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Volumn 20, Issue , 2013, Pages 92-100

Deoxysugar pathway interchange for erythromycin analogues heterologously produced through Escherichia coli

Author keywords

Analogue; Antibiotic; Deoxysugar; E. coli; Erythromycin

Indexed keywords

ANTIBIOTICS; BIOSYNTHESIS; ESCHERICHIA COLI; KETONES;

EID: 84885028788     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2013.09.005     Document Type: Article
Times cited : (17)

References (63)
  • 1
    • 33845709126 scopus 로고    scopus 로고
    • Molecular engineering approaches to peptide, polyketide and other antibiotics
    • Baltz R.H. Molecular engineering approaches to peptide, polyketide and other antibiotics. Nat. Biotechnol. 2006, 24:1533-1540.
    • (2006) Nat. Biotechnol. , vol.24 , pp. 1533-1540
    • Baltz, R.H.1
  • 2
    • 0035075686 scopus 로고    scopus 로고
    • Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin
    • Blanco G., Patallo E.P., Brana A.F., Trefzer A., Bechthold A., Rohr J., Mendez C., Salas J.A. Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin. Chem. Biol. 2001, 8:253-263.
    • (2001) Chem. Biol. , vol.8 , pp. 253-263
    • Blanco, G.1    Patallo, E.P.2    Brana, A.F.3    Trefzer, A.4    Bechthold, A.5    Rohr, J.6    Mendez, C.7    Salas, J.A.8
  • 3
    • 76749097100 scopus 로고    scopus 로고
    • Metabolic flux analysis and pharmaceutical production
    • Boghigian B.A., Seth G., Kiss R., Pfeifer B.A. Metabolic flux analysis and pharmaceutical production. Metab. Eng. 2010, 12:81-95.
    • (2010) Metab. Eng. , vol.12 , pp. 81-95
    • Boghigian, B.A.1    Seth, G.2    Kiss, R.3    Pfeifer, B.A.4
  • 4
    • 33746211329 scopus 로고    scopus 로고
    • Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses
    • Borisova S.A., Zhang C., Takahashi H., Zhang H., Wong A.W., Thorson J.S., Liu H.W. Substrate specificity of the macrolide-glycosylating enzyme pair DesVII/DesVIII: opportunities, limitations, and mechanistic hypotheses. Angew. Chem. Int. Ed. Engl. 2006, 45:2748-2753.
    • (2006) Angew. Chem. Int. Ed. Engl. , vol.45 , pp. 2748-2753
    • Borisova, S.A.1    Zhang, C.2    Takahashi, H.3    Zhang, H.4    Wong, A.W.5    Thorson, J.S.6    Liu, H.W.7
  • 5
    • 2542527641 scopus 로고    scopus 로고
    • Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics
    • Borisova S.A., Zhao L., Melancon I.C., Kao C.L., Liu H.W. Characterization of the glycosyltransferase activity of desVII: analysis of and implications for the biosynthesis of macrolide antibiotics. J. Am. Chem. Soc. 2004, 126:6534-6535.
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 6534-6535
    • Borisova, S.A.1    Zhao, L.2    Melancon, I.C.3    Kao, C.L.4    Liu, H.W.5
  • 7
    • 84862207929 scopus 로고    scopus 로고
    • Expanding the chemical palate of cells by combining systems biology and metabolic engineering
    • Curran K.A., Alper H. Expanding the chemical palate of cells by combining systems biology and metabolic engineering. Metab. Eng. 2012, 14:289-297.
