-
1
-
-
84925061498
-
De novo branching cascades for structural and functional diversity in small molecules
-
25784617
-
Garcia-Castro M Kremer L Reinkemeier CD: De novo branching cascades for structural and functional diversity in small molecules. Nat Commun. 2015;6: 6516. 25784617 10.1038/ncomms7516
-
(2015)
Nat Commun
, vol.6
-
-
Garcia-Castro, M.1
Kremer, L.2
Reinkemeier, C.D.3
-
2
-
-
84906766592
-
Biology-oriented synthesis: harnessing the power of evolution
-
25074019
-
van Hattum H Waldmann H: Biology-oriented synthesis: harnessing the power of evolution. J Am Chem Soc. 2014;136(34):11853-9. 25074019 10.1021/ja505861d
-
(2014)
J Am Chem Soc
, vol.136
, Issue.34
, pp. 11853-11859
-
-
van Hattum, H.1
Waldmann, H.2
-
3
-
-
84900852249
-
Yeast synthetic biology platform generates novel chemical structures as scaffolds for drug discovery
-
24742115, 4046787, F1000 Recommendation
-
Klein J Heal JR Hamilton WD: Yeast synthetic biology platform generates novel chemical structures as scaffolds for drug discovery. ACS Synth Biol. 2014;3(5):314-23. 24742115 10.1021/sb400177x 4046787 F1000 Recommendation
-
(2014)
ACS Synth Biol
, vol.3
, Issue.5
, pp. 314-323
-
-
Klein, J.1
Heal, J.R.2
Hamilton, W.D.3
-
4
-
-
80055000805
-
Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules
-
21901218, F1000 Recommendation
-
Gantt RW Peltier-Pain P Thorson JS: Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules. Nat Prod Rep. 2011;28(11):1811-53. 21901218 10.1039/c1np00045d F1000 Recommendation
-
(2011)
Nat Prod Rep
, vol.28
, Issue.11
, pp. 1811-1853
-
-
Gantt, R.W.1
Peltier-Pain, P.2
Thorson, J.S.3
-
5
-
-
84859643086
-
Combinatorial biosynthesis of polyketides--a perspective
-
22342766, 3328608
-
Wong FT Khosla C: Combinatorial biosynthesis of polyketides--a perspective. Curr Opin Chem Biol. 2012;16(1-2):117-23. 22342766 10.1016/j.cbpa.2012.01.018 3328608
-
(2012)
Curr Opin Chem Biol
, vol.16
, Issue.1-2
, pp. 117-123
-
-
Wong, F.T.1
Khosla, C.2
-
6
-
-
84906672709
-
Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases
-
25049383, 4151742
-
Xu Y Zhou T Zhang S: Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases. Proc Natl Acad Sci U S A. 2014;111(34):12354-9. 25049383 10.1073/pnas.1406999111 4151742
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, Issue.34
, pp. 12354-12359
-
-
Xu, Y.1
Zhou, T.2
Zhang, S.3
-
7
-
-
84887624536
-
Pathway and protein engineering approaches to produce novel and commodity small molecules
-
23498845
-
Bhan N Xu P Koffas MA: Pathway and protein engineering approaches to produce novel and commodity small molecules. Curr Opin Biotechnol. 2013;24(6):1137-43. 23498845 10.1016/j.copbio.2013.02.019
-
(2013)
Curr Opin Biotechnol
, vol.24
, Issue.6
, pp. 1137-1143
-
-
Bhan, N.1
Xu, P.2
Koffas, M.A.3
-
8
-
-
84923274600
-
Judging synthetic biology risks
-
25573995
-
Breitling R Takano E Gardner TS: Judging synthetic biology risks. Science. 2015;347(6218):107. 25573995 10.1126/science.aaa5253
-
(2015)
Science
, vol.347
, Issue.6218
, pp. 107
-
-
Breitling, R.1
Takano, E.2
Gardner, T.S.3
-
9
-
-
84900323973
-
Production of Macrocyclic Sesqui- and Diterpenes in Heterologous Microbial Hosts: A Systems Approach to Harness Nature's Molecular Diversity
-
Bruck T Kourist R Loll B: Production of Macrocyclic Sesqui- and Diterpenes in Heterologous Microbial Hosts: A Systems Approach to Harness Nature's Molecular Diversity. Chemcatchem. 2014;6(5):1142-1165. 10.1002/cctc.201300733
-
(2014)
Chemcatchem
, vol.6
, Issue.5
, pp. 1142-1165
-
-
Bruck, T.1
Kourist, R.2
Loll, B.3
-
10
-
-
84926205808
-
The re-emergence of natural products for drug discovery in the genomics era
-
25614221
-
Harvey AL Edrada-Ebel R Quinn RJ: The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov. 2015;14(2):111-29. 25614221 10.1038/nrd4510
-
(2015)
Nat Rev Drug Discov
, vol.14
, Issue.2
, pp. 111-129
-
-
Harvey, A.L.1
Edrada-Ebel, R.2
Quinn, R.J.3
-
11
-
-
84939541097
-
Reinvigorating natural product combinatorial biosynthesis with synthetic biology
-
26284672, 4757526, F1000 Recommendation
-
Kim E Moore BS Yoon YJ: Reinvigorating natural product combinatorial biosynthesis with synthetic biology. Nat Chem Biol. 2015;11(9):649-59. 26284672 10.1038/nchembio.1893 4757526 F1000 Recommendation
-
(2015)
Nat Chem Biol
, vol.11
, Issue.9
, pp. 649-659
-
-
Kim, E.1
Moore, B.S.2
Yoon, Y.J.3
-
12
-
-
84939536885
-
Computational approaches to natural product discovery
-
26284671
-
Medema MH Fischbach MA: Computational approaches to natural product discovery. Nat Chem Biol. 2015;11(9):639-48. 26284671 10.1038/nchembio.1884
-
(2015)
Nat Chem Biol
, vol.11
, Issue.9
, pp. 639-648
-
-
Medema, M.H.1
Fischbach, M.A.2
-
13
-
-
78649391538
-
Methods and options for the heterologous production of complex natural products
-
21060956
-
Zhang H Boghigian BA Armando J: Methods and options for the heterologous production of complex natural products. Nat Prod Rep. 2011;28(1):125-51. 21060956 10.1039/c0np00037j
-
(2011)
Nat Prod Rep
, vol.28
, Issue.1
, pp. 125-151
-
-
Zhang, H.1
Boghigian, B.A.2
Armando, J.3
-
14
-
-
84898068070
-
Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-(L)-methionine analogues
-
24616228, 4076696
-
Singh S Zhang J Huber TD: Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-(L)-methionine analogues. Angew Chem Int Ed Engl. 2014;53(15):3965-9. 24616228 10.1002/anie.201308272 4076696
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, Issue.15
, pp. 3965-3969
-
-
Singh, S.1
Zhang, J.2
Huber, T.D.3
-
15
-
-
33645218213
-
Allosteric control of an ionotropic glutamate receptor with an optical switch
-
16408092, 1447676, F1000 Recommendation
-
Volgraf M Gorostiza P Numano R: Allosteric control of an ionotropic glutamate receptor with an optical switch. Nat Chem Biol. 2006;2(1):47-52. 16408092 10.1038/nchembio756 1447676 F1000 Recommendation
-
(2006)
Nat Chem Biol
, vol.2
, Issue.1
, pp. 47-52
-
-
Volgraf, M.1
Gorostiza, P.2
Numano, R.3
-
16
-
-
33644948493
-
Natural product diversification using a non-natural cofactor analogue of S-adenosyl-L-methionine
-
16506729
-
