메뉴 건너뛰기




Volumn 13, Issue 8, 2015, Pages 509-523

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL EXTRACT; FUNGAL EXTRACT; BACTERIAL PROTEIN; BIOLOGICAL PRODUCT;

EID: 84937253653     PISSN: 17401526     EISSN: 17401534     Source Type: Journal    
DOI: 10.1038/nrmicro3496     Document Type: Review
Times cited : (706)

References (142)
  • 1
    • 62449089680 scopus 로고    scopus 로고
    • Microbial drug discovery: 80 years of progress
    • Demain, A. L. & Sanchez, S. Microbial drug discovery: 80 years of progress. J. Antibiot. 62, 5-16 (2009).
    • (2009) J. Antibiot. , vol.62 , pp. 5-16
    • Demain, A.L.1    Sanchez, S.2
  • 2
    • 84866454800 scopus 로고    scopus 로고
    • Natural products as sources for new pesticides
    • Cantrell, C. L., Dayan, F. E. & Duke, S. O. Natural products as sources for new pesticides. J. Nat. Prod. 75, 1231-1242 (2012).
    • (2012) J. Nat. Prod. , vol.75 , pp. 1231-1242
    • Cantrell, C.L.1    Dayan, F.E.2    Duke, S.O.3
  • 3
    • 77957980707 scopus 로고    scopus 로고
    • Origins and evolution of antibiotic resistance
    • Davies, J. & Davies, D. Origins and evolution of antibiotic resistance. Microbiol. Mol. Biol. Rev. 74, 417-433 (2010).
    • (2010) Microbiol. Mol. Biol. Rev. , vol.74 , pp. 417-433
    • Davies, J.1    Davies, D.2
  • 4
    • 1642344752 scopus 로고    scopus 로고
    • Safeguarding production-losses in major crops and the role of crop protection
    • Oerke, E.-C. & Dehne, H.-W. Safeguarding production-losses in major crops and the role of crop protection. Crop Prot. 23, 275-285 (2004).
    • (2004) Crop Prot. , vol.23 , pp. 275-285
    • Oerke, E.-C.1    Dehne, H.-W.2
  • 5
    • 33747365321 scopus 로고    scopus 로고
    • Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus
    • Fowler, V. G. et al. Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus. N. Engl. J. Med. 355, 653-655 (2006).
    • (2006) N. Engl. J. Med. , vol.355 , pp. 653-655
    • Fowler, V.G.1
  • 6
    • 79551527297 scopus 로고    scopus 로고
    • Fidaxomicin versus vancomycin for Clostridium difficile infection
    • Louie, T. J. et al. Fidaxomicin versus vancomycin for Clostridium difficile infection. N. Engl. J. Med. 364, 422-431 (2011).
    • (2011) N. Engl. J. Med. , vol.364 , pp. 422-431
    • Louie, T.J.1
  • 7
    • 84879588288 scopus 로고    scopus 로고
    • From epoxomicin to carfilzomib: Chemistry, biology, and medical outcomes
    • Kim, K. B. & Crews, C. M. From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes. Nat. Prod. Rep. 30, 600-604 (2013).
    • (2013) Nat. Prod. Rep. , vol.30 , pp. 600-604
    • Kim, K.B.1    Crews, C.M.2
  • 8
    • 15944368107 scopus 로고    scopus 로고
    • Rediscovery of known natural compounds: Nuisance or goldmine?
    • Tulp, M. & Bohlin, L. Rediscovery of known natural compounds: nuisance or goldmine? Trends Pharmacol. Sci. 26, 175-177 (2005).
    • (2005) Trends Pharmacol. Sci. , vol.26 , pp. 175-177
    • Tulp, M.1    Bohlin, L.2
  • 9
    • 33751206542 scopus 로고    scopus 로고
    • Seeking new antibiotics in nature's backyard
    • von Bubnoff, A. Seeking new antibiotics in nature's backyard. Cell 127, 867-869 (2006).
    • (2006) Cell , vol.127 , pp. 867-869
    • Von Bubnoff, A.1
  • 10
    • 0037046560 scopus 로고    scopus 로고
    • Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
    • Bentley, S. D. et al. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417, 141-147 (2002).
    • (2002) Nature , vol.417 , pp. 141-147
    • Bentley, S.D.1
  • 11
    • 0035834039 scopus 로고    scopus 로고
    • Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites
    • Omura, S. et al. Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc. Natl Acad. Sci. USA 98, 12215-12220 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 12215-12220
    • Omura, S.1
  • 12
    • 30544434099 scopus 로고    scopus 로고
    • Fungal secondary metabolism from biochemistry to genomics
    • Keller, N. P., Turner, G. & Bennett, J. W. Fungal secondary metabolism from biochemistry to genomics. Nat. Rev. Microbiol. 3, 937-947 (2005).
    • (2005) Nat. Rev. Microbiol. , vol.3 , pp. 937-947
    • Keller, N.P.1    Turner, G.2    Bennett, J.W.3
  • 13
    • 84895075252 scopus 로고    scopus 로고
    • Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways
    • Challis, G. L. Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways. J. Ind. Microbiol. Biotechnol. 41, 219-232 (2014).
    • (2014) J. Ind. Microbiol. Biotechnol. , vol.41 , pp. 219-232
    • Challis, G.L.1
  • 14
    • 0034659816 scopus 로고    scopus 로고
    • Coelichelin a new peptide siderophore encoded by the Streptomyces coelicolor genome: Structure prediction from the sequence of its non-ribosomal peptide synthetase
    • Challis, G. L. & Ravel, J. Coelichelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetase. FEMS Microbiol. Lett. 187, 111-114 (2000).
    • (2000) FEMS Microbiol. Lett. , vol.187 , pp. 111-114
    • Challis, G.L.1    Ravel, J.2
  • 15
    • 33846678395 scopus 로고    scopus 로고
    • A cryptic type i polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2)
    • Pawlik, K., Kotowska, M., Chater, K. F., Kuczek, K. & Takano, E. A cryptic type I polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2). Arch. Microbiol. 187, 87-99 (2007).
    • (2007) Arch. Microbiol. , vol.187 , pp. 87-99
    • Pawlik, K.1    Kotowska, M.2    Chater, K.F.3    Kuczek, K.4    Takano, E.5
  • 16
    • 70350722394 scopus 로고    scopus 로고
    • Genomic basis for natural product biosynthetic diversity in the actinomycetes
    • Nett, M., Ikeda, H. & Moore, B. S. Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat. Prod. Rep. 26, 1362-1384 (2009).
    • (2009) Nat. Prod. Rep. , vol.26 , pp. 1362-1384
    • Nett, M.1    Ikeda, H.2    Moore, B.S.3
  • 17
    • 34848911303 scopus 로고    scopus 로고
    • Polyketide synthases and nonribosomal peptide synthetases: The emerging view from bacterial genomics
    • Donadio, S., Monciardini, P. & Sosio, M. Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics. Nat. Prod. Rep. 24, 1073-1109 (2007).
