-
1
-
-
0242363670
-
Molecular pathways of neurodegeneration in Parkinson's disease
-
Dawson TM, Dawson VL, (2003) Molecular pathways of neurodegeneration in Parkinson's disease. Science 302: 819-822.
-
(2003)
Science
, vol.302
, pp. 819-822
-
-
Dawson, T.M.1
Dawson, V.L.2
-
3
-
-
33644543761
-
Expanding insights of mitochondrial dysfunction in Parkinson's disease
-
Abou-Sleiman PM, Muqit MM, Wood NW, (2006) Expanding insights of mitochondrial dysfunction in Parkinson's disease. Nat Rev Neurosci 7: 207-219.
-
(2006)
Nat Rev Neurosci
, vol.7
, pp. 207-219
-
-
Abou-Sleiman, P.M.1
Muqit, M.M.2
Wood, N.W.3
-
4
-
-
0141741347
-
Parkinson's disease: mechanisms and models
-
Dauer W, Przedborski S, (2003) Parkinson's disease: mechanisms and models. Neuron 39: 889-909.
-
(2003)
Neuron
, vol.39
, pp. 889-909
-
-
Dauer, W.1
Przedborski, S.2
-
5
-
-
0033681149
-
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
-
Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, et al. (2000) Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci 3: 1301-1306.
-
(2000)
Nat Neurosci
, vol.3
, pp. 1301-1306
-
-
Betarbet, R.1
Sherer, T.B.2
MacKenzie, G.3
Garcia-Osuna, M.4
Panov, A.V.5
-
6
-
-
37049004489
-
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
-
Schapira AH, (2008) Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol 7: 97-109.
-
(2008)
Lancet Neurol
, vol.7
, pp. 97-109
-
-
Schapira, A.H.1
-
7
-
-
62549133546
-
Neuroinflammation in Parkinson's disease: a target for neuroprotection?
-
Hirsch EC, Hunot S, (2009) Neuroinflammation in Parkinson's disease: a target for neuroprotection? Lancet Neurol 8: 382-397.
-
(2009)
Lancet Neurol
, vol.8
, pp. 382-397
-
-
Hirsch, E.C.1
Hunot, S.2
-
8
-
-
70349807619
-
Immune activation in brain aging and neurodegeneration: too much or too little?
-
Lucin KM, Wyss-Coray T, (2009) Immune activation in brain aging and neurodegeneration: too much or too little? Neuron 64: 110-122.
-
(2009)
Neuron
, vol.64
, pp. 110-122
-
-
Lucin, K.M.1
Wyss-Coray, T.2
-
9
-
-
58149466868
-
Oxidative and inflammatory pathways in Parkinson's disease
-
Miller RL, James-Kracke M, Sun GY, Sun AY, (2009) Oxidative and inflammatory pathways in Parkinson's disease. Neurochem Res 34: 55-65.
-
(2009)
Neurochem Res
, vol.34
, pp. 55-65
-
-
Miller, R.L.1
James-Kracke, M.2
Sun, G.Y.3
Sun, A.Y.4
-
10
-
-
13144258735
-
Microglial activation and dopamine terminal loss in early Parkinson's disease
-
Ouchi Y, Yoshikawa E, Sekine Y, Futatsubashi M, Kanno T, et al. (2005) Microglial activation and dopamine terminal loss in early Parkinson's disease. Ann Neurol 57: 168-175.
-
(2005)
Ann Neurol
, vol.57
, pp. 168-175
-
-
Ouchi, Y.1
Yoshikawa, E.2
Sekine, Y.3
Futatsubashi, M.4
Kanno, T.5
-
11
-
-
24144453087
-
Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism
-
Block ML, Hong JS, (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76: 77-98.
-
(2005)
Prog Neurobiol
, vol.76
, pp. 77-98
-
-
Block, M.L.1
Hong, J.S.2
-
13
-
-
47749126515
-
Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression
-
Gao HM, Hong JS, (2008) Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends Immunol 29: 357-365.
