Recent advances in combinatorial biosynthesis for drug discovery

Drug Design, Development and Therapy

Volumn 9, Issue , 2015, Pages 823-833

  Sun, Huihua ^a   Liu, Zihe ^a   Zhao, Huimin ^a,b   Ang, Ee Lui ^a  

^a INSTITUTE OF CHEMICAL AND ENGINEERING SCIENCES   (Singapore)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Biosynthetic pathways; Combinatorial biosynthesis; Drug discovery; Natural products; Nonribosomal peptide synthetases; Polyketide synthases

Indexed keywords

ANDRIMID; ANTIBIOTIC AGENT; BACILLIBACTIN; BLEOMYCIN; CYCLOSPORIN A; DACTINOMYCIN; DAPTOMYCIN; DIAZEPINOMICIN DERIVATIVE; DOXORUBICIN DERIVATIVE; ERYTHROMYCIN DERIVATIVE; GILVOCARCIN DERIVATIVE; MACROLIDE; MALONIC ACID DERIVATIVE; MITHRAMYCIN DERIVATIVE; NARBOMYCIN; NONRIBOSOMAL PEPTIDE SYNTHETASE; PACIDAMYCIN DERIVATIVE; POLYKETIDE; POLYKETIDE SYNTHASE; PREMONENSIN DERIVATIVE; RADILARIN; SALINOSPORAMIDE A; SANSANMYCIN DERIVATIVE; SAPONIN; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; ENZYME;

DRUG BINDING; DRUG DEVELOPMENT; DRUG SYNTHESIS; ENZYME MODIFICATION; HUMAN; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; CHEMISTRY; METABOLISM;

BIOLOGICAL PRODUCTS; DRUG DISCOVERY; ENZYMES; HUMANS;

EID: 84923072157     PISSN: 11778881     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S63023     Document Type: Review

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