Zhang C Weller RL Thorson JS: Natural product diversification using a non-natural cofactor analogue of S-adenosyl-L-methionine. J Am Chem Soc. 2006;128(9):2760-1. 16506729 10.1021/ja056231t
-
(2006)
J Am Chem Soc
, vol.128
, Issue.9
, pp. 2760-2761
-
-
Zhang, C.1
Weller, R.L.2
Thorson, J.S.3
-
17
-
-
84887540837
-
Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility
-
24123503, F1000 Recommendation
-
Yan Y Chen J Zhang L: Multiplexing of combinatorial chemistry in antimycin biosynthesis: expansion of molecular diversity and utility. Angew Chem Int Ed Engl. 2013;52(47):12308-12. 24123503 10.1002/anie.201305569 F1000 Recommendation
-
(2013)
Angew Chem Int Ed Engl
, vol.52
, Issue.47
, pp. 12308-12312
-
-
Yan, Y.1
Chen, J.2
Zhang, L.3
-
18
-
-
65649123015
-
A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450BM3
-
19271725, F1000 Recommendation
-
Dietrich JA Yoshikuni Y Fisher KJ: A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450 BM3. ACS Chem Biol. 2009;4(4):261-7. 19271725 10.1021/cb900006h F1000 Recommendation
-
(2009)
ACS Chem Biol
, vol.4
, Issue.4
, pp. 261-267
-
-
Dietrich, J.A.1
Yoshikuni, Y.2
Fisher, K.J.3
-
19
-
-
84859565523
-
Tuning P450 Enzymes as Oxidation Catalysts
-
Fasan R: Tuning P450 Enzymes as Oxidation Catalysts. Acs Catal. 2012;2(4):647-666. 10.1021/cs300001x
-
(2012)
Acs Catal
, vol.2
, Issue.4
, pp. 647-666
-
-
Fasan, R.1
-
20
-
-
84886984484
-
Pathway and Enzyme Engineering and Applications for Glycodiversification
-
Reference Source
-
Zhao LS Liu HW: Pathway and Enzyme Engineering and Applications for Glycodiversification. Enzyme Technologies: Metagenomics, Evolution, Biocatalysis, and Biosynthesis. 2011;1:309-362. Reference Source
-
(2011)
Enzyme Technologies: Metagenomics, Evolution, Biocatalysis, and Biosynthesis
, vol.1
, pp. 309-362
-
-
Zhao, L.S.1
Liu, H.W.2
-
21
-
-
84943277067
-
Halogenase Engineering for the Generation of New Natural Product Analogues
-
26256103
-
Brown S O'Connor SE: Halogenase Engineering for the Generation of New Natural Product Analogues. Chembiochem. 2015;16(15):2129-35. 26256103 10.1002/cbic.201500338
-
(2015)
Chembiochem
, vol.16
, Issue.15
, pp. 2129-2135
-
-
Brown, S.1
O'Connor, S.E.2
-
22
-
-
84896520980
-
Expanding P450 catalytic reaction space through evolution and engineering
-
24658056, 4008644
-
McIntosh JA Farwell CC Arnold FH: Expanding P450 catalytic reaction space through evolution and engineering. Curr Opin Chem Biol. 2014;19:126-34. 24658056 10.1016/j.cbpa.2014.02.001 4008644
-
(2014)
Curr Opin Chem Biol
, vol.19
, pp. 126-134
-
-
McIntosh, J.A.1
Farwell, C.C.2
Arnold, F.H.3
-
23
-
-
84921716406
-
Drug metabolism in microorganisms
-
25179825
-
Murphy CD: Drug metabolism in microorganisms. Biotechnol Lett. 2015;37(1):19-28. 25179825 10.1007/s10529-014-1653-8
-
(2015)
Biotechnol Lett
, vol.37
, Issue.1
, pp. 19-28
-
-
Murphy, C.D.1
-
24
-
-
84881341237
-
Cytochrome P450 bioreactors in the pharmaceutical industry: challenges and opportunities
-
23688136
-
Martinez CA Rupashinghe SG: Cytochrome P450 bioreactors in the pharmaceutical industry: challenges and opportunities. Curr Top Med Chem. 2013;13(12):1470-90. 23688136 10.2174/15680266113139990111
-
(2013)
Curr Top Med Chem
, vol.13
, Issue.12
, pp. 1470-1490
-
-
Martinez, C.A.1
Rupashinghe, S.G.2
-
25
-
-
84924189921
-
Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum
-
25691737, 4352836, F1000 Recommendation
-
McLean KJ Hans M Meijrink B: Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum. Proc Natl Acad Sci U S A. 2015;112(9):2847-52. 25691737 10.1073/pnas.1419028112 4352836 F1000 Recommendation
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, Issue.9
, pp. 2847-2852
-
-
McLean, K.J.1
Hans, M.2
Meijrink, B.3
-
26
-
-
84872495336
-
Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes
-
23258409, F1000 Recommendation
-
Coelho PS Brustad EM Kannan A: Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes. Science. 2013;339(6117):307-10. 23258409 10.1126/science.1231434 F1000 Recommendation
-
(2013)
Science
, vol.339
, Issue.6117
, pp. 307-310
-
-
Coelho, P.S.1
Brustad, E.M.2
Kannan, A.3
-
27
-
-
80052027792
-
Styrene biosynthesis from glucose by engineered E. coli
-
21722749
-
McKenna R Nielsen DR: Styrene biosynthesis from glucose by engineered E. coli. Metab Eng. 2011;13(5):544-54. 21722749 10.1016/j.ymben.2011.06.005
-
(2011)
Metab Eng
, vol.13
, Issue.5
, pp. 544-554
-
-
McKenna, R.1
Nielsen, D.R.2
-
28
-
-
84880921220
-
A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo
-
23792734, 3720782, F1000 Recommendation
-
Coelho PS Wang ZJ Ener ME: A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo. Nat Chem Biol. 2013;9(8):485-7. 23792734 10.1038/nchembio.1278 3720782 F1000 Recommendation
-
(2013)
Nat Chem Biol
, vol.9
, Issue.8
, pp. 485-487
-
-
Coelho, P.S.1
Wang, Z.J.2
Ener, M.E.3
-
29
-
-
84915745332
-
Non-natural olefin cyclopropanation catalyzed by diverse cytochrome P450s and other hemoproteins
-
25294253, 4287214, F1000 Recommendation
-
Heel T McIntosh JA Dodani SC: Non-natural olefin cyclopropanation catalyzed by diverse cytochrome P450s and other hemoproteins. Chembiochem. 2014;15(17):2556-62. 25294253 10.1002/cbic.201402286 4287214 F1000 Recommendation
-
(2014)
Chembiochem
, vol.15
, Issue.17
, pp. 2556-2562
-
-
Heel, T.1
McIntosh, J.A.2
Dodani, S.C.3
-
30
-
-
84903168457
-
Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran
-
24802161, 4120663, F1000 Recommendation
-
Wang ZJ Renata H Peck NE: Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran. Angew Chem Int Ed Engl. 2014;53(26):6810-3. 24802161 10.1002/anie.201402809 4120663 F1000 Recommendation
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, Issue.26
, pp. 6810-6813
-
-
Wang, Z.J.1
Renata, H.2
Peck, N.E.3
-
31
-
-
84928626673
-
Interfacing microbial styrene production with a biocompatible cyclopropanation reaction
-
25925138, 4494747, F1000 Recommendation
-
Wallace S Balskus EP: Interfacing microbial styrene production with a biocompatible cyclopropanation reaction. Angew Chem Int Ed Engl. 2015;54(24):7106-9. 25925138 10.1002/anie.201502185 4494747 F1000 Recommendation
-
(2015)
Angew Chem Int Ed Engl
, vol.54