    • (2012) Metab. Eng. , vol.14 , pp. 289-297
    • Curran, K.A.1    Alper, H.2
  • 8
    • 0033404581 scopus 로고    scopus 로고
    • Interspecies complementation in Saccharopolyspora erythraea: elucidation of the function of oleP1, oleG1 and oleG2 from the oleandomycin biosynthetic gene cluster of Streptomyces antibioticus and generation of new erythromycin derivatives
    • Doumith M., Legrand R., Lang C., Salas J.A., Raynal M.C. Interspecies complementation in Saccharopolyspora erythraea: elucidation of the function of oleP1, oleG1 and oleG2 from the oleandomycin biosynthetic gene cluster of Streptomyces antibioticus and generation of new erythromycin derivatives. Mol. Microbiol. 1999, 34:1039-1048.
    • (1999) Mol. Microbiol. , vol.34 , pp. 1039-1048
    • Doumith, M.1    Legrand, R.2    Lang, C.3    Salas, J.A.4    Raynal, M.C.5
  • 11
    • 79961051540 scopus 로고    scopus 로고
    • Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates
    • Han A.R., Park J.W., Lee M.K., Ban Y.H., Yoo Y.J., Kim E.J., Kim E., Kim B.G., Sohng J.K., Yoon Y.J. Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates. Appl. Environ. Microbiol. 2011, 77:4912-4923.
    • (2011) Appl. Environ. Microbiol. , vol.77 , pp. 4912-4923
    • Han, A.R.1    Park, J.W.2    Lee, M.K.3    Ban, Y.H.4    Yoo, Y.J.5    Kim, E.J.6    Kim, E.7    Kim, B.G.8    Sohng, J.K.9    Yoon, Y.J.10
  • 14
    • 0242515829 scopus 로고    scopus 로고
    • The C-glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses
    • Hoffmeister D., Drager G., Ichinose K., Rohr J., Bechthold A. The C-glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses. J. Am. Chem. Soc. 2003, 125:4678-4679.
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 4678-4679
    • Hoffmeister, D.1    Drager, G.2    Ichinose, K.3    Rohr, J.4    Bechthold, A.5
  • 15
    • 4444246615 scopus 로고    scopus 로고
    • New olivosyl derivatives of methymycin/pikromycin from an engineered strain of Streptomyces venezuelae
    • Hong J.S., Park S.H., Choi C.Y., Sohng J.K., Yoon Y.J. New olivosyl derivatives of methymycin/pikromycin from an engineered strain of Streptomyces venezuelae. FEMS Microbiol. Lett. 2004, 238:391-399.
    • (2004) FEMS Microbiol. Lett. , vol.238 , pp. 391-399
    • Hong, J.S.1    Park, S.H.2    Choi, C.Y.3    Sohng, J.K.4    Yoon, Y.J.5
  • 16
    • 33845512079 scopus 로고    scopus 로고
    • Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation
    • Hong J.S., Park S.J., Parajuli N., Park S.R., Koh H.S., Jung W.S., Choi C.Y., Yoon Y.J. Functional analysis of desVIII homologues involved in glycosylation of macrolide antibiotics by interspecies complementation. Gene 2007, 386:123-130.
    • (2007) Gene , vol.386 , pp. 123-130
    • Hong, J.S.1    Park, S.J.2    Parajuli, N.3    Park, S.R.4    Koh, H.S.5    Jung, W.S.6    Choi, C.Y.7    Yoon, Y.J.8
  • 17
    • 84879825498 scopus 로고    scopus 로고
    • Metabolic and pathway engineering to influence native and altered erythromycin production through E. coli
    • Jiang M., Pfeifer B.A. Metabolic and pathway engineering to influence native and altered erythromycin production through E. coli. Metab. Eng. 2013, 19:42-49.
    • (2013) Metab. Eng. , vol.19 , pp. 42-49
    • Jiang, M.1    Pfeifer, B.A.2
  • 18
    • 0027932534 scopus 로고
    • Engineered biosynthesis of a complete macrolactone in a heterologous host
    • Kao C.M., Katz L., Khosla C. Engineered biosynthesis of a complete macrolactone in a heterologous host. Science 1994, 265:509-512.