    • (2007) Nat. Prod. Rep. , vol.24 , pp. 1073-1109
    • Donadio, S.1    Monciardini, P.2    Sosio, M.3
  • 18
    • 84874051724 scopus 로고    scopus 로고
    • A genomic approach to the cryptic secondary metabolome of the anaerobic world
    • Letzel, A. C., Pidot, S. J. & Hertweck, C. A genomic approach to the cryptic secondary metabolome of the anaerobic world. Nat. Prod. Rep. 30, 392-428 (2013).
    • (2013) Nat. Prod. Rep. , vol.30 , pp. 392-428
    • Letzel, A.C.1    Pidot, S.J.2    Hertweck, C.3
  • 19
    • 84893542053 scopus 로고    scopus 로고
    • An environmental bacterial taxon with a large and distinct metabolic repertoire
    • Wilson, M. C. et al. An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature 506, 58-62 (2014).
    • (2014) Nature , vol.506 , pp. 58-62
    • Wilson, M.C.1
  • 20
    • 65549083361 scopus 로고    scopus 로고
    • Strategies for the discovery of new natural products by genome mining
    • Zerikly, M. & Challis, G. L. Strategies for the discovery of new natural products by genome mining. ChemBioChem 10, 625-633 (2009).
    • (2009) ChemBioChem , vol.10 , pp. 625-633
    • Zerikly, M.1    Challis, G.L.2
  • 21
    • 84918813440 scopus 로고    scopus 로고
    • Metabolic engineering of antibiotic factories: New tools for antibiotic production in actinomycetes
    • Weber, T. et al. Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes. Trends Biotechnol. 33, 15-26 (2015).
    • (2015) Trends Biotechnol. , vol.33 , pp. 15-26
    • Weber, T.1
  • 22
    • 72849144434 scopus 로고    scopus 로고
    • Sequencing technologies-The next generation
    • Metsker, M. L. Sequencing technologies-the next generation. Nat. Rev. Genet. 11, 31-46 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 31-46
    • Metsker, M.L.1
  • 23
    • 84900396854 scopus 로고    scopus 로고
    • Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors
    • Schorn, M. et al. Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. ACS Chem. Biol. 9, 301-309 (2014).
    • (2014) ACS Chem. Biol. , vol.9 , pp. 301-309
    • Schorn, M.1
  • 24
    • 84868100087 scopus 로고    scopus 로고
    • Posttranslational β-methylation and macrolactamidination in the biosynthesis of the bottromycin complex of ribosomal peptide antibiotics
    • Gomez-Escribano, J.-P., Song, L., Bibb, M. J. & Challis, G. L. Posttranslational β-methylation and macrolactamidination in the biosynthesis of the bottromycin complex of ribosomal peptide antibiotics. Chem. Sci. 3, 3522-3525 (2012).
    • (2012) Chem. Sci. , vol.3 , pp. 3522-3525
    • Gomez-Escribano, J.-P.1    Song, L.2    Bibb, M.J.3    Challis, G.L.4
  • 25
    • 84886667844 scopus 로고    scopus 로고
    • Cloning and heterologous expression of the thioviridamide biosynthesis gene cluster from Streptomyces olivoviridis
    • Izawa, M., Kawasaki, T. & Haykawa, Y. Cloning and heterologous expression of the thioviridamide biosynthesis gene cluster from Streptomyces olivoviridis. Appl. Environ. Microbiol. 79, 7110-7113 (2013).
    • (2013) Appl. Environ. Microbiol. , vol.79 , pp. 7110-7113
    • Izawa, M.1    Kawasaki, T.2    Haykawa, Y.3
  • 26
    • 79959920872 scopus 로고    scopus 로고
    • AntiSMASH: Rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters
    • Medema, M. H. et al. antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters. Nucleic Acids Res. 39, W339-W346 (2011).
    • (2011) Nucleic Acids Res. , vol.39 , pp. W339-W346
    • Medema, M.H.1
  • 27
    • 84883353135 scopus 로고    scopus 로고
    • AntiSMASH 2.0-A versatile platform for genome mining of secondary metabolite producers
    • Blin, K. et al. antiSMASH 2.0-a versatile platform for genome mining of secondary metabolite producers. Nucleic Acids Res. 41, W204-W212 (2013).
    • (2013) Nucleic Acids Res. , vol.41 , pp. W204-W212
    • Blin, K.1
  • 28
    • 84895873870 scopus 로고    scopus 로고
    • Improved lanthipeptide detection and prediction for antiSMASH
    • Blin, K., Kazempour, D., Wohlleben, W. & Weber, T. Improved lanthipeptide detection and prediction for antiSMASH. PLoS ONE 9, e89420 (2014).
    • (2014) PLoS ONE , vol.9 , pp. e89420
    • Blin, K.1    Kazempour, D.2    Wohlleben, W.3    Weber, T.4
  • 29
    • 77955274600 scopus 로고    scopus 로고
    • SMURF: Genomic mapping of fungal secondary metabolite clusters
    • Khaldi, N. et al. SMURF: genomic mapping of fungal secondary metabolite clusters. Fungal Genet. Biol. 47, 736-741 (2010).
    • (2010) Fungal Genet. Biol. , vol.47 , pp. 736-741
    • Khaldi, N.1
  • 30
    • 84883572507 scopus 로고    scopus 로고
    • BAGEL3: Automated identification of genes encoding bacteriocins and (non-) bactericidal posttranslationally modified peptides
    • van Heel, A. J., de Jong, A., Montalbán-López, M., Kok, J. & Kuipers, O. P. BAGEL3: automated identification of genes encoding bacteriocins and (non-) bactericidal posttranslationally modified peptides. Nucleic Acids Res. 41, W448-W453 (2013).
    • (2013) Nucleic Acids Res. , vol.41 , pp. W448-W453
    • Van Heel, A.J.1    De Jong, A.2    Montalbán-López, M.3    Kok, J.4    Kuipers, O.P.5
  • 31
    • 84899651850 scopus 로고    scopus 로고
    • In silico tools for the analysis of antibiotic biosynthetic pathways
    • Weber, T. In silico tools for the analysis of antibiotic biosynthetic pathways. Int. J. Med. Microbiol. 304, 230-235 (2014).
    • (2014) Int. J. Med. Microbiol. , vol.304 , pp. 230-235
    • Weber, T.1
  • 33
    • 33748631825 scopus 로고    scopus 로고
    • Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: Logic, machinery, and mechanisms
    • Fischbach, M. A. & Walsh, C. T. Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms. Chem. Rev. 106, 3468-3496 (2006).
    • (2006) Chem. Rev. , vol.106 , pp. 3468-3496
    • Fischbach, M.A.1    Walsh, C.T.2
  • 34
    • 83855165105 scopus 로고    scopus 로고
    • Repetitive DNA and next-generation sequencing: Computational challenges and solutions
    • Treangen, T. J. & Salzberg, S. L. Repetitive DNA and next-generation sequencing: computational challenges and solutions. Nat. Rev. Genet. 13, 36-46 (2012).
