-
1
-
-
62449089680
-
Microbial drug discovery: 80 years of progress
-
Demain, A. L. & Sanchez, S. Microbial drug discovery: 80 years of progress. J. Antibiot. 62, 5-16 (2009).
-
(2009)
J. Antibiot.
, vol.62
, pp. 5-16
-
-
Demain, A.L.1
Sanchez, S.2
-
2
-
-
84866454800
-
Natural products as sources for new pesticides
-
Cantrell, C. L., Dayan, F. E. & Duke, S. O. Natural products as sources for new pesticides. J. Nat. Prod. 75, 1231-1242 (2012).
-
(2012)
J. Nat. Prod.
, vol.75
, pp. 1231-1242
-
-
Cantrell, C.L.1
Dayan, F.E.2
Duke, S.O.3
-
3
-
-
77957980707
-
Origins and evolution of antibiotic resistance
-
Davies, J. & Davies, D. Origins and evolution of antibiotic resistance. Microbiol. Mol. Biol. Rev. 74, 417-433 (2010).
-
(2010)
Microbiol. Mol. Biol. Rev.
, vol.74
, pp. 417-433
-
-
Davies, J.1
Davies, D.2
-
4
-
-
1642344752
-
Safeguarding production-losses in major crops and the role of crop protection
-
Oerke, E.-C. & Dehne, H.-W. Safeguarding production-losses in major crops and the role of crop protection. Crop Prot. 23, 275-285 (2004).
-
(2004)
Crop Prot.
, vol.23
, pp. 275-285
-
-
Oerke, E.-C.1
Dehne, H.-W.2
-
5
-
-
33747365321
-
Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus
-
Fowler, V. G. et al. Daptomycin versus standard therapy for bacteremia and endocarditis caused by Staphylococcus aureus. N. Engl. J. Med. 355, 653-655 (2006).
-
(2006)
N. Engl. J. Med.
, vol.355
, pp. 653-655
-
-
Fowler, V.G.1
-
6
-
-
79551527297
-
Fidaxomicin versus vancomycin for Clostridium difficile infection
-
Louie, T. J. et al. Fidaxomicin versus vancomycin for Clostridium difficile infection. N. Engl. J. Med. 364, 422-431 (2011).
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 422-431
-
-
Louie, T.J.1
-
7
-
-
84879588288
-
From epoxomicin to carfilzomib: Chemistry, biology, and medical outcomes
-
Kim, K. B. & Crews, C. M. From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes. Nat. Prod. Rep. 30, 600-604 (2013).
-
(2013)
Nat. Prod. Rep.
, vol.30
, pp. 600-604
-
-
Kim, K.B.1
Crews, C.M.2
-
8
-
-
15944368107
-
Rediscovery of known natural compounds: Nuisance or goldmine?
-
Tulp, M. & Bohlin, L. Rediscovery of known natural compounds: nuisance or goldmine? Trends Pharmacol. Sci. 26, 175-177 (2005).
-
(2005)
Trends Pharmacol. Sci.
, vol.26
, pp. 175-177
-
-
Tulp, M.1
Bohlin, L.2
-
9
-
-
33751206542
-
Seeking new antibiotics in nature's backyard
-
von Bubnoff, A. Seeking new antibiotics in nature's backyard. Cell 127, 867-869 (2006).
-
(2006)
Cell
, vol.127
, pp. 867-869
-
-
Von Bubnoff, A.1
-
10
-
-
0037046560
-
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
-
Bentley, S. D. et al. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417, 141-147 (2002).
-
(2002)
Nature
, vol.417
, pp. 141-147
-
-
Bentley, S.D.1
-
11
-
-
0035834039
-
Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites
-
Omura, S. et al. Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc. Natl Acad. Sci. USA 98, 12215-12220 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 12215-12220
-
-
Omura, S.1
-
12
-
-
30544434099
-
Fungal secondary metabolism from biochemistry to genomics
-
Keller, N. P., Turner, G. & Bennett, J. W. Fungal secondary metabolism from biochemistry to genomics. Nat. Rev. Microbiol. 3, 937-947 (2005).
-
(2005)
Nat. Rev. Microbiol.
, vol.3
, pp. 937-947
-
-
Keller, N.P.1
Turner, G.2
Bennett, J.W.3
-
13
-
-
84895075252
-
Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways
-
Challis, G. L. Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways. J. Ind. Microbiol. Biotechnol. 41, 219-232 (2014).
-
(2014)
J. Ind. Microbiol. Biotechnol.
, vol.41
, pp. 219-232
-
-
Challis, G.L.1
-
14
-
-
0034659816
-
Coelichelin a new peptide siderophore encoded by the Streptomyces coelicolor genome: Structure prediction from the sequence of its non-ribosomal peptide synthetase
-
Challis, G. L. & Ravel, J. Coelichelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: structure prediction from the sequence of its non-ribosomal peptide synthetase. FEMS Microbiol. Lett. 187, 111-114 (2000).
