Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates

Applied and Environmental Microbiology

Volumn 77, Issue 14, 2011, Pages 4912-4923

  Han, Ah Reum ^a   Park, Je Won ^b,d   Lee, Mi Kyeong ^c   Ban, Yeon Hee ^b   Yoo, Young Ji ^b   Kim, Eun Ji ^b   Kim, Eunji ^b   Kim, Byung Gee ^a   Sohng, Jae Kyung ^d   Yoon, Yeo Joon ^b  

^a Seoul National University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Chungbuk National University   (South Korea)

^d SunMoon University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AGLYCONES; ANTHRACYCLINES; ANTI-CANCER AGENTS; ANTICANCER DRUG; BIOSYNTHETIC ENZYMES; CHEMICAL SYNTHESIS; COMPLEX SUGARS; DAUNORUBICIN; DEOXYSUGAR; DOXORUBICIN; EPIRUBICIN; GLYCOSYL TRANSFERASE; GLYCOSYLATED; POLYKETIDES; SIDE EFFECT; STREPTOMYCES VENEZUELAE;

BACTERIA; BIOCHEMISTRY; DRUG INTERACTIONS; KETONES; SUGARS;

BIOSYNTHESIS;

ANTHRACYCLINE; DAUNORUBICIN; DOXORUBICIN; EPIRUBICIN; GLYCOSYLTRANSFERASE; RHODOMYCIN; RHODOMYCINONE;

BACTERIUM; DRUG; ENZYME ACTIVITY; MICROBIAL ACTIVITY; MUTATION; SUGAR;

ARTICLE; CHEMISTRY; GENETIC ENGINEERING; GENETICS; GLYCOSYLATION; METABOLISM; MULTIGENE FAMILY; PLASMID; STREPTOMYCES;

ANTHRACYCLINES; DAUNORUBICIN; DOXORUBICIN; EPIRUBICIN; GENETIC ENGINEERING; GLYCOSYLATION; GLYCOSYLTRANSFERASES; MULTIGENE FAMILY; PLASMIDS; STREPTOMYCES;

STREPTOMYCES VENEZUELAE;

EID: 79961051540     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.02527-10     Document Type: Article

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