Shaping the dynamic mitochondrial network

BMC Biology

Volumn 12, Issue , 2014, Pages

  Lackner, Laura L ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; BIOLOGICAL MODEL; HUMAN; METABOLISM; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; MOVEMENT (PHYSIOLOGY); NERVE CELL; REVIEW; SACCHAROMYCES CEREVISIAE;

ANIMALS; HUMANS; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; MODELS, BIOLOGICAL; MOVEMENT; NEURONS; SACCHAROMYCES CEREVISIAE;

EID: 84901441806     PISSN: None     EISSN: 17417007     Source Type: Journal    
DOI: 10.1186/1741-7007-12-35     Document Type: Review

References (116)

1. Nunnari J, Suomalainen A. Mitochondria: in sickness and in health. Cell 2012, 148:1145-1159. 10.1016/j.cell.2012.02.035, 22424226.
2. Mitra K, Wunder C, Roysam B, Lin G, Lippincott-Schwartz J. A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase. Proc Natl Acad Sci U S A 2009, 106:11960-11965. 10.1073/pnas.0904875106, 2710990, 19617534.
3. Taguchi N, Ishihara N, Jofuku A, Oka T, Mihara K. Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem 2007, 282:11521-11529. 10.1074/jbc.M607279200, 17301055.
4. Gomes LC, Di Benedetto G, Scorrano L. During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol 2011, 13:589-598. 10.1038/ncb2220, 3088644, 21478857.
5. Rambold AS, Kostelecky B, Elia N, Lippincott-Schwartz J. Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci U S A 2011, 108:10190-10195. 10.1073/pnas.1107402108, 3121813, 21646527.
6. Li Z, Okamoto K, Hayashi Y, Sheng M. The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses. Cell 2004, 119:873-887. 10.1016/j.cell.2004.11.003, 15607982.
7. Verstreken P, Ly CV, Venken KJ, Koh TW, Zhou Y, Bellen HJ. Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions. Neuron 2005, 47:365-378. 10.1016/j.neuron.2005.06.018, 16055061.
8. Quintana A, Schwindling C, Wenning AS, Becherer U, Rettig J, Schwarz EC, Hoth M. T cell activation requires mitochondrial translocation to the immunological synapse. Proc Natl Acad Sci U S A 2007, 104:14418-14423. 10.1073/pnas.0703126104, 1964825, 17726106.
9. Chen H, Chan DC. Physiological functions of mitochondrial fusion. Ann N Y Acad Sci 2010, 1201:21-25. 10.1111/j.1749-6632.2010.05615.x, 20649534.
10. Lackner LL, Nunnari JM. The molecular mechanism and cellular functions of mitochondrial division. Biochim Biophys Acta 2009, 1792:1138-1144. 10.1016/j.bbadis.2008.11.011, 19100831.
11. Faelber K, Gao S, Held M, Posor Y, Haucke V, Noe F, Daumke O. Oligomerization of dynamin superfamily proteins in health and disease. Prog Mol Biol Transl Sci 2013, 117:411-443.
12. Praefcke GJ, McMahon HT. The dynamin superfamily: universal membrane tubulation and fission molecules?. Nat Rev Mol Cell Biol 2004, 5:133-147. 10.1038/nrm1313, 15040446.
13. Hoppins S, Lackner L, Nunnari J. The machines that divide and fuse mitochondria. Annu Rev Biochem 2007, 76:751-780. 10.1146/annurev.biochem.76.071905.090048, 17362197.
14. Bleazard W, McCaffery JM, King EJ, Bale S, Mozdy A, Tieu Q, Nunnari J, Shaw JM. The dynamin-related GTPases, Dnm1, regulates mitochondrial fission in yeast. Nature Cell Biol 1999, 1:298-304. 10.1038/13014, 3739991, 10559943.
15. Otsuga D, Keegan BR, Brisch E, Thantcher JW, Hermann GJ, Bleazard W, Shaw J. The dynamin GTPase, Dnm1p, controls mitochondrial morphology in yeast. J Cell Biol 1998, 143:333-349. 10.1083/jcb.143.2.333, 2132834, 9786946.
16. Sesaki H, Jensen RE. Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J Cell Biol 1999, 147:699-706. 10.1083/jcb.147.4.699, 2156171, 10562274.