-
(2000)
FEMS Microbiol. Lett.
, vol.187
, pp. 111-114
-
-
Challis, G.L.1
Ravel, J.2
-
15
-
-
33846678395
-
A cryptic type i polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2)
-
Pawlik, K., Kotowska, M., Chater, K. F., Kuczek, K. & Takano, E. A cryptic type I polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2). Arch. Microbiol. 187, 87-99 (2007).
-
(2007)
Arch. Microbiol.
, vol.187
, pp. 87-99
-
-
Pawlik, K.1
Kotowska, M.2
Chater, K.F.3
Kuczek, K.4
Takano, E.5
-
16
-
-
70350722394
-
Genomic basis for natural product biosynthetic diversity in the actinomycetes
-
Nett, M., Ikeda, H. & Moore, B. S. Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat. Prod. Rep. 26, 1362-1384 (2009).
-
(2009)
Nat. Prod. Rep.
, vol.26
, pp. 1362-1384
-
-
Nett, M.1
Ikeda, H.2
Moore, B.S.3
-
17
-
-
34848911303
-
Polyketide synthases and nonribosomal peptide synthetases: The emerging view from bacterial genomics
-
Donadio, S., Monciardini, P. & Sosio, M. Polyketide synthases and nonribosomal peptide synthetases: the emerging view from bacterial genomics. Nat. Prod. Rep. 24, 1073-1109 (2007).
-
(2007)
Nat. Prod. Rep.
, vol.24
, pp. 1073-1109
-
-
Donadio, S.1
Monciardini, P.2
Sosio, M.3
-
18
-
-
84874051724
-
A genomic approach to the cryptic secondary metabolome of the anaerobic world
-
Letzel, A. C., Pidot, S. J. & Hertweck, C. A genomic approach to the cryptic secondary metabolome of the anaerobic world. Nat. Prod. Rep. 30, 392-428 (2013).
-
(2013)
Nat. Prod. Rep.
, vol.30
, pp. 392-428
-
-
Letzel, A.C.1
Pidot, S.J.2
Hertweck, C.3
-
19
-
-
84893542053
-
An environmental bacterial taxon with a large and distinct metabolic repertoire
-
Wilson, M. C. et al. An environmental bacterial taxon with a large and distinct metabolic repertoire. Nature 506, 58-62 (2014).
-
(2014)
Nature
, vol.506
, pp. 58-62
-
-
Wilson, M.C.1
-
20
-
-
65549083361
-
Strategies for the discovery of new natural products by genome mining
-
Zerikly, M. & Challis, G. L. Strategies for the discovery of new natural products by genome mining. ChemBioChem 10, 625-633 (2009).
-
(2009)
ChemBioChem
, vol.10
, pp. 625-633
-
-
Zerikly, M.1
Challis, G.L.2
-
21
-
-
84918813440
-
Metabolic engineering of antibiotic factories: New tools for antibiotic production in actinomycetes
-
Weber, T. et al. Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes. Trends Biotechnol. 33, 15-26 (2015).
-
(2015)
Trends Biotechnol.
, vol.33
, pp. 15-26
-
-
Weber, T.1
-
22
-
-
72849144434
-
Sequencing technologies-The next generation
-
Metsker, M. L. Sequencing technologies-the next generation. Nat. Rev. Genet. 11, 31-46 (2010).
-
(2010)
Nat. Rev. Genet.
, vol.11
, pp. 31-46
-
-
Metsker, M.L.1
-
23
-
-
84900396854
-
Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors
-
Schorn, M. et al. Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. ACS Chem. Biol. 9, 301-309 (2014).
-
(2014)
ACS Chem. Biol.
, vol.9
, pp. 301-309
-
-
Schorn, M.1
-
24
-
-
84868100087
-
Posttranslational β-methylation and macrolactamidination in the biosynthesis of the bottromycin complex of ribosomal peptide antibiotics
-
Gomez-Escribano, J.-P., Song, L., Bibb, M. J. & Challis, G. L. Posttranslational β-methylation and macrolactamidination in the biosynthesis of the bottromycin complex of ribosomal peptide antibiotics. Chem. Sci. 3, 3522-3525 (2012).
-
(2012)
Chem. Sci.
