, R.6
  • 143
    • 84884337715 scopus 로고    scopus 로고
    • Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics
    • Guha M, Avadhani NG. Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics. Mitochondrion. 2013;13(6):577-91.
    • (2013) Mitochondrion. , vol.13 , Issue.6 , pp. 577-591
    • Guha, M.1    Avadhani, N.G.2
  • 144
    • 56049107038 scopus 로고    scopus 로고
    • PGC-1 coactivators and skeletal muscle adaptations in health and disease
    • Arany Z. PGC-1 coactivators and skeletal muscle adaptations in health and disease. Curr Opin Genet Dev. 2008;18(5):426-34.
    • (2008) Curr Opin Genet Dev. , vol.18 , Issue.5 , pp. 426-434
    • Arany, Z.1
  • 146
    • 0037218317 scopus 로고    scopus 로고
    • The concept of allostasis in biology and biomedicine
    • McEwen BS, Wingfield JC. The concept of allostasis in biology and biomedicine. Horm Behav. 2003;43(1):2-15.
    • (2003) Horm Behav. , vol.43 , Issue.1 , pp. 2-15
    • McEwen, B.S.1    Wingfield, J.C.2
  • 147
    • 84894150737 scopus 로고    scopus 로고
    • Activity-driven local ATP synthesis is required for synaptic function
    • Rangaraju V, Calloway N, Ryan TA. Activity-driven local ATP synthesis is required for synaptic function. Cell. 2014;156(4):825-35.
    • (2014) Cell. , vol.156 , Issue.4 , pp. 825-835
    • Rangaraju, V.1    Calloway, N.2    Ryan, T.A.3
  • 148
    • 84891906038 scopus 로고    scopus 로고
    • Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment
    • Hara Y, Yuk F, Puri R, Janssen WG, Rapp PR, Morrison JH. Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment. Proc Natl Acad Sci U S A. 2014;111(1):486-91.
    • (2014) Proc Natl Acad Sci U S A. , vol.111 , Issue.1 , pp. 486-491
    • Hara, Y.1    Yuk, F.2    Puri, R.3    Janssen, W.G.4    Rapp, P.R.5    Morrison, J.H.6
  • 149
    • 84867522393 scopus 로고    scopus 로고
    • Heteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognition
    • Sharpley MS, Marciniak C, Eckel-Mahan K, McManus M, Crimi M, Waymire K, et al. Heteroplasmy of mouse mtDNA is genetically unstable and results in altered behavior and cognition. Cell. 2012;151(2):333-43.
    • (2012) Cell. , vol.151 , Issue.2 , pp. 333-343
    • Sharpley, M.S.1    Marciniak, C.2    Eckel-Mahan, K.3    McManus, M.4    Crimi, M.5    Waymire, K.6
  • 150
    • 84881611195 scopus 로고    scopus 로고
    • Motile axonal mitochondria contribute to the variability of presynaptic strength
    • Sun T, Qiao H, Pan PY, Chen Y, Sheng ZH. Motile axonal mitochondria contribute to the variability of presynaptic strength. Cell Rep. 2013;4(3):413-9.
    • (2013) Cell Rep. , vol.4 , Issue.3 , pp. 413-419
    • Sun, T.1    Qiao, H.2    Pan, P.Y.3    Chen, Y.4    Sheng, Z.H.5
  • 151
    • 83455181308 scopus 로고    scopus 로고
    • Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease
    • Vos M, Lauwers E, Verstreken P. Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease. Front Synaptic Neurosci. 2010;2:139.
    • (2010) Front Synaptic Neurosci. , vol.2 , pp. 139
    • Vos, M.1    Lauwers, E.2    Verstreken, P.3
  • 152
    • 84891960724 scopus 로고    scopus 로고
    • Mitochondria impact brain function and cognition
    • Picard M, McEwen BS. Mitochondria impact brain function and cognition. Proc Natl Acad Sci U S A. 2014;111(1):7-8.
    • (2014) Proc Natl Acad Sci U S A. , vol.111 , Issue.1 , pp. 7-8
    • Picard, M.1    McEwen, B.S.2
  • 153
    • 0037314931 scopus 로고    scopus 로고
    • The spectrum of exercise tolerance in mitochondrial myopathies: A study of 40 patients
    • Taivassalo T, Jensen TD, Kennaway N, DiMauro S, Vissing J, Haller RG. The spectrum of exercise tolerance in mitochondrial myopathies: a study of 40 patients. Brain. 2003;126(Pt 2):413-23.