, Issue.24
, pp. 7106-7109
-
-
Wallace, S.1
Balskus, E.P.2
-
32
-
-
84918501426
-
Artificial concurrent catalytic processes involving enzymes
-
25350691
-
Köhler V Turner NJ: Artificial concurrent catalytic processes involving enzymes. Chem Commun (Camb). 2015;51(3):450-64. 25350691 10.1039/c4cc07277d
-
(2015)
Chem Commun (Camb)
, vol.51
, Issue.3
, pp. 450-464
-
-
Köhler, V.1
Turner, N.J.2
-
33
-
-
84898915058
-
Opportunities for merging chemical and biological synthesis
-
24747284, 4199929
-
Wallace S Balskus EP: Opportunities for merging chemical and biological synthesis. Curr Opin Biotechnol. 2014;30:1-8. 24747284 10.1016/j.copbio.2014.03.006 4199929
-
(2014)
Curr Opin Biotechnol
, vol.30
, pp. 1-8
-
-
Wallace, S.1
Balskus, E.P.2
-
34
-
-
84910131022
-
Enzymatic Biosynthesis of Novel Resveratrol Glucoside and Glycoside Derivatives
-
25239890, 4249177, F1000 Recommendation
-
Pandey RP Parajuli P Shin JY: Enzymatic Biosynthesis of Novel Resveratrol Glucoside and Glycoside Derivatives. Appl Environ Microbiol. 2014;80(23):7235-43. 25239890 10.1128/AEM.02076-14 4249177 F1000 Recommendation
-
(2014)
Appl Environ Microbiol
, vol.80
, Issue.23
, pp. 7235-7243
-
-
Pandey, R.P.1
Parajuli, P.2
Shin, J.Y.3
-
35
-
-
84923100134
-
Harnessing Sugar Biosynthesis and Glycosylation to Redesign Natural Products and to Increase Structural Diversity
-
Natural Products, In
-
Olano C Méndez C Salas JA: Harnessing Sugar Biosynthesis and Glycosylation to Redesign Natural Products and to Increase Structural Diversity. In Natural Products. John Wiley & Sons, Inc.2014;317-339. 10.1002/9781118794623.ch17
-
(2014)
, pp. 317-339
-
-
Olano, C.1
Méndez, C.2
Salas, J.A.3
-
36
-
-
34247496765
-
Substrate flexibility of vicenisaminyltransferase VinC involved in the biosynthesis of vicenistatin
-
17388594, F1000 Recommendation
-
Minami A Eguchi T: Substrate flexibility of vicenisaminyltransferase VinC involved in the biosynthesis of vicenistatin. J Am Chem Soc. 2007;129(16):5102-7. 17388594 10.1021/ja0685250 F1000 Recommendation
-
(2007)
J Am Chem Soc
, vol.129
, Issue.16
, pp. 5102-5107
-
-
Minami, A.1
Eguchi, T.2
-
37
-
-
78851472303
-
Clinical trials of resveratrol
-
21261655
-
Patel KR Scott E Brown VA: Clinical trials of resveratrol. Ann N Y Acad Sci. 2011;1215:161-9. 21261655 10.1111/j.1749-6632.2010.05853.x
-
(2011)
Ann N Y Acad Sci
, vol.1215
, pp. 161-169
-
-
Patel, K.R.1
Scott, E.2
Brown, V.A.3
-
38
-
-
33748302743
-
Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions
-
16946071, F1000 Recommendation
-
Zhang C Griffith BR Fu Q: Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions. Science. 2006;313(5791):1291-4. 16946071 10.1126/science.1130028 F1000 Recommendation
-
(2006)
Science
, vol.313
, Issue.5791
, pp. 1291-1294
-
-
Zhang, C.1
Griffith, B.R.2
Fu, Q.3
-
39
-
-
34548685673
-
Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution
-
17828251
-
Williams GJ Zhang C Thorson JS: Expanding the promiscuity of a natural-product glycosyltransferase by directed evolution. Nat Chem Biol. 2007;3(10):657-62. 17828251 10.1038/nchembio.2007.28
-
(2007)
Nat Chem Biol
, vol.3
, Issue.10
, pp. 657-662
-
-
Williams, G.J.1
Zhang, C.2
Thorson, J.S.3
-
40
-
-
84877359433
-
Broadening the scope of glycosyltransferase-catalyzed sugar nucleotide synthesis
-
23610417, 3651490, F1000 Recommendation
-
Gantt RW Peltier-Pain P Singh S: Broadening the scope of glycosyltransferase-catalyzed sugar nucleotide synthesis. Proc Natl Acad Sci U S A. 2013;110(19):7648-53. 23610417 10.1073/pnas.1220220110 3651490 F1000 Recommendation
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.19
, pp. 7648-7653
-
-
Gantt, R.W.1
Peltier-Pain, P.2
Singh, S.3
-
41
-
-
84895453461
-
Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites
-
24189093
-
Hwang KS Kim HU Charusanti P: Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites. Biotechnol Adv. 2014;32(2):255-68. 24189093 10.1016/j.biotechadv.2013.10.008
-
(2014)
Biotechnol Adv
, vol.32
, Issue.2
, pp. 255-268
-
-
Hwang, K.S.1
Kim, H.U.2
Charusanti, P.3
-
42
-
-
0031974553
-
Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius
-
9447597, F1000 Recommendation
-
Madduri K Kennedy J Rivola G: Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius. Nat Biotechnol. 1998;16(1):69-74. 9447597 10.1038/nbt0198-69 F1000 Recommendation
-
(1998)
Nat Biotechnol
, vol.16
, Issue.1
, pp. 69-74
-
-
Madduri, K.1
Kennedy, J.2
Rivola, G.3
-
43
-
-
79960801297
-
Metabolic engineering is key to a sustainable chemical industry
-
21666928
-
Murphy AC: Metabolic engineering is key to a sustainable chemical industry. Nat Prod Rep. 2011;28(8):1406-25. 21666928 10.1039/c1np00029b
-
(2011)
Nat Prod Rep
, vol.28
, Issue.8
, pp. 1406-1425
-
-
Murphy, A.C.1
-
44
-
-
79959424209
-
Metabolic engineering for the production of natural products
-
22432617, 4077471
-
Pickens LB Tang Y Chooi YH: Metabolic engineering for the production of natural products. Annu Rev Chem Biomol Eng. 2011;2:211-36. 22432617 10.1146/annurev-chembioeng-061010-114209 4077471
-
(2011)
Annu Rev Chem Biomol Eng
, vol.2
, pp. 211-236
-
-
Pickens, L.B.1
Tang, Y.2
Chooi, Y.H.3
-
45
-
-
84885028788
-
Deoxysugar pathway interchange for erythromycin analogues heterologously produced through Escherichia coli
-
24060454
-
Jiang M Zhang H Park SH: Deoxysugar pathway interchange for erythromycin analogues heterologously produced through Escherichia coli. Metab Eng. 2013;20:92-100. 24060454 10.1016/j.ymben.2013.09.005
-
(2013)
Metab Eng
, vol.20
, pp. 92-100
-
-
Jiang, M.1
Zhang, H.2
Park, S.H.3
-
46
-
-
79961051540
-
Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates
-
21602397, 3147398
-
Han AR Park JW Lee MK: Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates. Appl Environ Microbiol. 2011;77(14):4912-23. 21602397 10.1128/AEM.02527-10 3147398
-
(2011)
Appl Environ Microbiol
, vol.77
, Issue.14
, pp. 4912-4923
-
-
Han, A.R.1
Park, J.W.2
Lee, M.K.3
-
47
-
-
79251501973
-
Recombinant E. coli prototype strains for in vivo glycorandomization
-
20886903, 3025069
-
Williams GJ Yang J Zhang C: Recombinant E. coli prototype strains for in vivo glycorandomization. ACS Chem Biol. 2011;6(1):95-100. 20886903 10.1021/cb100267k 3025069