, vol.3
, pp. 3522-3525
-
-
Gomez-Escribano, J.-P.1
Song, L.2
Bibb, M.J.3
Challis, G.L.4
-
25
-
-
84886667844
-
Cloning and heterologous expression of the thioviridamide biosynthesis gene cluster from Streptomyces olivoviridis
-
Izawa, M., Kawasaki, T. & Haykawa, Y. Cloning and heterologous expression of the thioviridamide biosynthesis gene cluster from Streptomyces olivoviridis. Appl. Environ. Microbiol. 79, 7110-7113 (2013).
-
(2013)
Appl. Environ. Microbiol.
, vol.79
, pp. 7110-7113
-
-
Izawa, M.1
Kawasaki, T.2
Haykawa, Y.3
-
26
-
-
79959920872
-
AntiSMASH: Rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters
-
Medema, M. H. et al. antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters. Nucleic Acids Res. 39, W339-W346 (2011).
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. W339-W346
-
-
Medema, M.H.1
-
27
-
-
84883353135
-
AntiSMASH 2.0-A versatile platform for genome mining of secondary metabolite producers
-
Blin, K. et al. antiSMASH 2.0-a versatile platform for genome mining of secondary metabolite producers. Nucleic Acids Res. 41, W204-W212 (2013).
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. W204-W212
-
-
Blin, K.1
-
28
-
-
84895873870
-
Improved lanthipeptide detection and prediction for antiSMASH
-
Blin, K., Kazempour, D., Wohlleben, W. & Weber, T. Improved lanthipeptide detection and prediction for antiSMASH. PLoS ONE 9, e89420 (2014).
-
(2014)
PLoS ONE
, vol.9
, pp. e89420
-
-
Blin, K.1
Kazempour, D.2
Wohlleben, W.3
Weber, T.4
-
29
-
-
77955274600
-
SMURF: Genomic mapping of fungal secondary metabolite clusters
-
Khaldi, N. et al. SMURF: genomic mapping of fungal secondary metabolite clusters. Fungal Genet. Biol. 47, 736-741 (2010).
-
(2010)
Fungal Genet. Biol.
, vol.47
, pp. 736-741
-
-
Khaldi, N.1
-
30
-
-
84883572507
-
BAGEL3: Automated identification of genes encoding bacteriocins and (non-) bactericidal posttranslationally modified peptides
-
van Heel, A. J., de Jong, A., Montalbán-López, M., Kok, J. & Kuipers, O. P. BAGEL3: automated identification of genes encoding bacteriocins and (non-) bactericidal posttranslationally modified peptides. Nucleic Acids Res. 41, W448-W453 (2013).
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. W448-W453
-
-
Van Heel, A.J.1
De Jong, A.2
Montalbán-López, M.3
Kok, J.4
Kuipers, O.P.5
-
31
-
-
84899651850
-
In silico tools for the analysis of antibiotic biosynthetic pathways
-
Weber, T. In silico tools for the analysis of antibiotic biosynthetic pathways. Int. J. Med. Microbiol. 304, 230-235 (2014).
-
(2014)
Int. J. Med. Microbiol.
, vol.304
, pp. 230-235
-
-
Weber, T.1
-
32
-
-
84934442432
-
-
(eds Keller N. P. & Turner G.) Humana
-
Fedorova, N., Moktali, V. & Medema, M. in Fungal Secondary Metabolism (eds Keller, N. P. & Turner, G.) 23-45 (Humana, 2012).
-
(2012)
Fungal Secondary Metabolism
, pp. 23-45
-
-
Fedorova, N.1
Moktali, V.2
Medema, M.3
-
33
-
-
33748631825
-
Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: Logic, machinery, and mechanisms
-
Fischbach, M. A. & Walsh, C. T. Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms. Chem. Rev. 106, 3468-3496 (2006).
-
(2006)
Chem. Rev.
, vol.106
, pp. 3468-3496
-
-
Fischbach, M.A.1
Walsh, C.T.2
-
34
-
-
83855165105
-
Repetitive DNA and next-generation sequencing: Computational challenges and solutions
-
Treangen, T. J. & Salzberg, S. L. Repetitive DNA and next-generation sequencing: computational challenges and solutions. Nat. Rev. Genet. 13, 36-46 (2012).
-
(2012)
Nat. Rev. Genet.
, vol.13
, pp. 36-46
-
-
Treangen, T.J.1
Salzberg, S.L.2
-
35
-
-
84997783038
-
De novo assembly of the Streptomyces sp strain Mg1 genome using PacBio single-molecule sequencing
-
Hoefler, B. C., Konganti, K. & Straight, P. D. De novo assembly of the Streptomyces sp. strain Mg1 genome using PacBio single-molecule sequencing. Genome Announc. 1, e00535-13 (2013).
-
(2013)
Genome Announc.
