Mechanism and specificity of an acyltransferase domain from a modular polyketide synthase

Biochemistry

Volumn 52, Issue 11, 2013, Pages 1839-1841

  Dunn, Briana J ^a   Cane, David E ^c   Khosla, Chaitan ^a,b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL CARRIER PROTEINS; ACYLTRANSFERASE; ALTERNATIVE SUBSTRATES; DOMAIN SPECIFICITY; NATURAL SUBSTRATES; POLYKETIDE SYNTHASES;

REACTION INTERMEDIATES; SUBSTRATES;

PLANTS (BOTANY);

ACYL CARRIER PROTEIN; ACYLTRANSFERASE; MALONYL COENZYME A; PANTETHEINE; POLYKETIDE SYNTHASE;

ACYLATION; ARTICLE; CATALYSIS; ELECTROPHILICITY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROLYSIS; KINETICS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN INTERACTION;

ACYL COENZYME A; ACYLTRANSFERASES; POLYKETIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY; SACCHAROPOLYSPORA; SUBSTRATE SPECIFICITY;

EID: 84875459266     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400185v     Document Type: Article

References (16)

1. Khosla, C., Gokhale, R. S., Jacobsen, J. R., and Cane, D. E. (1999) Annu. Rev. Biochem. 68, 219-253
2. Oliynyk, M., Brown, M. J., Cortes, J., Staunton, J., and Leadlay, P. F. (1996) Chem. Biol. 3, 833-839
3. Lau, J., Fu, H., Cane, D. E., and Khosla, C. (1999) Biochemistry 38, 1643-1651
4. Stassi, D. L., Kakavas, S. J., Reynolds, K. A., Gunawardana, G., Swanson, S., Zeidner, D., Jackson, M., Liu, H., Buko, A., and Katz, L. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 7305-7309
5. Ruan, X., Pereda, A., Stassi, D. L., Zeidner, D., Summers, R. G., Jackson, M., Shivakumar, A., Kakavas, S., Staver, M., Donadio, S., and Katz, L. (1997) J. Bacteriol. 179, 6416-6425
6. Hans, M., Hornung, A., Dziarnowski, A., Cane, D. E., and Khosla, C. (2003) J. Am. Chem. Soc. 125, 5366-5374
7. Tang, Y., Kim, C. Y., Mathews, I. I., Cane, D. E., and Khosla, C. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 11124-11129
8. Tang, Y., Chen, A. Y., Kim, C. Y., Cane, D. E., and Khosla, C. (2007) Chem. Biol. 14, 931-943
9. Reeves, C. D., Murli, S., Ashley, G. W., Piagentini, M., Hutchinson, C. R., and McDaniel, R. (2001) Biochemistry 40, 15464-15470
10. Sundermann, U., Bravo-Rodriguez, K., Klopries, S., Kushnir, S., Gomez, H., Sanchez-Garcia, E., and Schulz, F. (2013) ACS Chem. Biol. 8, 443-450
11. Khosla, C., Tang, Y., Chen, A. Y., Schnarr, N. A., and Cane, D. E. (2007) Annu. Rev. Biochem. 76, 195-221
12. Molnos, J., Gardiner, R., Dale, G. E., and Lange, R. (2003) Anal. Biochem. 319, 171-176
13. Chen, A. Y., Cane, D. E., and Khosla, C. (2007) Chem. Biol. 14, 784-792
14. Bonnett, S. A., Rath, C. M., Shareef, A. R., Joels, J. R., Chemler, J. A., Hakansson, K., Reynolds, K., and Sherman, D. H. (2011) Chem. Biol. 18, 1075-1081
15. Wu, N., Cane, D. E., and Khosla, C. (2002) Biochemistry 41, 5056-5066
16. Chen, A. Y., Schnarr, N. A., Kim, C. Y., Cane, D. E., and Khosla, C. (2006) J. Am. Chem. Soc. 128, 3067-3074