17. Smirnova E, Griparic L, Shurland DL, van Der Bliek AM. Dynamin-related protein drp1 is required for mitochondrial division in mammalian cells. Mol Biol Cell 2001, 12:2245-2256. 10.1091/mbc.12.8.2245, 58592, 11514614.
18. Smirnova E, Shurland D, Ryazantsev S, Van Der Bliek A. A human dynamin-related protein controls the distribution of mitochondria. J Cell Biol 1998, 143:351-358. 10.1083/jcb.143.2.351, 2132828, 9786947.
19. Ingerman E, Perkins EM, Marino M, Mears JA, McCaffery JM, Hinshaw JE, Nunnari J. Dnm1 forms spirals that are structurally tailored to fit mitochondria. J Cell Biol 2005, 170:1021-1027. 10.1083/jcb.200506078, 2171542, 16186251.
20. Labrousse AM, Zappaterra MD, Rube DA, van der Bliek AM. C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane. Mol Cell 1999, 4:815-826. 10.1016/S1097-2765(00)80391-3, 10619028.
21. Legesse-Miller A, Massol RH, Kirchhausen T. Constriction and dnm1p recruitment are distinct processes in mitochondrial fission. Mol Biol Cell 2003, 14:1953-1963. 10.1091/mbc.E02-10-0657, 165089, 12802067.
22. Chappie JS, Acharya S, Leonard M, Schmid SL, Dyda F. G domain dimerization controls dynamin's assembly-stimulated GTPase activity. Nature 2010, 465:435-440. 10.1038/nature09032, 2879890, 20428113.
23. Faelber K, Posor Y, Gao S, Held M, Roske Y, Schulze D, Haucke V, Noe F, Daumke O. Crystal structure of nucleotide-free dynamin. Nature 2011, 477:556-560. 10.1038/nature10369, 21927000.
24. Ford MG, Jenni S, Nunnari J. The crystal structure of dynamin. Nature 2011, 477:561-566. 10.1038/nature10441, 21927001.
25. Frohlich C, Grabiger S, Schwefel D, Faelber K, Rosenbaum E, Mears J, Rocks O, Daumke O. Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein. EMBO J 2013, 32:1280-1292. 10.1038/emboj.2013.74, 3642683, 23584531.
26. Naylor K, Ingerman E, Okreglak V, Marino M, Hinshaw JE, Nunnari J. Mdv1 interacts with assembled dnm1 to promote mitochondrial division. J Biol Chem 2006, 281:2177-2183. 10.1074/jbc.M507943200, 16272155.
27. Mears JA, Lackner LL, Fang S, Ingerman E, Nunnari J, Hinshaw JE. Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. Nat Struct Mol Biol 2011, 18:20-26. 10.1038/nsmb.1949, 3059246, 21170049.
28. Otera H, Ishihara N, Mihara K. New insights into the function and regulation of mitochondrial fission. Biochim Biophys Acta 1833, 2013:1256-1268.
29. Strack S, Wilson TJ, Cribbs JT. Cyclin-dependent kinases regulate splice-specific targeting of dynamin-related protein 1 to microtubules. J Cell Biol 2013, 201:1037-1051. 10.1083/jcb.201210045, 3691453, 23798729.
30. Tieu Q, Nunnari J. Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division. J Cell Biol 2000, 151:353-365. 10.1083/jcb.151.2.353, 2192646, 11038182.
31. Cerveny KL, McCaffery JM, Jensen RE. Division of mitochondria requires a novel DNM1-interacting protein, Net2p. Mol Biol Cell 2001, 12:309-321. 10.1091/mbc.12.2.309, 30945, 11179417.
32. Fekkes P, Shepard KA, Yaffe MP. Gag3p, an outer membrane protein required for fission of mitochondrial tubules. J Cell Biol 2000, 151:333-340. 10.1083/jcb.151.2.333, 2192644, 11038180.
33. Gandre-Babbe S, van der Bliek AM. The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell 2008, 19:2402-2412. 10.1091/mbc.E07-12-1287, 2397315, 18353969.
34. Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, Mihara K. Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol 2010, 191:1141-1158. 10.1083/jcb.201007152, 3002033, 21149567.
