Mitochondrial dysfunction in a transgenic mouse model expressing human amyloid precursor protein (APP) with the Arctic mutation

Journal of Neurochemistry

Volumn 136, Issue 3, 2016, Pages 497-502

  Rönnbäck, Annica ^a   Pavlov, Pavel F ^a   Mansory, Mansorah ^a   Gonze, Prisca ^a   Marlière, Nicolas ^a   Winblad, Bengt ^a   Graff, Caroline ^a,b   Behbahani, Homira ^a,c  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c Division of Neurogeriatrics and Clinical Geriatrics   (Sweden)

Author keywords

Alzheimer Disease; amyloid beta; arctic APP mutation; mitochondria; MMP; ROS

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CYTOCHROME C; REACTIVE OXYGEN METABOLITE; 8-OXO-7-HYDRODEOXYGUANOSINE; CYTOCHROME C OXIDASE; DEOXYGUANOSINE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GENE MUTATION; HIPPOCAMPAL CA1 REGION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSGENIC MOUSE; WILD TYPE MOUSE; AGE; ANALOGS AND DERIVATIVES; ANALYSIS OF VARIANCE; ANIMAL; BRAIN; C57BL MOUSE; DISEASE MODEL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY;

AGE FACTORS; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; BRAIN; DEOXYGUANOSINE; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT COMPLEX IV; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MUTATION; REACTIVE OXYGEN SPECIES;

EID: 84955346453     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13410     Document Type: Article

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