Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 34, 2014, Pages 12354-12359

  Xu, Yuquan ^a,b   Zhou, Tong ^c   Zhang, Shuwei ^c   Espinosa Artiles, Patricia ^b   Wang, Luoyi ^c   Zhang, Wei ^a   Lin, Min ^a   Gunatilaka, A A Leslie ^b   Zhan, Jixun ^c   Molnár, István ^b  

^a INSTITUTE OF PLANT PROTECTION   (China)

^b UNIVERSITY OF ARIZONA   (United States)

^c Utah State University   (United States)

Author keywords

Fungal genetics; Secondary metabolites

Indexed keywords

ANTINEOPLASTIC AGENT; BENZENEDIOL LACTONE; DOXORUBICIN; LACTONE DERIVATIVE; MONOCILLIN I; POLYKETIDE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; LACTONE; PROTEIN SUBUNIT; RECOMBINANT PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN;

ALDOL REACTION; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOSYNTHESIS; CANCER CELL LINE; CATALYST; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HEAT SHOCK RESPONSE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; ANIMAL; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; PROCEDURES; PROTEIN SUBUNIT; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; COMBINATORIAL CHEMISTRY TECHNIQUES; HEAT-SHOCK RESPONSE; HUMANS; LACTONES; MICE; POLYKETIDE SYNTHASES; POLYKETIDES; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84906672709     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1406999111     Document Type: Article

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