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 36-46
    • Treangen, T.J.1    Salzberg, S.L.2
  • 35
    • 84997783038 scopus 로고    scopus 로고
    • De novo assembly of the Streptomyces sp strain Mg1 genome using PacBio single-molecule sequencing
    • Hoefler, B. C., Konganti, K. & Straight, P. D. De novo assembly of the Streptomyces sp. strain Mg1 genome using PacBio single-molecule sequencing. Genome Announc. 1, e00535-13 (2013).
    • (2013) Genome Announc. , vol.1 , pp. e00535-e00613
    • Hoefler, B.C.1    Konganti, K.2    Straight, P.D.3
  • 36
    • 78651285748 scopus 로고    scopus 로고
    • CDD: A Conserved Domain Database for the functional annotation of proteins
    • Marchler-Bauer, A. et al. CDD: a Conserved Domain Database for the functional annotation of proteins. Nucleic Acids Res. 39, D225-D229 (2011).
    • (2011) Nucleic Acids Res. , vol.39 , pp. D225-D229
    • Marchler-Bauer, A.1
  • 37
    • 0034013269 scopus 로고    scopus 로고
    • Predictive, structure-based model of amino acid recognition by non-ribosomal peptide synthetase adenylation domains
    • Challis, G. L., Ravel, J. & Townsend, C. A. Predictive, structure-based model of amino acid recognition by non-ribosomal peptide synthetase adenylation domains. Chem. Biol. 7, 211-224 (2000).
    • (2000) Chem. Biol. , vol.7 , pp. 211-224
    • Challis, G.L.1    Ravel, J.2    Townsend, C.A.3
  • 38
    • 0033179468 scopus 로고    scopus 로고
    • The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
    • Stachelhaus, T., Mootz, H. D. & Marahiel, M. A. The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chem. Biol. 6, 493-505 (1999).
    • (1999) Chem. Biol. , vol.6 , pp. 493-505
    • Stachelhaus, T.1    Mootz, H.D.2    Marahiel, M.A.3
  • 39
    • 0028841535 scopus 로고
    • Divergent sequence motifs correlated with the substrate specificity of (methyl) malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases
    • Haydock, S. F. et al. Divergent sequence motifs correlated with the substrate specificity of (methyl) malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases. FEBS Lett. 374, 246-248 (1995).
    • (1995) FEBS Lett. , vol.374 , pp. 246-248
    • Haydock, S.F.1
  • 40
    • 34547945950 scopus 로고    scopus 로고
    • A tylosin ketoreductase reveals how chirality is determined in polyketides
    • Keatinge-Clay, A. T. A tylosin ketoreductase reveals how chirality is determined in polyketides. Chem. Biol. 14, 898-908 (2007).
    • (2007) Chem. Biol. , vol.14 , pp. 898-908
    • Keatinge-Clay, A.T.1
  • 41
    • 56049119642 scopus 로고    scopus 로고
    • Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases
    • Kwan, D. H. et al. Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases. Chem. Biol. 15, 1231-1240 (2008).
    • (2008) Chem. Biol. , vol.15 , pp. 1231-1240
    • Kwan, D.H.1
  • 42
    • 38949203821 scopus 로고    scopus 로고
    • Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection
    • Nguyen, T. et al. Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection. Nat. Biotechnol. 26, 225-233 (2008).
    • (2008) Nat. Biotechnol. , vol.26 , pp. 225-233
    • Nguyen, T.1
  • 43
    • 79959936207 scopus 로고    scopus 로고
    • NRPSpredictor2-A web server for predicting NRPS adenylation domain specificity
    • Röttig, M. et al. NRPSpredictor2-a web server for predicting NRPS adenylation domain specificity. Nucleic Acids Res. 39, W362-W367 (2011).
    • (2011) Nucleic Acids Res. , vol.39 , pp. W362-W367
    • Röttig, M.1
  • 44
    • 64249084052 scopus 로고    scopus 로고
    • In silico prediction of microbial secondary metabolic pathways from DNA sequence data
    • Bachmann, B. O. & Ravel, J. In silico prediction of microbial secondary metabolic pathways from DNA sequence data. Meth. Enzymol. 458, 181-217 (2009).
    • (2009) Meth. Enzymol. , vol.458 , pp. 181-217
    • Bachmann, B.O.1    Ravel, J.2
  • 45
    • 77954265333 scopus 로고    scopus 로고
    • SBSPKS: Structure based sequence analysis of polyketide synthases
    • Anand, S. et al. SBSPKS: structure based sequence analysis of polyketide synthases. Nucleic Acids Res. 38, W487-W496 (2010).
    • (2010) Nucleic Acids Res. , vol.38 , pp. W487-W496
    • Anand, S.1
  • 46
    • 84876340080 scopus 로고    scopus 로고
    • Classification of the adenylation and acyl-transferase activity of NRPS and PKS systems using ensembles of substrate specific hidden Markov models
    • Khayatt, B. I., Overmars L., Siezen, R. J. & Francke, C. Classification of the adenylation and acyl-transferase activity of NRPS and PKS systems using ensembles of substrate specific hidden Markov models. PLoS ONE 8, e62136 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e62136
    • Khayatt, B.I.1    Overmars, L.2    Siezen, R.J.3    Francke, C.4
  • 47
    • 33744994317 scopus 로고    scopus 로고
    • Platensimycin is a selective FabF inhibitor with potent antibiotic properties
    • Wang, J. et al. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 441, 358-361 (2006).
    • (2006) Nature , vol.441 , pp. 358-361
    • Wang, J.1
  • 48
    • 84871292787 scopus 로고    scopus 로고
    • Regulation of fungal secondary metabolism
    • Brakhage, A. A. Regulation of fungal secondary metabolism. Nat. Rev. Microbiol. 11, 21-32 (2013).
    • (2013) Nat. Rev. Microbiol. , vol.11 , pp. 21-32
    • Brakhage, A.A.1
  • 49
    • 80052077061 scopus 로고    scopus 로고
    • The regulation of the secondary metabolism of Streptomyces: New links and experimental advances
    • van Wezel, G. P. & McDowall, K. J. The regulation of the secondary metabolism of Streptomyces: new links and experimental advances. Nat. Prod. Rep. 28, 1311-1333 (2011).
    • (2011) Nat. Prod. Rep. , vol.28 , pp. 1311-1333
    • Van Wezel, G.P.1    McDowall, K.J.2
  • 50
    • 79851515868 scopus 로고    scopus 로고
    • Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms
    • Chiang, Y. M., Chang, S. L., Oakley, B. R. & Wang, C. C. Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms. Curr. Opin. Chem. Biol. 15, 137-143 (2011).
    • (2011) Curr. Opin. Chem. Biol. , vol.15 , pp. 137-143
    • Chiang, Y.M.1    Chang, S.L.2    Oakley, B.R.3    Wang, C.C.4
  • 51
    • 33748254906 scopus 로고    scopus 로고
    • Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining
    • Scherlach, K. & Hertweck, C. Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining. Org. Biomol. Chem. 4, 3517-3520 (2006).