    • (2003) Brain. , vol.126 , Issue.PART. 2 , pp. 413-423
    • Taivassalo, T.1    Jensen, T.D.2    Kennaway, N.3    DiMauro, S.4    Vissing, J.5    Haller, R.G.6
  • 154
    • 84856735702 scopus 로고    scopus 로고
    • Increased capillaries in mitochondrial myopathy: Implications for the regulation of oxygen delivery
    • Taivassalo T, Ayyad K, Haller RG. Increased capillaries in mitochondrial myopathy: implications for the regulation of oxygen delivery. Brain. 2012;135(Pt 1):53-61.
    • (2012) Brain. , vol.135 , Issue.PART. 1 , pp. 53-61
    • Taivassalo, T.1    Ayyad, K.2    Haller, R.G.3
  • 155
    • 34447629382 scopus 로고    scopus 로고
    • Physiology and neurobiology of stress and adaptation: Central role of the brain
    • McEwen BS. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev. 2007;87(3):873-904.
    • (2007) Physiol Rev. , vol.87 , Issue.3 , pp. 873-904
    • McEwen, B.S.1
  • 157
    • 84940195045 scopus 로고    scopus 로고
    • Peripheral and central effects of circulating catecholamines
    • Tank AW, Lee WD. Peripheral and central effects of circulating catecholamines. Compr Physiol. 2015;5(1):1-15.
    • (2015) Compr Physiol. , vol.5 , Issue.1 , pp. 1-15
    • Tank, A.W.1    Lee, W.D.2
  • 158
    • 60349089146 scopus 로고    scopus 로고
    • Behavior and stress reactivity in mouse strains with mitochondrial DNA variations
    • Gimsa U, Kanitz E, Otten W, Ibrahim SM. Behavior and stress reactivity in mouse strains with mitochondrial DNA variations. Ann N Y Acad Sci. 2009;1153:131-8.
    • (2009) Ann N Y Acad Sci. , vol.1153 , pp. 131-138
    • Gimsa, U.1    Kanitz, E.2    Otten, W.3    Ibrahim, S.M.4
  • 159
    • 84948679316 scopus 로고    scopus 로고
    • Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress
    • Picard M, McManus MJ, Gray JD, Nasca C, Moffat C, Kopinski PK, et al. Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress. Proc Natl Acad Sci U S A. 2015;112(48):E6614-23.
    • (2015) Proc Natl Acad Sci U S A. , vol.112 , Issue.48 , pp. E6614-E6623
    • Picard, M.1    McManus, M.J.2    Gray, J.D.3    Nasca, C.4    Moffat, C.5    Kopinski, P.K.6
  • 160
    • 84863003306 scopus 로고    scopus 로고
    • Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency
    • Meimaridou E, Kowalczyk J, Guasti L, Hughes CR, Wagner F, Frommolt P, et al. Mutations in NNT encoding nicotinamide nucleotide transhydrogenase cause familial glucocorticoid deficiency. Nat Genet. 2012;44(7):740-2.
    • (2012) Nat Genet. , vol.44 , Issue.7 , pp. 740-742
    • Meimaridou, E.1    Kowalczyk, J.2    Guasti, L.3    Hughes, C.R.4    Wagner, F.5    Frommolt, P.6
  • 161
    • 84948679316 scopus 로고    scopus 로고
    • Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress
    • Picard M, McManus MJ, Gray JD, Nasca C, Moffat C, Kopinski PK, et al. Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress. Proc Natl Acad Sci. 2015;112(48):E6614-23.
    • (2015) Proc Natl Acad Sci. , vol.112 , Issue.48 , pp. E6614-E6623
    • Picard, M.1    McManus, M.J.2    Gray, J.D.3    Nasca, C.4    Moffat, C.5    Kopinski, P.K.6
  • 162
    • 84874507192 scopus 로고    scopus 로고
    • Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup
    • Strauss KA, DuBiner L, Simon M, Zaragoza M, Sengupta PP, Li P, et al. Severity of cardiomyopathy associated with adenine nucleotide translocator-1 deficiency correlates with mtDNA haplogroup. Proc Natl Acad Sci U S A. 2013;110(9):3453-8.