    • (1994) Science , vol.265 , pp. 509-512
    • Kao, C.M.1    Katz, L.2    Khosla, C.3
  • 19
    • 37549038629 scopus 로고    scopus 로고
    • Where chemistry meets biology: the chemoenzymatic synthesis of nonribosomal peptides and polyketides
    • Kopp F., Marahiel M.A. Where chemistry meets biology: the chemoenzymatic synthesis of nonribosomal peptides and polyketides. Curr. Opin. Biotechnol. 2007, 18:513-520.
    • (2007) Curr. Opin. Biotechnol. , vol.18 , pp. 513-520
    • Kopp, F.1    Marahiel, M.A.2
  • 20
    • 4043053572 scopus 로고    scopus 로고
    • Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway
    • Lee H.Y., Chung H.S., Hang C., Khosla C., Walsh C.T., Kahne D., Walker S. Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway. J. Am. Chem. Soc. 2004, 126:9924-9925.
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 9924-9925
    • Lee, H.Y.1    Chung, H.S.2    Hang, C.3    Khosla, C.4    Walsh, C.T.5    Kahne, D.6    Walker, S.7
  • 21
    • 79251603379 scopus 로고    scopus 로고
    • Improved precursor-directed biosynthesis in E. coli via directed evolution
    • Lee H.Y., Harvey C.J., Cane D.E., Khosla C. Improved precursor-directed biosynthesis in E. coli via directed evolution. J. Antibiot. (Tokyo) 2011, 64:59-64.
    • (2011) J. Antibiot. (Tokyo) , vol.64 , pp. 59-64
    • Lee, H.Y.1    Harvey, C.J.2    Cane, D.E.3    Khosla, C.4
  • 22
    • 33847000219 scopus 로고    scopus 로고
    • Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli
    • Lee H.Y., Khosla C. Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli. PLoS Biol. 2007, 5:e45.
    • (2007) PLoS Biol. , vol.5
    • Lee, H.Y.1    Khosla, C.2
  • 23
    • 19544377358 scopus 로고    scopus 로고
    • AknT is an activating protein for the glycosyltransferase AknS in l-aminodeoxysugar transfer to the aglycone of aclacinomycin A
    • Lu W., Leimkuhler C., Gatto G.J., Kruger R.G., Oberthur M., Kahne D., Walsh C.T. AknT is an activating protein for the glycosyltransferase AknS in l-aminodeoxysugar transfer to the aglycone of aclacinomycin A. Chem. Biol. 2005, 12:527-534.
    • (2005) Chem. Biol. , vol.12 , pp. 527-534
    • Lu, W.1    Leimkuhler, C.2    Gatto, G.J.3    Kruger, R.G.4    Oberthur, M.5    Kahne, D.6    Walsh, C.T.7
  • 25
    • 0033515090 scopus 로고    scopus 로고
    • Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products
    • McDaniel R., Thamchaipenet A., Gustafsson C., Fu H., Betlach M., Ashley G. Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. Proc. Natl. Acad. Sci. USA 1999, 96:1846-1851.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 1846-1851
    • McDaniel, R.1    Thamchaipenet, A.2    Gustafsson, C.3    Fu, H.4    Betlach, M.5    Ashley, G.6
  • 26
    • 68949159560 scopus 로고    scopus 로고
    • The chemical biology of modular biosynthetic enzymes
    • Meier J.L., Burkart M.D. The chemical biology of modular biosynthetic enzymes. Chem. Soc. Rev. 2009, 38:2012-2045.
    • (2009) Chem. Soc. Rev. , vol.38 , pp. 2012-2045
    • Meier, J.L.1    Burkart, M.D.2
  • 27
    • 11244310524 scopus 로고    scopus 로고
    • Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesis
    • Melancon C.E., Takahashi H., Liu H.W. Characterization of tylM3/tylM2 and mydC/mycB pairs required for efficient glycosyltransfer in macrolide antibiotic biosynthesis. J. Am. Chem. Soc. 2004, 126:16726-16727.
