NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure

Neurobiology of Aging

Volumn 36, Issue 9, 2015, Pages 2533-2543

  Chen, Liuji ^a   Na, Ren ^a   Boldt, Erin ^a   Ran, Qitao ^a,b  

^a University of Texas Health Science Center   (United States)

^b SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

Alzheimer's disease; A ; Inflammation; Mitochondria; NLRP3 inflammasome; Oxidative stress; Paraquat; Toxin exposure

Indexed keywords

AMYLOID BETA PROTEIN; CRYOPYRIN; HYDROGEN PEROXIDE; INFLAMMASOME; PARAQUAT; PEROXIREDOXIN 3; REACTIVE OXYGEN METABOLITE; AMYLOID PRECURSOR PROTEIN; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; CYTOCHROME C OXIDASE; HERBICIDE; NERVE PROTEIN; PRESENILIN 1; PSEN1 PROTEIN, HUMAN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRESS; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE DURATION; DISEASE EXACERBATION; DISEASE MODEL; ENCEPHALITIS; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE; ALZHEIMER DISEASE; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; COGNITION DISORDERS; COMPLICATION; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; MITOCHONDRION; PATHOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CARRIER PROTEINS; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX IV; HERBICIDES; HUMANS; HYDROGEN PEROXIDE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; PARAQUAT; PRESENILIN-1; REACTIVE OXYGEN SPECIES;

EID: 84940467057     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2015.05.018     Document Type: Article

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