, vol.1
, pp. e00535-e00613
-
-
Hoefler, B.C.1
Konganti, K.2
Straight, P.D.3
-
36
-
-
78651285748
-
CDD: A Conserved Domain Database for the functional annotation of proteins
-
Marchler-Bauer, A. et al. CDD: a Conserved Domain Database for the functional annotation of proteins. Nucleic Acids Res. 39, D225-D229 (2011).
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. D225-D229
-
-
Marchler-Bauer, A.1
-
37
-
-
0034013269
-
Predictive, structure-based model of amino acid recognition by non-ribosomal peptide synthetase adenylation domains
-
Challis, G. L., Ravel, J. & Townsend, C. A. Predictive, structure-based model of amino acid recognition by non-ribosomal peptide synthetase adenylation domains. Chem. Biol. 7, 211-224 (2000).
-
(2000)
Chem. Biol.
, vol.7
, pp. 211-224
-
-
Challis, G.L.1
Ravel, J.2
Townsend, C.A.3
-
38
-
-
0033179468
-
The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
-
Stachelhaus, T., Mootz, H. D. & Marahiel, M. A. The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chem. Biol. 6, 493-505 (1999).
-
(1999)
Chem. Biol.
, vol.6
, pp. 493-505
-
-
Stachelhaus, T.1
Mootz, H.D.2
Marahiel, M.A.3
-
39
-
-
0028841535
-
Divergent sequence motifs correlated with the substrate specificity of (methyl) malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases
-
Haydock, S. F. et al. Divergent sequence motifs correlated with the substrate specificity of (methyl) malonyl-CoA:acyl carrier protein transacylase domains in modular polyketide synthases. FEBS Lett. 374, 246-248 (1995).
-
(1995)
FEBS Lett.
, vol.374
, pp. 246-248
-
-
Haydock, S.F.1
-
40
-
-
34547945950
-
A tylosin ketoreductase reveals how chirality is determined in polyketides
-
Keatinge-Clay, A. T. A tylosin ketoreductase reveals how chirality is determined in polyketides. Chem. Biol. 14, 898-908 (2007).
-
(2007)
Chem. Biol.
, vol.14
, pp. 898-908
-
-
Keatinge-Clay, A.T.1
-
41
-
-
56049119642
-
Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases
-
Kwan, D. H. et al. Prediction and manipulation of the stereochemistry of enoylreduction in modular polyketide synthases. Chem. Biol. 15, 1231-1240 (2008).
-
(2008)
Chem. Biol.
, vol.15
, pp. 1231-1240
-
-
Kwan, D.H.1
-
42
-
-
38949203821
-
Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection
-
Nguyen, T. et al. Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection. Nat. Biotechnol. 26, 225-233 (2008).
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 225-233
-
-
Nguyen, T.1
-
43
-
-
79959936207
-
NRPSpredictor2-A web server for predicting NRPS adenylation domain specificity
-
Röttig, M. et al. NRPSpredictor2-a web server for predicting NRPS adenylation domain specificity. Nucleic Acids Res. 39, W362-W367 (2011).
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. W362-W367
-
-
Röttig, M.1
-
44
-
-
64249084052
-
In silico prediction of microbial secondary metabolic pathways from DNA sequence data
-
Bachmann, B. O. & Ravel, J. In silico prediction of microbial secondary metabolic pathways from DNA sequence data. Meth. Enzymol. 458, 181-217 (2009).
-
(2009)
Meth. Enzymol.
, vol.458
, pp. 181-217
-
-
Bachmann, B.O.1
Ravel, J.2
-
45
-
-
77954265333
-
SBSPKS: Structure based sequence analysis of polyketide synthases
-
Anand, S. et al. SBSPKS: structure based sequence analysis of polyketide synthases. Nucleic Acids Res. 38, W487-W496 (2010).
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. W487-W496
-
-
Anand, S.1
-
46
-
-
84876340080
-
Classification of the adenylation and acyl-transferase activity of NRPS and PKS systems using ensembles of substrate specific hidden Markov models
-
Khayatt, B. I., Overmars L., Siezen, R. J. & Francke, C. Classification of the adenylation and acyl-transferase activity of NRPS and PKS systems using ensembles of substrate specific hidden Markov models. PLoS ONE 8, e62136 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e62136
-
-
Khayatt, B.I.1
Overmars, L.2
Siezen, R.J.3
Francke, C.4
-
47
-
-
33744994317
-
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
-
Wang, J. et al. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 441, 358-361 (2006).
-
(2006)
Nature
, vol.441
, pp. 358-361
-
-
Wang, J.1
-
48
-
-
84871292787
-
Regulation of fungal secondary metabolism
-
Brakhage, A. A. Regulation of fungal secondary metabolism. Nat. Rev. Microbiol. 11, 21-32 (2013).
-
(2013)
Nat. Rev. Microbiol.
