Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 14, 2015, Pages 4221-4226

  Owen, Jeremy G ^a   Charlop Powers, Zachary ^a   Smith, Alexandra G ^a   Ternei, Melinda A ^a   Calle, Paula Y ^a   Reddy, Boojala Vijay B ^a   Montiel, Daniel ^a   Brady, Sean F ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Drug discovery; Environmental DNA; Nonribosomal peptide; Polyketide; Proteasome inhibitor

Indexed keywords

CLAREPOXCIN A; CLAREPOXCIN B; CLAREPOXCIN C; CLAREPOXCIN D; CLAREPOXCIN E; EPOXOMICIN; LANDEPOXCIN A; LANDEPOXCIN B; NATURAL PRODUCT; NONRIBOSOMAL PEPTIDE SYNTHETASE; POLYKETIDE SYNTHASE; PROTEASOME INHIBITOR; UNCLASSIFIED DRUG; DNA; KETONE; PEPTIDE; POLYKETIDE; PROTEASOME;

ARTICLE; BIOSYNTHESIS; COMPUTER MODEL; CONTROLLED STUDY; DNA SEQUENCE; DNA STRUCTURE; DRUG POTENCY; ELECTROSPRAY MASS SPECTROMETRY; GENE CLUSTER; HETEROLOGOUS EXPRESSION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HUMAN; HUMAN CELL; IC50; LIQUID CHROMATOGRAPHY; METAGENOME; METAGENOMICS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE LIQUID CHROMATOGRAPHY; SHORT DNA SEQUENCE; BACTERIAL GENOME; BIOLOGY; CHEMISTRY; DRUG DESIGN; DRUG DEVELOPMENT; GENETIC VARIATION; GENOME; GEOGRAPHY; MICROBIOLOGY; MOLECULAR GENETICS; MULTIGENE FAMILY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYLOGENY; PROCEDURES; SOFTWARE;

BACTERIA (MICROORGANISMS);

COMPUTATIONAL BIOLOGY; DNA; DRUG DESIGN; DRUG DISCOVERY; GENETIC VARIATION; GENOME; GENOME, BACTERIAL; GEOGRAPHY; KETONES; MAGNETIC RESONANCE SPECTROSCOPY; METAGENOME; METAGENOMICS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PEPTIDES; PHYLOGENY; POLYKETIDES; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; SOFTWARE; SOIL MICROBIOLOGY;

EID: 84929493030     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1501124112     Document Type: Article

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