Improved cyclopropanation activity of histidine-ligated cytochromeP450 enables the enantioselective formal synthesis of levomilnacipran

Angewandte Chemie - International Edition

Volumn 53, Issue 26, 2014, Pages 6810-6813

  Wang, Z Jane ^a   Renata, Hans ^a   Peck, Nicole E ^a   Farwell, Christopher C ^a   Coelho, Pedro S ^a   Arnold, Frances H ^a  

^a California Institute of Technology   (United States)

Author keywords

biocatalysis; cyclopropanation; cytochromeP450; enzymes; protein engineering

Indexed keywords

AMINO ACIDS; BACTERIOLOGY; ELECTRONIC PROPERTIES; ENANTIOSELECTIVITY; ENZYMES; LIGANDS; SUBSTRATES; SYNTHESIS (CHEMICAL);

BACILLUS MEGATERIUM; BIOCATALYSIS; CYCLOPROPANATION; CYTOCHROMEP450; ENANTIOSELECTIVE CATALYSTS; ENANTIOSELECTIVE SYNTHESIS; NATURAL SUBSTRATES; PROTEIN ENGINEERING;

BIOCHEMICAL ENGINEERING;

CYCLOPROPANE; CYCLOPROPANE DERIVATIVE; CYTOCHROME P450; ENZYME; HISTIDINE; MILNACIPRAN;

BACILLUS MEGATERIUM; CHEMISTRY; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; METABOLISM; PROTEIN ENGINEERING; SITE DIRECTED MUTAGENESIS; STEREOISOMERISM; SYNTHESIS;

BACILLUS MEGATERIUM; CATALYTIC DOMAIN; CYCLOPROPANES; CYTOCHROME P-450 ENZYME SYSTEM; ENZYMES; HISTIDINE; MUTAGENESIS, SITE-DIRECTED; PROTEIN ENGINEERING; STEREOISOMERISM;

EID: 84903168457     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201402809     Document Type: Article

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