, vol.11
, pp. 21-32
-
-
Brakhage, A.A.1
-
49
-
-
80052077061
-
The regulation of the secondary metabolism of Streptomyces: New links and experimental advances
-
van Wezel, G. P. & McDowall, K. J. The regulation of the secondary metabolism of Streptomyces: new links and experimental advances. Nat. Prod. Rep. 28, 1311-1333 (2011).
-
(2011)
Nat. Prod. Rep.
, vol.28
, pp. 1311-1333
-
-
Van Wezel, G.P.1
McDowall, K.J.2
-
50
-
-
79851515868
-
Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms
-
Chiang, Y. M., Chang, S. L., Oakley, B. R. & Wang, C. C. Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms. Curr. Opin. Chem. Biol. 15, 137-143 (2011).
-
(2011)
Curr. Opin. Chem. Biol.
, vol.15
, pp. 137-143
-
-
Chiang, Y.M.1
Chang, S.L.2
Oakley, B.R.3
Wang, C.C.4
-
51
-
-
33748254906
-
Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining
-
Scherlach, K. & Hertweck, C. Discovery of aspoquinolones A-D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining. Org. Biomol. Chem. 4, 3517-3520 (2006).
-
(2006)
Org. Biomol. Chem.
, vol.4
, pp. 3517-3520
-
-
Scherlach, K.1
Hertweck, C.2
-
52
-
-
77955108832
-
Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans
-
Scherlach, K., Schuemann, J., Dahse, H.-M. & Hertweck, C. Aspernidine A and B, prenylated isoindolinone alkaloids from the model fungus Aspergillus nidulans. J. Antibiot. 63, 375-377 (2010).
-
(2010)
J. Antibiot.
, vol.63
, pp. 375-377
-
-
Scherlach, K.1
Schuemann, J.2
Dahse, H.-M.3
Hertweck, C.4
-
53
-
-
77949363508
-
Closthioamide: An unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum
-
Lincke, T., Behnken, S., Ishida, K., Roth, M. & Hertweck, C. Closthioamide: an unprecedented polythioamide antibiotic from the strictly anaerobic bacterium Clostridium cellulolyticum. Angew. Chem. Int. Ed. Engl. 49, 2011-2013 (2010).
-
(2010)
Angew. Chem. Int. Ed. Engl.
, vol.49
, pp. 2011-2013
-
-
Lincke, T.1
Behnken, S.2
Ishida, K.3
Roth, M.4
Hertweck, C.5
-
54
-
-
34547885750
-
The rare earth, scandium, causes antibiotic overproduction in Streptomyces spp
-
Kawai, K., Wang, G., Okamoto, S. & Ochi, K. The rare earth, scandium, causes antibiotic overproduction in Streptomyces spp. FEMS Microbiol. Lett. 274, 311-315 (2007).
-
(2007)
FEMS Microbiol. Lett.
, vol.274
, pp. 311-315
-
-
Kawai, K.1
Wang, G.2
Okamoto, S.3
Ochi, K.4
-
55
-
-
77956254493
-
Rare earth elements activate the secondary metabolite-biosynthetic gene clusters in Streptomyces coelicolor A3(2)
-
Tanaka, Y., Hosaka, T. & Ochi, K. Rare earth elements activate the secondary metabolite-biosynthetic gene clusters in Streptomyces coelicolor A3(2). J. Antibiot. 63, 477-481 (2010).
-
(2010)
J. Antibiot.
, vol.63
, pp. 477-481
-
-
Tanaka, Y.1
Hosaka, T.2
Ochi, K.3
-
56
-
-
84901000640
-
High-throughput platform for the discovery of elicitors of silent bacterial gene clusters
-
Seyedsayamdost, M. R. High-throughput platform for the discovery of elicitors of silent bacterial gene clusters. Proc. Natl Acad. Sci. USA 111, 7266-7271 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 7266-7271
-
-
Seyedsayamdost, M.R.1
-
57
-
-
84865477861
-
Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism
-
Craney, A., Ozimok, C., Pimentel-Elardo, S. M., Capretta, A. & Nodwell, J. R. Chemical perturbation of secondary metabolism demonstrates important links to primary metabolism. Chem. Biol. 19, 1020-1027 (2012).
-
(2012)
Chem. Biol.
, vol.19
, pp. 1020-1027
-
-
Craney, A.1
Ozimok, C.2
Pimentel-Elardo, S.M.3
Capretta, A.4
Nodwell, J.R.5
-
58
-
-
0037052320
-
Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment
-
Kaeberlein, T., Lewis, K. & Epstein, S. S. Isolating "uncultivable" microorganisms in pure culture in a simulated natural environment. Science 296, 1127-1129 (2002).