    • (2013) Proc Natl Acad Sci U S A. , vol.110 , Issue.9 , pp. 3453-3458
    • Strauss, K.A.1    DuBiner, L.2    Simon, M.3    Zaragoza, M.4    Sengupta, P.P.5    Li, P.6
  • 163
    • 84886287512 scopus 로고    scopus 로고
    • Defining cardiac adaptations and safety of endurance training in patients with m.3243A>Grelated mitochondrial disease
    • Bates MG, Newman JH, Jakovljevic DG, Hollingsworth KG, Alston CL, Zalewski P, et al. Defining cardiac adaptations and safety of endurance training in patients with m.3243A>Grelated mitochondrial disease. Int J Cardiol. 2013;168(4):3599-608.
    • (2013) Int J Cardiol. , vol.168 , Issue.4 , pp. 3599-3608
    • Bates, M.G.1    Newman, J.H.2    Jakovljevic, D.G.3    Hollingsworth, K.G.4    Alston, C.L.5    Zalewski, P.6
  • 164
    • 84880932809 scopus 로고    scopus 로고
    • Lactate metabolism during exercise in patients with mitochondrial myopathy
    • Jeppesen TD, Orngreen MC, Van Hall G, Vissing J. Lactate metabolism during exercise in patients with mitochondrial myopathy. Neuromuscul Dis NMD. 2013;23(8):629-36.
    • (2013) Neuromuscul Dis NMD. , vol.23 , Issue.8 , pp. 629-636
    • Jeppesen, T.D.1    Orngreen, M.C.2    Van Hall, G.3    Vissing, J.4
  • 165
  • 167
    • 84899471500 scopus 로고    scopus 로고
    • Mitochondrial allostatic load puts the 'gluc' back in glucocorticoids
    • Picard M, Juster RP, McEwen BS. Mitochondrial allostatic load puts the 'gluc' back in glucocorticoids. Nat Rev Endocrinol. 2014;10(5):303-10.
    • (2014) Nat Rev Endocrinol. , vol.10 , Issue.5 , pp. 303-310
    • Picard, M.1    Juster, R.P.2    McEwen, B.S.3
  • 168
    • 84900988267 scopus 로고    scopus 로고
    • Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases
    • Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol Ser A Biol Med Sci. 2014;69 Suppl 1:S4-9.
    • (2014) J Gerontol Ser A Biol Med Sci. , vol.69 , pp. S4-S9
    • Franceschi, C.1    Campisi, J.2
  • 169
    • 77949500380 scopus 로고    scopus 로고
    • Release of the mitochondrial endosymbiont helps explain sterile inflammation
    • Masters SL, Walsh PT. Release of the mitochondrial endosymbiont helps explain sterile inflammation. Proc Natl Acad Sci U S A. 2010;107(10):E32.
    • (2010) Proc Natl Acad Sci U S A. , vol.107 , Issue.10 , pp. E32
    • Masters, S.L.1    Walsh, P.T.2
  • 170
    • 25844524877 scopus 로고    scopus 로고
    • Neurodegenerative diseases: An overview of environmental risk factors
    • Brown RC, Lockwood AH, Sonawane BR. Neurodegenerative diseases: an overview of environmental risk factors. Environ Health Perspect. 2005;113(9):1250-6.
    • (2005) Environ Health Perspect. , vol.113 , Issue.9 , pp. 1250-1256
    • Brown, R.C.1    Lockwood, A.H.2    Sonawane, B.R.3
  • 171
    • 84899513393 scopus 로고    scopus 로고
    • Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for "inflamm-aging"
    • Pinti M, Cevenini E, Nasi M, De Biasi S, Salvioli S, Monti D, et al. Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for "inflamm-aging". Eur J Immunol. 2014;44(5):1552-62.
    • (2014) Eur J Immunol. , vol.44 , Issue.5 , pp. 1552-1562
    • Pinti, M.1    Cevenini, E.2    Nasi, M.3    De Biasi, S.4    Salvioli, S.5    Monti, D.6
  • 172
    • 84921913008 scopus 로고    scopus 로고
    • Alpha 7 nicotinic acetylcholine receptor signaling inhibits inflammasome activation by preventing mitochondrial DNA release
    • Lu B, Kwan K, Levine YA, Olofsson PS, Yang H, Li J, et al. Alpha 7 nicotinic acetylcholine receptor signaling inhibits inflammasome activation by preventing mitochondrial DNA release. Mol Med. 2014;20:350-8.
    • (2014) Mol Med. , vol.20 , pp. 350-358
    • Lu, B.1    Kwan, K.2    Levine, Y.A.3    Olofsson, P.S.4    Yang, H.5    Li, J.6
  • 173
    • 84928537166 scopus 로고    scopus 로고
    • Mitochondrial DNA stress primes the antiviral innate immune response
    • West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, et al. Mitochondrial DNA stress primes the antiviral innate immune response. Nature. 2015;520(7548):553-7.