-
(2011)
ACS Chem Biol
, vol.6
, Issue.1
, pp. 95-100
-
-
Williams, G.J.1
Yang, J.2
Zhang, C.3
-
48
-
-
84905239896
-
Bioconversion of deoxysugar moieties to the biosynthetic intermediates of daunorubicin in an engineered strain of Streptomyces coeruleobidus
-
24793498
-
Yuan T Xie L Zhu B: Bioconversion of deoxysugar moieties to the biosynthetic intermediates of daunorubicin in an engineered strain of Streptomyces coeruleobidus. Biotechnol Lett. 2014;36(9):1809-18. 24793498 10.1007/s10529-014-1542-1
-
(2014)
Biotechnol Lett
, vol.36
, Issue.9
, pp. 1809-1818
-
-
Yuan, T.1
Xie, L.2
Zhu, B.3
-
49
-
-
84899932496
-
The 4-phosphopantetheinyl transferase of Trichoderma virens plays a role in plant protection against Botrytis cinerea through volatile organic compound emission
-
Contreras-Cornejo HA Macias-Rodriguez L Herrera-Estrella A: The 4-phosphopantetheinyl transferase of Trichoderma virens plays a role in plant protection against Botrytis cinerea through volatile organic compound emission. Plant Soil. 2014;379(1):261-274. 10.1007/s11104-014-2069-x
-
(2014)
Plant Soil
, vol.379
, Issue.1
, pp. 261-274
-
-
Contreras-Cornejo, H.A.1
Macias-Rodriguez, L.2
Herrera-Estrella, A.3
-
50
-
-
69549109765
-
Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution
-
20111684, 2812827
-
Iriti M Faoro F: Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution. Int J Mol Sci. 2009;10(8):3371-99. 20111684 10.3390/ijms10083371 2812827
-
(2009)
Int J Mol Sci
, vol.10
, Issue.8
, pp. 3371-3399
-
-
Iriti, M.1
Faoro, F.2
-
51
-
-
84939638571
-
Translating biosynthetic gene clusters into fungal armor and weaponry
-
26284674, 4682562
-
Keller NP: Translating biosynthetic gene clusters into fungal armor and weaponry. Nat Chem Biol. 2015;11(9):671-7. 26284674 10.1038/nchembio.1897 4682562
-
(2015)
Nat Chem Biol
, vol.11
, Issue.9
, pp. 671-677
-
-
Keller, N.P.1
-
52
-
-
84861510526
-
Diversity-oriented synthesis of diverse polycyclic scaffolds inspired by the logic of sesquiterpene lactones biosynthesis
-
22517777
-
Valot G Garcia J Duplan V: Diversity-oriented synthesis of diverse polycyclic scaffolds inspired by the logic of sesquiterpene lactones biosynthesis. Angew Chem Int Ed Engl. 2012;51(22):5391-4. 22517777 10.1002/anie.201201157
-
(2012)
Angew Chem Int Ed Engl
, vol.51
, Issue.22
, pp. 5391-5394
-
-
Valot, G.1
Garcia, J.2
Duplan, V.3
-
53
-
-
84905489992
-
Diversity-oriented synthesis of Lycopodium alkaloids inspired by the hidden functional group pairing pattern
-
25082077
-
Zhang J Wu J Hong B: Diversity-oriented synthesis of Lycopodium alkaloids inspired by the hidden functional group pairing pattern. Nat Commun. 2014;5: 4614. 25082077 10.1038/ncomms5614
-
(2014)
Nat Commun
, vol.5
-
-
Zhang, J.1
Wu, J.2
Hong, B.3
-
54
-
-
84937573245
-
A New Metabolite with a Unique 4-Pyranone-γ-Lactam-1,4-Thiazine Moiety from a Hawaiian-Plant Associated Fungus
-
26107089
-
Li CS Ding Y Yang BJ: A New Metabolite with a Unique 4-Pyranone-γ-Lactam-1,4-Thiazine Moiety from a Hawaiian-Plant Associated Fungus. Org Lett. 2015;17(14):3556-9. 26107089 10.1021/acs.orglett.5b01650
-
(2015)
Org Lett
, vol.17
, Issue.14
, pp. 3556-3559
-
-
Li, C.S.1
Ding, Y.2
Yang, B.J.3
-
55
-
-
84924227574
-
Lycopodiellactone, an unusual delta-lactone-isochromanone from a Hawaiian plant-associated fungus Paraphaeosphaeria neglecta FT462
-
Li C Yang B Fenstemacher R: Lycopodiellactone, an unusual delta-lactone-isochromanone from a Hawaiian plant-associated fungus Paraphaeosphaeria neglecta FT462. Tetrahedron Lett. 2015;56(13):1724-1727. 10.1016/j.tetlet.2015.02.076
-
(2015)
Tetrahedron Lett
, vol.56
, Issue.13
, pp. 1724-1727
-
-
Li, C.1
Yang, B.2
Fenstemacher, R.3
-
56
-
-
84903553792
-
Emerging strategies and integrated systems microbiology technologies for biodiscovery of marine bioactive compounds
-
24918453, 4071589
-
Rocha-Martin J Harrington C Dobson AD: Emerging strategies and integrated systems microbiology technologies for biodiscovery of marine bioactive compounds. Mar Drugs. 2014;12(6):3516-59. 24918453 10.3390/md12063516 4071589
-
(2014)
Mar Drugs
, vol.12
, Issue.6
, pp. 3516-3559
-
-
Rocha-Martin, J.1
Harrington, C.2
Dobson, A.D.3
-
57
-
-
84926309301
-
Metabolic engineering of Escherichia coli for the biosynthesis of various phenylpropanoid derivatives
-
25819309, F1000 Recommendation
-
Wang S Zhang S Xiao A: Metabolic engineering of Escherichia coli for the biosynthesis of various phenylpropanoid derivatives. Metab Eng. 2015;29:153-9. 25819309 10.1016/j.ymben.2015.03.011 F1000 Recommendation
-
(2015)
Metab Eng
, vol.29
, pp. 153-159
-
-
Wang, S.1
Zhang, S.2
Xiao, A.3
-
58
-
-
69549103148
-
Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae
-
19678954, 2732597, F1000 Recommendation
-
Naesby M Nielsen SV Nielsen CA: Yeast artificial chromosomes employed for random assembly of biosynthetic pathways and production of diverse compounds in Saccharomyces cerevisiae. Microb Cell Fact. 2009;8:45. 19678954 10.1186/1475-2859-8-45 2732597 F1000 Recommendation
-
(2009)
Microb Cell Fact
, vol.8
, pp. 45
-
-
Naesby, M.1
Nielsen, S.V.2
Nielsen, C.A.3
-
59
-
-
33748631825
-
Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms
-
16895337
-
Fischbach MA Walsh CT: Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms. Chem Rev. 2006;106(8):3468-96. 16895337 10.1021/cr0503097
-
(2006)
Chem Rev
, vol.106
, Issue.8
, pp. 3468-3496
-
-
Fischbach, M.A.1
Walsh, C.T.2
-
60
-
-
84941730383
-
Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination
-
26230368, 4666801, F1000 Recommendation
-
Chemler JA Tripathi A Hansen DA: Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination. J Am Chem Soc. 2015;137(33):10603-9. 26230368 10.1021/jacs.5b04842 4666801 F1000 Recommendation
-
(2015)
J Am Chem Soc
, vol.137
, Issue.33
, pp. 10603-10609
-
-
Chemler, J.A.1
Tripathi, A.2
Hansen, D.A.3
-
61
-
-
84883484875
-
Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways
-
24009388, 4057101, F1000 Recommendation
-