-
(2008)
Trends Immunol
, vol.29
, pp. 357-365
-
-
Gao, H.M.1
Hong, J.S.2
-
14
-
-
34447328426
-
Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb
-
Vroon A, Drukarch B, Bol JG, Cras P, Breve JJ, et al. (2007) Neuroinflammation in Parkinson's patients and MPTP-treated mice is not restricted to the nigrostriatal system: microgliosis and differential expression of interleukin-1 receptors in the olfactory bulb. Exp Gerontol 42: 762-771.
-
(2007)
Exp Gerontol
, vol.42
, pp. 762-771
-
-
Vroon, A.1
Drukarch, B.2
Bol, J.G.3
Cras, P.4
Breve, J.J.5
-
15
-
-
36248951667
-
Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation
-
Zhou F, Wu JY, Sun XL, Yao HH, Ding JH, et al. (2007) Iptakalim alleviates rotenone-induced degeneration of dopaminergic neurons through inhibiting microglia-mediated neuroinflammation. Neuropsychopharmacology 32: 2570-2580.
-
(2007)
Neuropsychopharmacology
, vol.32
, pp. 2570-2580
-
-
Zhou, F.1
Wu, J.Y.2
Sun, X.L.3
Yao, H.H.4
Ding, J.H.5
-
16
-
-
77950363010
-
Mechanisms underlying inflammation in neurodegeneration
-
Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH, (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140: 918-934.
-
(2010)
Cell
, vol.140
, pp. 918-934
-
-
Glass, C.K.1
Saijo, K.2
Winner, B.3
Marchetto, M.C.4
Gage, F.H.5
-
17
-
-
63049083734
-
A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
-
Saijo K, Winner B, Carson CT, Collier JG, Boyer L, et al. (2009) A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 137: 47-59.
-
(2009)
Cell
, vol.137
, pp. 47-59
-
-
Saijo, K.1
Winner, B.2
Carson, C.T.3
Collier, J.G.4
Boyer, L.5
-
18
-
-
79954603165
-
Non-steroidal anti-inflammatory drug use and the risk of Parkinson's disease
-
Manthripragada AD, Schernhammer ES, Qiu J, Friis S, Wermuth L, et al. (2011) Non-steroidal anti-inflammatory drug use and the risk of Parkinson's disease. Neuroepidemiology 36: 155-161.
-
(2011)
Neuroepidemiology
, vol.36
, pp. 155-161
-
-
Manthripragada, A.D.1
Schernhammer, E.S.2
Qiu, J.3
Friis, S.4
Wermuth, L.5
-
19
-
-
33847759064
-
Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
-
Qin L, Wu X, Block ML, Liu Y, Breese GR, et al. (2007) Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55: 453-462.
-
(2007)
Glia
, vol.55
, pp. 453-462
-
-
Qin, L.1
Wu, X.2
Block, M.L.3
Liu, Y.4
Breese, G.R.5
-
20
-
-
84863135790
-
Synergistic dopaminergic neurotoxicity of MPTP and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease
-
Gao HM, Liu B, Zhang W, Hong JS, (2003) Synergistic dopaminergic neurotoxicity of MPTP and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease. FASEB J 17: 1957-1959.
-
(2003)
FASEB J
, vol.17
, pp. 1957-1959
-
-
Gao, H.M.1
Liu, B.2
Zhang, W.3
Hong, J.S.4
-
21
-
-
0034718598
-
Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation
-
Wada R, Tifft CJ, Proia RL, (2000) Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation. Proc Natl Acad Sci U S A 97: 10954-10959.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 10954-10959
-
-
Wada, R.1
Tifft, C.J.2
Proia, R.L.3
-
22
-
-
84865291933
-
The protease Omi cleaves the mitogen-activated protein kinase kinase MEK1 to inhibit microglial activation
-
Hu Q, Li B, Xu R, Chen D, Mu C, et al. (2012) The protease Omi cleaves the mitogen-activated protein kinase kinase MEK1 to inhibit microglial activation. Sci Signal 5: ra61.