35. Palmer CS, Osellame LD, Laine D, Koutsopoulos OS, Frazier AE, Ryan MT. MiD49 and MiD51, new components of the mitochondrial fission machinery. EMBO Rep 2011, 12:565-573. 10.1038/embor.2011.54, 3128275, 21508961.
36. Zhao J, Liu T, Jin S, Wang X, Qu M, Uhlen P, Tomilin N, Shupliakov O, Lendahl U, Nister M. Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. EMBO J 2011, 30:2762-2778. 10.1038/emboj.2011.198, 3160255, 21701560.
37. Lackner LL, Horner JS, Nunnari J. Mechanistic analysis of a dynamin effector. Science 2009, 325:874-877. 10.1126/science.1176921, 19679814.
38. Loson OC, Liu R, Rome ME, Meng S, Kaiser JT, Shan SO, Chan DC. The Mitochondrial Fission Receptor MiD51 Requires ADP as a Cofactor. Structure 2014, 22:367-377. 10.1016/j.str.2014.01.001, 24508339.
39. Loson OC, Song Z, Chen H, Chan DC. Fis1, Mff, MiD49 and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol Biol Cell 2013, 24:659-667. 10.1091/mbc.E12-10-0721, 3583668, 23283981.
40. Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM. Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc Natl Acad Sci U S A 2013, 110:E1342-E1351. 10.1073/pnas.1300855110, 3625255, 23530241.
41. Richter V, Palmer CS, Osellame LD, Singh AP, Elgass K, Stroud DA, Sesaki H, Kvansakul M, Ryan MT. Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission. J Cell Biol 2014, 204:477-486. 10.1083/jcb.201311014, 24515348.
42. Friedman JR, Lackner LL, West M, Dibenedetto JR, Nunnari J, Voeltz GK. ER Tubules Mark Sites of Mitochondrial Division. Science 2011, 334:358-362. 10.1126/science.1207385, 3366560, 21885730.
43. Korobova F, Ramabhadran V, Higgs HN. An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2. Science 2013, 339:464-467. 10.1126/science.1228360, 3843506, 23349293.
44. Korobova F, Gauvin TJ, Higgs HN. A role for myosin II in mammalian mitochondrial fission. Curr Biol 2014, 24:409-414. 10.1016/j.cub.2013.12.032, 24485837.
45. Murley A, Lackner LL, Osman C, West M, Voeltz GK, Walter P, Nunnari J. ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast. Elife 2013, 2:e00422. 10.7554/eLife.00422, 3654481, 23682313.
46. Boldogh IR, Nowakowski DW, Yang HC, Chung H, Karmon S, Royes P, Pon LA. A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery. Mol Biol Cell 2003, 14:4618-4627. 10.1091/mbc.E03-04-0225, 266777, 13679517.
47. Meeusen S, Nunnari J. Evidence for a two membrane-spanning autonomous mitochondrial DNA replisome. J Cell Biol 2003, 163:503-510. 10.1083/jcb.200304040, 2173662, 14597773.
48. Ban-Ishihara R, Ishihara T, Sasaki N, Mihara K, Ishihara N. Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c. Proc Natl Acad Sci U S A 2013, 110:11863-11868. 10.1073/pnas.1301951110, 3718159, 23821750.
49. Itoh K, Tamura Y, Iijima M, Sesaki H. Effects of Fcj1-Mos1 and mitochondrial division on aggregation of mitochondrial DNA nucleoids and organelle morphology. Mol Biol Cell 2013, 24:1842-1851. 10.1091/mbc.E13-03-0125, 3681690, 23615445.
50. Kornmann B, Osman C, Walter P. The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections. Proc Natl Acad Sci U S A 2011, 108:14151-14156. 10.1073/pnas.1111314108, 3161550, 21825164.
51. Stroud DA, Oeljeklaus S, Wiese S, Bohnert M, Lewandrowski U, Sickmann A, Guiard B, van der Laan M, Warscheid B, Wiedemann N. Composition and topology of the endoplasmic reticulum-mitochondria encounter structure. J Mol Biol 2011, 413:743-750. 10.1016/j.jmb.2011.09.012, 21945531.
52. Hermann GJ, Thatcher JW, Mills JP, Hales KG, Fuller MT, Nunnari J, Shaw JM. Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p. J Cell Biol 1998, 143:359-374. 10.1083/jcb.143.2.359, 2132826, 9786948.