Walker MC Thuronyi BW Charkoudian LK: Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways. Science. 2013;341(6150):1089-94. 24009388 10.1126/science.1242345 4057101 F1000 Recommendation
-
(2013)
Science
, vol.341
, Issue.6150
, pp. 1089-1094
-
-
Walker, M.C.1
Thuronyi, B.W.2
Charkoudian, L.K.3
-
62
-
-
7744235042
-
Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity
-
15459756
-
Moss SJ Martin CJ Wilkinson B: Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity. Nat Prod Rep. 2004;21(5):575-93. 15459756 10.1039/b315020h
-
(2004)
Nat Prod Rep
, vol.21
, Issue.5
, pp. 575-593
-
-
Moss, S.J.1
Martin, C.J.2
Wilkinson, B.3
-
63
-
-
85027927172
-
Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives
-
25044264
-
Bravo-Rodriguez K Ismail-Ali AF Klopries S: Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives. Chembiochem. 2014;15(13):1991-7. 25044264 10.1002/cbic.201402206
-
(2014)
Chembiochem
, vol.15
, Issue.13
, pp. 1991-1997
-
-
Bravo-Rodriguez, K.1
Ismail-Ali, A.F.2
Klopries, S.3
-
64
-
-
84876714094
-
Evolution-guided engineering of nonribosomal peptide synthetase adenylation domains
-
Crusemann M Kohlhaas C Piel J: Evolution-guided engineering of nonribosomal peptide synthetase adenylation domains. Chem Sci. 2013;4:1041-1045. 10.1039/C2SC21722H
-
(2013)
Chem Sci
, vol.4
, pp. 1041-1045
-
-
Crusemann, M.1
Kohlhaas, C.2
Piel, J.3
-
65
-
-
84875459266
-
Mechanism and specificity of an acyltransferase domain from a modular polyketide synthase
-
23452124, 3612939
-
Dunn BJ Cane DE Khosla C: Mechanism and specificity of an acyltransferase domain from a modular polyketide synthase. Biochemistry. 2013;52(11):1839-41. 23452124 10.1021/bi400185v 3612939
-
(2013)
Biochemistry
, vol.52
, Issue.11
, pp. 1839-1841
-
-
Dunn, B.J.1
Cane, D.E.2
Khosla, C.3
-
66
-
-
84911486743
-
Reprogramming nonribosomal peptide synthetases for "clickable" amino acids
-
25081643
-
Kries H Wachtel R Pabst A: Reprogramming nonribosomal peptide synthetases for "clickable" amino acids. Angew Chem Int Ed Engl. 2014;53(38):10105-8. 25081643 10.1002/anie.201405281
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, Issue.38
, pp. 10105-10108
-
-
Kries, H.1
Wachtel, R.2
Pabst, A.3
-
67
-
-
84863822575
-
Introduction of a non-natural amino acid into a nonribosomal peptide antibiotic by modification of adenylation domain specificity
-
22711659
-
Thirlway J Lewis R Nunns L: Introduction of a non-natural amino acid into a nonribosomal peptide antibiotic by modification of adenylation domain specificity. Angew Chem Int Ed Engl. 2012;51(29):7181-4. 22711659 10.1002/anie.201202043
-
(2012)
Angew Chem Int Ed Engl
, vol.51
, Issue.29
, pp. 7181-7184
-
-
Thirlway, J.1
Lewis, R.2
Nunns, L.3
-
68
-
-
84869474456
-
Functional modular dissection of DEBS1-TE changes triketide lactone ratios and provides insight into Acyl group loading, hydrolysis, and ACP transfer
-
23116287
-
Yan J Hazzard C Bonnett SA: Functional modular dissection of DEBS1-TE changes triketide lactone ratios and provides insight into Acyl group loading, hydrolysis, and ACP transfer. Biochemistry. 2012;51(46):9333-41. 23116287 10.1021/bi300830q
-
(2012)
Biochemistry
, vol.51
, Issue.46
, pp. 9333-9341
-
-
Yan, J.1
Hazzard, C.2
Bonnett, S.A.3
-
69
-
-
84896929356
-
Rational domain swaps reveal insights about chain length control by ketosynthase domains in fungal nonreducing polyketide synthases
-
24593241, 3993715
-
Liu T Sanchez JF Chiang YM: Rational domain swaps reveal insights about chain length control by ketosynthase domains in fungal nonreducing polyketide synthases. Org Lett. 2014;16(6):1676-9. 24593241 10.1021/ol5003384 3993715
-
(2014)
Org Lett
, vol.16
, Issue.6
, pp. 1676-1679
-
-
Liu, T.1
Sanchez, J.F.2
Chiang, Y.M.3
-
70
-
-
84924208708
-
Macrodiolide formation by the thioesterase of a modular polyketide synthase
-
25753953, 4471547
-
Zhou Y Prediger P Dias LC: Macrodiolide formation by the thioesterase of a modular polyketide synthase. Angew Chem Int Ed Engl. 2015;54(17):5232-5. 25753953 10.1002/anie.201500401 4471547
-
(2015)
Angew Chem Int Ed Engl
, vol.54
, Issue.17
, pp. 5232-5235
-
-
Zhou, Y.1
Prediger, P.2
Dias, L.C.3
-
71
-
-
77956261727
-
Programming of erythromycin biosynthesis by a modular polyketide synthase
-
20522551, 2934617
-
Cane DE: Programming of erythromycin biosynthesis by a modular polyketide synthase. J Biol Chem. 2010;285(36):27517-23. 20522551 10.1074/jbc.R110.144618 2934617
-
(2010)
J Biol Chem
, vol.285
, Issue.36
, pp. 27517-27523
-
-
Cane, D.E.1
-
72
-
-
84907811102
-
An unusual dehydratase acting on glycerate and a ketoreducatse stereoselectively reducing α-ketone in polyketide starter unit biosynthesis
-
25160004, F1000 Recommendation
-
He HY Yuan H Tang MC: An unusual dehydratase acting on glycerate and a ketoreducatse stereoselectively reducing α-ketone in polyketide starter unit biosynthesis. Angew Chem Int Ed Engl. 2014;53(42):11315-9. 25160004 10.1002/anie.201406602 F1000 Recommendation
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, Issue.42
, pp. 11315-11319
-
-
He, H.Y.1
Yuan, H.2
Tang, M.C.3
-
73
-
-
84893465357
-
Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line
-
24402879, F1000 Recommendation
-
Sugimoto Y Ding L Ishida K: Rational design of modular polyketide synthases: morphing the aureothin pathway into a luteoreticulin assembly line. Angew Chem Int Ed Engl. 2014;53(6):1560-4. 24402879 10.1002/anie.201308176 F1000 Recommendation
-
(2014)
Angew Chem Int Ed Engl
, vol.53
, Issue.6
, pp. 1560-1564
-
-
Sugimoto, Y.1
Ding, L.2
Ishida, K.3
-
74
-
-
1142293995
-
Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase
-
15112993
-
Tang GL Cheng YQ Shen B: Leinamycin biosynthesis revealing unprecedented architectural complexity for a hybrid polyketide synthase and nonribosomal peptide synthetase. Chem Biol. 2004;11(1):33-45. 15112993 10.1016/j.chembiol.2003.12.014
-
(2004)
Chem Biol
, vol.11
, Issue.1
, pp. 33-45
-
-
Tang, G.L.1
Cheng, Y.Q.2
Shen, B.3
-
75
-
-
84903436332
-
Structure of a modular polyketide synthase
-
24965652, 4278352, F1000 Recommendation
-
Dutta S Whicher JR Hansen DA: Structure of a modular polyketide synthase. Nature. 2014;510(7506):512-7. 24965652 10.1038/nature13423 4278352 F1000 Recommendation
