Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle

Journal of Biological Chemistry

Volumn 288, Issue 18, 2013, Pages 12967-12977

  Gameiro, Paulo A ^a,b,c,e   Laviolette, Laura A ^b,c,d   Kelleher, Joanne K ^a   Iliopoulos, Othon ^b,c   Stephanopoulos, Gregory ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRAL CARBON METABOLISMS; GLUCOSE DEPRIVATION; ISOCITRATE DEHYDROGENASE; MITOCHONDRIAL ENZYMES; PROLIFERATING CELLS; PYRUVATE CARBOXYLASE; RENAL CARCINOMA CELLS; TRICARBOXYLIC ACIDS;

AMIDES; AMINO ACIDS; CARBOXYLATION; CELL PROLIFERATION; METABOLISM; NUCLEOTIDES;

GLUCOSE;

NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; PYRUVATE CARBOXYLASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXYLATION; CARCINOMA CELL; CELL PROLIFERATION; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBSTRATE; GENE OVEREXPRESSION; GENE SILENCING; GLUCOSE OXIDATION; GLYCOLYSIS; KIDNEY CARCINOMA; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REDUCTIVE CARBOXYLATION;

GLUTAMINE; METABOLIC TRACERS; MITOCHONDRIA; NADPH; NNT; PYRUVATE CARBOXYLASE; REDOX REGULATION; REDUCTIVE CARBOXYLATION;

ANIMALS; CELL LINE; CITRIC ACID CYCLE; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; MICE; MICE, NUDE; MITOCHONDRIAL PROTEINS; NAD; NADP; NADP TRANSHYDROGENASE, AB-SPECIFIC; OXIDATION-REDUCTION;

EID: 84877109282     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.396796     Document Type: Article

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