    • (2006) Org. Biomol. Chem. , vol.4 , pp. 3517-3520
    • Scherlach, K.1    Hertweck, C.2
  • 52
    • 77955108832 scopus 로고    scopus 로고
    • Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans
    • Scherlach, K., Schuemann, J., Dahse, H.-M. & Hertweck, C. Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans. J. Antibiot. 63, 375-377 (2010).
    • (2010) J. Antibiot. , vol.63 , pp. 375-377
    • Scherlach, K.1    Schuemann, J.2    Dahse, H.-M.3    Hertweck, C.4
  • 53
    • 77949363508 scopus 로고    scopus 로고
    • Closthioamide: An unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum
    • Lincke, T., Behnken, S., Ishida, K., Roth, M. & Hertweck, C. Closthioamide: an unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum. Angew. Chem. Int. Ed. Engl. 49, 2011-2013 (2010).
    • (2010) Angew. Chem. Int. Ed. Engl. , vol.49 , pp. 2011-2013
    • Lincke, T.1    Behnken, S.2    Ishida, K.3    Roth, M.4    Hertweck, C.5
  • 54
    • 34547885750 scopus 로고    scopus 로고
    • The rare earth, scandium, causes antibiotic overproduction in Streptomyces spp
    • Kawai, K., Wang, G., Okamoto, S. & Ochi, K. The rare earth, scandium, causes antibiotic overproduction in Streptomyces spp. FEMS Microbiol. Lett. 274, 311-315 (2007).
    • (2007) FEMS Microbiol. Lett. , vol.274 , pp. 311-315
    • Kawai, K.1    Wang, G.2    Okamoto, S.3    Ochi, K.4
  • 55
    • 77956254493 scopus 로고    scopus 로고
    • Rare earth elements activate the secondary metabolite-biosynthetic gene clusters in Streptomyces coelicolor A3(2)
    • Tanaka, Y., Hosaka, T. & Ochi, K. Rare earth elements activate the secondary metabolite-biosynthetic gene clusters in Streptomyces coelicolor A3(2). J. Antibiot. 63, 477-481 (2010).
    • (2010) J. Antibiot. , vol.63 , pp. 477-481
    • Tanaka, Y.1    Hosaka, T.2    Ochi, K.3
  • 56
    • 84901000640 scopus 로고    scopus 로고
    • High-throughput platform for the discovery of elicitors of silent bacterial gene clusters
    • Seyedsayamdost, M. R. High-throughput platform for the discovery of elicitors of silent bacterial gene clusters. Proc. Natl Acad. Sci. USA 111, 7266-7271 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 7266-7271
    • Seyedsayamdost, M.R.1
  • 57
    • 84865477861 scopus 로고    scopus 로고
    • Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism
    • Craney, A., Ozimok, C., Pimentel-Elardo, S. M., Capretta, A. & Nodwell, J. R. Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism. Chem. Biol. 19, 1020-1027 (2012).
    • (2012) Chem. Biol. , vol.19 , pp. 1020-1027
    • Craney, A.1    Ozimok, C.2    Pimentel-Elardo, S.M.3    Capretta, A.4    Nodwell, J.R.5
  • 58
    • 0037052320 scopus 로고    scopus 로고
    • Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment
    • Kaeberlein, T., Lewis, K. & Epstein, S. S. Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment. Science 296, 1127-1129 (2002).
    • (2002) Science , vol.296 , pp. 1127-1129
    • Kaeberlein, T.1    Lewis, K.2    Epstein, S.S.3
  • 59
    • 77950560416 scopus 로고    scopus 로고
    • Use of ichip for high-throughput in situ cultivation of "uncultivable" microbial species
    • Nichols, D. et al. Use of ichip for high-throughput in situ cultivation of "uncultivable" microbial species. Appl. Environ. Microbiol. 76, 2445-2450 (2010).
    • (2010) Appl. Environ. Microbiol. , vol.76 , pp. 2445-2450
    • Nichols, D.1
  • 60
    • 84899576523 scopus 로고    scopus 로고
    • Lassomycin, a ribosomally synthesized cyclic peptide, kills Mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2
    • Gavrish, E. et al. Lassomycin, a ribosomally synthesized cyclic peptide, kills Mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. Chem. Biol. 21, 509-518 (2014).
    • (2014) Chem. Biol. , vol.21 , pp. 509-518
    • Gavrish, E.1
  • 61
    • 84922937832 scopus 로고    scopus 로고
    • A new antibiotic kills pathogens without detectable resistance
    • Ling, L. L. et al. A new antibiotic kills pathogens without detectable resistance. Nature 517, 455-459 (2015).
    • (2015) Nature , vol.517 , pp. 455-459
    • Ling, L.L.1
  • 62
    • 84923010512 scopus 로고    scopus 로고
    • Antibiotics: An irresistible newcomer
    • Wright, G. Antibiotics: an irresistible newcomer. Nature 517, 442-444 (2015).
    • (2015) Nature , vol.517 , pp. 442-444
    • Wright, G.1
  • 63
    • 70149109184 scopus 로고    scopus 로고
    • Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans
    • Schroeckh, V. et al. Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc. Natl Acad. Sci. USA 106, 14558-14563 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 14558-14563
    • Schroeckh, V.1
  • 65
    • 79551488636 scopus 로고    scopus 로고
    • Mycolic acid-containing bacteria induce natural-product biosynthesis in Streptomyces species
    • Onaka, H., Mori, Y., Igarashi, Y. & Furumai, T. Mycolic acid-containing bacteria induce natural-product biosynthesis in Streptomyces species. Appl. Environ. Microbiol. 77, 400-406 (2011).
    • (2011) Appl. Environ. Microbiol. , vol.77 , pp. 400-406
    • Onaka, H.1    Mori, Y.2    Igarashi, Y.3    Furumai, T.4
  • 66
    • 84878012899 scopus 로고    scopus 로고
    • Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus
    • König, C. C. et al. Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus. ChemBioChem 14, 938-942 (2013).
    • (2013) ChemBioChem , vol.14 , pp. 938-942
    • König, C.C.1
  • 67
    • 84881361067 scopus 로고    scopus 로고
    • Imaging mass spectrometry of a coral microbe interaction with fungi
    • Moree, W. et al. Imaging mass spectrometry of a coral microbe interaction with fungi. J. Chem. Ecol. 39, 1045-1054 (2013).
    • (2013) J. Chem. Ecol. , vol.39 , pp. 1045-1054
    • Moree, W.1
  • 68
    • 84865288536 scopus 로고    scopus 로고
    • Interkingdom metabolic transformations captured by microbial imaging mass spectrometry
    • Moree, W. J. et al. Interkingdom metabolic transformations captured by microbial imaging mass spectrometry. Proc. Natl Acad. Sci. USA 109, 13811-13816 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 13811-13816
    • Moree, W.J.1
  • 69
    • 84907584619 scopus 로고    scopus 로고
    • Pep2Path: Automated mass spectrometry-guided genome mining of peptidic natural products
    • Medema, M. H. et al. Pep2Path: automated mass spectrometry-guided genome mining of peptidic natural products. PLoS Comp. Biol. 10, e1003822 (2014).