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 16726-16727
    • Melancon, C.E.1    Takahashi, H.2    Liu, H.W.3
  • 28
    • 34250704344 scopus 로고    scopus 로고
    • Combinatorial biosynthesis for drug development
    • Menzella H.G., Reeves C.D. Combinatorial biosynthesis for drug development. Curr. Opin. Microbiol. 2007, 10:238-245.
    • (2007) Curr. Opin. Microbiol. , vol.10 , pp. 238-245
    • Menzella, H.G.1    Reeves, C.D.2
  • 29
    • 1642364447 scopus 로고    scopus 로고
    • Biosynthesis of deoxyaminosugars in antibiotic-producing bacteria
    • Nedal A., Zotchev S.B. Biosynthesis of deoxyaminosugars in antibiotic-producing bacteria. Appl. Microbiol. Biotechnol. 2004, 64:7-15.
    • (2004) Appl. Microbiol. Biotechnol. , vol.64 , pp. 7-15
    • Nedal, A.1    Zotchev, S.B.2
  • 30
    • 50249084003 scopus 로고    scopus 로고
    • Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering
    • Olano C., Lombo F., Mendez C., Salas J.A. Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering. Metab. Eng. 2008, 10:281-292.
    • (2008) Metab. Eng. , vol.10 , pp. 281-292
    • Olano, C.1    Lombo, F.2    Mendez, C.3    Salas, J.A.4
  • 31
    • 77950127253 scopus 로고    scopus 로고
    • Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis
    • Olano C., Mendez C., Salas J.A. Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis. Nat. Prod. Rep. 2010, 27:571-616.
    • (2010) Nat. Prod. Rep. , vol.27 , pp. 571-616
    • Olano, C.1    Mendez, C.2    Salas, J.A.3
  • 32
    • 58549102566 scopus 로고    scopus 로고
    • Expanding substrate specificity of GT-B fold glycosyltransferase via domain swapping and high-throughput screening
    • Park S.H., Park H.Y., Sohng J.K., Lee H.C., Liou K., Yoon Y.J., Kim B.G. Expanding substrate specificity of GT-B fold glycosyltransferase via domain swapping and high-throughput screening. Biotechnol. Bioeng. 2009, 102:988-994.
    • (2009) Biotechnol. Bioeng. , vol.102 , pp. 988-994
    • Park, S.H.1    Park, H.Y.2    Sohng, J.K.3    Lee, H.C.4    Liou, K.5    Yoon, Y.J.6    Kim, B.G.7
  • 33
    • 0025355803 scopus 로고
    • Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli
    • Paulus T.J., Tuan J.S., Luebke V.E., Maine G.T., DeWitt J.P., Katz L. Mutation and cloning of eryG, the structural gene for erythromycin O-methyltransferase from Saccharopolyspora erythraea, and expression of eryG in Escherichia coli. J. Bacteriol. 1990, 172:2541-2546.
    • (1990) J. Bacteriol. , vol.172 , pp. 2541-2546
    • Paulus, T.J.1    Tuan, J.S.2    Luebke, V.E.3    Maine, G.T.4    DeWitt, J.P.5    Katz, L.6
  • 34
  • 35
    • 0035793858 scopus 로고    scopus 로고
    • Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli
    • Pfeifer B.A., Admiraal S.J., Gramajo H., Cane D.E., Khosla C. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science 2001, 291:1790-1792.
    • (2001) Science , vol.291 , pp. 1790-1792
    • Pfeifer, B.A.1    Admiraal, S.J.2    Gramajo, H.3    Cane, D.E.4    Khosla, C.5
  • 36
    • 34249301015 scopus 로고    scopus 로고
    • Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production
    • Reeves A.R., Brikun I.A., Cernota W.H., Leach B.I., Gonzalez M.C., Weber J.M. Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production. Metab. Eng. 2007, 9:293-303.