-
(2002)
Science
, vol.296
, pp. 1127-1129
-
-
Kaeberlein, T.1
Lewis, K.2
Epstein, S.S.3
-
59
-
-
77950560416
-
Use of ichip for high-throughput in situ cultivation of "uncultivable" microbial species
-
Nichols, D. et al. Use of ichip for high-throughput in situ cultivation of "uncultivable" microbial species. Appl. Environ. Microbiol. 76, 2445-2450 (2010).
-
(2010)
Appl. Environ. Microbiol.
, vol.76
, pp. 2445-2450
-
-
Nichols, D.1
-
60
-
-
84899576523
-
Lassomycin, a ribosomally synthesized cyclic peptide, kills Mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2
-
Gavrish, E. et al. Lassomycin, a ribosomally synthesized cyclic peptide, kills Mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. Chem. Biol. 21, 509-518 (2014).
-
(2014)
Chem. Biol.
, vol.21
, pp. 509-518
-
-
Gavrish, E.1
-
61
-
-
84922937832
-
A new antibiotic kills pathogens without detectable resistance
-
Ling, L. L. et al. A new antibiotic kills pathogens without detectable resistance. Nature 517, 455-459 (2015).
-
(2015)
Nature
, vol.517
, pp. 455-459
-
-
Ling, L.L.1
-
62
-
-
84923010512
-
Antibiotics: An irresistible newcomer
-
Wright, G. Antibiotics: an irresistible newcomer. Nature 517, 442-444 (2015).
-
(2015)
Nature
, vol.517
, pp. 442-444
-
-
Wright, G.1
-
63
-
-
70149109184
-
Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans
-
Schroeckh, V. et al. Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc. Natl Acad. Sci. USA 106, 14558-14563 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 14558-14563
-
-
Schroeckh, V.1
-
64
-
-
84937255789
-
-
Japanese patent application JP11001480
-
Sato, S., Morishita, T., Hosoya, T. & Ishikawa, Y. Novel pentacyclic compounds, F-9775A and F-9775B, their manufacture with Paecilomyces carneus, and their use for treatment of osteoporosis. Japanese patent application JP11001480 (1999).
-
(1999)
Novel Pentacyclic Compounds, F-9775A and F-9775B, Their Manufacture with Paecilomyces Carneus, and Their Use for Treatment of Osteoporosis
-
-
Sato, S.1
Morishita, T.2
Hosoya, T.3
Ishikawa, Y.4
-
65
-
-
79551488636
-
Mycolic acid-containing bacteria induce natural-product biosynthesis in Streptomyces species
-
Onaka, H., Mori, Y., Igarashi, Y. & Furumai, T. Mycolic acid-containing bacteria induce natural-product biosynthesis in Streptomyces species. Appl. Environ. Microbiol. 77, 400-406 (2011).
-
(2011)
Appl. Environ. Microbiol.
, vol.77
, pp. 400-406
-
-
Onaka, H.1
Mori, Y.2
Igarashi, Y.3
Furumai, T.4
-
66
-
-
84878012899
-
Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus
-
König, C. C. et al. Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus. ChemBioChem 14, 938-942 (2013).
-
(2013)
ChemBioChem
, vol.14
, pp. 938-942
-
-
König, C.C.1
-
67
-
-
84881361067
-
Imaging mass spectrometry of a coral microbe interaction with fungi
-
Moree, W. et al. Imaging mass spectrometry of a coral microbe interaction with fungi. J. Chem. Ecol. 39, 1045-1054 (2013).
-
(2013)
J. Chem. Ecol.
, vol.39
, pp. 1045-1054
-
-
Moree, W.1
-
68
-
-
84865288536
-
Interkingdom metabolic transformations captured by microbial imaging mass spectrometry
-
Moree, W. J. et al. Interkingdom metabolic transformations captured by microbial imaging mass spectrometry. Proc. Natl Acad. Sci. USA 109, 13811-13816 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 13811-13816
-
-
Moree, W.J.1
-
69
-
-
84907584619
-
Pep2Path: Automated mass spectrometry-guided genome mining of peptidic natural products
-
Medema, M. H. et al. Pep2Path: automated mass spectrometry-guided genome mining of peptidic natural products. PLoS Comp. Biol. 10, e1003822 (2014).
-
(2014)
PLoS Comp. Biol.
, vol.10
, pp. e1003822
-
-
Medema, M.H.1
-
70
-
-
84906678559
-
NRPquest: Coupling mass spectrometry and genome mining for nonribosomal peptide discovery
-
Mohimani, H. et al. NRPquest: coupling mass spectrometry and genome mining for nonribosomal peptide discovery. J. Nat. Prod. 77, 1902-1909 (2014).
