메뉴 건너뛰기




Volumn 32, Issue 2, 2014, Pages 255-268

Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

Author keywords

ACP; AT; COBRA; Constraint based flux analysis; Databases; DoBISCUIT; Knowledgebases; MRSA; NRPS; Omics techniques; PCP; PKS; PrISM; SBSPKS; Secondary metabolites; Streptomyces species; Systems biology; Systems biotechnology; Systems metabolic engineering

Indexed keywords

BACTERIA; BIOMOLECULES; BIOTECHNOLOGY; DATABASE SYSTEMS; METABOLIC ENGINEERING; METABOLISM; PRISMS;

EID: 84895453461     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2013.10.008     Document Type: Review
Times cited : (170)

References (133)
  • 1
    • 70350181581 scopus 로고    scopus 로고
    • Dynamic changes in the extracellular proteome caused by absence of a pleiotropic regulator AdpA in Streptomyces griseus
    • Akanuma G., Hara H., Ohnishi Y., Horinouchi S. Dynamic changes in the extracellular proteome caused by absence of a pleiotropic regulator AdpA in Streptomyces griseus. Mol Microbiol 2009, 73:898-912.
    • (2009) Mol Microbiol , vol.73 , pp. 898-912
    • Akanuma, G.1    Hara, H.2    Ohnishi, Y.3    Horinouchi, S.4
  • 3
    • 84868160004 scopus 로고    scopus 로고
    • Diverse control of metabolism and other cellular processes in Streptomyces coelicolor by the PhoP transcription factor: genome-wide identification of in vivo targets
    • Allenby N.E., Laing E., Bucca G., Kierzek A.M., Smith C.P. Diverse control of metabolism and other cellular processes in Streptomyces coelicolor by the PhoP transcription factor: genome-wide identification of in vivo targets. Nucleic Acids Res 2012, 40:9543-9556.
    • (2012) Nucleic Acids Res , vol.40 , pp. 9543-9556
    • Allenby, N.E.1    Laing, E.2    Bucca, G.3    Kierzek, A.M.4    Smith, C.P.5
  • 5
    • 78650647970 scopus 로고    scopus 로고
    • Evolution, genomic analysis, and reconstruction of isobutanol tolerance in Escherichia coli
    • Atsumi S., Wu T.Y., Machado I.M., Huang W.C., Chen P.Y., Pellegrini M., et al. Evolution, genomic analysis, and reconstruction of isobutanol tolerance in Escherichia coli. Mol Syst Biol 2010, 6:449.
    • (2010) Mol Syst Biol , vol.6 , pp. 449
    • Atsumi, S.1    Wu, T.Y.2    Machado, I.M.3    Huang, W.C.4    Chen, P.Y.5    Pellegrini, M.6
  • 6
    • 54849405130 scopus 로고    scopus 로고
    • Renaissance in antibacterial discovery from actinomycetes
    • Baltz R.H. Renaissance in antibacterial discovery from actinomycetes. Curr Opin Pharmacol 2008, 8:557-563.
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 557-563
    • Baltz, R.H.1
  • 7
    • 80051671943 scopus 로고    scopus 로고
    • Strain improvement in actinomycetes in the postgenomic era
    • Baltz R.H. Strain improvement in actinomycetes in the postgenomic era. J Ind Microbiol Biotechnol 2011, 38:657-666.
    • (2011) J Ind Microbiol Biotechnol , vol.38 , pp. 657-666
    • Baltz, R.H.1
  • 9
    • 14544294545 scopus 로고    scopus 로고
    • Bioactive microbial metabolites
    • Berdy J. Bioactive microbial metabolites. J Antibiot (Tokyo) 2005, 58:1-26.
    • (2005) J Antibiot (Tokyo) , vol.58 , pp. 1-26
    • Berdy, J.1
  • 11
    • 20444397992 scopus 로고    scopus 로고
    • Genome-scale analysis of Streptomyces coelicolor A3(2) metabolism
    • Borodina I., Krabben P., Nielsen J. Genome-scale analysis of Streptomyces coelicolor A3(2) metabolism. Genome Res 2005, 15:820-829.
    • (2005) Genome Res , vol.15 , pp. 820-829
    • Borodina, I.1    Krabben, P.2    Nielsen, J.3
  • 12
    • 18444388587 scopus 로고    scopus 로고
    • Metabolic network analysis of Streptomyces tenebrarius, a Streptomyces species with an active entner-doudoroff pathway
    • Borodina I., Scholler C., Eliasson A., Nielsen J. Metabolic network analysis of Streptomyces tenebrarius, a Streptomyces species with an active entner-doudoroff pathway. Appl Environ Microbiol 2005, 71:2294-2302.
    • (2005) Appl Environ Microbiol , vol.71 , pp. 2294-2302
    • Borodina, I.1    Scholler, C.2    Eliasson, A.3    Nielsen, J.4
  • 13
    • 54449101282 scopus 로고    scopus 로고
    • Antibiotic overproduction in Streptomyces coelicolor A3 2 mediated by phosphofructokinase deletion
    • Borodina I., Siebring J., Zhang J., Smith C.P., van Keulen G., Dijkhuizen L., et al. Antibiotic overproduction in Streptomyces coelicolor A3 2 mediated by phosphofructokinase deletion. J Biol Chem 2008, 283:25186-25199.
    • (2008) J Biol Chem , vol.283 , pp. 25186-25199
    • Borodina, I.1    Siebring, J.2    Zhang, J.3    Smith, C.P.4    van Keulen, G.5    Dijkhuizen, L.6
  • 14
    • 84885595954 scopus 로고    scopus 로고
    • Vinylogous chain branching catalysed by a dedicated polyketide synthase module
    • Bretschneider T., Heim J.B., Heine D., Winkler R., Busch B., Kusebauch B., et al. Vinylogous chain branching catalysed by a dedicated polyketide synthase module. Nature 2013, 502:124-128.
    • (2013) Nature , vol.502 , pp. 124-128
    • Bretschneider, T.1    Heim, J.B.2    Heine, D.3    Winkler, R.4    Busch, B.5    Kusebauch, B.6
  • 15
    • 70349959824 scopus 로고    scopus 로고
    • A proteomics approach to discovering natural products and their biosynthetic pathways
    • Bumpus S.B., Evans B.S., Thomas P.M., Ntai I., Kelleher N.L. A proteomics approach to discovering natural products and their biosynthetic pathways. Nat Biotechnol 2009, 27:951-956.
    • (2009) Nat Biotechnol , vol.27 , pp. 951-956
    • Bumpus, S.B.1    Evans, B.S.2    Thomas, P.M.3    Ntai, I.4    Kelleher, N.L.5
  • 18
    • 52649133814 scopus 로고    scopus 로고
    • Isoprenoid-like alkylations in polyketide biosynthesis
    • Calderone C.T. Isoprenoid-like alkylations in polyketide biosynthesis. Nat Prod Rep 2008, 25:845-853.