    • (2014) PLoS Comp. Biol. , vol.10 , pp. e1003822
    • Medema, M.H.1
  • 70
    • 84906678559 scopus 로고    scopus 로고
    • NRPquest: Coupling mass spectrometry and genome mining for nonribosomal peptide discovery
    • Mohimani, H. et al. NRPquest: coupling mass spectrometry and genome mining for nonribosomal peptide discovery. J. Nat. Prod. 77, 1902-1909 (2014).
    • (2014) J. Nat. Prod. , vol.77 , pp. 1902-1909
    • Mohimani, H.1
  • 71
    • 84904547209 scopus 로고    scopus 로고
    • Automated genome mining of ribosomal peptide natural products
    • Mohimani, H. et al. Automated genome mining of ribosomal peptide natural products. ACS Chem. Biol. 9, 1545-1551 (2014).
    • (2014) ACS Chem. Biol. , vol.9 , pp. 1545-1551
    • Mohimani, H.1
  • 72
    • 84872353481 scopus 로고    scopus 로고
    • New strategies for drug discovery: Activation of silent or weakly expressed microbial gene clusters
    • Ochi, K. & Hosaka, T. New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters. Appl. Microbiol. Biotechnol. 97, 87-98 (2013).
    • (2013) Appl. Microbiol. Biotechnol. , vol.97 , pp. 87-98
    • Ochi, K.1    Hosaka, T.2
  • 73
    • 0030448016 scopus 로고    scopus 로고
    • Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2)
    • Shima, J., Hesketh, A., Okamoto, S., Kawamoto, S. & Ochi, K. Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2). J. Bacteriol. 178, 7276-7284 (1996).
    • (1996) J. Bacteriol. , vol.178 , pp. 7276-7284
    • Shima, J.1    Hesketh, A.2    Okamoto, S.3    Kawamoto, S.4    Ochi, K.5
  • 74
    • 15744383448 scopus 로고    scopus 로고
    • Regulation of secondary metabolism in streptomycetes
    • Bibb, M. J. Regulation of secondary metabolism in streptomycetes. Curr. Opin. Microbiol. 8, 208-215 (2005).
    • (2005) Curr. Opin. Microbiol. , vol.8 , pp. 208-215
    • Bibb, M.J.1
  • 75
    • 2042475439 scopus 로고    scopus 로고
    • Structural basis for transcription regulation by alarmone ppGpp
    • Artsimovitch, I. et al. Structural basis for transcription regulation by alarmone ppGpp. Cell 117, 299-310 (2004).
    • (2004) Cell , vol.117 , pp. 299-310
    • Artsimovitch, I.1
  • 76
    • 42149158392 scopus 로고    scopus 로고
    • Control of bacterial transcription, translation and replication by (p)ppGpp
    • Srivatsan, A. & Wang, J. D. Control of bacterial transcription, translation and replication by (p)ppGpp. Curr. Opin. Microbiol. 11, 100-105 (2008).
    • (2008) Curr. Opin. Microbiol. , vol.11 , pp. 100-105
    • Srivatsan, A.1    Wang, J.D.2
  • 77
    • 0036460093 scopus 로고    scopus 로고
    • A rifampicin resistance mutation in the rpoB gene confers ppGpp-independent antibiotic production in Streptomyces coelicolor A3(2)
    • Xu, J., Tozawa, Y., Lai, C., Hayashi, H. & Ochi, K. A rifampicin resistance mutation in the rpoB gene confers ppGpp-independent antibiotic production in Streptomyces coelicolor A3(2). Mol. Genet. Genom. 268, 179-189 (2002).
    • (2002) Mol. Genet. Genom. , vol.268 , pp. 179-189
    • Xu, J.1    Tozawa, Y.2    Lai, C.3    Hayashi, H.4    Ochi, K.5
  • 78
    • 66149185679 scopus 로고    scopus 로고
    • Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12
    • Hosaka, T. et al. Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12. Nat. Biotechnol. 27, 462-464 (2009).
    • (2009) Nat. Biotechnol. , vol.27 , pp. 462-464
    • Hosaka, T.1
  • 79
    • 84864447599 scopus 로고    scopus 로고
    • Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145
    • Gomez-Escribano, J. P. et al. Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145. Chem. Sci. 3, 2716-2720 (2012).
    • (2012) Chem. Sci. , vol.3 , pp. 2716-2720
    • Gomez-Escribano, J.P.1
  • 80
    • 77955343496 scopus 로고    scopus 로고
    • Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2)
    • Gottelt, M., Kol, S., Gomez-Escribano, J. P., Bibb, M. & Takano, E. Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2). Microbiology 156, 2343-2353 (2010).
    • (2010) Microbiology , vol.156 , pp. 2343-2353
    • Gottelt, M.1    Kol, S.2    Gomez-Escribano, J.P.3    Bibb, M.4    Takano, E.5
  • 81
    • 79959769183 scopus 로고    scopus 로고
    • Transcriptional regulatory elements in fungal secondary metabolism
    • Yin, W. & Keller, N. Transcriptional regulatory elements in fungal secondary metabolism. J. Microbiol. 49, 329-339 (2011).
    • (2011) J. Microbiol. , vol.49 , pp. 329-339
    • Yin, W.1    Keller, N.2
  • 82
    • 45849147020 scopus 로고    scopus 로고
    • VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism
    • Bayram, Ö. et al. VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science 320, 1504-1506 (2008).
    • (2008) Science , vol.320 , pp. 1504-1506
    • Bayram Ö.1
  • 83
    • 4143090400 scopus 로고    scopus 로고
    • LaeA, a regulator of secondary metabolism in Aspergillus spp
    • Bok, J. W. & Keller, N. P. LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot. Cell 3, 527-535 (2004).
    • (2004) Eukaryot. Cell , vol.3 , pp. 527-535
    • Bok, J.W.1    Keller, N.P.2
  • 84
    • 30744456748 scopus 로고    scopus 로고
    • Genomic mining for Aspergillus natural products
    • Bok, J. W. et al. Genomic mining for Aspergillus natural products. Chem. Biol. 13, 31-37 (2006).
    • (2006) Chem. Biol. , vol.13 , pp. 31-37
    • Bok, J.W.1
  • 85
    • 19944427730 scopus 로고    scopus 로고
    • Cytotoxic and other metabolites of Aspergillus inhabiting the rhizosphere of Sonoran desert plants
    • He, J. et al. Cytotoxic and other metabolites of Aspergillus inhabiting the rhizosphere of Sonoran desert plants. J. Nat. Prod. 67, 1985-1991 (2004).
    • (2004) J. Nat. Prod. , vol.67 , pp. 1985-1991
    • He, J.1
  • 86
    • 84857931220 scopus 로고    scopus 로고
    • Antiterminator-mediated unveiling of cryptic polythioamides in an anaerobic bacterium
    • Behnken, S., Lincke, T., Kloss, F., Ishida, K. & Hertweck, C. Antiterminator-mediated unveiling of cryptic polythioamides in an anaerobic bacterium. Angew. Chem. Int. Ed. Engl. 51, 2425-2428 (2012).