-
(2014)
Nature
, vol.510
, Issue.7506
, pp. 512-517
-
-
Dutta, S.1
Whicher, J.R.2
Hansen, D.A.3
-
76
-
-
84925355124
-
Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 system
-
25636838, 4357945
-
Jiang Y Chen B Duan C: Multigene editing in the Escherichia coli genome via the CRISPR-Cas9 system. Appl Environ Microbiol. 2015;81(7):2506-14. 25636838 10.1128/AEM.04023-14 4357945
-
(2015)
Appl Environ Microbiol
, vol.81
, Issue.7
, pp. 2506-2514
-
-
Jiang, Y.1
Chen, B.2
Duan, C.3
-
77
-
-
34147178365
-
Chimeras of two isoprenoid synthases catalyze all four coupling reactions in isoprenoid biosynthesis
-
17412950, F1000 Recommendation
-
Thulasiram HV Erickson HK Poulter CD: Chimeras of two isoprenoid synthases catalyze all four coupling reactions in isoprenoid biosynthesis. Science. 2007;316(5821):73-6. 17412950 10.1126/science.1137786 F1000 Recommendation
-
(2007)
Science
, vol.316
, Issue.5821
, pp. 73-76
-
-
Thulasiram, H.V.1
Erickson, H.K.2
Poulter, C.D.3
-
78
-
-
84879416874
-
Heterologous expression and characterization of bacterial 2-C-methyl-D-erythritol-4-phosphate pathway in Saccharomyces cerevisiae
-
23636690
-
Carlsen S Ajikumar PK Formenti LR: Heterologous expression and characterization of bacterial 2- C-methyl-D-erythritol-4-phosphate pathway in Saccharomyces cerevisiae. Appl Microbiol Biotechnol. 2013;97(13):5753-69. 23636690 10.1007/s00253-013-4877-y
-
(2013)
Appl Microbiol Biotechnol
, vol.97
, Issue.13
, pp. 5753-5769
-
-
Carlsen, S.1
Ajikumar, P.K.2
Formenti, L.R.3
-
79
-
-
77956371200
-
Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control
-
20643967, 2922259
-
Leonard E Ajikumar PK Thayer K: Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control. Proc Natl Acad Sci U S A. 2010;107(31):13654-9. 20643967 10.1073/pnas.1006138107 2922259
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.31
, pp. 13654-13659
-
-
Leonard, E.1
Ajikumar, P.K.2
Thayer, K.3
-
80
-
-
0038391517
-
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
-
12778056, F1000 Recommendation
-
Martin VJ Pitera DJ Withers ST: Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol. 2003;21(7):796-802. 12778056 10.1038/nbt833 F1000 Recommendation
-
(2003)
Nat Biotechnol
, vol.21
, Issue.7
, pp. 796-802
-
-
Martin, V.J.1
Pitera, D.J.2
Withers, S.T.3
-
81
-
-
76849089864
-
Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering
-
19777230, 2811251
-
Morrone D Lowry L Determan MK: Increasing diterpene yield with a modular metabolic engineering system in E. coli: comparison of MEV and MEP isoprenoid precursor pathway engineering. Appl Microbiol Biotechnol. 2010;85(6):1893-906. 19777230 10.1007/s00253-009-2219-x 2811251
-
(2010)
Appl Microbiol Biotechnol
, vol.85
, Issue.6
, pp. 1893-1906
-
-
Morrone, D.1
Lowry, L.2
Determan, M.K.3
-
82
-
-
84877892431
-
Engineered heterologous FPP synthases-mediated Z,E-FPP synthesis in E. coli
-
23608473
-
Wang C Zhou J Jang HJ: Engineered heterologous FPP synthases-mediated Z, E-FPP synthesis in E. coli. Metab Eng. 2013;18:53-9. 23608473 10.1016/j.ymben.2013.04.002
-
(2013)
Metab Eng
, vol.18
, pp. 53-59
-
-
Wang, C.1
Zhou, J.2
Jang, H.J.3
-
83
-
-
84899085998
-
Efficient synthesis of eriodictyol from L-tyrosine in Escherichia coli
-
24610848, 4018925
-
Zhu S Wu J Du G: Efficient synthesis of eriodictyol from L-tyrosine in Escherichia coli. Appl Environ Microbiol. 2014;80(10):3072-80. 24610848 10.1128/AEM.03986-13 4018925
-
(2014)
Appl Environ Microbiol
, vol.80
, Issue.10
, pp. 3072-3080
-
-
Zhu, S.1
Wu, J.2
Du, G.3
-
84
-
-
34547696794
-
Rational conversion of substrate and product specificity in a Salvia monoterpene synthase: structural insights into the evolution of terpene synthase function
-
17557809, 1955729
-
Kampranis SC Ioannidis D Purvis A: Rational conversion of substrate and product specificity in a Salvia monoterpene synthase: structural insights into the evolution of terpene synthase function. Plant Cell. 2007;19(6):1994-2005. 17557809 10.1105/tpc.106.047779 1955729
-
(2007)
Plant Cell
, vol.19
, Issue.6
, pp. 1994-2005
-
-
Kampranis, S.C.1
Ioannidis, D.2
Purvis, A.3
-
85
-
-
84908125451
-
Evolutionary and mechanistic insights from the reconstruction of α-humulene synthases from a modern (+)-germacrene A synthase
-
25230152
-
Gonzalez V Touchet S Grundy DJ: Evolutionary and mechanistic insights from the reconstruction of α-humulene synthases from a modern (+)-germacrene A synthase. J Am Chem Soc. 2014;136(41):14505-12. 25230152 10.1021/ja5066366
-
(2014)
J Am Chem Soc
, vol.136
, Issue.41
, pp. 14505-14512
-
-
Gonzalez, V.1
Touchet, S.2
Grundy, D.J.3
-
86
-
-
84889587004
-
Targeted Engineering of Cyclooctat-9-en-7-ol Synthase: A Stereospecific Access to Two New Non-natural Fusicoccane-Type Diterpenes
-
Gorner C Hauslein I Schrepfer P: Targeted Engineering of Cyclooctat-9-en-7-ol Synthase: A Stereospecific Access to Two New Non-natural Fusicoccane-Type Diterpenes. Chemcatchem. 2013;5(11):3289-3298. 10.1002/cctc.201300285
-
(2013)
Chemcatchem
, vol.5
, Issue.11
, pp. 3289-3298
-
-
Gorner, C.1
Hauslein, I.2
Schrepfer, P.3
-
87
-
-
42949168883
-
Increasing complexity of a diterpene synthase reaction with a single residue switch
-
18366162
-
Morrone D Xu M Fulton DB: Increasing complexity of a diterpene synthase reaction with a single residue switch. J Am Chem Soc. 2008;130(16):5400-1. 18366162 10.1021/ja710524w
-
(2008)
J Am Chem Soc
, vol.130
, Issue.16
, pp. 5400-5401
-
-
Morrone, D.1
Xu, M.2
Fulton, D.B.3
-
88
-
-
33646178621
-
Designed divergent evolution of enzyme function
-
16495946, F1000 Recommendation
-
Yoshikuni Y Ferrin TE Keasling JD: Designed divergent evolution of enzyme function. Nature. 2006;440(7087):1078-82. 16495946 10.1038/nature04607 F1000 Recommendation
-
(2006)
Nature
, vol.440
, Issue.7087
, pp. 1078-1082
-
-
Yoshikuni, Y.1
Ferrin, T.E.2
Keasling, J.D.3
-
89
-
-
84947988750
-
Emergence of terpene cyclization in Artemisia annua
-
25644758, 4327562, F1000 Recommendation
-
Salmon M Laurendon C Vardakou M: Emergence of terpene cyclization in Artemisia annua. Nat Commun. 2015;6: 6143. 25644758 10.1038/ncomms7143 4327562 F1000 Recommendation
