Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death

Cell Death and Disease

Volumn 3, Issue 12, 2012, Pages

  Chiara, F ^a   Gambalunga, A ^a   Sciacovelli, M ^a   Nicolli, A ^a   Ronconi, L ^a   Fregona, D ^a   Bernardi, P ^a   Rasola, A ^a   Trevisan, A ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

apoptosis; cancer; chemotherapeutics; oxidative stress; permeability transition pore

Indexed keywords

CISPLATIN; CYCLOPHILIN D; CYCLOSPORIN A; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; GOLD COMPLEX; GOLD DITHIOCARBAMATO COMPLEX; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL DEATH; CELL MEMBRANE PERMEABILITY; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MICE; MICE, INBRED BALB C; MITOCHONDRIA; NEOPLASMS; OXIDATIVE STRESS; PROTEIN BINDING;

EID: 84871186542     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.184     Document Type: Article

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