    • (2008) Nat Prod Rep , vol.25 , pp. 845-853
    • Calderone, C.T.1
  • 21
    • 84863359225 scopus 로고    scopus 로고
    • Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction
    • Charusanti P., Fong N.L., Nagarajan H., Pereira A.R., Li H.J., Abate E.A., et al. Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction. PLoS One 2012, 7:e33727.
    • (2012) PLoS One , vol.7
    • Charusanti, P.1    Fong, N.L.2    Nagarajan, H.3    Pereira, A.R.4    Li, H.J.5    Abate, E.A.6
  • 22
    • 49449102829 scopus 로고    scopus 로고
    • Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts
    • Chen Y., Wendt-Pienkowski E., Shen B. Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts. J Bacteriol 2008, 190:5587-5596.
    • (2008) J Bacteriol , vol.190 , pp. 5587-5596
    • Chen, Y.1    Wendt-Pienkowski, E.2    Shen, B.3
  • 23
    • 68949197494 scopus 로고    scopus 로고
    • Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis
    • Chen L., Chen J., Jiang Y., Zhang W., Jiang W., Lu Y. Transcriptomics analyses reveal global roles of the regulator AveI in Streptomyces avermitilis. FEMS Microbiol Lett 2009, 298:199-207.
    • (2009) FEMS Microbiol Lett , vol.298 , pp. 199-207
    • Chen, L.1    Chen, J.2    Jiang, Y.3    Zhang, W.4    Jiang, W.5    Lu, Y.6
  • 24
    • 77149133405 scopus 로고    scopus 로고
    • Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation
    • Chen Y., Smanski M.J., Shen B. Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation. Appl Microbiol Biotechnol 2010, 86:19-25.
    • (2010) Appl Microbiol Biotechnol , vol.86 , pp. 19-25
    • Chen, Y.1    Smanski, M.J.2    Shen, B.3
  • 25
    • 84862907959 scopus 로고    scopus 로고
    • A proteomic survey of nonribosomal peptide and polyketide biosynthesis in actinobacteria
    • Chen Y., Ntai I., Ju K.S., Unger M., Zamdborg L., Robinson S.J., et al. A proteomic survey of nonribosomal peptide and polyketide biosynthesis in actinobacteria. J Proteome Res 2012, 11:85-94.
    • (2012) J Proteome Res , vol.11 , pp. 85-94
    • Chen, Y.1    Ntai, I.2    Ju, K.S.3    Unger, M.4    Zamdborg, L.5    Robinson, S.J.6
  • 26
    • 84879409731 scopus 로고    scopus 로고
    • Metabolic analysis reveals the amino acid responses of Streptomyces lydicus to pitching ratios during improving streptolydigin production
    • Cheng J.S., Liang Y.Q., Ding M.Z., Cui S.F., Lv X.M., Yuan Y.J. Metabolic analysis reveals the amino acid responses of Streptomyces lydicus to pitching ratios during improving streptolydigin production. Appl Microbiol Biotechnol 2013, 97:5943-5954.
    • (2013) Appl Microbiol Biotechnol , vol.97 , pp. 5943-5954
    • Cheng, J.S.1    Liang, Y.Q.2    Ding, M.Z.3    Cui, S.F.4    Lv, X.M.5    Yuan, Y.J.6
  • 27
    • 79851515868 scopus 로고    scopus 로고
    • Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms
    • Chiang Y.M., Chang S.L., Oakley B.R., Wang C.C. Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms. Curr Opin Chem Biol 2011, 15:137-143.
    • (2011) Curr Opin Chem Biol , vol.15 , pp. 137-143
    • Chiang, Y.M.1    Chang, S.L.2    Oakley, B.R.3    Wang, C.C.4
  • 28
    • 77958012949 scopus 로고    scopus 로고
    • Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides
    • Claesen J., Bibb M. Genome mining and genetic analysis of cypemycin biosynthesis reveal an unusual class of posttranslationally modified peptides. Proc Natl Acad Sci U S A 2010, 107:16297-16302.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 16297-16302
    • Claesen, J.1    Bibb, M.2
  • 29
    • 84876566794 scopus 로고    scopus 로고
    • ClusterMine360: a database of microbial PKS/NRPS biosynthesis
    • Conway K.R., Boddy C.N. ClusterMine360: a database of microbial PKS/NRPS biosynthesis. Nucleic Acids Res 2013, 41:D402-D407.
    • (2013) Nucleic Acids Res , vol.41
    • Conway, K.R.1    Boddy, C.N.2
  • 30
    • 84865477861 scopus 로고    scopus 로고
    • Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism
    • Craney A., Ozimok C., Pimentel-Elardo S.M., Capretta A., Nodwell J.R. Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism. Chem Biol 2012, 19:1020-1027.
    • (2012) Chem Biol , vol.19 , pp. 1020-1027
    • Craney, A.1    Ozimok, C.2    Pimentel-Elardo, S.M.3    Capretta, A.4    Nodwell, J.R.5
  • 31
    • 84881009432 scopus 로고    scopus 로고
    • Towards a new science of secondary metabolism
    • Craney A., Ahmed S., Nodwell J. Towards a new science of secondary metabolism. J Antibiot (Tokyo) 2013, 66:387-400.
    • (2013) J Antibiot (Tokyo) , vol.66 , pp. 387-400
    • Craney, A.1    Ahmed, S.2    Nodwell, J.3
  • 32
    • 84863440730 scopus 로고    scopus 로고
    • Genome-scale metabolic flux analysis of Streptomyces lividans growing on a complex medium
    • D'Huys P.J., Lule I., Vercammen D., Anne J., Van Impe J.F., Bernaerts K. Genome-scale metabolic flux analysis of Streptomyces lividans growing on a complex medium. J Biotechnol 2012, 161:1-13.
    • (2012) J Biotechnol , vol.161 , pp. 1-13
    • D'Huys, P.J.1    Lule, I.2    Vercammen, D.3    Anne, J.4    Van Impe, J.F.5    Bernaerts, K.6
  • 34
    • 33748631825 scopus 로고    scopus 로고
    • Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms
    • Fischbach M.A., Walsh C.T. Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms. Chem Rev 2006, 106:3468-3496.
    • (2006) Chem Rev , vol.106 , pp. 3468-3496
    • Fischbach, M.A.1    Walsh, C.T.2
  • 35
    • 69549111337 scopus 로고    scopus 로고
    • Antibiotics for emerging pathogens
    • Fischbach M.A., Walsh C.T. Antibiotics for emerging pathogens. Science 2009, 325:1089-1093.
    • (2009) Science , vol.325 , pp. 1089-1093
    • Fischbach, M.A.1    Walsh, C.T.2
  • 36
    • 55549086417 scopus 로고    scopus 로고
    • Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium
    • Flardh K., Buttner M.J. Streptomyces morphogenetics: dissecting differentiation in a filamentous bacterium. Nat Rev Microbiol 2009, 7:36-49.