    • (2007) Metab. Eng. , vol.9 , pp. 293-303
    • Reeves, A.R.1    Brikun, I.A.2    Cernota, W.H.3    Leach, B.I.4    Gonzalez, M.C.5    Weber, J.M.6
  • 37
    • 33645101170 scopus 로고    scopus 로고
    • In vivo characterization of the dTDP-d-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea
    • Rodriguez E., Peiru S., Carney J.R., Gramajo H. In vivo characterization of the dTDP-d-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea. Microbiology 2006, 152:667-673.
    • (2006) Microbiology , vol.152 , pp. 667-673
    • Rodriguez, E.1    Peiru, S.2    Carney, J.R.3    Gramajo, H.4
  • 38
    • 0031981439 scopus 로고    scopus 로고
    • Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea
    • Salah-Bey K., Doumith M., Michel J.M., Haydock S., Cortes J., Leadlay P.F., Raynal M.C. Targeted gene inactivation for the elucidation of deoxysugar biosynthesis in the erythromycin producer Saccharopolyspora erythraea. Mol. Gen. Genet. 1998, 257:542-553.
    • (1998) Mol. Gen. Genet. , vol.257 , pp. 542-553
    • Salah-Bey, K.1    Doumith, M.2    Michel, J.M.3    Haydock, S.4    Cortes, J.5    Leadlay, P.F.6    Raynal, M.C.7
  • 41
    • 34848843433 scopus 로고    scopus 로고
    • The type I fatty acid and polyketide synthases: a tale of two megasynthases
    • Smith S., Tsai S.C. The type I fatty acid and polyketide synthases: a tale of two megasynthases. Nat. Prod. Rep. 2007, 24:1041-1072.
    • (2007) Nat. Prod. Rep. , vol.24 , pp. 1041-1072
    • Smith, S.1    Tsai, S.C.2
  • 42
    • 0027455631 scopus 로고
    • Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis
    • Stassi D., Donadio S., Staver M.J., Katz L. Identification of a Saccharopolyspora erythraea gene required for the final hydroxylation step in erythromycin biosynthesis. J. Bacteriol. 1993, 175:182-189.
    • (1993) J. Bacteriol. , vol.175 , pp. 182-189
    • Stassi, D.1    Donadio, S.2    Staver, M.J.3    Katz, L.4
  • 43
    • 0030831132 scopus 로고    scopus 로고
    • Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in l-mycarose and d-desosamine production
    • Summers R.G., Donadio S., Staver M.J., Wendt-Pienkowski E., Hutchinson C.R., Katz L. Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in l-mycarose and d-desosamine production. Microbiology 1997, 143(Pt 10):3251-3262.
    • (1997) Microbiology , vol.143 , Issue.PART 10 , pp. 3251-3262
    • Summers, R.G.1    Donadio, S.2    Staver, M.J.3    Wendt-Pienkowski, E.4    Hutchinson, C.R.5    Katz, L.6
  • 44
    • 27444445135 scopus 로고    scopus 로고
    • Biosynthesis of TDP-d-desosamine: identification of a strategy for C4 deoxygenation
    • Szu P.H., He X., Zhao L., Liu H.W. Biosynthesis of TDP-d-desosamine: identification of a strategy for C4 deoxygenation. Angew. Chem. Int. Ed. Engl. 2005, 44:6742-6746.
    • (2005) Angew. Chem. Int. Ed. Engl. , vol.44 , pp. 6742-6746
    • Szu, P.H.1    He, X.2    Zhao, L.3    Liu, H.W.4
  • 45
    • 0034974319 scopus 로고    scopus 로고
    • Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity
    • Tang L., McDaniel R. Construction of desosamine containing polyketide libraries using a glycosyltransferase with broad substrate specificity. Chem. Biol. 2001, 8:547-555.