-
(2015)
Nat Commun
, vol.6
-
-
Salmon, M.1
Laurendon, C.2
Vardakou, M.3
-
90
-
-
84937152625
-
Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase
-
25897591, 4570970, F1000 Recommendation
-
Rising KA Crenshaw CM Koo HJ: Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase. ACS Chem Biol. 2015;10(7):1729-36. 25897591 10.1021/acschembio.5b00145 4570970 F1000 Recommendation
-
(2015)
ACS Chem Biol
, vol.10
, Issue.7
, pp. 1729-1736
-
-
Rising, K.A.1
Crenshaw, C.M.2
Koo, H.J.3
-
91
-
-
84930928085
-
Plant diterpene synthases: exploring modularity and metabolic diversity for bioengineering
-
26003209
-
Zerbe P Bohlmann J: Plant diterpene synthases: exploring modularity and metabolic diversity for bioengineering. Trends Biotechnol. 2015;33(7):419-28. 26003209 10.1016/j.tibtech.2015.04.006
-
(2015)
Trends Biotechnol
, vol.33
, Issue.7
, pp. 419-428
-
-
Zerbe, P.1
Bohlmann, J.2
-
92
-
-
77957329119
-
Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli
-
20929806, 3034138, F1000 Recommendation
-
Ajikumar PK Xiao WH Tyo KE: Isoprenoid pathway optimization for Taxol precursor overproduction in Escherichia coli. Science. 2010;330(6000):70-4. 20929806 10.1126/science.1191652 3034138 F1000 Recommendation
-
(2010)
Science
, vol.330
, Issue.6000
, pp. 70-74
-
-
Ajikumar, P.K.1
Xiao, W.H.2
Tyo, K.E.3
-
93
-
-
84879142653
-
High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli
-
19221601, 2637983
-
Tsuruta H Paddon CJ Eng D: High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli. PLoS One. 2009;4(2):e4489. 19221601 10.1371/journal.pone.0004489 2637983
-
(2009)
PLoS One
, vol.4
, Issue.2
, pp. e4489
-
-
Tsuruta, H.1
Paddon, C.J.2
Eng, D.3
-
94
-
-
84920747664
-
Engineering validamycin production by tandem deletion of γ-butyrolactone receptor genes in Streptomyces hygroscopicus 5008
-
25527439, F1000 Recommendation
-
Tan GY Peng Y Lu C: Engineering validamycin production by tandem deletion of γ-butyrolactone receptor genes in Streptomyces hygroscopicus 5008. Metab Eng. 2015;28:74-81. 25527439 10.1016/j.ymben.2014.12.003 F1000 Recommendation
-
(2015)
Metab Eng
, vol.28
, pp. 74-81
-
-
Tan, G.Y.1
Peng, Y.2
Lu, C.3
-
95
-
-
84925244299
-
De novo production of the plant-derived alkaloid strictosidine in yeast
-
25675512, 4371906
-
Brown S Clastre M Courdavault V: De novo production of the plant-derived alkaloid strictosidine in yeast. Proc Natl Acad Sci U S A. 2015;112(11):3205-10. 25675512 10.1073/pnas.1423555112 4371906
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, Issue.11
, pp. 3205-3210
-
-
Brown, S.1
Clastre, M.2
Courdavault, V.3
-
96
-
-
84922212497
-
When plants produce not enough or at all: metabolic engineering of flavonoids in microbial hosts
-
25688249, 4310283
-
Trantas EA Koffas MA Xu P: When plants produce not enough or at all: metabolic engineering of flavonoids in microbial hosts. Front Plant Sci. 2015;6:7. 25688249 10.3389/fpls.2015.00007 4310283
-
(2015)
Front Plant Sci
, vol.6
, pp. 7
-
-
Trantas, E.A.1
Koffas, M.A.2
Xu, P.3
-
97
-
-
42549093749
-
Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms
-
18355030
-
Ajikumar PK Tyo K Carlsen S: Terpenoids: opportunities for biosynthesis of natural product drugs using engineered microorganisms. Mol Pharm. 2008;5(2):167-90. 18355030 10.1021/mp700151b
-
(2008)
Mol Pharm
, vol.5
, Issue.2
, pp. 167-190
-
-
Ajikumar, P.K.1
Tyo, K.2
Carlsen, S.3
-
98
-
-
83255174106
-
Relative potential of biosynthetic pathways for biofuels and bio-based products
-
22158355
-
Dugar D Stephanopoulos G: Relative potential of biosynthetic pathways for biofuels and bio-based products. Nat Biotechnol. 2011;29(12):1074-8. 22158355 10.1038/nbt.2055
-
(2011)
Nat Biotechnol
, vol.29
, Issue.12
, pp. 1074-1078
-
-
Dugar, D.1
Stephanopoulos, G.2
-
99
-
-
53049109464
-
De novo biosynthetic pathways: rational design of microbial chemical factories
-
18725289
-
Prather KL Martin CH: De novo biosynthetic pathways: rational design of microbial chemical factories. Curr Opin Biotechnol. 2008;19(5):468-74. 18725289 10.1016/j.copbio.2008.07.009
-
(2008)
Curr Opin Biotechnol
, vol.19
, Issue.5
, pp. 468-474
-
-
Prather, K.L.1
Martin, C.H.2
-
100
-
-
84926646130
-
Distributing a metabolic pathway among a microbial consortium enhances production of natural products
-
25558867
-
Zhou K Qiao K Edgar S: Distributing a metabolic pathway among a microbial consortium enhances production of natural products. Nat Biotechnol. 2015;33(4):377-83. 25558867 10.1038/nbt.3095
-
(2015)
Nat Biotechnol
, vol.33
, Issue.4
, pp. 377-383
-
-
Zhou, K.1
Qiao, K.2
Edgar, S.3
-
101
-
-
84877256074
-
Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols
-
23417095, 3659820
-
Avalos JL Fink GR Stephanopoulos G: Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols. Nat Biotechnol. 2013;31(4):335-41. 23417095 10.1038/nbt.2509 3659820
-
(2013)
Nat Biotechnol
, vol.31
, Issue.4
, pp. 335-341
-
-
Avalos, J.L.1
Fink, G.R.2
Stephanopoulos, G.3
-
102
-
-
80052030821
-
Harnessing yeast subcellular compartments for the production of plant terpenoids
-
21601648
-
Farhi M Marhevka E Masci T: Harnessing yeast subcellular compartments for the production of plant terpenoids. Metab Eng. 2011;13(5):474-81. 21601648 10.1016/j.ymben.2011.05.001
-
(2011)
Metab Eng
, vol.13
, Issue.5
, pp. 474-481
-
-
Farhi, M.1
Marhevka, E.2
Masci, T.3
-
103
-
-
84878928916
-
Untapped mutualistic paradigms linking host plant and endophytic fungal production of similar bioactive secondary metabolites
-
22954732
-
Kusari S Pandey SP Spiteller M: Untapped mutualistic paradigms linking host plant and endophytic fungal production of similar bioactive secondary metabolites. Phytochemistry. 2013;91:81-7. 22954732 10.1016/j.phytochem.2012.07.021
-
(2013)
Phytochemistry
, vol.91
, pp. 81-87
-
-
Kusari, S.1
Pandey, S.P.2
Spiteller, M.3
-
104
-
-
84920566739
-
A chemical ecogenomics approach to understand the roles of secondary metabolites in fungal cereal pathogens
-
25477876, 4237128
-
Chooi YH Solomon PS: A chemical ecogenomics approach to understand the roles of secondary metabolites in fungal cereal pathogens. Front Microbiol. 2014;5:640. 25477876 10.3389/fmicb.2014.00640 4237128