53. Santel A, Fuller MT. Control of mitochondrial morphology by a human mitofusin. J Cell Sci 2001, 114:867-874.
54. Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser SE, Chan DC. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 2003, 160:189-200. 10.1083/jcb.200211046, 2172648, 12527753.
55. Cipolat S, Martins de Brito O, Dal Zilio B, Scorrano L. OPA1 requires mitofusin 1 to promote mitochondrial fusion. Proc Natl Acad Sci U S A 2004, 101:15927-15932. 10.1073/pnas.0407043101, 528769, 15509649.
56. Meeusen S, McCaffery JM, Nunnari J. Mitochondrial fusion intermediates revealed in vitro. Science 2004, 305:1747-1752. 10.1126/science.1100612, 15297626.
57. Meeusen S, Devay R, Block J, Cassidy-Stone A, Wayson S, McCaffery JM, Nunnari J. Mitochondrial inner-membrane fusion and crista maintenance requires the dynamin-related GTPase Mgm1. Cell 2006, 127:383-395. 10.1016/j.cell.2006.09.021, 17055438.
58. Song Z, Ghochani M, McCaffery JM, Frey TG, Chan DC. Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. Mol Biol Cell 2009, 20:3525-3532. 10.1091/mbc.E09-03-0252, 2719570, 19477917.
59. DeVay RM, Dominguez-Ramirez L, Lackner LL, Hoppins S, Stahlberg H, Nunnari J. Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion. J Cell Biol 2009, 186:793-803. 10.1083/jcb.200906098, 2753158, 19752025.
60. Rujiviphat J, Meglei G, Rubinstein JL, McQuibban GA. Phospholipid association is essential for dynamin-related protein Mgm1 to function in mitochondrial membrane fusion. J Biol Chem 2009, 284:28682-28686. 10.1074/jbc.M109.044933, 2781412, 19703904.
61. Ban T, Heymann JA, Song Z, Hinshaw JE, Chan DC. OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation. Hum Mol Genet 2010, 19:2113-2122. 10.1093/hmg/ddq088, 2865371, 20185555.
62. Abutbul-Ionita I, Rujiviphat J, Nir I, McQuibban GA, Danino D. Membrane tethering and nucleotide-dependent conformational changes drive mitochondrial genome maintenance (Mgm1) protein-mediated membrane fusion. J Biol Chem 2012, 287:36634-36638. 10.1074/jbc.C112.406769, 3481265, 22977249.
63. Baker MJ, Lampe PA, Stojanovski D, Korwitz A, Anand R, Tatsuta T, Langer T. Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics. EMBO J 2014, 33:578-593. 10.1002/embj.201386474, 24550258.
64. Mishra P, Carelli V, Manfredi G, Chan DC. Proteolytic cleavage of opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation. Cell Metab 2014, 19:630-641. 10.1016/j.cmet.2014.03.011, 24703695.
65. Samant SA, Zhang HJ, Hong Z, Pillai VB, Sundaresan NR, Wolfgeher D, Archer SL, Chan DC, Gupta MP. SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress. Mol Cell Biol 2014, 34:807-819. 10.1128/MCB.01483-13, 24344202.
66. Park YY, Nguyen OT, Kang H, Cho H. MARCH5-mediated quality control on acetylated Mfn1 facilitates mitochondrial homeostasis and cell survival. Cell Death Dis 2014, 5:e1172. 10.1038/cddis.2014.142, 24722297.
67. Gegg ME, Cooper JM, Chau KY, Rojo M, Schapira AH, Taanman JW. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy. Hum Mol Genet 2010, 19:4861-4870. 10.1093/hmg/ddq419, 3583518, 20871098.
68. Poole AC, Thomas RE, Yu S, Vincow ES, Pallanck L. The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway. PLoS One 2010, 5:e10054. 10.1371/journal.pone.0010054, 2850930, 20383334.
69. Leboucher GP, Tsai YC, Yang M, Shaw KC, Zhou M, Veenstra TD, Glickman MH, Weissman AM. Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis. Mol Cell 2012, 47:547-557. 10.1016/j.molcel.2012.05.041, 3526191, 22748923.
