Investigation of the subunit composition and the pharmacology of the mitochondrial ATP-dependent K+ channel in the brain

Brain Research

Volumn 994, Issue 1, 2003, Pages 27-36

  Lacza, Zsombor ^a,b   Snipes, James A ^a   Kis, Béla ^a   Szabó, Csaba ^b,c   Grover, Gary ^d   Busija, David W ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c INOTEK CORPORATION   (United States)

^d BRISTOL MYERS SQUIBB   (United States)

Author keywords

ATP dependent potassium channel; Ischemic preconditioning; Mitochondrial nitric oxide synthase; mtNOS; Sulfonylurea receptor

Indexed keywords

DIAZOXIDE; GLIBENCLAMIDE; PROTEIN SUBUNIT; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SULFONYLUREA RECEPTOR; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN MITOCHONDRION; CHANNEL GATING; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG PROTEIN BINDING; IMMUNOGOLD ELECTRON MICROSCOPY; MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOLECULAR WEIGHT; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; PROTEIN VARIANT; RAT; WESTERN BLOTTING;

EID: 0344012088     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2003.09.046     Document Type: Article

References (33)

1. Aguilar-Bryan L., Bryan J. Molecular biology of adenosine triphosphate-sensitive potassium channels. Endocr. Rev. 20:1999;101-135.
2. Baines C.P., Pass J.M., Ping P. Protein kinases and kinase-modulated effectors in the late phase of ischemic preconditioning. Basic Res. Cardiol. 96:2001;207-218.
3. Bajgar R., Seetharaman S., Kowaltowski A.J., Garlid K.D., Paucek P. Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain. J. Biol. Chem. 276:2001;33369-33374.
4. Buckman J.F., Hernandez H., Kress G.J., Votyakova T.V., Pal S., Reynolds I.J. MitoTracker labeling in primary neuronal and astrocytic cultures: influence of mitochondrial membrane potential and oxidants. J. Neurosci. Methods. 104:2001;165-176.
5. Domoki F., Perciaccante J.V., Veltkamp R., Bari F., Busija D.W. Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs. Stroke. 30:1999;2713-2718.
6. Garcia d.A.S., Franke H., Pissarek M., Nieber K., Illes P. Neuroprotection by ATP-dependent potassium channels in rat neocortical brain slices during hypoxia. Neurosci. Lett. 273:1999;13-16.
7. Garlid K.D., Paucek P., Yarov-Yarovoy V., Murray H.N., Darbenzio R.B., D'Alonzo A.J., Lodge N.J., Smith M.A., Grover G.J. Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection. Circ. Res. 81:1997;1072-1082.
8. Ghafourifar P., Schenk U., Klein S.D., Richter C. Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation. J. Biol. Chem. 274:1999;31185-31188.
9. Grover G.J., D'Alonzo A.J., Garlid K.D., Bajgar R., Lodge N.J., Sleph P.G., Darbenzio R.B., Hess T.A., Smith M.A., Paucek P., Atwal K.S. Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity. J. Pharmacol. Exp. Ther. 297:2001;1184-1192.
10. Hampson R.E., Mu J., Deadwyler S.A. Cannabinoid and kappa opioid receptors reduce potassium K current via activation of G(s) proteins in cultured hippocampal neurons. J. Neurophysiol. 84:2000;2356-2364.
11. Hanley P.J., Mickel M., Loffler M., Brandt U., Daut J. K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart. J. Physiol. 542:2002;735-741.
12. Iadecola C. Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci. 20:1997;132-139.
13. Jourd'heuil D. Increased nitric oxide-dependent nitrosylation of 4,5-diaminofluorescein by oxidants: implications for the measurement of intracellular nitric oxide. Free Radic. Biol. Med. 33:2002;676-684.
14. Lacza Z., Puskar M., Figueroa J.P., Zhang J., Rajapakse N., Busija D.W. Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia. Free Radic. Biol. Med. 31:2001;1609-1615.