    • (2015) Nature. , vol.520 , Issue.7548 , pp. 553-557
    • West, A.P.1    Khoury-Hanold, W.2    Staron, M.3    Tal, M.C.4    Pineda, C.M.5    Lang, S.M.6
  • 174
    • 77950275298 scopus 로고    scopus 로고
    • Circulating mitochondrial DAMPs cause inflammatory responses to injury
    • Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, et al. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010;464(7285):104-7.
    • (2010) Nature. , vol.464 , Issue.7285 , pp. 104-107
    • Zhang, Q.1    Raoof, M.2    Chen, Y.3    Sumi, Y.4    Sursal, T.5    Junger, W.6
  • 175
    • 84862777872 scopus 로고    scopus 로고
    • Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
    • Shimada K, Crother TR, Karlin J, Dagvadorj J, Chiba N, Chen S, et al. Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity. 2012;36(3):401-14.
    • (2012) Immunity. , vol.36 , Issue.3 , pp. 401-414
    • Shimada, K.1    Crother, T.R.2    Karlin, J.3    Dagvadorj, J.4    Chiba, N.5    Chen, S.6
  • 176
    • 45749090539 scopus 로고    scopus 로고
    • Formyl-methionyl-leucylphenylalanine-induced dopaminergic neurotoxicity via microglial activation: A mediator between peripheral infection and neurodegeneration?
    • Gao X, Hu X, Qian L, Yang S, Zhang W, Zhang D, et al. Formyl-methionyl-leucylphenylalanine-induced dopaminergic neurotoxicity via microglial activation: a mediator between peripheral infection and neurodegeneration? Environ Health Perspect. 2008;116(5):593-8.
    • (2008) Environ Health Perspect. , vol.116 , Issue.5 , pp. 593-598
    • Gao, X.1    Hu, X.2    Qian, L.3    Yang, S.4    Zhang, W.5    Zhang, D.6
  • 177
    • 84924099385 scopus 로고    scopus 로고
    • Mitochondrial lysates induce inflammation and Alzheimer's disease-relevant changes in microglial and neuronal cells
    • Wilkins HM, Carl SM, Weber SG, Ramanujan SA, Festoff BW, Linseman DA, et al. Mitochondrial lysates induce inflammation and Alzheimer's disease-relevant changes in microglial and neuronal cells. J Alzheimers Dis JAD. 2015;45(1):305-18.
    • (2015) J Alzheimers Dis JAD. , vol.45 , Issue.1 , pp. 305-318
    • Wilkins, H.M.1    Carl, S.M.2    Weber, S.G.3    Ramanujan, S.A.4    Festoff, B.W.5    Linseman, D.A.6
  • 178
    • 84940467057 scopus 로고    scopus 로고
    • NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure
    • Chen L, Na R, Boldt E, Ran Q. NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure. Neurobiol Aging. 2015;36(9):2533-43.
    • (2015) Neurobiol Aging. , vol.36 , Issue.9 , pp. 2533-2543
    • Chen, L.1    Na, R.2    Boldt, E.3    Ran, Q.4
  • 179
    • 84862835766 scopus 로고    scopus 로고
    • Degraded mitochondrial DNA is a newly identified subtype of the damage associated molecular pattern (DAMP) family and possible trigger of neurodegeneration
    • Mathew A, Lindsley TA, Sheridan A, Bhoiwala DL, Hushmendy SF, Yager EJ, et al. Degraded mitochondrial DNA is a newly identified subtype of the damage associated molecular pattern (DAMP) family and possible trigger of neurodegeneration. J Alzheimers Dis JAD. 2012;30(3):617-27.
    • (2012) J Alzheimers Dis JAD. , vol.30 , Issue.3 , pp. 617-627
    • Mathew, A.1    Lindsley, T.A.2    Sheridan, A.3    Bhoiwala, D.L.4    Hushmendy, S.F.5    Yager, E.J.6
  • 180
    • 84873087532 scopus 로고    scopus 로고
    • NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
    • Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature. 2013;493(7434):674-8.
    • (2013) Nature. , vol.493 , Issue.7434 , pp. 674-678
    • Heneka, M.T.1    Kummer, M.P.2    Stutz, A.3    Delekate, A.4    Schwartz, S.5    Vieira-Saecker, A.6
  • 181
    • 84909579208 scopus 로고    scopus 로고
    • Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5
    • Wan M, Hua X, Su J, Thiagarajan D, Frostegard AG, Haeggstrom JZ, et al. Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5. Atherosclerosis. 2014;235(2):592-8.