-
(2012)
Sci Signal
, vol.5
-
-
Hu, Q.1
Li, B.2
Xu, R.3
Chen, D.4
Mu, C.5
-
23
-
-
84866557361
-
Selenite benefits embryonic stem cells therapy in Parkinson's disease
-
Tian LP, Zhang S, Xu L, Li W, Wang Y, et al. (2012) Selenite benefits embryonic stem cells therapy in Parkinson's disease. Curr Mol Med 12: 1005-1014.
-
(2012)
Curr Mol Med
, vol.12
, pp. 1005-1014
-
-
Tian, L.P.1
Zhang, S.2
Xu, L.3
Li, W.4
Wang, Y.5
-
24
-
-
0034746919
-
NF-kappaB: a key role in inflammatory diseases
-
Tak PP, Firestein GS, (2001) NF-kappaB: a key role in inflammatory diseases. J Clin Invest 107: 7-11.
-
(2001)
J Clin Invest
, vol.107
, pp. 7-11
-
-
Tak, P.P.1
Firestein, G.S.2
-
25
-
-
67650744586
-
The role of ubiquitin in NF-kappaB regulatory pathways
-
Skaug B, Jiang X, Chen ZJ, (2009) The role of ubiquitin in NF-kappaB regulatory pathways. Annu Rev Biochem 78: 769-796.
-
(2009)
Annu Rev Biochem
, vol.78
, pp. 769-796
-
-
Skaug, B.1
Jiang, X.2
Chen, Z.J.3
-
26
-
-
33750466230
-
Introduction to NF-kappaB: players, pathways, perspectives
-
Gilmore TD, (2006) Introduction to NF-kappaB: players, pathways, perspectives. Oncogene 25: 6680-6684.
-
(2006)
Oncogene
, vol.25
, pp. 6680-6684
-
-
Gilmore, T.D.1
-
27
-
-
77950362382
-
The inflammasomes
-
Schroder K, Tschopp J, (2010) The inflammasomes. Cell 140: 821-832.
-
(2010)
Cell
, vol.140
, pp. 821-832
-
-
Schroder, K.1
Tschopp, J.2
-
28
-
-
38849199203
-
Shared principles in NF-kappaB signaling
-
Hayden MS, Ghosh S, (2008) Shared principles in NF-kappaB signaling. Cell 132: 344-362.
-
(2008)
Cell
, vol.132
, pp. 344-362
-
-
Hayden, M.S.1
Ghosh, S.2
-
29
-
-
33748422072
-
Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-{kappa}B activation via EGFR transactivation in a lung epithelial cell line
-
Kuwahara I, Lillehoj EP, Lu W, Singh IS, Isohama Y, et al. (2006) Neutrophil elastase induces IL-8 gene transcription and protein release through p38/NF-{kappa}B activation via EGFR transactivation in a lung epithelial cell line. Am J Physiol Lung Cell Mol Physiol 291: L407-416.
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.291
-
-
Kuwahara, I.1
Lillehoj, E.P.2
Lu, W.3
Singh, I.S.4
Isohama, Y.5
-
30
-
-
0035065836
-
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
-
Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, et al. (2001) ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep 2: 222-228.
-
(2001)
EMBO Rep
, vol.2
, pp. 222-228
-
-
Tobiume, K.1
Matsuzawa, A.2
Takahashi, T.3
Nishitoh, H.4
Morita, K.5
-
31
-
-
20644433073
-
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity
-
Matsuzawa A, Saegusa K, Noguchi T, Sadamitsu C, Nishitoh H, et al. (2005) ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat Immunol 6: 587-592.
-
(2005)
Nat Immunol
, vol.6
, pp. 587-592
-
-
Matsuzawa, A.1
Saegusa, K.2
Noguchi, T.3
Sadamitsu, C.4
Nishitoh, H.5
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