Mitochondrial import and accumulation of α-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

Journal of Biological Chemistry

Volumn 283, Issue 14, 2008, Pages 9089-9100

  Devi, Latha ^a   Raghavendran, Vijayendran ^a   Prabhu, Badanavalu M ^a   Avadhani, Narayan G ^a   Anandatheerthavarada, Hindupur K ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; ANIMAL CELL CULTURE; BRAIN; COLLOIDS; ELECTROPHORESIS; GELATION; NEURONS; ORGANIC ACIDS; OXYGEN; PROBABILITY DENSITY FUNCTION;

BRAIN REGIONS; DOPAMINERGIC NEURONS; GEL ELECTROPHORESIS; HUMAN BRAINS; INNER MEMBRANES; MITOCHONDRIAL COMPLEXES; MITOCHONDRIAL FUNCTIONS; MITOCHONDRIAL IMPORTS; NEURONAL CULTURES; PARKINSON DISEASES; REACTIVE OXYGEN SPECIES; STRIATUM; SUBSTANTIA NIGRA; SYNUCLEIN; TIME POINTS;

MITOCHONDRIA;

ALPHA SYNUCLEIN; AMINO ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); DOPAMINE; SIGNAL PEPTIDE;

ARTICLE; BRAIN; BRAIN REGION; CEREBELLUM; COMPARATIVE STUDY; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; ENZYME ACTIVITY; FETUS; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MITOCHONDRION; MUTATION; NERVE CELL CULTURE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; SUBSTANTIA NIGRA; WILD TYPE; AGED; AMINO ACID SUBSTITUTION; ANTIBODY SPECIFICITY; FEMALE; GENETICS; MALE; METABOLISM; MIDDLE AGED; MISSENSE MUTATION; MITOCHONDRIAL MEMBRANE; NERVE CELL; PATHOLOGY; PROTEIN TRANSPORT; ULTRASTRUCTURE;

AGED; AGED, 80 AND OVER; ALPHA-SYNUCLEIN; AMINO ACID SUBSTITUTION; DOPAMINE; ELECTRON TRANSPORT COMPLEX I; FEMALE; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MUTATION, MISSENSE; NEURONS; ORGAN SPECIFICITY; PARKINSON DISEASE; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES;

EID: 44049099669     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M710012200     Document Type: Article

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