    • (2014) Atherosclerosis. , vol.235 , Issue.2 , pp. 592-598
    • Wan, M.1    Hua, X.2    Su, J.3    Thiagarajan, D.4    Frostegard, A.G.5    Haeggstrom, J.Z.6
  • 183
    • 40649085962 scopus 로고    scopus 로고
    • Plasma heat shock protein 60 and cardiovascular disease risk: The role of psychosocial, genetic, and biological factors
    • Shamaei-Tousi A, Steptoe A, O'Donnell K, Palmen J, Stephens JW, Hurel SJ, et al. Plasma heat shock protein 60 and cardiovascular disease risk: the role of psychosocial, genetic, and biological factors. Cell Stress Chaperones. 2007;12(4):384-92.
    • (2007) Cell Stress Chaperones. , vol.12 , Issue.4 , pp. 384-392
    • Shamaei-Tousi, A.1    Steptoe, A.2    O'Donnell, K.3    Palmen, J.4    Stephens, J.W.5    Hurel, S.J.6
  • 184
    • 6044254763 scopus 로고    scopus 로고
    • Differential immunization identifies PHB1/PHB2 as blood-borne tumor antigens
    • Mengwasser J, Piau A, Schlag P, Sleeman JP. Differential immunization identifies PHB1/PHB2 as blood-borne tumor antigens. Oncogene. 2004;23(44):7430-5.
    • (2004) Oncogene. , vol.23 , Issue.44 , pp. 7430-7435
    • Mengwasser, J.1    Piau, A.2    Schlag, P.3    Sleeman, J.P.4
  • 185
    • 84876962833 scopus 로고    scopus 로고
    • Humanin: A harbinger of mitochondrial-derived peptides?
    • Lee C, Yen K, Cohen P. Humanin: a harbinger of mitochondrial-derived peptides? Trends Endocrinol Metab TEM. 2013;24(5):222-8.
    • (2013) Trends Endocrinol Metab TEM. , vol.24 , Issue.5 , pp. 222-228
    • Lee, C.1    Yen, K.2    Cohen, P.3
  • 186
    • 84924358856 scopus 로고    scopus 로고
    • The mitochondrialderived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
    • Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, et al. The mitochondrialderived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015;21(3):443-54.
    • (2015) Cell Metab. , vol.21 , Issue.3 , pp. 443-454
    • Lee, C.1    Zeng, J.2    Drew, B.G.3    Sallam, T.4    Martin-Montalvo, A.5    Wan, J.6
  • 187
    • 40449097556 scopus 로고    scopus 로고
    • A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS
    • Lehnardt S, Schott E, Trimbuch T, Laubisch D, Krueger C, Wulczyn G, et al. A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS. J Neurosci Off J Soc Neurosci. 2008;28(10):2320-31.
    • (2008) J Neurosci Off J Soc Neurosci. , vol.28 , Issue.10 , pp. 2320-2331
    • Lehnardt, S.1    Schott, E.2    Trimbuch, T.3    Laubisch, D.4    Krueger, C.5    Wulczyn, G.6
  • 188
    • 84949318730 scopus 로고    scopus 로고
    • Preclinical evidence for a role of the nicotinic cholinergic system in Parkinson's disease
    • Perez XA. Preclinical evidence for a role of the nicotinic cholinergic system in Parkinson's disease. Neuropsychol Rev. 2015;25(4):371-83.
    • (2015) Neuropsychol Rev. , vol.25 , Issue.4 , pp. 371-383
    • Perez, X.A.1
  • 189
    • 75049085215 scopus 로고    scopus 로고
    • Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: Role of alpha4 and alpha7 receptors in neuroprotection
    • Akaike A, Takada-Takatori Y, Kume T, Izumi Y. Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. J Mol Neurosci MN. 2010;40(1-2):211-6.
    • (2010) J Mol Neurosci MN. , vol.40 , Issue.1-2 , pp. 211-216
    • Akaike, A.1    Takada-Takatori, Y.2    Kume, T.3    Izumi, Y.4
  • 190
    • 79957597757 scopus 로고    scopus 로고
    • Mitochondria in innate immune responses
    • West AP, Shadel GS, Ghosh S. Mitochondria in innate immune responses. Nat Rev Immunol. 2011;11(6):389-402.
