Degraded mitochondrial dna is a newly identified subtype of the damage associated molecular pattern (DAMP) family and possible trigger of neurodegeneration

Journal of Alzheimer's Disease

Volumn 30, Issue 3, 2012, Pages 617-627

  Mathew, Alex ^a   Lindsley, Tara A ^a   Sheridan, Anna ^a   Bhoiwala, Devang L ^a   Hushmendy, Shazaan F ^a   Yager, Eric J ^a,b   Ruggiero, Elizabeth A ^a   Crawford, Dana R ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

Author keywords

Astrocytes; damage associated molecular patterns (DAMPs); degraded mitochondrial polynucleotides (DeMPs); hydrogen peroxide; inflammasome; mitochondria; oxidative stress; proinflammatory cytokine

Indexed keywords

DEGRADED MITOCHONDRIAL POLYNUCLEOTIDE; HYDROGEN PEROXIDE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 6; MITOCHONDRIAL DNA; POLYNUCLEOTIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; CEREBROSPINAL FLUID; CONTROLLED STUDY; CYTOKINE RELEASE; DNA DEGRADATION; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 84862835766     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-120145     Document Type: Article

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