-
(2014)
Front Microbiol
, vol.5
, pp. 640
-
-
Chooi, Y.H.1
Solomon, P.S.2
-
105
-
-
84934955600
-
Large-Scale Evolutionary Analysis of Genes and Supergene Clusters from Terpenoid Modular Pathways Provides Insights into Metabolic Diversification in Flowering Plants
-
26046541, 4457800
-
Hofberger JA Ramirez AM Bergh Ev: Large-Scale Evolutionary Analysis of Genes and Supergene Clusters from Terpenoid Modular Pathways Provides Insights into Metabolic Diversification in Flowering Plants. PLoS One. 2015;10(6):e0128808. 26046541 10.1371/journal.pone.0128808 4457800
-
(2015)
PLoS One
, vol.10
, Issue.6
, pp. e0128808
-
-
Hofberger, J.A.1
Ramirez, A.M.2
Bergh, E.3
-
106
-
-
84859776222
-
The future of metabolic engineering and synthetic biology: towards a systematic practice
-
22629571, 3615475
-
Yadav VG De Mey M Lim CG: The future of metabolic engineering and synthetic biology: towards a systematic practice. Metab Eng. 2012;14(3):233-41. 22629571 10.1016/j.ymben.2012.02.001 3615475
-
(2012)
Metab Eng
, vol.14
, Issue.3
, pp. 233-241
-
-
Yadav, V.G.1
De Mey, M.2
Lim, C.G.3
-
107
-
-
84874517365
-
De Novo transcriptome assembly (NGS) of Curcuma longa L. rhizome reveals novel transcripts related to anticancer and antimalarial terpenoids
-
23468859, 3585318
-
Annadurai RS Neethiraj R Jayakumar V: De Novo transcriptome assembly (NGS) of Curcuma longa L. rhizome reveals novel transcripts related to anticancer and antimalarial terpenoids. PLoS One. 2013;8(2):e56217. 23468859 10.1371/journal.pone.0056217 3585318
-
(2013)
PLoS One
, vol.8
, Issue.2
, pp. e56217
-
-
Annadurai, R.S.1
Neethiraj, R.2
Jayakumar, V.3
-
108
-
-
84921496414
-
Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection
-
25554073
-
Guo F Xiang S Li L: Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection. Metab Eng. 2015;28:134-42. 25554073 10.1016/j.ymben.2014.12.006
-
(2015)
Metab Eng
, vol.28
, pp. 134-142
-
-
Guo, F.1
Xiang, S.2
Li, L.3
-
109
-
-
84937253653
-
Discovery of microbial natural products by activation of silent biosynthetic gene clusters
-
26119570
-
Rutledge PJ Challis GL: Discovery of microbial natural products by activation of silent biosynthetic gene clusters. Nat Rev Microbiol. 2015;13(8):509-23. 26119570 10.1038/nrmicro3496
-
(2015)
Nat Rev Microbiol
, vol.13
, Issue.8
, pp. 509-523
-
-
Rutledge, P.J.1
Challis, G.L.2
-
110
-
-
84940086904
-
Expression of heterologous sigma factors enables functional screening of metagenomic and heterologous genomic libraries
-
25944046, 4432631, F1000 Recommendation
-
Gaida SM Sandoval NR Nicolaou SA: Expression of heterologous sigma factors enables functional screening of metagenomic and heterologous genomic libraries. Nat Commun. 2015;6:7045. 25944046 10.1038/ncomms8045 4432631 F1000 Recommendation
-
(2015)
Nat Commun
, vol.6
, pp. 7045
-
-
Gaida, S.M.1
Sandoval, N.R.2
Nicolaou, S.A.3
-
111
-
-
84937604736
-
A portable expression resource for engineering cross-species genetic circuits and pathways
-
26184393, 4518296, F1000 Recommendation
-
Kushwaha M Salis HM: A portable expression resource for engineering cross-species genetic circuits and pathways. Nat Commun. 2015;6: 7832. 26184393 10.1038/ncomms8832 4518296 F1000 Recommendation
-
(2015)
Nat Commun
, vol.6
-
-
Kushwaha, M.1
Salis, H.M.2
-
112
-
-
84929493030
-
Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors
-
25831524, 4394318, F1000 Recommendation
-
Owen JG Charlop-Powers Z Smith AG: Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors. Proc Natl Acad Sci U S A. 2015;112(14):4221-6. 25831524 10.1073/pnas.1501124112 4394318 F1000 Recommendation
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, Issue.14
, pp. 4221-4226
-
-
Owen, J.G.1
Charlop-Powers, Z.2
Smith, A.G.3
-
113
-
-
84880370987
-
Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products
-
23824289, 3718090, F1000 Recommendation
-
Owen JG Reddy BV Ternei MA: Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products. Proc Natl Acad Sci U S A. 2013;110(29):11797-802. 23824289 10.1073/pnas.1222159110 3718090 F1000 Recommendation
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.29
, pp. 11797-11802
-
-
Owen, J.G.1
Reddy, B.V.2
Ternei, M.A.3
-
114
-
-
84893456760
-
Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A
-
24449899, 3918841, F1000 Recommendation
-
Yamanaka K Reynolds KA Kersten RD: Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc Natl Acad Sci U S A. 2014;111(5):1957-62. 24449899 10.1073/pnas.1319584111 3918841 F1000 Recommendation
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, Issue.5
, pp. 1957-1962
-
-
Yamanaka, K.1
Reynolds, K.A.2
Kersten, R.D.3
-
115
-
-
84931573824
-
An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose
-
25984720, F1000 Recommendation
-
DeLoache WC Russ ZN Narcross L: An enzyme-coupled biosensor enables ( S)-reticuline production in yeast from glucose. Nat Chem Biol. 2015;11(7):465-71. 25984720 10.1038/nchembio.1816 F1000 Recommendation
-
(2015)
Nat Chem Biol
, vol.11
, Issue.7
, pp. 465-471
-
-
DeLoache, W.C.1
Russ, Z.N.2
Narcross, L.3
-
116
-
-
84964694551
-
Engineered yeast paves way for home-brew heroin
-
25993934
-
Ehrenberg R: Engineered yeast paves way for home-brew heroin. Nature. 2015;521(7552):267-8. 25993934 10.1038/251267a
-
(2015)
Nature
, vol.521
, Issue.7552
, pp. 267-268
-
-
Ehrenberg, R.1
-
117
-
-
84923072157
-
Recent advances in combinatorial biosynthesis for drug discovery
-
25709407, 4334309
-
Sun H Liu Z Zhao H: Recent advances in combinatorial biosynthesis for drug discovery. Drug Des Devel Ther. 2015;9:823-33. 25709407 10.2147/DDDT.S63023 4334309
-
(2015)
Drug Des Devel Ther
, vol.9
, pp. 823-833
-
-
Sun, H.1
Liu, Z.2
Zhao, H.3
-
118
-
-
84939557642
-
Minimum Information about a Biosynthetic Gene cluster
-
26284661, F1000 Recommendation
-
Medema MH Kottmann R Yilmaz P: Minimum Information about a Biosynthetic Gene cluster. Nat Chem Biol. 2015;11(9):625-31. 26284661 10.1038/nchembio.1890 F1000 Recommendation
-
(2015)
Nat Chem Biol
, vol.11
, Issue.9
, pp. 625-631
-
-
Medema, M.H.1
Kottmann, R.2
Yilmaz, P.3
|