    • (2012) Angew. Chem. Int. Ed. Engl. , vol.51 , pp. 2425-2428
    • Behnken, S.1    Lincke, T.2    Kloss, F.3    Ishida, K.4    Hertweck, C.5
  • 87
    • 77953082083 scopus 로고    scopus 로고
    • E. Coli NusG inhibits backtracking and accelerates pause-free transcription by promoting forward translocation of RNA polymerase
    • Herbert, K. M. et al. E. coli NusG inhibits backtracking and accelerates pause-free transcription by promoting forward translocation of RNA polymerase. J. Mol. Biol. 399, 17-30 (2010).
    • (2010) J. Mol. Biol. , vol.399 , pp. 17-30
    • Herbert, K.M.1
  • 88
    • 77951742010 scopus 로고    scopus 로고
    • Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1
    • McKenzie, N. L. et al. Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1. J. Antibiot. 63, 177-182 (2010).
    • (2010) J. Antibiot. , vol.63 , pp. 177-182
    • McKenzie, N.L.1
  • 89
    • 85015069067 scopus 로고    scopus 로고
    • Controlling the double helix
    • Felsenfeld, G. & Groudine, M. Controlling the double helix. Nature 421, 448-453 (2003).
    • (2003) Nature , vol.421 , pp. 448-453
    • Felsenfeld, G.1    Groudine, M.2
  • 90
    • 42149147377 scopus 로고    scopus 로고
    • Histone modifications and chromatin dynamics: A focus on filamentous fungi
    • Brosch, G., Loidl, P. & Graessle, S. Histone modifications and chromatin dynamics: a focus on filamentous fungi. FEMS Microbiol. Rev. 32, 409-439 (2008).
    • (2008) FEMS Microbiol. Rev. , vol.32 , pp. 409-439
    • Brosch, G.1    Loidl, P.2    Graessle, S.3
  • 91
    • 73949102298 scopus 로고    scopus 로고
    • Epigenome manipulation as a pathway to new natural product scaffolds and their congeners
    • Cichewicz, R. H. Epigenome manipulation as a pathway to new natural product scaffolds and their congeners. Nat. Prod. Rep. 27, 11-22 (2010).
    • (2010) Nat. Prod. Rep. , vol.27 , pp. 11-22
    • Cichewicz, R.H.1
  • 92
    • 34748829074 scopus 로고    scopus 로고
    • Histone deacetylase activity regulates chemical diversity in Aspergillus
    • Shwab, E. K. et al. Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryot. Cell 6, 1656-1664 (2007).
    • (2007) Eukaryot. Cell , vol.6 , pp. 1656-1664
    • Shwab, E.K.1
  • 93
    • 67650321573 scopus 로고    scopus 로고
    • Chromatin-level regulation of biosynthetic gene clusters
    • Bok, J. W. et al. Chromatin-level regulation of biosynthetic gene clusters. Nat. Chem. Biol. 5, 462-464 (2009).
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 462-464
    • Bok, J.W.1
  • 94
    • 35348975068 scopus 로고    scopus 로고
    • Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium
    • Wu, Y. et al. Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium. Life Sci. 81, 1332-1338 (2007).
    • (2007) Life Sci. , vol.81 , pp. 1332-1338
    • Wu, Y.1
  • 96
    • 58849110677 scopus 로고    scopus 로고
    • A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger
    • Henrikson, J. C., Hoover, A. R., Joyner, P. M. & Cichewicz, R. H. A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger. Org. Biomol. Chem. 7, 435-438 (2009).
    • (2009) Org. Biomol. Chem. , vol.7 , pp. 435-438
    • Henrikson, J.C.1    Hoover, A.R.2    Joyner, P.M.3    Cichewicz, R.H.4
  • 97
    • 84880028198 scopus 로고    scopus 로고
    • Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression
    • Asai, T. et al. Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression. Org. Lett. 15, 3346-3349 (2013).
    • (2013) Org. Lett. , vol.15 , pp. 3346-3349
    • Asai, T.1
  • 98
    • 77953005706 scopus 로고    scopus 로고
    • Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an Atlantic-Forest-soil-derived Penicillium citreonigrum
    • Wang, X. et al. Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an Atlantic-Forest-soil-derived Penicillium citreonigrum. J. Nat. Prod. 73, 942-948 (2010).
    • (2010) J. Nat. Prod. , vol.73 , pp. 942-948
    • Wang, X.1
  • 99
    • 33947308882 scopus 로고    scopus 로고
    • Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans
    • Bergmann, S. et al. Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat. Chem. Biol. 3, 213-217 (2007).
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 213-217
    • Bergmann, S.1
  • 100
    • 34548206283 scopus 로고    scopus 로고
    • Identification and in vivo functional analysis by gene disruption of ctnA, an activator gene involved in citrinin biosynthesis in Monascus purpureus
    • Shimizu, T., Kinoshita, H. & Nihira, T. Identification and in vivo functional analysis by gene disruption of ctnA, an activator gene involved in citrinin biosynthesis in Monascus purpureus. Appl. Environ. Microbiol. 73, 5097-5103 (2007).
    • (2007) Appl. Environ. Microbiol. , vol.73 , pp. 5097-5103
    • Shimizu, T.1    Kinoshita, H.2    Nihira, T.3
  • 101
    • 68049088909 scopus 로고    scopus 로고
    • A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans
    • Chiang, Y. M. et al. A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans. J. Am. Chem. Soc. 131, 2965-2970 (2009).
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 2965-2970
    • Chiang, Y.M.1
  • 102
    • 0035977612 scopus 로고    scopus 로고
    • Isolation and structure elucidation of chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp
    • Duncan, S. J. et al. Isolation and structure elucidation of chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp. J. Am. Chem. Soc. 123, 554-560 (2001).
    • (2001) J. Am. Chem. Soc. , vol.123 , pp. 554-560
    • Duncan, S.J.1
  • 103
    • 79954997859 scopus 로고    scopus 로고
    • Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
    • Laureti, L. et al. Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proc. Natl Acad. Sci. USA 108, 6258-6263 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 6258-6263
    • Laureti, L.1
  • 104
    • 56249143138 scopus 로고    scopus 로고
    • 2-alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining
    • Corre, C., Song, L., O'Rourke, S., Chater, K. F. & Challis, G. L. 2-alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining. Proc. Nat. Acad. Sci. USA 105, 17510-17515 (2008).
    • (2008) Proc. Nat. Acad. Sci. USA , vol.105 , pp. 17510-17515
    • Corre, C.1    Song, L.2    O'Rourke, S.3    Chater, K.F.4    Challis, G.L.5
  • 105
    • 79951642419 scopus 로고    scopus 로고
    • Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of kinamycins
    • Bunet, R. et al. Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of kinamycins. J. Bacteriol. 193, 1142-1153 (2011).