    • (2011) Nat Rev Immunol. , vol.11 , Issue.6 , pp. 389-402
    • West, A.P.1    Shadel, G.S.2    Ghosh, S.3
  • 191
    • 84869178487 scopus 로고    scopus 로고
    • Microglia and neurodegeneration: The role of systemic inflammation
    • Cunningham C. Microglia and neurodegeneration: the role of systemic inflammation. Glia. 2013;61(1):71-90.
    • (2013) Glia. , vol.61 , Issue.1 , pp. 71-90
    • Cunningham, C.1
  • 192
    • 79551716551 scopus 로고    scopus 로고
    • Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling
    • Koshiba T, Yasukawa K, Yanagi Y, Kawabata S. Mitochondrial membrane potential is required for MAVS-mediated antiviral signaling. Sci Signal. 2011;4(158):ra7.
    • (2011) Sci Signal. , vol.4 , Issue.158 , pp. ra7
    • Koshiba, T.1    Yasukawa, K.2    Yanagi, Y.3    Kawabata, S.4
  • 193
    • 79955532516 scopus 로고    scopus 로고
    • TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
    • West AP, Brodsky IE, Rahner C, Woo DK, Erdjument-Bromage H, Tempst P, et al. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature. 2011;472(7344):476-80.
    • (2011) Nature. , vol.472 , Issue.7344 , pp. 476-480
    • West, A.P.1    Brodsky, I.E.2    Rahner, C.3    Woo, D.K.4    Erdjument-Bromage, H.5    Tempst, P.6
  • 194
    • 84948695894 scopus 로고    scopus 로고
    • The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome
    • (in press).
    • Frank MG, Weber MD, Fonken LK, Hershman SA, Watkins LR, Maier SF. The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: a role for the NLRP3 inflammasome. Brain Behav Immun. 2015; doi: 10.1016/j.bbi.2015.10.009 (in press).
    • (2015) Brain Behav Immun.
    • Frank, M.G.1    Weber, M.D.2    Fonken, L.K.3    Hershman, S.A.4    Watkins, L.R.5    Maier, S.F.6
  • 196
    • 84903713915 scopus 로고    scopus 로고
    • Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression
    • Karabatsiakis A, Bock C, Salinas-Manrique J, Kolassa S, Calzia E, Dietrich DE, et al. Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression. Transl Psychiatr. 2014;4:e397.
    • (2014) Transl Psychiatr. , vol.4 , pp. e397
    • Karabatsiakis, A.1    Bock, C.2    Salinas-Manrique, J.3    Kolassa, S.4    Calzia, E.5    Dietrich, D.E.6
  • 199
    • 84902302648 scopus 로고    scopus 로고
    • Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways: Insights into mitochondrial-nuclear interactions
    • Kenney MC, Chwa M, Atilano SR, Falatoonzadeh P, Ramirez C, Malik D, et al. Inherited mitochondrial DNA variants can affect complement, inflammation and apoptosis pathways:insights into mitochondrial-nuclear interactions. Hum Mol Genet. 2014;23(13):3537-51.
    • (2014) Hum Mol Genet. , vol.23 , Issue.13 , pp. 3537-3551
    • Kenney, M.C.1    Chwa, M.2    Atilano, S.R.3    Falatoonzadeh, P.4    Ramirez, C.5    Malik, D.6
  • 200
    • 84897976299 scopus 로고    scopus 로고
    • Microglial priming in neurodegenerative disease
    • Perry VH, Holmes C. Microglial priming in neurodegenerative disease. Nat Rev Neurol. 2014;10(4):217-24.
    • (2014) Nat Rev Neurol. , vol.10 , Issue.4 , pp. 217-224
    • Perry, V.H.1    Holmes, C.2
  • 201
    • 84870540270 scopus 로고    scopus 로고
    • Energy intake and exercise as determinants of brain health and vulnerability to injury and disease
    • Mattson MP. Energy intake and exercise as determinants of brain health and vulnerability to injury and disease. Cell Metab. 2012;16(6):706-22.
    • (2012) Cell Metab. , vol.16 , Issue.6 , pp. 706-722
    • Mattson, M.P.1
  • 202
    • 77957087405 scopus 로고    scopus 로고
    • Midlife psychological stress and risk of dementia: A 35-year longitudinal population study
    • Johansson L, Guo X, Waern M, Ostling S, Gustafson D, Bengtsson C, et al. Midlife psychological stress and risk of dementia: a 35-year longitudinal population study. Brain. 2010;133(Pt 8):2217-24.