70. Anton F, Dittmar G, Langer T, Escobar-Henriques M. Two deubiquitylases act on mitofusin and regulate mitochondrial fusion along independent pathways. Mol Cell 2013, 49:487-498. 10.1016/j.molcel.2012.12.003, 23317502.
71. Shutt T, Geoffrion M, Milne R, McBride HM. The intracellular redox state is a core determinant of mitochondrial fusion. EMBO Rep 2012, 13:909-915. 10.1038/embor.2012.128, 3463964, 22945481.
72. de Brito OM, Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 2008, 456:605-610. 10.1038/nature07534, 19052620.
73. Nunnari J, Marshall W, Straight A, Murray A, Sedat JW, Walter P. Mitochondrial transmission during mating in S. cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mtDNA. Mol Biol Cell 1997, 8:1233-1242. 10.1091/mbc.8.7.1233, 276149, 9243504.
74. Huang P, Galloway CA, Yoon Y. Control of mitochondrial morphology through differential interactions of mitochondrial fusion and fission proteins. PLoS One 2011, 6:e20655. 10.1371/journal.pone.0020655, 3103587, 21647385.
75. Anand R, Wai T, Baker MJ, Kladt N, Schauss AC, Rugarli E, Langer T. The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J Cell Biol 2014, 204:919-929. 10.1083/jcb.201308006, 24616225.
76. Itoh T, Toh EA, Matsui Y. Mmr1p is a mitochondrial factor for Myo2p-dependent inheritance of mitochondria in the budding yeast. EMBO J 2004, 23:2520-2530. 10.1038/sj.emboj.7600271, 449781, 15201867.
77. Itoh T, Watabe A, Toh EA, Matsui Y. Complex formation with Ypt11p, a rab-type small GTPase, is essential to facilitate the function of Myo2p, a class V myosin, in mitochondrial distribution in Saccharomyces cerevisiae. Mol Cell Biol 2002, 22:7744-7757. 10.1128/MCB.22.22.7744-7757.2002, 134717, 12391144.
78. Altmann K, Frank M, Neumann D, Jakobs S, Westermann B. The class V myosin motor protein, Myo2, plays a major role in mitochondrial motility in Saccharomyces cerevisiae. J Cell Biol 2008, 181:119-130. 10.1083/jcb.200709099, 2287292, 18391073.
79. Eves PT, Jin Y, Brunner M, Weisman LS. Overlap of cargo binding sites on myosin V coordinates the inheritance of diverse cargoes. J Cell Biol 2012, 198:69-85. 10.1083/jcb.201201024, 3392941, 22753895.
80. Fortsch J, Hummel E, Krist M, Westermann B. The myosin-related motor protein Myo2 is an essential mediator of bud-directed mitochondrial movement in yeast. J Cell Biol 2011, 194:473-488. 10.1083/jcb.201012088, 3153652, 21807878.
81. Chernyakov I, Santiago-Tirado F, Bretscher A. Active segregation of yeast mitochondria by Myo2 is essential and mediated by Mmr1 and Ypt11. Curr Biol 2013, 23:1818-1824. 10.1016/j.cub.2013.07.053, 24012315.
82. Lewandowska A, Macfarlane J, Shaw JM. Mitochondrial association, protein phosphorylation, and degradation regulate the availability of the active Rab GTPase Ypt11 for mitochondrial inheritance. Mol Biol Cell 2013, 24:1185-1195. 10.1091/mbc.E12-12-0848, 3623639, 23427260.
83. Swayne TC, Zhou C, Boldogh IR, Charalel JK, McFaline-Figueroa JR, Thoms S, Yang C, Leung G, McInnes J, Erdmann R, Pon LA. Role for cER and Mmr1p in anchorage of mitochondria at sites of polarized surface growth in budding yeast. Curr Biol 2011, 21:1994-1999. 10.1016/j.cub.2011.10.019, 3237857, 22119524.
84. Lackner LL, Ping H, Graef M, Murley A, Nunnari J. Endoplasmic reticulum-associated mitochondria-cortex tether functions in the distribution and inheritance of mitochondria. Proc Natl Acad Sci U S A 2013, 110:E458-E467. 10.1073/pnas.1215232110, 3568303, 23341591.
