Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives

Chembiochem : a European journal of chemical biology

Volumn 15, Issue 13, 2014, Pages 1991-1997

  Bravo Rodriguez, Kenny ^a   Ismail Ali, Ahmed F ^a   Klopries, Stephan ^a   Kushnir, Susanna ^a   Ismail, Shehab ^a   Fansa, Eyad K ^a   Wittinghofer, Alfred ^a   Schulz, Frank ^a   Sanchez Garcia, Elsa ^a  

^a MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

Author keywords

computational chemistry; free energy calculations; molecular dynamics; monensin; polyketide biosynthesis; QM MM

Indexed keywords

ACYLTRANSFERASE; BIOLOGICAL PRODUCT; MALONIC ACID DERIVATIVE; MONENSIN; POLYKETIDE SYNTHASE;

ANALOGS AND DERIVATIVES; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; FERMENTATION; METABOLISM; PROTEIN CONFORMATION; STREPTOMYCES; SYNTHESIS;

ACYLTRANSFERASES; BIOLOGICAL PRODUCTS; COMPUTATIONAL BIOLOGY; ESCHERICHIA COLI; FERMENTATION; MALONATES; MODELS, MOLECULAR; MONENSIN; POLYKETIDE SYNTHASES; PROTEIN CONFORMATION; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 85027927172     PISSN: None     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201402206     Document Type: Article

References (0)