    • (2011) J. Bacteriol. , vol.193 , pp. 1142-1153
    • Bunet, R.1
  • 106
    • 84888617134 scopus 로고    scopus 로고
    • Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster
    • Sidda, J. D. et al. Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster. Chem. Sci. 5, 86-89 (2014).
    • (2014) Chem. Sci. , vol.5 , pp. 86-89
    • Sidda, J.D.1
  • 107
    • 79952593656 scopus 로고    scopus 로고
    • Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis
    • Biggins, J. B., Gleber, C. D. & Brady, S. F. Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis. Org. Lett. 13, 1536-1539 (2011).
    • (2011) Org. Lett. , vol.13 , pp. 1536-1539
    • Biggins, J.B.1    Gleber, C.D.2    Brady, S.F.3
  • 108
    • 77957709176 scopus 로고    scopus 로고
    • Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant
    • Ishida, K., Lincke, T., Behnken, S. & Hertweck, C. Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant. J. Am. Chem. Soc. 132, 13966-13968 (2010).
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 13966-13968
    • Ishida, K.1    Lincke, T.2    Behnken, S.3    Hertweck, C.4
  • 109
    • 84921496414 scopus 로고    scopus 로고
    • Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection
    • Guo, F. et al. Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection. Metab. Eng. 28, 134-142 (2015).
    • (2015) Metab. Eng. , vol.28 , pp. 134-142
    • Guo, F.1
  • 110
    • 84868515764 scopus 로고    scopus 로고
    • Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species
    • Franke, J., Ishida, K. & Hertweck, C. Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species. Angew. Chem. Int. Ed. Engl. 51, 11611-11615 (2012).
    • (2012) Angew. Chem. Int. Ed. Engl. , vol.51 , pp. 11611-11615
    • Franke, J.1    Ishida, K.2    Hertweck, C.3
  • 111
    • 84897952067 scopus 로고    scopus 로고
    • Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074
    • Olano, C. et al. Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074. Microb. Biotechnol. 7, 242-256 (2014).
    • (2014) Microb. Biotechnol. , vol.7 , pp. 242-256
    • Olano, C.1
  • 112
    • 0021336760 scopus 로고
    • Terferol, an inhibitor of cyclic adenosine-3, 5-monophosphate phosphodiesterase. II. Structure elucidation
    • Nakagawa, F. et al. Terferol, an inhibitor of cyclic adenosine-3, 5-monophosphate phosphodiesterase. II. Structure elucidation. J. Antibiot. 37, 10-12 (1984).
    • (1984) J. Antibiot. , vol.37 , pp. 10-12
    • Nakagawa, F.1
  • 113
    • 79951537655 scopus 로고    scopus 로고
    • Metabolites from the induced expression of cryptic single operons found in the genome of Burkholderia pseudomallei
    • Biggins, J. B., Liu, X., Feng, Z. & Brady, S. F. Metabolites from the induced expression of cryptic single operons found in the genome of Burkholderia pseudomallei. J. Am. Chem. Soc. 133, 1638-1641 (2011).
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 1638-1641
    • Biggins, J.B.1    Liu, X.2    Feng, Z.3    Brady, S.F.4
  • 114
    • 33646512641 scopus 로고    scopus 로고
    • Genome mining in Streptomyces coelicolor: Molecular cloning and characterization of a new sesquiterpene synthase
    • Lin, X., Hopson, R. & Cane, D. E. Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase. J. Am. Chem. Soc. 128, 6022-6023 (2006).
    • (2006) J. Am. Chem. Soc. , vol.128 , pp. 6022-6023
    • Lin, X.1    Hopson, R.2    Cane, D.E.3
  • 115
    • 77954303579 scopus 로고    scopus 로고
    • Genome mining in Streptomyces avermitilis: Cloning and characterization of SAV-76, the synthase for a new sesquiterpene, avermitilol
    • Chou, W. K. W. et al. Genome mining in Streptomyces avermitilis: cloning and characterization of SAV-76, the synthase for a new sesquiterpene, avermitilol. J. Am. Chem. Soc. 132, 8850-8851 (2010).
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 8850-8851
    • Chou, W.K.W.1
  • 116
    • 33751204753 scopus 로고    scopus 로고
    • Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic
    • McClerren, A. L. et al. Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc. Natl Acad. Sci. USA 103, 17243-17248 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 17243-17248
    • McClerren, A.L.1
  • 117
    • 84880075289 scopus 로고    scopus 로고
    • Phage P1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster
    • Jones, A. C. et al. Phage P1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster. PLoS ONE 8, e69319 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e69319
    • Jones, A.C.1
  • 118
    • 84893456760 scopus 로고    scopus 로고
    • Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A
    • Yamanaka, K. et al. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc. Natl Acad. Sci. USA 111, 1957-1962 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 1957-1962
    • Yamanaka, K.1
  • 119
    • 77954630177 scopus 로고    scopus 로고
    • Cloning large natural product gene clusters from the environment: Piecing environmental DNA gene clusters back together with TAR
    • Kim, J. H. et al. Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR. Biopolymers 93, 833-844 (2010).
    • (2010) Biopolymers , vol.93 , pp. 833-844
    • Kim, J.H.1
  • 120
    • 84907144112 scopus 로고    scopus 로고
    • Reconstructing fungal natural product biosynthetic pathways
    • Lazarus, C. M., Williams, K. & Bailey, A. M. Reconstructing fungal natural product biosynthetic pathways. Nat. Prod. Rep. 31, 1339-1347 (2014).
    • (2014) Nat. Prod. Rep. , vol.31 , pp. 1339-1347
    • Lazarus, C.M.1    Williams, K.2    Bailey, A.M.3
  • 122
    • 59649108349 scopus 로고    scopus 로고
    • DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways
    • Shao, Z., Zhao, H. & Zhao, H. DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways. Nucleic Acids Res. 37, e16 (2009).
    • (2009) Nucleic Acids Res. , vol.37 , pp. e16
    • Shao, Z.1    Zhao, H.2    Zhao, H.3
  • 123
    • 79952642503 scopus 로고    scopus 로고
    • Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler
    • Shao, Z., Luo, Y. & Zhao, H. Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler. Mol. Biosyst. 7, 1056-1059 (2011).
    • (2011) Mol. Biosyst. , vol.7 , pp. 1056-1059
    • Shao, Z.1    Luo, Y.2    Zhao, H.3
  • 124
    • 84890086658 scopus 로고    scopus 로고
    • Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster
    • Luo, Y. et al. Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster. Nat. Commun. 4, 2894 (2013).
    • (2013) Nat. Commun. , vol.4 , pp. 2894
    • Luo, Y.1
  • 125
    • 84921517479 scopus 로고    scopus 로고
    • Functional optimization of gene clusters by combinatorial design and assembly
    • Smanski, M. J. et al. Functional optimization of gene clusters by combinatorial design and assembly. Nat. Biotechnol. 32, 1241-1249 (2014).