15. Latzkovits L., Cserr H.F., Park J.T., Patlak C.S., Pettigrew K.D., Rimanoczy A. Effects of arginine vasopressin and atriopeptin on glial cell volume measured as 3-MG space. Am. J. Physiol. 264:1993;C603-C608.
16. Lawrence C.L., Billups B., Rodrigo G.C., Standen N.B. The KATP channel opener diazoxide protects cardiac myocytes during metabolic inhibition without causing mitochondrial depolarization or flavoprotein oxidation. Br. J. Pharmacol. 134:2001;535-542.
17. Lebuffe G., Schumacker P.T., Shao Z.H., Anderson T., Iwase H., Vanden H.T.L. ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel. Am. J. Physiol, Heart Circ. Physiol. 284:2003;H299-H308.
18. Liaudet L., Soriano F.G., Szabo C. Biology of nitric oxide signaling. Crit. Care Med. 28:2000;N37-N52.
19. Liu D., Lu C., Wan R., Auyeung W.W., Mattson M.P. Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release. J. Cereb. Blood Flow Metab. 22:2002;431-443.
20. Lopez M.F., Kristal B.S., Chernokalskaya E., Lazarev A., Shestopalov A.I., Bogdanova A., Robinson M. High-throughput profiling of the mitochondrial proteome using affinity fractionation and automation. Electrophoresis. 21:2000;3427-3440.
21. Mattson M.P., Zhang Y., Bose S. Growth factors prevent mitochondrial dysfunction, loss of calcium homeostasis, and cell injury, but not ATP depletion in hippocampal neurons deprived of glucose. Exp. Neurol. 121:1993;1-13.
22. Murry C.E., Jennings R.B., Reimer K.A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 74:1986;1124-1136.
23. Nakagawa I., Nakase H., Aketa S., Kamada Y., Yamashita M., Sakaki T. ATP-dependent potassium channel mediates neuroprotection by chemical preconditioning with 3-nitropropionic acid in gerbil hippocampus. Neurosci. Lett. 320:2002;33-36.
24. Rajapakse N., Shimizu K., Kis B., Snipes J., Lacza Z., Busija D. Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats. Neurosci. Lett. 327:2002;208-212.
25. Roychowdhury S., Luthe A., Keilhoff G., Wolf G., Horn T.F. Oxidative stress in glial cultures: detection by DAF-2 fluorescence used as a tool to measure peroxynitrite rather than nitric oxide. Glia. 38:2002;103-114.
26. Sasaki N., Sato T., Ohler A., O'Rourke B., Marban E. Activation of mitochondrial ATP-dependent potassium channels by nitric oxide. Circulation. 101:2000;439-445.
27. Seharaseyon J., Ohler A., Sasaki N., Fraser H., Sato T., Johns D.C., O'Rourke B., Marban E. Molecular composition of mitochondrial ATP-sensitive potassium channels probed by viral Kir gene transfer. J. Mol. Cell. Cardiol. 32:2000;1923-1930.
28. Shake J.G., Peck E.A., Marban E., Gott V.L., Johnston M.V., Troncoso J.C., Redmond J.M., Baumgartner W.A. Pharmacologically induced preconditioning with diazoxide: a novel approach to brain protection. Ann. Thorac. Surg. 72:2001;1849-1854.
29. Shimizu K., Lacza Z., Rajapakse N., Horiguchi T., Snipes J., Busija D.W. MitoK(ATP) opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat. Am. J. Physiol, Heart Circ. Physiol. 283:2002;H1005-H1011.
30. Suzuki M., Li R.A., Miki T., Uemura H., Sakamoto N., Ohmoto-Sekine Y., Tamagawa M., Ogura T., Seino S., Marban E., Nakaya H. Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice. Circ. Res. 88:2001;570-577.
31. Suzuki M., Sasaki N., Miki T., Sakamoto N., Ohmoto-Sekine Y., Tamagawa M., Seino S., Marban E., Nakaya H. Role of sarcolemmal K(ATP) channels in cardioprotection against ischemia/reperfusion injury in mice. J. Clin. Invest. 109:2002;509-516.
32. Szewczyk A., Mikolajek B., Pikula S., Nalecz M.J. Potassium channel openers induce mitochondrial matrix volume changes via activation of ATP-sensitive K+ channel. Pol. J. Pharmacol. 45:1993;437-443.
33. Zhou M., Tanaka O., Sekiguchi M., Sakabe K., Anzai M., Izumida I., Inoue T., Kawahara K., Abe H. Localization of the ATP-sensitive potassium channel subunit (Kir6.1/uK(ATP)-1) in rat brain. Brain Res. Mol. Brain Res. 74:1999;15-25.