    • (2009) Nat Rev Microbiol , vol.7 , pp. 36-49
    • Flardh, K.1    Buttner, M.J.2
  • 37
    • 84887624961 scopus 로고    scopus 로고
    • Design-based re-engineering of biosynthetic gene clusters: plug-and-play in practice
    • [in press]
    • Frasch H.J., Medema M.H., Takano E., Breitling R. Design-based re-engineering of biosynthetic gene clusters: plug-and-play in practice. Curr Opin Biotechnol 2013, http://www.sciencedirect.com/science/article/pii/S0958166913000633 [in press].
    • (2013) Curr Opin Biotechnol
    • Frasch, H.J.1    Medema, M.H.2    Takano, E.3    Breitling, R.4
  • 38
    • 84872166811 scopus 로고    scopus 로고
    • Crp is a global regulator of antibiotic production in streptomyces
    • Gao C., Hindra Mulder D., Yin C., Elliot M.A. Crp is a global regulator of antibiotic production in streptomyces. MBio 2012, 3.
    • (2012) MBio , vol.3
    • Gao, C.1    Hindra, M.D.2    Yin, C.3    Elliot, M.A.4
  • 40
    • 77955343496 scopus 로고    scopus 로고
    • Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2)
    • Gottelt M., Kol S., Gomez-Escribano J.P., Bibb M., Takano E. Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2). Microbiology 2010, 156:2343-2353.
    • (2010) Microbiology , vol.156 , pp. 2343-2353
    • Gottelt, M.1    Kol, S.2    Gomez-Escribano, J.P.3    Bibb, M.4    Takano, E.5
  • 41
    • 79961051540 scopus 로고    scopus 로고
    • Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates
    • Han A.R., Park J.W., Lee M.K., Ban Y.H., Yoo Y.J., Kim E.J., et al. Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates. Appl Environ Microbiol 2011, 77:4912-4923.
    • (2011) Appl Environ Microbiol , vol.77 , pp. 4912-4923
    • Han, A.R.1    Park, J.W.2    Lee, M.K.3    Ban, Y.H.4    Yoo, Y.J.5    Kim, E.J.6
  • 42
    • 69949123857 scopus 로고    scopus 로고
    • DNA microarray analysis of global gene regulation by A-factor in Streptomyces griseus
    • Hara H., Ohnishi Y., Horinouchi S. DNA microarray analysis of global gene regulation by A-factor in Streptomyces griseus. Microbiology 2009, 155:2197-2210.
    • (2009) Microbiology , vol.155 , pp. 2197-2210
    • Hara, H.1    Ohnishi, Y.2    Horinouchi, S.3
  • 44
    • 69249202590 scopus 로고    scopus 로고
    • The biosynthetic logic of polyketide diversity
    • Hertweck C. The biosynthetic logic of polyketide diversity. Angew Chem 2009, 48:4688-4716.
    • (2009) Angew Chem , vol.48 , pp. 4688-4716
    • Hertweck, C.1
  • 45
    • 35748948065 scopus 로고    scopus 로고
    • New pleiotropic effects of eliminating a rare tRNA from Streptomyces coelicolor, revealed by combined proteomic and transcriptomic analysis of liquid cultures
    • Hesketh A., Bucca G., Laing E., Flett F., Hotchkiss G., Smith C.P., et al. New pleiotropic effects of eliminating a rare tRNA from Streptomyces coelicolor, revealed by combined proteomic and transcriptomic analysis of liquid cultures. BMC Genomics 2007, 8:261.
    • (2007) BMC Genomics , vol.8 , pp. 261
    • Hesketh, A.1    Bucca, G.2    Laing, E.3    Flett, F.4    Hotchkiss, G.5    Smith, C.P.6
  • 46
    • 84863594224 scopus 로고    scopus 로고
    • Genome-wide distribution of AdpA, a global regulator for secondary metabolism and morphological differentiation in Streptomyces, revealed the extent and complexity of the AdpA regulatory network
    • Higo A., Hara H., Horinouchi S., Ohnishi Y. Genome-wide distribution of AdpA, a global regulator for secondary metabolism and morphological differentiation in Streptomyces, revealed the extent and complexity of the AdpA regulatory network. DNA Res 2012, 19:259-273.
    • (2012) DNA Res , vol.19 , pp. 259-273
    • Higo, A.1    Hara, H.2    Horinouchi, S.3    Ohnishi, Y.4
  • 47
    • 0035576880 scopus 로고    scopus 로고
    • Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays
    • Huang J., Lih C.J., Pan K.H., Cohen S.N. Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays. Genes Dev 2001, 15:3183-3192.
    • (2001) Genes Dev , vol.15 , pp. 3183-3192
    • Huang, J.1    Lih, C.J.2    Pan, K.H.3    Cohen, S.N.4
  • 48
    • 28244432190 scopus 로고    scopus 로고
    • Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor
    • Huang J., Shi J., Molle V., Sohlberg B., Weaver D., Bibb M.J., et al. Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor. Mol Microbiol 2005, 58:1276-1287.
    • (2005) Mol Microbiol , vol.58 , pp. 1276-1287
    • Huang, J.1    Shi, J.2    Molle, V.3    Sohlberg, B.4    Weaver, D.5    Bibb, M.J.6
  • 49
    • 84862796646 scopus 로고    scopus 로고
    • In silico aided metabolic engineering of Streptomyces roseosporus for daptomycin yield improvement
    • Huang D., Wen J., Wang G., Yu G., Jia X., Chen Y. In silico aided metabolic engineering of Streptomyces roseosporus for daptomycin yield improvement. Appl Microbiol Biotechnol 2012, 94:637-649.
    • (2012) Appl Microbiol Biotechnol , vol.94 , pp. 637-649
    • Huang, D.1    Wen, J.2    Wang, G.3    Yu, G.4    Jia, X.5    Chen, Y.6
  • 50
    • 84878003979 scopus 로고    scopus 로고
    • Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement
    • Huang D., Li S., Xia M., Wen J., Jia X. Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement. Microb Cell Fact 2013, 12:52.
    • (2013) Microb Cell Fact , vol.12 , pp. 52
    • Huang, D.1    Li, S.2    Xia, M.3    Wen, J.4    Jia, X.5
  • 52
    • 0038561132 scopus 로고    scopus 로고
    • Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis
    • Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T., et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol 2003, 21:526-531.
    • (2003) Nat Biotechnol , vol.21 , pp. 526-531
    • Ikeda, H.1    Ishikawa, J.2    Hanamoto, A.3    Shinose, M.4    Kikuchi, H.5    Shiba, T.6
  • 53
    • 77952021862 scopus 로고    scopus 로고
    • Multitagging proteomic strategy to estimate protein turnover rates in dynamic systems
    • Jayapal K.P., Sui S., Philp R.J., Kok Y.J., Yap M.G., Griffin T.J., et al. Multitagging proteomic strategy to estimate protein turnover rates in dynamic systems. J Proteome Res 2010, 9:2087-2097.
    • (2010) J Proteome Res , vol.9 , pp. 2087-2097
    • Jayapal, K.P.1    Sui, S.2    Philp, R.J.3    Kok, Y.J.4    Yap, M.G.5    Griffin, T.J.6
  • 54
    • 70349231218 scopus 로고    scopus 로고
    • Bioinformatic perspectives on NRPS/PKS megasynthases: advances and challenges
    • Jenke-Kodama H., Dittmann E. Bioinformatic perspectives on NRPS/PKS megasynthases: advances and challenges. Nat Prod Rep 2009, 26:874-883.