    • (2010) Brain. , vol.133 , Issue.PART. 8 , pp. 2217-2224
    • Johansson, L.1    Guo, X.2    Waern, M.3    Ostling, S.4    Gustafson, D.5    Bengtsson, C.6
  • 204
    • 84955371298 scopus 로고    scopus 로고
    • Mitochondrial SIRT3 mediates adaptive responses of neurons to exercise and metabolic and excitatory challenges
    • Cheng A, Yang Y, Zhou Y, Maharana C, Lu D, Peng W, et al. Mitochondrial SIRT3 mediates adaptive responses of neurons to exercise and metabolic and excitatory challenges. Cell Metab. 2015;23(1):128-42.
    • (2015) Cell Metab. , vol.23 , Issue.1 , pp. 128-142
    • Cheng, A.1    Yang, Y.2    Zhou, Y.3    Maharana, C.4    Lu, D.5    Peng, W.6
  • 206
    • 84874421794 scopus 로고    scopus 로고
    • Linking the metabolic state and mitochondrial DNA in chronic disease, health, and aging
    • Picard M, Turnbull DM. Linking the metabolic state and mitochondrial DNA in chronic disease, health, and aging. Diabetes. 2013;62(3):672-8.
    • (2013) Diabetes. , vol.62 , Issue.3 , pp. 672-678
    • Picard, M.1    Turnbull, D.M.2
  • 207
    • 84889571471 scopus 로고    scopus 로고
    • Impaired glycemia increases disease progression in mild cognitive impairment
    • Morris JK, Vidoni ED, Honea RA, Burns JM. Impaired glycemia increases disease progression in mild cognitive impairment. Neurobiol Aging. 2014;35(3):585-9.
    • (2014) Neurobiol Aging. , vol.35 , Issue.3 , pp. 585-589
    • Morris, J.K.1    Vidoni, E.D.2    Honea, R.A.3    Burns, J.M.4
  • 208
    • 84930405360 scopus 로고    scopus 로고
    • Hyperglycemia modulates extracellular amyloid-beta concentrations and neuronal activity in vivo
    • Macauley SL, Stanley M, Caesar EE, Yamada SA, Raichle ME, Perez R, et al. Hyperglycemia modulates extracellular amyloid-beta concentrations and neuronal activity in vivo. J Clin Invest. 2015;125(6):2463-7.
    • (2015) J Clin Invest. , vol.125 , Issue.6 , pp. 2463-2467
    • Macauley, S.L.1    Stanley, M.2    Caesar, E.E.3    Yamada, S.A.4    Raichle, M.E.5    Perez, R.6
  • 209
    • 18244384051 scopus 로고    scopus 로고
    • Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease
    • Adlard PA, Perreau VM, Pop V, Cotman CW. Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease. J Neurosci Off J Soc Neurosci. 2005;25(17):4217-21.
    • (2005) J Neurosci Off J Soc Neurosci. , vol.25 , Issue.17 , pp. 4217-4221
    • Adlard, P.A.1    Perreau, V.M.2    Pop, V.3    Cotman, C.W.4
  • 210
    • 84947556460 scopus 로고    scopus 로고
    • A spectrum of exercise training reduces soluble Abeta in a dose-dependent manner in a mouse model of Alzheimer's disease
    • Moore KM, Girens RE, Larson SK, Jones MR, Restivo JL, Holtzman DM, et al. A spectrum of exercise training reduces soluble Abeta in a dose-dependent manner in a mouse model of Alzheimer's disease. Neurobiol Dis. 2015;85:218-24.
    • (2015) Neurobiol Dis. , vol.85 , pp. 218-224
    • Moore, K.M.1    Girens, R.E.2    Larson, S.K.3    Jones, M.R.4    Restivo, J.L.5    Holtzman, D.M.6
  • 211
    • 84877103900 scopus 로고    scopus 로고
    • Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid beta (Abeta) peptide catabolism and functionality
    • Leal MC, Magnani N, Villordo S, Buslje CM, Evelson P, Castano EM, et al. Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid beta (Abeta) peptide catabolism and functionality. J Biol Chem. 2013;288(18):12920-31.
    • (2013) J Biol Chem. , vol.288 , Issue.18 , pp. 12920-12931
    • Leal, M.C.1    Magnani, N.2    Villordo, S.3    Buslje, C.M.4    Evelson, P.5    Castano, E.M.6
  • 212
    • 84863266835 scopus 로고    scopus 로고
    • Psychosocial stress at work is associated with increased dementia risk in late life
    • Wang HX, Wahlberg M, Karp A, Winblad B, Fratiglioni L. Psychosocial stress at work is associated with increased dementia risk in late life. Alzheimers Dement. 2012;8(2):114-20.
