Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease

Neurobiology of Disease

Volumn 76, Issue , 2015, Pages 13-23

  Chen, Chun Hau ^a   Li, Wenzong ^b   Sultana, Rukhsana ^c   You, Mi Hyeon ^a   Kondo, Asami ^a   Shahpasand, Koorosh ^a   Kim, Byeong Mo ^a   Luo, Man Li ^a   Nechama, Morris ^a   Lin, Yu Min ^a   Yao, Yandan ^a   Lee, Tae Ho ^a   Zhou, Xiao Zhen ^a   Swomley, Aaron M ^c   Allan Butterfield, D ^c,d   Zhang, Yan ^b   Lu, Kun Ping ^a,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

^e FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; APP; Oxidation; Pin1; Tau

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DIAMINE; HYDROGEN PEROXIDE; PEPTIDYLPROLYL ISOMERASE PIN1; REACTIVE OXYGEN METABOLITE; TAU PROTEIN; ANTIBODY; NIMA-INTERACTING PEPTIDYLPROLYL ISOMERASE; PEPTIDYLPROLYL ISOMERASE;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CATALYSIS; CELL FUNCTION; CELL SURVIVAL; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISEASE ASSOCIATION; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME MODIFICATION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; HYDROGEN BOND; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; ISOMERIZATION; MOUSE; NEUROBLASTOMA CELL; NEUROPATHOLOGY; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; POSITIVE FEEDBACK; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN STABILITY; PROTEIN SYNTHESIS; REGULATORY MECHANISM; RISK REDUCTION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; CHEMISTRY; IMMUNOLOGY; METABOLISM; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANTIBODIES; CATALYTIC DOMAIN; CELL LINE, TUMOR; HIPPOCAMPUS; HUMANS; OXIDATION-REDUCTION; PEPTIDYLPROLYL ISOMERASE; TAU PROTEINS;

EID: 84922347183     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.12.027     Document Type: Article

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