-
(2014)
J. Nat. Prod.
, vol.77
, pp. 1902-1909
-
-
Mohimani, H.1
-
71
-
-
84904547209
-
Automated genome mining of ribosomal peptide natural products
-
Mohimani, H. et al. Automated genome mining of ribosomal peptide natural products. ACS Chem. Biol. 9, 1545-1551 (2014).
-
(2014)
ACS Chem. Biol.
, vol.9
, pp. 1545-1551
-
-
Mohimani, H.1
-
72
-
-
84872353481
-
New strategies for drug discovery: Activation of silent or weakly expressed microbial gene clusters
-
Ochi, K. & Hosaka, T. New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters. Appl. Microbiol. Biotechnol. 97, 87-98 (2013).
-
(2013)
Appl. Microbiol. Biotechnol.
, vol.97
, pp. 87-98
-
-
Ochi, K.1
Hosaka, T.2
-
73
-
-
0030448016
-
Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2)
-
Shima, J., Hesketh, A., Okamoto, S., Kawamoto, S. & Ochi, K. Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2). J. Bacteriol. 178, 7276-7284 (1996).
-
(1996)
J. Bacteriol.
, vol.178
, pp. 7276-7284
-
-
Shima, J.1
Hesketh, A.2
Okamoto, S.3
Kawamoto, S.4
Ochi, K.5
-
74
-
-
15744383448
-
Regulation of secondary metabolism in streptomycetes
-
Bibb, M. J. Regulation of secondary metabolism in streptomycetes. Curr. Opin. Microbiol. 8, 208-215 (2005).
-
(2005)
Curr. Opin. Microbiol.
, vol.8
, pp. 208-215
-
-
Bibb, M.J.1
-
75
-
-
2042475439
-
Structural basis for transcription regulation by alarmone ppGpp
-
Artsimovitch, I. et al. Structural basis for transcription regulation by alarmone ppGpp. Cell 117, 299-310 (2004).
-
(2004)
Cell
, vol.117
, pp. 299-310
-
-
Artsimovitch, I.1
-
76
-
-
42149158392
-
Control of bacterial transcription, translation and replication by (p)ppGpp
-
Srivatsan, A. & Wang, J. D. Control of bacterial transcription, translation and replication by (p)ppGpp. Curr. Opin. Microbiol. 11, 100-105 (2008).
-
(2008)
Curr. Opin. Microbiol.
, vol.11
, pp. 100-105
-
-
Srivatsan, A.1
Wang, J.D.2
-
77
-
-
0036460093
-
A rifampicin resistance mutation in the rpoB gene confers ppGpp-independent antibiotic production in Streptomyces coelicolor A3(2)
-
Xu, J., Tozawa, Y., Lai, C., Hayashi, H. & Ochi, K. A rifampicin resistance mutation in the rpoB gene confers ppGpp-independent antibiotic production in Streptomyces coelicolor A3(2). Mol. Genet. Genom. 268, 179-189 (2002).
-
(2002)
Mol. Genet. Genom.
, vol.268
, pp. 179-189
-
-
Xu, J.1
Tozawa, Y.2
Lai, C.3
Hayashi, H.4
Ochi, K.5
-
78
-
-
66149185679
-
Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12
-
Hosaka, T. et al. Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12. Nat. Biotechnol. 27, 462-464 (2009).
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 462-464
-
-
Hosaka, T.1
-
79
-
-
84864447599
-
Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145
-
Gomez-Escribano, J. P. et al. Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145. Chem. Sci. 3, 2716-2720 (2012).
-
(2012)
Chem. Sci.
, vol.3
, pp. 2716-2720
-
-
Gomez-Escribano, J.P.1
-
80
-
-
77955343496
-
Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2)
-
Gottelt, M., Kol, S., Gomez-Escribano, J. P., Bibb, M. & Takano, E. Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2). Microbiology 156, 2343-2353 (2010).
-
(2010)
Microbiology
, vol.156
, pp. 2343-2353
-
-
Gottelt, M.1
Kol, S.2
Gomez-Escribano, J.P.3
Bibb, M.4
Takano, E.5
-
81
-
-
79959769183
-
Transcriptional regulatory elements in fungal secondary metabolism
-
Yin, W. & Keller, N. Transcriptional regulatory elements in fungal secondary metabolism. J. Microbiol. 49, 329-339 (2011).
-
(2011)
J. Microbiol.
, vol.49
, pp. 329-339
-
-
Yin, W.1
Keller, N.2
-
82
-
-
45849147020
-
VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism
-
Bayram, Ö. et al. VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science 320, 1504-1506 (2008).
-
(2008)
Science
, vol.320
, pp. 1504-1506
-
-
Bayram Ö.1
-
83
-
-
4143090400
-
LaeA, a regulator of secondary metabolism in Aspergillus spp
-
Bok, J. W. & Keller, N. P. LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryot. Cell 3, 527-535 (2004).
