Engineering validamycin production by tandem deletion of γ-butyrolactone receptor genes in Streptomyces hygroscopicus 5008

Metabolic Engineering

Volumn 28, Issue , 2015, Pages 74-81

  Tan, Gao Yi ^a,b   Peng, Yao ^a   Lu, Chenyang ^a   Bai, Linquan ^a   Zhong, Jian Jiang ^a,c  

^a Shanghai Jiao Tong University   (China)

^b WUHAN UNIVERSITY   (China)

^c EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antibiotic fermentation; Engineering; Secondary metabolism regulation; Streptomyces; Tandem deletion; butyrolactone regulatory system

Indexed keywords

ANTIBIOTICS; BACTERIA; BIOCHEMISTRY; BIOSYNTHESIS; ENGINEERING; METABOLISM; SUBSTRATES;

ANTIBIOTIC FERMENTATION; REGULATORY SYSTEMS; SECONDARY METABOLISM; STREPTOMYCES; TANDEM DELETION;

GENES;

ABC TRANSPORTER; GAMMA BUTYROLACTONE; GLUTAMATE AMMONIA LIGASE; OXOGLUTARATE DEHYDROGENASE; VALIDAMYCIN DERIVATIVE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4-BUTYROLACTONE RECEPTOR; ANTIFUNGAL AGENT; BACTERIAL PROTEIN; INOSITOL; VALIDAMYCINS;

ARTICLE; BACTERIAL STRAIN; BIOSYNTHESIS; FERMENTATION; GENE CLUSTER; GENE DELETION; HOUSEKEEPING GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR GENE; REGULATOR GENE; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SECONDARY METABOLISM; STREPTOMYCES HYGROSCOPICUS; ANALOGS AND DERIVATIVES; BACTERIAL GENE; GENETICS; METABOLISM; STREPTOMYCES;

STREPTOMYCES; STREPTOMYCES HYGROSCOPICUS;

ANTIFUNGAL AGENTS; BACTERIAL PROTEINS; GENE DELETION; GENES, BACTERIAL; INOSITOL; RECEPTORS, GABA-A; STREPTOMYCES;

EID: 84920747664     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2014.12.003     Document Type: Article

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