    • (2009) Nat Prod Rep , vol.26 , pp. 874-883
    • Jenke-Kodama, H.1    Dittmann, E.2
  • 55
    • 84877147429 scopus 로고    scopus 로고
    • Improvement of natamycin production by engineering of phosphopantetheinyl transferases in Streptomyces chattanoogensis L10
    • Jiang H., Wang Y.Y., Ran X.X., Fan W.M., Jiang X.H., Guan W.J., et al. Improvement of natamycin production by engineering of phosphopantetheinyl transferases in Streptomyces chattanoogensis L10. Appl Environ Microbiol 2013, 79:3346-3354.
    • (2013) Appl Environ Microbiol , vol.79 , pp. 3346-3354
    • Jiang, H.1    Wang, Y.Y.2    Ran, X.X.3    Fan, W.M.4    Jiang, X.H.5    Guan, W.J.6
  • 56
    • 79951815135 scopus 로고    scopus 로고
    • Forkhead-associated proteins genetically linked to the serine/threonine kinase PknB regulate carbon flux towards antibiotic biosynthesis in Streptomyces coelicolor
    • Jones G., Del Sol R., Dudley E., Dyson P. Forkhead-associated proteins genetically linked to the serine/threonine kinase PknB regulate carbon flux towards antibiotic biosynthesis in Streptomyces coelicolor. Microb Biotechnol 2011, 4:263-274.
    • (2011) Microb Biotechnol , vol.4 , pp. 263-274
    • Jones, G.1    Del Sol, R.2    Dudley, E.3    Dyson, P.4
  • 57
    • 0034923126 scopus 로고    scopus 로고
    • Changes of in vivo fluxes through central metabolic pathways during the production of nystatin by Streptomyces noursei in batch culture
    • Jonsbu E., Christensen B., Nielsen J. Changes of in vivo fluxes through central metabolic pathways during the production of nystatin by Streptomyces noursei in batch culture. Appl Microbiol Biotechnol 2001, 56:93-100.
    • (2001) Appl Microbiol Biotechnol , vol.56 , pp. 93-100
    • Jonsbu, E.1    Christensen, B.2    Nielsen, J.3
  • 58
    • 79551520607 scopus 로고    scopus 로고
    • Identification of a napsamycin biosynthesis gene cluster by genome mining
    • Kaysser L., Tang X., Wemakor E., Sedding K., Hennig S., Siebenberg S., et al. Identification of a napsamycin biosynthesis gene cluster by genome mining. Chembiochem 2011, 12:477-487.
    • (2011) Chembiochem , vol.12 , pp. 477-487
    • Kaysser, L.1    Tang, X.2    Wemakor, E.3    Sedding, K.4    Hennig, S.5    Siebenberg, S.6
  • 59
    • 80054865417 scopus 로고    scopus 로고
    • A mass spectrometry-guided genome mining approach for natural product peptidogenomics
    • Kersten R.D., Yang Y.L., Xu Y., Cimermancic P., Nam S.J., Fenical W., et al. A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol 2011, 7:794-802.
    • (2011) Nat Chem Biol , vol.7 , pp. 794-802
    • Kersten, R.D.1    Yang, Y.L.2    Xu, Y.3    Cimermancic, P.4    Nam, S.J.5    Fenical, W.6
  • 60
    • 50249113230 scopus 로고    scopus 로고
    • Selection of objective function in genome scale flux balance analysis for process feed development in antibiotic production
    • Khannapho C., Zhao H., Bonde B.K., Kierzek A.M., Avignone-Rossa C.A., Bushell M.E. Selection of objective function in genome scale flux balance analysis for process feed development in antibiotic production. Metab Eng 2008, 10:227-233.
    • (2008) Metab Eng , vol.10 , pp. 227-233
    • Khannapho, C.1    Zhao, H.2    Bonde, B.K.3    Kierzek, A.M.4    Avignone-Rossa, C.A.5    Bushell, M.E.6
  • 61
    • 84864566650 scopus 로고    scopus 로고
    • PKMiner: a database for exploring type II polyketide synthases
    • Kim J., Yi G.S. PKMiner: a database for exploring type II polyketide synthases. BMC Microbiol 2012, 12:169.
    • (2012) BMC Microbiol , vol.12 , pp. 169
    • Kim, J.1    Yi, G.S.2
  • 62
    • 6044268083 scopus 로고    scopus 로고
    • Metabolic flux analysis for calcium dependent antibiotic (CDA) production in Streptomyces coelicolor
    • Kim H.B., Smith C.P., Micklefield J., Mavituna F. Metabolic flux analysis for calcium dependent antibiotic (CDA) production in Streptomyces coelicolor. Metab Eng 2004, 6:313-325.
    • (2004) Metab Eng , vol.6 , pp. 313-325
    • Kim, H.B.1    Smith, C.P.2    Micklefield, J.3    Mavituna, F.4
  • 63
    • 59149105985 scopus 로고    scopus 로고
    • Acidic pH shock induces the expressions of a wide range of stress-response genes
    • Kim Y.J., Moon M.H., Song J.Y., Smith C.P., Hong S.K., Chang Y.K. Acidic pH shock induces the expressions of a wide range of stress-response genes. BMC Genomics 2008, 9:604.
    • (2008) BMC Genomics , vol.9 , pp. 604
    • Kim, Y.J.1    Moon, M.H.2    Song, J.Y.3    Smith, C.P.4    Hong, S.K.5    Chang, Y.K.6
  • 64
    • 79953172246 scopus 로고    scopus 로고
    • Transcriptome analysis of an antibiotic downregulator mutant and synergistic Actinorhodin stimulation via disruption of a precursor flux regulator in Streptomyces coelicolor
    • Kim S.H., Lee H.N., Kim H.J., Kim E.S. Transcriptome analysis of an antibiotic downregulator mutant and synergistic Actinorhodin stimulation via disruption of a precursor flux regulator in Streptomyces coelicolor. Appl Environ Microbiol 2011, 77:1872-1877.
    • (2011) Appl Environ Microbiol , vol.77 , pp. 1872-1877
    • Kim, S.H.1    Lee, H.N.2    Kim, H.J.3    Kim, E.S.4
  • 66
    • 77249153701 scopus 로고    scopus 로고
    • Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism
    • Komatsu M., Uchiyama T., Omura S., Cane D.E., Ikeda H. Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proc Natl Acad Sci U S A 2010, 107:2646-2651.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 2646-2651
    • Komatsu, M.1    Uchiyama, T.2    Omura, S.3    Cane, D.E.4    Ikeda, H.5
  • 67
    • 84879996598 scopus 로고    scopus 로고
    • Promiscuity of a modular polyketide synthase towards natural and non-natural extender units
    • Koryakina I., McArthur J.B., Draelos M.M., Williams G.J. Promiscuity of a modular polyketide synthase towards natural and non-natural extender units. Org Biomol Chem 2013, 11:4449-4458.