    • (2001) Chem. Biol. , vol.8 , pp. 547-555
    • Tang, L.1    McDaniel, R.2
  • 46
    • 57549105096 scopus 로고    scopus 로고
    • Natural-product sugar biosynthesis and enzymatic glycodiversification
    • Thibodeaux C.J., Melancon C.E., Liu H.W. Natural-product sugar biosynthesis and enzymatic glycodiversification. Angew. Chem. Int. Ed. Engl. 2008, 47:9814-9859.
    • (2008) Angew. Chem. Int. Ed. Engl. , vol.47 , pp. 9814-9859
    • Thibodeaux, C.J.1    Melancon, C.E.2    Liu, H.W.3
  • 47
    • 34247626294 scopus 로고    scopus 로고
    • Unusual sugar biosynthesis and natural product glycodiversification
    • Thibodeaux C.J., Melancon C.E., Liu H.W. Unusual sugar biosynthesis and natural product glycodiversification. Nature 2007, 446:1008-1016.
    • (2007) Nature , vol.446 , pp. 1008-1016
    • Thibodeaux, C.J.1    Melancon, C.E.2    Liu, H.W.3
  • 48
    • 3843086796 scopus 로고    scopus 로고
    • Genes and enzymes involved in deoxysugar biosynthesis in bacteria
    • Trefzer A., Salas J.A., Bechthold A. Genes and enzymes involved in deoxysugar biosynthesis in bacteria. Nat. Prod. Rep. 1999, 16:283-299.
    • (1999) Nat. Prod. Rep. , vol.16 , pp. 283-299
    • Trefzer, A.1    Salas, J.A.2    Bechthold, A.3
  • 49
    • 17444421169 scopus 로고    scopus 로고
    • Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance
    • Tu D., Blaha G., Moore P.B., Steitz T.A. Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance. Cell 2005, 121:257-270.
    • (2005) Cell , vol.121 , pp. 257-270
    • Tu, D.1    Blaha, G.2    Moore, P.B.3    Steitz, T.A.4
  • 50
    • 0024419124 scopus 로고
    • Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus)
    • Vara J., Lewandowska-Skarbek M., Wang Y.G., Donadio S., Hutchinson C.R. Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus). J. Bacteriol. 1989, 171:5872-5881.
    • (1989) J. Bacteriol. , vol.171 , pp. 5872-5881
    • Vara, J.1    Lewandowska-Skarbek, M.2    Wang, Y.G.3    Donadio, S.4    Hutchinson, C.R.5
  • 52
    • 0025859219 scopus 로고
    • An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea
    • Weber J.M., Leung J.O., Swanson S.J., Idler K.B., McAlpine J.B. An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea. Science 1991, 252:114-117.
    • (1991) Science , vol.252 , pp. 114-117
    • Weber, J.M.1    Leung, J.O.2    Swanson, S.J.3    Idler, K.B.4    McAlpine, J.B.5
  • 53
    • 0023677102 scopus 로고
    • The use of a chromosome integration vector to map erythromycin resistance and production genes in Saccharopolyspora erythraea (Streptomyces erythraeus)
    • Weber J.M., Losick R. The use of a chromosome integration vector to map erythromycin resistance and production genes in Saccharopolyspora erythraea (Streptomyces erythraeus). Gene 1988, 68:173-180.
    • (1988) Gene , vol.68 , pp. 173-180
    • Weber, J.M.1    Losick, R.2
  • 54
    • 0024517087 scopus 로고
    • Identification of a gene required for the terminal step in erythromycin A biosynthesis in Saccharopolyspora erythraea (Streptomyces erythreus)
    • Weber J.M., Schoner B., Losick R. Identification of a gene required for the terminal step in erythromycin A biosynthesis in Saccharopolyspora erythraea (Streptomyces erythreus). Gene 1989, 75:235-241.
