The mitochondria-targeted antioxidant mitoq prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease

Journal of Neuroscience

Volumn 31, Issue 44, 2011, Pages 15703-15715

  Mcmanus, Meagan J ^b   Murphy, Michael P ^c   Franklin, James L ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ANTIOXIDANT; CASPASE 3; CASPASE 7; MITOQ; MITOQUINONE MESYLATE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASTROCYTOSIS; BRAIN MITOCHONDRION; BRAIN NERVE CELL; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; IN VIVO STUDY; MEMORY CONSOLIDATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE DEGENERATION; NERVE FIBER GROWTH; NEUROPATHOLOGY; NEUROTOXICITY; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SPATIAL MEMORY; SYNAPTIC LOSS; TRANSGENIC MOUSE;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; CASPASES; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; GLUTATHIONE; HUMANS; LIPID PEROXIDATION; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; NEURONS; ORGANOPHOSPHORUS COMPOUNDS; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; RETENTION (PSYCHOLOGY); RHODAMINES; SPACE PERCEPTION; TIME FACTORS; TYROSINE; UBIQUINONE;

EID: 80155148269     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0552-11.2011     Document Type: Article

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