    • (2013) Org Biomol Chem , vol.11 , pp. 4449-4458
    • Koryakina, I.1    McArthur, J.B.2    Draelos, M.M.3    Williams, G.J.4
  • 68
    • 44949247269 scopus 로고    scopus 로고
    • Dynamic analysis of integrated signaling, metabolic, and regulatory networks
    • Lee J.M., Gianchandani E.P., Eddy J.A., Papin J.A. Dynamic analysis of integrated signaling, metabolic, and regulatory networks. PLoS Comput Biol 2008, 4:e1000086.
    • (2008) PLoS Comput Biol , vol.4
    • Lee, J.M.1    Gianchandani, E.P.2    Eddy, J.A.3    Papin, J.A.4
  • 69
    • 84861440312 scopus 로고    scopus 로고
    • Systems metabolic engineering of microorganisms for natural and non-natural chemicals
    • Lee J.W., Na D., Park J.M., Lee J., Choi S., Lee S.Y. Systems metabolic engineering of microorganisms for natural and non-natural chemicals. Nat Chem Biol 2012, 8:536-546.
    • (2012) Nat Chem Biol , vol.8 , pp. 536-546
    • Lee, J.W.1    Na, D.2    Park, J.M.3    Lee, J.4    Choi, S.5    Lee, S.Y.6
  • 70
    • 78649502553 scopus 로고    scopus 로고
    • Metabolic and evolutionary insights into the closely-related species Streptomyces coelicolor and Streptomyces lividans deduced from high-resolution comparative genomic hybridization
    • Lewis R.A., Laing E., Allenby N., Bucca G., Brenner V., Harrison M., et al. Metabolic and evolutionary insights into the closely-related species Streptomyces coelicolor and Streptomyces lividans deduced from high-resolution comparative genomic hybridization. BMC Genomics 2010, 11:682.
    • (2010) BMC Genomics , vol.11 , pp. 682
    • Lewis, R.A.1    Laing, E.2    Allenby, N.3    Bucca, G.4    Brenner, V.5    Harrison, M.6
  • 71
    • 84858439602 scopus 로고    scopus 로고
    • Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods
    • Lewis N.E., Nagarajan H., Palsson B.O. Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods. Nat Rev Microbiol 2012, 10:291-305.
    • (2012) Nat Rev Microbiol , vol.10 , pp. 291-305
    • Lewis, N.E.1    Nagarajan, H.2    Palsson, B.O.3
  • 72
    • 33646082272 scopus 로고    scopus 로고
    • Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus
    • Li R., Townsend C.A. Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus. Metab Eng 2006, 8:240-252.
    • (2006) Metab Eng , vol.8 , pp. 240-252
    • Li, R.1    Townsend, C.A.2
  • 73
    • 78650526727 scopus 로고    scopus 로고
    • Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus
    • Li B., Walsh C.T. Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus. Proc Natl Acad Sci U S A 2010, 107:19731-19735.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 19731-19735
    • Li, B.1    Walsh, C.T.2
  • 75
    • 40949165022 scopus 로고    scopus 로고
    • Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2)
    • Lian W., Jayapal K.P., Charaniya S., Mehra S., Glod F., Kyung Y.S., et al. Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2). BMC Genomics 2008, 9:56.
    • (2008) BMC Genomics , vol.9 , pp. 56
    • Lian, W.1    Jayapal, K.P.2    Charaniya, S.3    Mehra, S.4    Glod, F.5    Kyung, Y.S.6
  • 76
  • 78
    • 0031974553 scopus 로고    scopus 로고
    • Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius
    • Madduri K., Kennedy J., Rivola G., Inventi-Solari A., Filippini S., Zanuso G., et al. Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius. Nat Biotechnol 1998, 16:69-74.
    • (1998) Nat Biotechnol , vol.16 , pp. 69-74
    • Madduri, K.1    Kennedy, J.2    Rivola, G.3    Inventi-Solari, A.4    Filippini, S.5    Zanuso, G.6
  • 79
    • 77954460353 scopus 로고    scopus 로고
    • Self-resistance mechanism in Streptomyces peucetius: overexpression of drrA, drrB and drrC for doxorubicin enhancement
    • Malla S., Niraula N.P., Liou K., Sohng J.K. Self-resistance mechanism in Streptomyces peucetius: overexpression of drrA, drrB and drrC for doxorubicin enhancement. Microbiol Res 2010, 165:259-267.
    • (2010) Microbiol Res , vol.165 , pp. 259-267
    • Malla, S.1    Niraula, N.P.2    Liou, K.3    Sohng, J.K.4
  • 80
    • 77956329728 scopus 로고    scopus 로고
    • Quantitative proteome analysis of Streptomyces coelicolor Nonsporulating liquid cultures demonstrates a complex differentiation process comparable to that occurring in sporulating solid cultures
    • Manteca A., Jung H.R., Schwammle V., Jensen O.N., Sanchez J. Quantitative proteome analysis of Streptomyces coelicolor Nonsporulating liquid cultures demonstrates a complex differentiation process comparable to that occurring in sporulating solid cultures. J Proteome Res 2010, 9:4801-4811.
    • (2010) J Proteome Res , vol.9 , pp. 4801-4811
    • Manteca, A.1    Jung, H.R.2    Schwammle, V.3    Jensen, O.N.4    Sanchez, J.5
  • 81
    • 77954701883 scopus 로고    scopus 로고
    • Quantitative proteomics analysis of Streptomyces coelicolor development demonstrates that onset of secondary metabolism coincides with hypha differentiation
    • Manteca A., Sanchez J., Jung H.R., Schwammle V., Jensen O.N. Quantitative proteomics analysis of Streptomyces coelicolor development demonstrates that onset of secondary metabolism coincides with hypha differentiation. Mol Cell Proteomics 2010, 9:1423-1436.
    • (2010) Mol Cell Proteomics , vol.9 , pp. 1423-1436
    • Manteca, A.1    Sanchez, J.2    Jung, H.R.3    Schwammle, V.4    Jensen, O.N.5
  • 82
    • 0031873963 scopus 로고    scopus 로고
    • New aspects of genes and enzymes for beta-lactam antibiotic biosynthesis
    • Martin J.F. New aspects of genes and enzymes for beta-lactam antibiotic biosynthesis. Appl Microbiol Biotechnol 1998, 50:1-15.
    • (1998) Appl Microbiol Biotechnol , vol.50 , pp. 1-15
    • Martin, J.F.1
  • 83
    • 77958475358 scopus 로고    scopus 로고
    • The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways
    • Medema M.H., Trefzer A., Kovalchuk A., van den Berg M., Muller U., Heijne W., et al. The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways. Genome Biol Evol 2010, 2:212-224.
    • (2010) Genome Biol Evol , vol.2 , pp. 212-224
    • Medema, M.H.1    Trefzer, A.2    Kovalchuk, A.3    van den Berg, M.4    Muller, U.5    Heijne, W.6
  • 84
    • 79959920872 scopus 로고    scopus 로고
    • AntiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
    • Medema M.H., Blin K., Cimermancic P., de Jager V., Zakrzewski P., Fischbach M.A., et al. antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucleic Acids Res 2011, 39:W339-W346.
