Increasing diterpene yield with a modular metabolic engineering system in E. coli: Comparison of MEV and MEP isoprenoid precursor pathway engineering

Applied Microbiology and Biotechnology

Volumn 85, Issue 6, 2010, Pages 1893-1906

  Morrone, Dana ^a   Lowry, Luke ^a   Determan, Mara K ^a   Hershey, David M ^a   Xu, Meimei ^a   Peters, Reuben J ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

Isoprenoid; Metabolic engineering; Natural products biosynthesis; Terpenoid

Indexed keywords

ISOPRENOIDS; METABOLIC ENGINEERING; NATURAL PRODUCTS; NATURAL PRODUCTS BIOSYNTHESIS; TERPENOIDS;

BIOCHEMISTRY; BIOSYNTHESIS; ENGINEERING; ESCHERICHIA COLI; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLEFINS; RESONANCE;

BIOCHEMICAL ENGINEERING;

DITERPENE; ERYTHRITOL; ISOPRENOID; METHYL ERYTHRITOL PHOSPHATE; MEVALONIC ACID; PROTEIN; PROTEIN DXR; PROTEIN DXS; PROTEIN IDI; PYRUVIC ACID; TERPENOID; UNCLASSIFIED DRUG;

BACTERIUM; BIOTECHNOLOGY; ENZYME ACTIVITY; ISOPRENOID; MAGNETIC METHOD; METABOLITE;

ARTICLE; BACTERIUM CULTURE; BIOREACTOR; COMPARATIVE STUDY; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ESCHERICHIA COLI; GENE CASSETTE; GENE INSERTION; GENE OVEREXPRESSION; METABOLIC ENGINEERING; METABOLIC REGULATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRECURSOR; SIGNAL TRANSDUCTION;

DITERPENES; ERYTHRITOL; ESCHERICHIA COLI; GENETIC ENGINEERING; HEMITERPENES; MEVALONIC ACID; ORGANOPHOSPHORUS COMPOUNDS; SUGAR PHOSPHATES;

ESCHERICHIA COLI; MINK ENTERITIS VIRUS;

EID: 76849089864     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-2219-x     Document Type: Article

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