Evolution of Efficient Modular Polyketide Synthases by Homologous Recombination

Journal of the American Chemical Society

Volumn 137, Issue 33, 2015, Pages 10603-10609

  Chemler, Joseph A ^a,d   Tripathi, Ashootosh ^a   Hansen, Douglas A ^a   O'Neil Johnson, Mark ^c   Williams, Russell B ^c   Starks, Courtney ^c   Park, Sung Ryeol ^a   Sherman, David H ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c Sequoia Sciences Inc   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; DRUG PRODUCTS; KETONES; METABOLITES; MODULAR CONSTRUCTION; PLANTS (BOTANY); YEAST;

HOMOLOGOUS RECOMBINATION; HYBRID LIBRARIES; MODULAR BUILDINGS; PLASMID PURIFICATION; POLYKETIDE SYNTHASES; PROTEIN EXPRESSIONS; STREPTOMYCES VENEZUELAE; VERSATILE METHODS;

ENZYMES;

3 DEHYDRO 10 DEOXYMETHYNOLIDE; DIHYDROPIKROMYCIN; ERYTHROMYCIN; MACROLIDE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; PIKROMYCIN;

ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ENGINEERING; ENZYME KINETICS; ESCHERICHIA COLI; HOMOLOGOUS RECOMBINATION; HYBRID GENE; IN VITRO STUDY; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; STREPTOMYCES VENEZUELAE; GENETICS; METABOLISM; PROTEIN ENGINEERING; STREPTOMYCES;

ERYTHROMYCIN; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; HOMOLOGOUS RECOMBINATION; MACROLIDES; POLYKETIDE SYNTHASES; PROTEIN ENGINEERING; SACCHAROMYCES CEREVISIAE; STREPTOMYCES;

EID: 84941730383     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b04842     Document Type: Article

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