    • (2011) Nucleic Acids Res , vol.39
    • Medema, M.H.1    Blin, K.2    Cimermancic, P.3    de Jager, V.4    Zakrzewski, P.5    Fischbach, M.A.6
  • 85
    • 50249163201 scopus 로고    scopus 로고
    • A bistable gene switch for antibiotic biosynthesis: the butyrolactone regulon in Streptomyces coelicolor
    • Mehra S., Charaniya S., Takano E., Hu W.S. A bistable gene switch for antibiotic biosynthesis: the butyrolactone regulon in Streptomyces coelicolor. PLoS One 2008, 3:e2724.
    • (2008) PLoS One , vol.3
    • Mehra, S.1    Charaniya, S.2    Takano, E.3    Hu, W.S.4
  • 86
    • 73449131845 scopus 로고    scopus 로고
    • An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis
    • Meier J.L., Niessen S., Hoover H.S., Foley T.L., Cravatt B.F., Burkart M.D. An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis. ACS Chem Biol 2009, 4:948-957.
    • (2009) ACS Chem Biol , vol.4 , pp. 948-957
    • Meier, J.L.1    Niessen, S.2    Hoover, H.S.3    Foley, T.L.4    Cravatt, B.F.5    Burkart, M.D.6
  • 87
    • 27144509740 scopus 로고    scopus 로고
    • Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes
    • Menzella H.G., Reid R., Carney J.R., Chandran S.S., Reisinger S.J., Patel K.G., et al. Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes. Nat Biotechnol 2005, 23:1171-1176.
    • (2005) Nat Biotechnol , vol.23 , pp. 1171-1176
    • Menzella, H.G.1    Reid, R.2    Carney, J.R.3    Chandran, S.S.4    Reisinger, S.J.5    Patel, K.G.6
  • 88
    • 0036007875 scopus 로고    scopus 로고
    • Biosynthesis and attachment of novel bacterial polyketide synthase starter units
    • Moore B.S., Hertweck C. Biosynthesis and attachment of novel bacterial polyketide synthase starter units. Nat Prod Rep 2002, 19:70-99.
    • (2002) Nat Prod Rep , vol.19 , pp. 70-99
    • Moore, B.S.1    Hertweck, C.2
  • 89
    • 7744235042 scopus 로고    scopus 로고
    • Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity
    • Moss S.J., Martin C.J., Wilkinson B. Loss of co-linearity by modular polyketide synthases: a mechanism for the evolution of chemical diversity. Nat Prod Rep 2004, 21:575-593.
    • (2004) Nat Prod Rep , vol.21 , pp. 575-593
    • Moss, S.J.1    Martin, C.J.2    Wilkinson, B.3
  • 90
    • 84864348214 scopus 로고    scopus 로고
    • Discrete acyltransferases involved in polyketide biosynthesis
    • Musiol E.M., Weber T. Discrete acyltransferases involved in polyketide biosynthesis. Med Chem Comm 2012, 3:871-886.
    • (2012) Med Chem Comm , vol.3 , pp. 871-886
    • Musiol, E.M.1    Weber, T.2
  • 91
    • 0034086734 scopus 로고    scopus 로고
    • Metabolic flux analysis in Streptomyces coelicolor under various nutrient limitations
    • Naeimpoor F., Mavituna F. Metabolic flux analysis in Streptomyces coelicolor under various nutrient limitations. Metab Eng 2000, 2:140-148.
    • (2000) Metab Eng , vol.2 , pp. 140-148
    • Naeimpoor, F.1    Mavituna, F.2
  • 92
    • 70350722394 scopus 로고    scopus 로고
    • Genomic basis for natural product biosynthetic diversity in the actinomycetes
    • Nett M., Ikeda H., Moore B.S. Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat Prod Rep 2009, 26:1362-1384.
    • (2009) Nat Prod Rep , vol.26 , pp. 1362-1384
    • Nett, M.1    Ikeda, H.2    Moore, B.S.3
  • 93
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25years
    • Newman D.J., Cragg G.M. Natural products as sources of new drugs over the last 25years. J Nat Prod 2007, 70:461-477.
    • (2007) J Nat Prod , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 95
    • 0032847109 scopus 로고    scopus 로고
    • The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor
    • Ohnishi Y., Kameyama S., Onaka H., Horinouchi S. The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor. Mol Microbiol 1999, 34:102-111.
    • (1999) Mol Microbiol , vol.34 , pp. 102-111
    • Ohnishi, Y.1    Kameyama, S.2    Onaka, H.3    Horinouchi, S.4
  • 96
    • 50249084003 scopus 로고    scopus 로고
    • Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering
    • Olano C., Lombo F., Mendez C., Salas J.A. Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering. Metab Eng 2008, 10:281-292.
    • (2008) Metab Eng , vol.10 , pp. 281-292
    • Olano, C.1    Lombo, F.2    Mendez, C.3    Salas, J.A.4
  • 98
    • 84859165788 scopus 로고    scopus 로고
    • The Genomes OnLine Database (GOLD) v. 4: status of genomic and metagenomic projects and their associated metadata
    • Pagani I., Liolios K., Jansson J., Chen I.M., Smirnova T., Nosrat B., et al. The Genomes OnLine Database (GOLD) v. 4: status of genomic and metagenomic projects and their associated metadata. Nucleic Acids Res 2012, 40:D571-D579.
    • (2012) Nucleic Acids Res , vol.40
    • Pagani, I.1    Liolios, K.2    Jansson, J.3    Chen, I.M.4    Smirnova, T.5    Nosrat, B.6
  • 99
    • 0041816073 scopus 로고    scopus 로고
    • Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster
    • Palaniappan N., Kim B.S., Sekiyama Y., Osada H., Reynolds K.A. Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster. J Biol Chem 2003, 278:35552-35557.
    • (2003) J Biol Chem , vol.278 , pp. 35552-35557
    • Palaniappan, N.1    Kim, B.S.2    Sekiyama, Y.3    Osada, H.4    Reynolds, K.A.5
  • 100
    • 34548635755 scopus 로고    scopus 로고
    • Analysis of intracellular short organic acid-coenzyme A esters from actinomycetes using liquid chromatography-electrospray ionization-mass spectrometry
    • Park J.W., Jung W.S., Park S.R., Park B.C., Yoon Y.J. Analysis of intracellular short organic acid-coenzyme A esters from actinomycetes using liquid chromatography-electrospray ionization-mass spectrometry. J Mass Spectrom 2007, 42:1136-1147.
    • (2007) J Mass Spectrom , vol.42 , pp. 1136-1147
    • Park, J.W.1    Jung, W.S.2    Park, S.R.3    Park, B.C.4    Yoon, Y.J.5
  • 101
    • 79959424209 scopus 로고    scopus 로고
    • Metabolic engineering for the production of natural products
    • Pickens L.B., Tang Y., Chooi Y.H. Metabolic engineering for the production of natural products. Annu Rev Chem Biomol Eng 2011, 2:211-236.