85. Klecker T, Scholz D, Fortsch J, Westermann B. The yeast cell cortical protein Num1 integrates mitochondrial dynamics into cellular architecture. J Cell Sci 2013, 126:2924-2930. 10.1242/jcs.126045, 23641071.
86. Rafelski SM, Viana MP, Zhang Y, Chan YH, Thorn KS, Yam P, Fung JC, Li H, Costa Lda F, Marshall WF. Mitochondrial network size scaling in budding yeast. Science 2012, 338:822-824. 10.1126/science.1225720, 3602416, 23139336.
87. Longo VD, Shadel GS, Kaeberlein M, Kennedy B. Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab 2012, 16:18-31. 10.1016/j.cmet.2012.06.002, 3392685, 22768836.
88. McFaline-Figueroa JR, Vevea J, Swayne TC, Zhou C, Liu C, Leung G, Boldogh IR, Pon LA. Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeast. Aging Cell 2011, 10:885-895. 10.1111/j.1474-9726.2011.00731.x, 3173513, 21726403.
89. Baixauli F, Martin-Cofreces NB, Morlino G, Carrasco YR, Calabia-Linares C, Veiga E, Serrador JM, Sanchez-Madrid F. The mitochondrial fission factor dynamin-related protein 1 modulates T-cell receptor signalling at the immune synapse. EMBO J 2011, 30:1238-1250. 10.1038/emboj.2011.25, 3094108, 21326213.
90. Schwarz TL. Mitochondrial trafficking in neurons. Cold Spring Harb Perspect Biol 2013, 5:a011304.
91. Sheng ZH. Mitochondrial trafficking and anchoring in neurons: New insight and implications. J Cell Biol 2014, 204:1087-1098. 10.1083/jcb.201312123, 24687278.
92. Glater EE, Megeath LJ, Stowers RS, Schwarz TL. Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent. J Cell Biol 2006, 173:545-557. 10.1083/jcb.200601067, 2063864, 16717129.
93. Fransson S, Ruusala A, Aspenstrom P. The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking. Biochem Biophys Res Commun 2006, 344:500-510. 10.1016/j.bbrc.2006.03.163, 16630562.
94. Klosowiak JL, Focia PJ, Chakravarthy S, Landahl EC, Freymann DM, Rice SE. Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro. EMBO Rep 2013, 14:968-974. 10.1038/embor.2013.151, 24071720.
95. Russo GJ, Louie K, Wellington A, Macleod GT, Hu F, Panchumarthi S, Zinsmaier KE. Drosophila Miro is required for both anterograde and retrograde axonal mitochondrial transport. J Neurosci 2009, 29:5443-5455. 10.1523/JNEUROSCI.5417-08.2009, 2693725, 19403812.
96. van Spronsen M, Mikhaylova M, Lipka J, Schlager MA, van den Heuvel DJ, Kuijpers M, Wulf PS, Keijzer N, Demmers J, Kapitein LC, Jaarsma D, Gerritsen HC, Akhmanova A, Hoogenraad CC. TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites. Neuron 2013, 77:485-502. 10.1016/j.neuron.2012.11.027, 23395375.
97. Saotome M, Safiulina D, Szabadkai G, Das S, Fransson A, Aspenstrom P, Rizzuto R, Hajnoczky G. Bidirectional Ca2 + -dependent control of mitochondrial dynamics by the Miro GTPase. Proc Natl Acad Sci U S A 2008, 105:20728-20733. 10.1073/pnas.0808953105, 2634948, 19098100.
98. Macaskill AF, Rinholm JE, Twelvetrees AE, Arancibia-Carcamo IL, Muir J, Fransson A, Aspenstrom P, Attwell D, Kittler JT. Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses. Neuron 2009, 61:541-555. 10.1016/j.neuron.2009.01.030, 2670979, 19249275.
99. Wang X, Schwarz TL. The mechanism of Ca2+ - dependent regulation of kinesin-mediated mitochondrial motility. Cell 2009, 136:163-174. 10.1016/j.cell.2008.11.046, 2768392, 19135897.
100. Chen Y, Sheng ZH. Kinesin-1-syntaphilin coupling mediates activity-dependent regulation of axonal mitochondrial transport. J Cell Biol 2013, 202:351-364. 10.1083/jcb.201302040, 3718985, 23857772.