    • (2012) Alzheimers Dement. , vol.8 , Issue.2 , pp. 114-120
    • Wang, H.X.1    Wahlberg, M.2    Karp, A.3    Winblad, B.4    Fratiglioni, L.5
  • 213
    • 84857046107 scopus 로고    scopus 로고
    • Midlife psychological distress associated with late-life brain atrophy and white matter lesions: A 32-year population study of women
    • Johansson L, Skoog I, Gustafson DR, Olesen PJ, Waern M, Bengtsson C, et al. Midlife psychological distress associated with late-life brain atrophy and white matter lesions: a 32-year population study of women. Psychosom Med. 2012;74(2):120-5.
    • (2012) Psychosom Med. , vol.74 , Issue.2 , pp. 120-125
    • Johansson, L.1    Skoog, I.2    Gustafson, D.R.3    Olesen, P.J.4    Waern, M.5    Bengtsson, C.6
  • 215
    • 80051792747 scopus 로고    scopus 로고
    • Glucocorticoids induce mitochondrial gene transcription in HepG2 cells: Role of the mitochondrial glucocorticoid receptor
    • Psarra AM, Sekeris CE. Glucocorticoids induce mitochondrial gene transcription in HepG2 cells: role of the mitochondrial glucocorticoid receptor. Biochim Biophys Acta. 2011;1813(10):1814-21.
    • (2011) Biochim Biophys Acta. , vol.1813 , Issue.10 , pp. 1814-1821
    • Psarra, A.M.1    Sekeris, C.E.2
  • 216
    • 84895452716 scopus 로고    scopus 로고
    • Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation
    • de Pablos RM, Herrera AJ, Espinosa-Oliva AM, Sarmiento M, Munoz MF, Machado A, et al. Chronic stress enhances microglia activation and exacerbates death of nigral dopaminergic neurons under conditions of inflammation. J Neuroinflammation. 2014;11:34.
    • (2014) J Neuroinflammation. , vol.11 , pp. 34
    • de Pablos, R.M.1    Herrera, A.J.2    Espinosa-Oliva, A.M.3    Sarmiento, M.4    Munoz, M.F.5    Machado, A.6
  • 218
    • 84904264999 scopus 로고    scopus 로고
    • Potential for primary prevention of Alzheimer's disease: An analysis of population-based data
    • Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer's disease: an analysis of population-based data. Lancet Neurol. 2014;13(8):788-94.
    • (2014) Lancet Neurol. , vol.13 , Issue.8 , pp. 788-794
    • Norton, S.1    Matthews, F.E.2    Barnes, D.E.3    Yaffe, K.4    Brayne, C.5
  • 219
    • 84941601152 scopus 로고    scopus 로고
    • Advances in the treatment of cognitive impairment in Parkinson's disease
    • Goldman JG, Weintraub D. Advances in the treatment of cognitive impairment in Parkinson's disease. Mov Disord. 2015;30(11):1471-89.
    • (2015) Mov Disord. , vol.30 , Issue.11 , pp. 1471-1489
    • Goldman, J.G.1    Weintraub, D.2
  • 220
    • 77955845440 scopus 로고    scopus 로고
    • The power of exercise: Buffering the effect of chronic stress on telomere length
    • Puterman E, Lin J, Blackburn E, O'Donovan A, Adler N, Epel E. The power of exercise:buffering the effect of chronic stress on telomere length. PLoS One. 2010;5(5):e10837.
    • (2010) PLoS One. , vol.5 , Issue.5 , pp. e10837
    • Puterman, E.1    Lin, J.2    Blackburn, E.3    O'Donovan, A.4    Adler, N.5    Epel, E.6
  • 222
    • 84899852433 scopus 로고    scopus 로고
    • Mitochondria modify exercise-induced development of stem cell-derived neurons in the adult brain
    • Steib K, Schaffner I, Jagasia R, Ebert B, Lie DC. Mitochondria modify exercise-induced development of stem cell-derived neurons in the adult brain. J Neurosci Off J Soc Neurosci. 2014;34(19):6624-33.
    • (2014) J Neurosci Off J Soc Neurosci. , vol.34 , Issue.19 , pp. 6624-6633
    • Steib, K.1    Schaffner, I.2    Jagasia, R.3    Ebert, B.4    Lie, D.C.5


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