    • (2011) Annu Rev Chem Biomol Eng , vol.2 , pp. 211-236
    • Pickens, L.B.1    Tang, Y.2    Chooi, Y.H.3
  • 103
    • 46449120734 scopus 로고    scopus 로고
    • Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces
    • Rigali S., Titgemeyer F., Barends S., Mulder S., Thomae A.W., Hopwood D.A., et al. Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces. EMBO Rep 2008, 9:670-675.
    • (2008) EMBO Rep , vol.9 , pp. 670-675
    • Rigali, S.1    Titgemeyer, F.2    Barends, S.3    Mulder, S.4    Thomae, A.W.5    Hopwood, D.A.6
  • 104
    • 0036774667 scopus 로고    scopus 로고
    • Modification of post-PKS tailoring steps through combinatorial biosynthesis
    • Rix U., Fischer C., Remsing L.L., Rohr J. Modification of post-PKS tailoring steps through combinatorial biosynthesis. Nat Prod Rep 2002, 19:542-580.
    • (2002) Nat Prod Rep , vol.19 , pp. 542-580
    • Rix, U.1    Fischer, C.2    Remsing, L.L.3    Rohr, J.4
  • 105
    • 84864077784 scopus 로고    scopus 로고
    • Impact of malic enzymes on antibiotic and triacylglycerol production in Streptomyces coelicolor
    • Rodriguez E., Navone L., Casati P., Gramajo H. Impact of malic enzymes on antibiotic and triacylglycerol production in Streptomyces coelicolor. Appl Environ Microbiol 2012, 78:4571-4579.
    • (2012) Appl Environ Microbiol , vol.78 , pp. 4571-4579
    • Rodriguez, E.1    Navone, L.2    Casati, P.3    Gramajo, H.4
  • 106
    • 36348976352 scopus 로고    scopus 로고
    • Systems biology of antibiotic production by microorganisms
    • Rokem J.S., Lantz A.E., Nielsen J. Systems biology of antibiotic production by microorganisms. Nat Prod Rep 2007, 24:1262-1287.
    • (2007) Nat Prod Rep , vol.24 , pp. 1262-1287
    • Rokem, J.S.1    Lantz, A.E.2    Nielsen, J.3
  • 108
    • 84856805770 scopus 로고    scopus 로고
    • A novel two-component system involved in the transition to secondary metabolism in Streptomyces coelicolor
    • Rozas D., Gullon S., Mellado R.P. A novel two-component system involved in the transition to secondary metabolism in Streptomyces coelicolor. PLoS One 2012, 7:e31760.
    • (2012) PLoS One , vol.7
    • Rozas, D.1    Gullon, S.2    Mellado, R.P.3
  • 109
    • 33750969392 scopus 로고    scopus 로고
    • Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolor
    • Ryu Y.G., Butler M.J., Chater K.F., Lee K.J. Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolor. Appl Environ Microbiol 2006, 72:7132-7139.
    • (2006) Appl Environ Microbiol , vol.72 , pp. 7132-7139
    • Ryu, Y.G.1    Butler, M.J.2    Chater, K.F.3    Lee, K.J.4
  • 110
    • 0037524493 scopus 로고    scopus 로고
    • Nonribosomal peptides: from genes to products
    • Schwarzer D., Finking R., Marahiel M.A. Nonribosomal peptides: from genes to products. Nat Prod Rep 2003, 20:275-287.
    • (2003) Nat Prod Rep , vol.20 , pp. 275-287
    • Schwarzer, D.1    Finking, R.2    Marahiel, M.A.3
  • 111
    • 0037069467 scopus 로고    scopus 로고
    • Analysis of optimality in natural and perturbed metabolic networks
    • Segre D., Vitkup D., Church G.M. Analysis of optimality in natural and perturbed metabolic networks. Proc Natl Acad Sci U S A 2002, 99:15112-15117.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 15112-15117
    • Segre, D.1    Vitkup, D.2    Church, G.M.3
  • 112
    • 84887870749 scopus 로고    scopus 로고
    • Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold
    • [in press]
    • Shao Z., Rao G., Li C., Abil Z., Luo Y., Zhao H. Refactoring the silent spectinabilin gene cluster using a plug-and-play scaffold. ACS Synth Biol 2013, http://pubs.acs.org/doi/abs/10.1021/sb400058n [in press].
    • (2013) ACS Synth Biol
    • Shao, Z.1    Rao, G.2    Li, C.3    Abil, Z.4    Luo, Y.5    Zhao, H.6
  • 113
    • 11844296791 scopus 로고    scopus 로고
    • Biochemical activities of the absA two-component system of Streptomyces coelicolor
    • Sheeler N.L., MacMillan S.V., Nodwell J.R. Biochemical activities of the absA two-component system of Streptomyces coelicolor. J Bacteriol 2005, 187:687-696.
    • (2005) J Bacteriol , vol.187 , pp. 687-696
    • Sheeler, N.L.1    MacMillan, S.V.2    Nodwell, J.R.3
  • 114
    • 0038284769 scopus 로고    scopus 로고
    • The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans
    • Sola-Landa A., Moura R.S., Martin J.F. The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc Natl Acad Sci U S A 2003, 100:6133-6138.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 6133-6138
    • Sola-Landa, A.1    Moura, R.S.2    Martin, J.F.3
  • 115
    • 57149112966 scopus 로고    scopus 로고
    • ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures
    • Starcevic A., Zucko J., Simunkovic J., Long P.F., Cullum J., Hranueli D. ClustScan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures. Nucleic Acids Res 2008, 36:6882-6892.
    • (2008) Nucleic Acids Res , vol.36 , pp. 6882-6892
    • Starcevic, A.1    Zucko, J.2    Simunkovic, J.3    Long, P.F.4    Cullum, J.5    Hranueli, D.6
  • 116
    • 84874030515 scopus 로고    scopus 로고
    • Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase
    • Sundermann U., Bravo-Rodriguez K., Klopries S., Kushnir S., Gomez H., Sanchez-Garcia E., et al. Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase. ACS Chem Biol 2013, 8:443-450.
    • (2013) ACS Chem Biol , vol.8 , pp. 443-450
    • Sundermann, U.1    Bravo-Rodriguez, K.2    Klopries, S.3    Kushnir, S.4    Gomez, H.5    Sanchez-Garcia, E.6
  • 117
    • 69249223048 scopus 로고    scopus 로고
    • MapsiDB: an integrated web database for type I polyketide synthases
    • Tae H., Sohng J.K., Park K. MapsiDB: an integrated web database for type I polyketide synthases. Bioprocess Biosyst Eng 2009, 32:723-727.
    • (2009) Bioprocess Biosyst Eng , vol.32 , pp. 723-727
    • Tae, H.1    Sohng, J.K.2    Park, K.3
  • 118
    • 0036040203 scopus 로고    scopus 로고
    • Protein serine/threonine kinases in signal transduction for secondary metabolism and morphogenesis in Streptomyces
    • Umeyama T., Lee P.C., Horinouchi S. Protein serine/threonine kinases in signal transduction for secondary metabolism and morphogenesis in Streptomyces. Appl Microbiol Biotechnol 2002, 59:419-425.
