Rational design of modular polyketide synthases: Morphing the aureothin pathway into a luteoreticulin assembly line

Angewandte Chemie - International Edition

Volumn 53, Issue 6, 2014, Pages 1560-1564

  Sugimoto, Yuki ^a   Ding, Ling ^a   Ishida, Keishi ^a   Hertweck, Christian ^a,b  

^a HANS KNÖLL INSTITUTE   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

biosynthesis; evolution; polyketide synthases; polypropionates; Streptomyces thioluteus

Indexed keywords

BIOSYNTHESIS GENE CLUSTER; EVOLUTION; EVOLUTIONARY PROCESS; GENETIC RECOMBINATIONS; POLYKETIDE SYNTHASES; POLYPROPIONATES; STREPTOMYCES SPECIES; STREPTOMYCES THIOLUTEUS;

ASSEMBLY; ASSEMBLY MACHINES; BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; GENES; KETONES;

PLANTS (BOTANY);

AUREOTHAN; CHROMONE DERIVATIVE; LUTEORETICULIN; METHYLTRANSFERASE; POLYKETIDE SYNTHASE; PYRONE DERIVATIVE;

ARTICLE; BIOSYNTHESIS; CHEMISTRY; EVOLUTION; METABOLISM; MULTIGENE FAMILY; POLYPROPIONATES; STEREOISOMERISM; STREPTOMYCES; STREPTOMYCES THIOLUTEUS;

BIOSYNTHESIS; EVOLUTION; POLYKETIDE SYNTHASES; POLYPROPIONATES; STREPTOMYCES THIOLUTEUS;

CHROMONES; METHYLTRANSFERASES; MULTIGENE FAMILY; POLYKETIDE SYNTHASES; PYRONES; STEREOISOMERISM; STREPTOMYCES;

EID: 84893465357     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201308176     Document Type: Article

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