    • (2014) Nat. Biotechnol. , vol.32 , pp. 1241-1249
    • Smanski, M.J.1
  • 126
    • 84899632544 scopus 로고    scopus 로고
    • Synthetic biology tools for bioprospecting of natural products in eukaryotes
    • Unkles, S. E., Valiante, V., Mattern, Derek, J. & Brakhage, A. A. Synthetic biology tools for bioprospecting of natural products in eukaryotes. Chem. Biol. 21, 502-508 (2014).
    • (2014) Chem. Biol. , vol.21 , pp. 502-508
    • Unkles, S.E.1    Valiante, V.2    Mattern Derek, J.3    Brakhage, A.A.4
  • 127
    • 84900852249 scopus 로고    scopus 로고
    • Yeast synthetic biology platform generates novel chemical structures as scaffolds for drug discovery
    • Klein, J. et al. Yeast synthetic biology platform generates novel chemical structures as scaffolds for drug discovery. ACS Synthet. Biol. 3, 314-323 (2014).
    • (2014) ACS Synthet. Biol. , vol.3 , pp. 314-323
    • Klein, J.1
  • 128
    • 84900859146 scopus 로고    scopus 로고
    • Secondary metabolomics: The impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products
    • Krug, D. & Müller, R. Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products. Nat. Prod. Rep. 31, 768-783 (2014).
    • (2014) Nat. Prod. Rep. , vol.31 , pp. 768-783
    • Krug, D.1    Müller, R.2
  • 129
    • 84874956949 scopus 로고    scopus 로고
    • Natural product isolation-how to get from biological material to pure compounds
    • Bucar, F., Wube, A. & Schmid, M. Natural product isolation-how to get from biological material to pure compounds. Nat. Prod. Rep. 30, 525-545 (2013).
    • (2013) Nat. Prod. Rep. , vol.30 , pp. 525-545
    • Bucar, F.1    Wube, A.2    Schmid, M.3
  • 130
    • 84874999469 scopus 로고    scopus 로고
    • Using NMR to identify and characterize natural products
    • Breton, R. C. & Reynolds, W. F. Using NMR to identify and characterize natural products. Nat. Prod. Rep. 30, 501-524 (2013).
    • (2013) Nat. Prod. Rep. , vol.30 , pp. 501-524
    • Breton, R.C.1    Reynolds, W.F.2
  • 131
    • 84880370987 scopus 로고    scopus 로고
    • Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products
    • Owen, J. G. et al. Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products. Proc. Natl Acad. Sci. USA 110, 11797-11802 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 11797-11802
    • Owen, J.G.1
  • 132
    • 84870714378 scopus 로고    scopus 로고
    • Tetarimycin A an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters
    • Kallifidas, D., Kang, H. S. & Brady, S. F. Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters. J. Am. Chem. Soc. 134, 19552-19555 (2012).
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 19552-19555
    • Kallifidas, D.1    Kang, H.S.2    Brady, S.F.3
  • 133
    • 84889261817 scopus 로고    scopus 로고
    • Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment
    • Chang, F. Y., Ternei, M. A., Calle, P. Y. & Brady, S. F. Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment. J. Am. Chem. Soc. 135, 17906-17912 (2013).
    • (2013) J. Am. Chem. Soc. , vol.135 , pp. 17906-17912
    • Chang, F.Y.1    Ternei, M.A.2    Calle, P.Y.3    Brady, S.F.4
  • 134
    • 84893581440 scopus 로고    scopus 로고
    • Microbiology: A talented genus
    • Jaspars, M. & Challis, G. L. Microbiology: a talented genus. Nature 506, 38-39 (2014).
    • (2014) Nature , vol.506 , pp. 38-39
    • Jaspars, M.1    Challis, G.L.2
  • 135
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: Confronting the challenges of antibacterial discovery
    • Payne, D. J., Gwynn, M. N., Holmes, D. J. & Pompliano, D. L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6, 29-40 (2007).
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 29-40
    • Payne, D.J.1    Gwynn, M.N.2    Holmes, D.J.3    Pompliano, D.L.4
  • 136
    • 33847381100 scopus 로고    scopus 로고
    • A decade of fragment-based drug design: Strategic advances and lessons learned
    • Hajduk, P. J. & Greer, J. A decade of fragment-based drug design: strategic advances and lessons learned. Nat. Rev. Drug Discov. 6, 211-219 (2007).
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 211-219
    • Hajduk, P.J.1    Greer, J.2
  • 137
    • 69249202590 scopus 로고    scopus 로고
    • The biosynthetic logic of polyketide diversity
    • Hertweck, C. The biosynthetic logic of polyketide diversity. Angew. Chem. Int. Ed. Engl. 48, 4688-4716 (2009).
    • (2009) Angew. Chem. Int. Ed. Engl. , vol.48 , pp. 4688-4716
    • Hertweck, C.1
  • 138
    • 77954675603 scopus 로고    scopus 로고
    • Biosynthesis of polyketides by trans-AT polyketide synthases
    • Piel, J. Biosynthesis of polyketides by trans-AT polyketide synthases. Nat. Prod. Rep. 27, 996-1047 (2010).
    • (2010) Nat. Prod. Rep. , vol.27 , pp. 996-1047
    • Piel, J.1
  • 139
    • 84870918230 scopus 로고    scopus 로고
    • Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature
    • Arnison, P. G. et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat. Prod. Rep. 30, 108-160 (2013).
    • (2013) Nat. Prod. Rep. , vol.30 , pp. 108-160
    • Arnison, P.G.1
  • 140
    • 77951294519 scopus 로고    scopus 로고
    • Nonribosomal peptide synthetases: Structures and dynamics
    • Strieker, M., Tanovic, A. & Marahiel, M. A. Nonribosomal peptide synthetases: structures and dynamics. Curr. Opin. Struct. Biol. 20, 234-240 (2010).
    • (2010) Curr. Opin. Struct. Biol. , vol.20 , pp. 234-240
    • Strieker, M.1    Tanovic, A.2    Marahiel, M.A.3
  • 141
    • 70350643410 scopus 로고    scopus 로고
    • The long-overlooked enzymology of a nonribosomal-peptide synthetase independent pathway for virulence-conferring siderophore biosynthesis
    • Oves-Costales, D., Kadi, N. & Challis, G. L. The long-overlooked enzymology of a nonribosomal-peptide synthetase independent pathway for virulence-conferring siderophore biosynthesis. Chem. Commun. 2009, 6530-6541 (2009).
    • (2009) Chem. Commun. , vol.2009 , pp. 6530-6541
    • Oves-Costales, D.1    Kadi, N.2    Challis, G.L.3
  • 142
    • 84871576542 scopus 로고    scopus 로고
    • Terpenoid synthase structures: A so far incomplete view of complex catalysis
    • Gao, Y., Honzatko, R. B. & Peters, R. J. Terpenoid synthase structures: a so far incomplete view of complex catalysis. Nat. Prod. Rep. 29, 1153-1175 (2012).
    • (2012) Nat. Prod. Rep. , vol.29 , pp. 1153-1175
    • Gao, Y.1    Honzatko, R.B.2    Peters, R.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.