    • (2002) Appl Microbiol Biotechnol , vol.59 , pp. 419-425
    • Umeyama, T.1    Lee, P.C.2    Horinouchi, S.3
  • 119
    • 84865590210 scopus 로고    scopus 로고
    • Engineering and adaptive evolution of Escherichia coli for D-lactate fermentation reveals GatC as a xylose transporter
    • Utrilla J., Licona-Cassani C., Marcellin E., Gosset G., Nielsen L.K., Martinez A. Engineering and adaptive evolution of Escherichia coli for D-lactate fermentation reveals GatC as a xylose transporter. Metab Eng 2012, 14:469-476.
    • (2012) Metab Eng , vol.14 , pp. 469-476
    • Utrilla, J.1    Licona-Cassani, C.2    Marcellin, E.3    Gosset, G.4    Nielsen, L.K.5    Martinez, A.6
  • 120
    • 80052077061 scopus 로고    scopus 로고
    • The regulation of the secondary metabolism of Streptomyces: new links and experimental advances
    • van Wezel G.P., McDowall K.J. The regulation of the secondary metabolism of Streptomyces: new links and experimental advances. Nat Prod Rep 2011, 28:1311-1333.
    • (2011) Nat Prod Rep , vol.28 , pp. 1311-1333
    • van Wezel, G.P.1    McDowall, K.J.2
  • 121
    • 84861445578 scopus 로고    scopus 로고
    • Characterization of new class III lantibiotics-erythreapeptin, avermipeptin and griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus demonstrates stepwise N-terminal leader processing
    • Voller G.H., Krawczyk J.M., Pesic A., Krawczyk B., Nachtigall J., Sussmuth R.D. Characterization of new class III lantibiotics-erythreapeptin, avermipeptin and griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus demonstrates stepwise N-terminal leader processing. Chembiochem 2012, 13:1174-1183.
    • (2012) Chembiochem , vol.13 , pp. 1174-1183
    • Voller, G.H.1    Krawczyk, J.M.2    Pesic, A.3    Krawczyk, B.4    Nachtigall, J.5    Sussmuth, R.D.6
  • 122
    • 77649305354 scopus 로고    scopus 로고
    • Natural products version 2.0: connecting genes to molecules
    • Walsh C.T., Fischbach M.A. Natural products version 2.0: connecting genes to molecules. J Am Chem Soc 2010, 132:2469-2493.
    • (2010) J Am Chem Soc , vol.132 , pp. 2469-2493
    • Walsh, C.T.1    Fischbach, M.A.2
  • 123
    • 84861880578 scopus 로고    scopus 로고
    • Optimized submerged batch fermentation strategy for systems scale studies of metabolic switching in Streptomyces coelicolor A3(2)
    • Wentzel A., Bruheim P., Overby A., Jakobsen O.M., Sletta H., Omara W.A., et al. Optimized submerged batch fermentation strategy for systems scale studies of metabolic switching in Streptomyces coelicolor A3(2). BMC Syst Biol 2012, 6:59.
    • (2012) BMC Syst Biol , vol.6 , pp. 59
    • Wentzel, A.1    Bruheim, P.2    Overby, A.3    Jakobsen, O.M.4    Sletta, H.5    Omara, W.A.6
  • 125
    • 84859643086 scopus 로고    scopus 로고
    • Combinatorial biosynthesis of polyketides-a perspective
    • Wong F.T., Khosla C. Combinatorial biosynthesis of polyketides-a perspective. Curr Opin Chem Biol 2012, 16:117-123.
    • (2012) Curr Opin Chem Biol , vol.16 , pp. 117-123
    • Wong, F.T.1    Khosla, C.2
  • 126
    • 84055199781 scopus 로고    scopus 로고
    • Modernization: one step at a time
    • Xu Z. Modernization: one step at a time. Nature 2011, 480:S90-S92.
    • (2011) Nature , vol.480
    • Xu, Z.1
  • 127
    • 0037466331 scopus 로고    scopus 로고
    • Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases
    • Yadav G., Gokhale R.S., Mohanty D. Computational approach for prediction of domain organization and substrate specificity of modular polyketide synthases. J Mol Biol 2003, 328:335-363.
    • (2003) J Mol Biol , vol.328 , pp. 335-363
    • Yadav, G.1    Gokhale, R.S.2    Mohanty, D.3
  • 128
    • 84875483830 scopus 로고    scopus 로고
    • Transcriptomic analysis of Streptomyces coelicolor differentiation in solid sporulating cultures: first compartmentalized and second multinucleated mycelia have different and distinctive transcriptomes
    • Yague P., Rodriguez-Garcia A., Lopez-Garcia M.T., Martin J.F., Rioseras B., Sanchez J., et al. Transcriptomic analysis of Streptomyces coelicolor differentiation in solid sporulating cultures: first compartmentalized and second multinucleated mycelia have different and distinctive transcriptomes. PLoS One 2013, 8:e60665.
    • (2013) PLoS One , vol.8
    • Yague, P.1    Rodriguez-Garcia, A.2    Lopez-Garcia, M.T.3    Martin, J.F.4    Rioseras, B.5    Sanchez, J.6
  • 129
    • 84859083398 scopus 로고    scopus 로고
    • Type III polyketide synthases in natural product biosynthesis
    • Yu D., Xu F., Zeng J., Zhan J. Type III polyketide synthases in natural product biosynthesis. IUBMB life 2012, 64:285-295.
    • (2012) IUBMB life , vol.64 , pp. 285-295
    • Yu, D.1    Xu, F.2    Zeng, J.3    Zhan, J.4
  • 131
    • 79961045257 scopus 로고    scopus 로고
    • TRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics
    • Zhang W., Ntai I., Kelleher N.L., Walsh C.T. tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics. Proc Natl Acad Sci U S A 2011, 108:12249-12253.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 12249-12253
    • Zhang, W.1    Ntai, I.2    Kelleher, N.L.3    Walsh, C.T.4
  • 132
    • 79951833485 scopus 로고    scopus 로고
    • Genome mining in Streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone
    • Zhu D., Seo M.J., Ikeda H., Cane D.E. Genome mining in Streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone. J Am Chem Soc 2011, 133:2128-2131.
    • (2011) J Am Chem Soc , vol.133 , pp. 2128-2131
    • Zhu, D.1    Seo, M.J.2    Ikeda, H.3    Cane, D.E.4
  • 133
    • 84859078407 scopus 로고    scopus 로고
    • The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity
    • Ziemert N., Podell S., Penn K., Badger J.H., Allen E., Jensen P.R. The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity. PLoS One 2012, 7:e34064.
    • (2012) PLoS One , vol.7
    • Ziemert, N.1    Podell, S.2    Penn, K.3    Badger, J.H.4    Allen, E.5    Jensen, P.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.