Release of the mitochondrial endosymbiont helps explain sterile inflammation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 10, 2010, Pages

  Masters, Seth L ^a   Walsh, Patrick T ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; MITOCHONDRIAL DNA; TOLL LIKE RECEPTOR;

ALPHAPROTEOBACTERIA; BACTERIUM; ENDOSYMBIONT; EUKARYOTE; IMMUNE RESPONSE; INFLAMMATION; INNATE IMMUNITY; LETTER; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RICKETTSIA;

ADENOSINE TRIPHOSPHATE; ANIMALS; INFLAMMATION; INTERLEUKIN-1BETA; MICE; MITOCHONDRIA; SYMBIOSIS;

EID: 77949500380     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1000366107     Document Type: Letter

References (5)

1. Iyer SS, et al. (2009) Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome. Proc Natl Acad Sci USA 106:20388-20393.
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3. Damås JK, et al. (2006) Increased levels of soluble CD40L in African tick bite fever: Possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. J Immunol 177:2699-2706.
4. Collins LV, Hajizadeh S, Holme E, Jonsson IM, Tarkowski A (2004) Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses. J Leukoc Biol 75: 995-1000.
5. Crouser ED, et al. (2009) Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors. Crit Care Med 37:2000-2009.