    • (1989) Gene , vol.75 , pp. 235-241
    • Weber, J.M.1    Schoner, B.2    Losick, R.3
  • 55
    • 0031127564 scopus 로고    scopus 로고
    • The role of carbohydrates in biologically active natural products
    • Weymouth-Wilson A.C. The role of carbohydrates in biologically active natural products. Nat. Prod. Rep. 1997, 14:99-110.
    • (1997) Nat. Prod. Rep. , vol.14 , pp. 99-110
    • Weymouth-Wilson, A.C.1
  • 56
    • 54049149694 scopus 로고    scopus 로고
    • The impact of enzyme engineering upon natural product glycodiversification
    • Williams G.J., Gantt R.W., Thorson J.S. The impact of enzyme engineering upon natural product glycodiversification. Curr. Opin. Chem. Biol. 2008, 12:556-564.
    • (2008) Curr. Opin. Chem. Biol. , vol.12 , pp. 556-564
    • Williams, G.J.1    Gantt, R.W.2    Thorson, J.S.3
  • 57
  • 58
    • 0036008847 scopus 로고    scopus 로고
    • Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae
    • Yoon Y.J., Beck B.J., Kim B.S., Kang H.Y., Reynolds K.A., Sherman D.H. Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chem. Biol. 2002, 9:203-214.
    • (2002) Chem. Biol. , vol.9 , pp. 203-214
    • Yoon, Y.J.1    Beck, B.J.2    Kim, B.S.3    Kang, H.Y.4    Reynolds, K.A.5    Sherman, D.H.6
  • 59
    • 26844543758 scopus 로고    scopus 로고
    • In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides
    • Yuan Y., Chung H.S., Leimkuhler C., Walsh C.T., Kahne D., Walker S. In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides. J. Am. Chem. Soc. 2005, 127:14128-14129.
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 14128-14129
    • Yuan, Y.1    Chung, H.S.2    Leimkuhler, C.3    Walsh, C.T.4    Kahne, D.5    Walker, S.6
  • 60
    • 34247518972 scopus 로고    scopus 로고
    • The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification
    • Zhang C., Fu Q., Albermann C., Li L., Thorson J.S. The in vitro characterization of the erythronolide mycarosyltransferase EryBV and its utility in macrolide diversification. ChemBioChem 2007, 8:385-390.
    • (2007) ChemBioChem , vol.8 , pp. 385-390
    • Zhang, C.1    Fu, Q.2    Albermann, C.3    Li, L.4    Thorson, J.S.5
  • 61
    • 78649391538 scopus 로고    scopus 로고
    • Methods and options for the heterologous production of complex natural products
    • Zhang H., Boghigian B.A., Armando J., Pfeifer B.A. Methods and options for the heterologous production of complex natural products. Nat. Prod. Rep. 2011, 28:125-151.
    • (2011) Nat. Prod. Rep. , vol.28 , pp. 125-151
    • Zhang, H.1    Boghigian, B.A.2    Armando, J.3    Pfeifer, B.A.4
  • 62
    • 78649386219 scopus 로고    scopus 로고
    • Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host
    • Zhang H., Wang Y., Wu J., Skalina K., Pfeifer B.A. Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host. Chem. Biol. 2010, 17:1232-1240.
    • (2010) Chem. Biol. , vol.17 , pp. 1232-1240
    • Zhang, H.1    Wang, Y.2    Wu, J.3    Skalina, K.4    Pfeifer, B.A.5
  • 63
    • 0034808121 scopus 로고    scopus 로고
    • Study of C-4 deoxygenation in the biosynthesis of desosamine: evidence implicating a novel mechanism
    • Zhao L., Borisova S., Yeung S.M., Liu H. Study of C-4 deoxygenation in the biosynthesis of desosamine: evidence implicating a novel mechanism. J. Am. Chem. Soc. 2001, 123:7909-7910.
    • (2001) J. Am. Chem. Soc. , vol.123 , pp. 7909-7910
    • Zhao, L.1    Borisova, S.2    Yeung, S.M.3    Liu, H.4


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