101. Kang JS, Tian JH, Pan PY, Zald P, Li C, Deng C, Sheng ZH. Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation. Cell 2008, 132:137-148. 10.1016/j.cell.2007.11.024, 2259239, 18191227.
102. Morlino G, Barreiro O, Baixauli F, Robles-Valero J, González-Granado JM, Villa-Bellosta R, Cuenca J, Sánchez-Sorzano CO, Veiga E, Martín-Cófreces NB, Sánchez-Madrid F. Miro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity. Mol Cell Biol 2014, 34:1412-1426. 10.1128/MCB.01177-13, 24492963.
103. Quintana A, Hoth M. Mitochondrial dynamics and their impact on T cell function. Cell Calcium 2012, 52:57-63. 10.1016/j.ceca.2012.02.005, 22425631.
104. Toulmay A, Prinz WA. Lipid transfer and signaling at organelle contact sites: the tip of the iceberg. Curr Opin Cell Biol 2011, 23:458-463. 10.1016/j.ceb.2011.04.006, 3148286, 21555211.
105. Kornmann B, Currie E, Collins SR, Schuldiner M, Nunnari J, Weissman JS, Walter P. An ER-mitochondria tethering complex revealed by a synthetic biology screen. Science 2009, 325:477-481. 10.1126/science.1175088, 2933203, 19556461.
106. Area-Gomez E, Del Carmen Lara Castillo M, Tambini MD, Guardia-Laguarta C, de Groof AJ, Madra M, Ikenouchi J, Umeda M, Bird TD, Sturley SL, Schon EA. Upregulated function of mitochondria-associated ER membranes in Alzheimer disease. EMBO J 2012, 31:4106-4123. 10.1038/emboj.2012.202, 3492725, 22892566.
107. Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T. Autophagosomes form at ER-mitochondria contact sites. Nature 2013, 495:389-393. 10.1038/nature11910, 23455425.
108. Head BP, Zulaika M, Ryazantsev S, van der Bliek AM. A novel mitochondrial outer membrane protein, MOMA-1, that affects cristae morphology in Caenorhabditis elegans. Mol Biol Cell 2014, 22:831-841.
109. Iwasawa R, Mahul-Mellier AL, Datler C, Pazarentzos E, Grimm S. Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction. EMBO J 2011, 30:556-568. 10.1038/emboj.2010.346, 3034017, 21183955.
110. Daniele T, Hurbain I, Vago R, Casari G, Raposo G, Tacchetti C, Schiaffino MV. Mitochondria and melanosomes establish physical contacts modulated by Mfn2 and involved in organelle biogenesis. Curr Biol 2014, 24:393-403. 10.1016/j.cub.2014.01.007, 24485836.
111. Zehmer JK, Huang Y, Peng G, Pu J, Anderson RG, Liu P. A role for lipid droplets in inter-membrane lipid traffic. Proteomics 2009, 9:914-921. 10.1002/pmic.200800584, 2676673, 19160396.
112. Achleitner G, Gaigg B, Krasser A, Kainersdorfer E, Kohlwein SD, Perktold A, Zellnig G, Daum G. Association between the endoplasmic reticulum and mitochondria of yeast facilitates interorganelle transport of phospholipids through membrane contact. Eur J Biochem 1999, 264:545-553. 10.1046/j.1432-1327.1999.00658.x, 10491102.
113. Cerveny KL, Studer SL, Jensen RE, Sesaki H. Yeast mitochondrial division and distribution require the cortical num1 protein. Dev Cell 2007, 12:363-375. 10.1016/j.devcel.2007.01.017, 17336903.
114. Hammermeister M, Schodel K, Westermann B. Mdm36 is a mitochondrial fission-promoting protein in Saccharomyces cerevisiae. Mol Biol Cell 2010, 21:2443-2452. 10.1091/mbc.E10-02-0096, 2903673, 20505073.
115. Roux A, Uyhazi K, Frost A, De Camilli P. GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission. Nature 2006, 441:528-531. 10.1038/nature04718, 16648839.
116. Misko A, Jiang S, Wegorzewska I, Milbrandt J, Baloh RH. Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex. J Neurosci 2010, 30:4232-4240. 10.1523/JNEUROSCI.6248-09.2010, 2852190, 20335458.