-
(2004)
Eukaryot. Cell
, vol.3
, pp. 527-535
-
-
Bok, J.W.1
Keller, N.P.2
-
84
-
-
30744456748
-
Genomic mining for Aspergillus natural products
-
Bok, J. W. et al. Genomic mining for Aspergillus natural products. Chem. Biol. 13, 31-37 (2006).
-
(2006)
Chem. Biol.
, vol.13
, pp. 31-37
-
-
Bok, J.W.1
-
85
-
-
19944427730
-
Cytotoxic and other metabolites of Aspergillus inhabiting the rhizosphere of Sonoran desert plants
-
He, J. et al. Cytotoxic and other metabolites of Aspergillus inhabiting the rhizosphere of Sonoran desert plants. J. Nat. Prod. 67, 1985-1991 (2004).
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 1985-1991
-
-
He, J.1
-
86
-
-
84857931220
-
Antiterminator-mediated unveiling of cryptic polythioamides in an anaerobic bacterium
-
Behnken, S., Lincke, T., Kloss, F., Ishida, K. & Hertweck, C. Antiterminator-mediated unveiling of cryptic polythioamides in an anaerobic bacterium. Angew. Chem. Int. Ed. Engl. 51, 2425-2428 (2012).
-
(2012)
Angew. Chem. Int. Ed. Engl.
, vol.51
, pp. 2425-2428
-
-
Behnken, S.1
Lincke, T.2
Kloss, F.3
Ishida, K.4
Hertweck, C.5
-
87
-
-
77953082083
-
E. Coli NusG inhibits backtracking and accelerates pause-free transcription by promoting forward translocation of RNA polymerase
-
Herbert, K. M. et al. E. coli NusG inhibits backtracking and accelerates pause-free transcription by promoting forward translocation of RNA polymerase. J. Mol. Biol. 399, 17-30 (2010).
-
(2010)
J. Mol. Biol.
, vol.399
, pp. 17-30
-
-
Herbert, K.M.1
-
88
-
-
77951742010
-
Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1
-
McKenzie, N. L. et al. Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1. J. Antibiot. 63, 177-182 (2010).
-
(2010)
J. Antibiot.
, vol.63
, pp. 177-182
-
-
McKenzie, N.L.1
-
89
-
-
85015069067
-
Controlling the double helix
-
Felsenfeld, G. & Groudine, M. Controlling the double helix. Nature 421, 448-453 (2003).
-
(2003)
Nature
, vol.421
, pp. 448-453
-
-
Felsenfeld, G.1
Groudine, M.2
-
90
-
-
42149147377
-
Histone modifications and chromatin dynamics: A focus on filamentous fungi
-
Brosch, G., Loidl, P. & Graessle, S. Histone modifications and chromatin dynamics: a focus on filamentous fungi. FEMS Microbiol. Rev. 32, 409-439 (2008).
-
(2008)
FEMS Microbiol. Rev.
, vol.32
, pp. 409-439
-
-
Brosch, G.1
Loidl, P.2
Graessle, S.3
-
91
-
-
73949102298
-
Epigenome manipulation as a pathway to new natural product scaffolds and their congeners
-
Cichewicz, R. H. Epigenome manipulation as a pathway to new natural product scaffolds and their congeners. Nat. Prod. Rep. 27, 11-22 (2010).
-
(2010)
Nat. Prod. Rep.
, vol.27
, pp. 11-22
-
-
Cichewicz, R.H.1
-
92
-
-
34748829074
-
Histone deacetylase activity regulates chemical diversity in Aspergillus
-
Shwab, E. K. et al. Histone deacetylase activity regulates chemical diversity in Aspergillus. Eukaryot. Cell 6, 1656-1664 (2007).
-
(2007)
Eukaryot. Cell
, vol.6
, pp. 1656-1664
-
-
Shwab, E.K.1
-
93
-
-
67650321573
-
Chromatin-level regulation of biosynthetic gene clusters
-
Bok, J. W. et al. Chromatin-level regulation of biosynthetic gene clusters. Nat. Chem. Biol. 5, 462-464 (2009).
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 462-464
-
-
Bok, J.W.1
-
94
-
-
35348975068
-
Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium
-
Wu, Y. et al. Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium. Life Sci. 81, 1332-1338 (2007).
-
(2007)
Life Sci.
, vol.81
, pp. 1332-1338
-
-
Wu, Y.1
-
95
-
-
43749086015
-
Epigenetic remodeling of the fungal secondary metabolome
-
Williams, R. B., Henrikson, J. C., Hoover, A. R., Lee, A. E. & Cichewicz, R. H. Epigenetic remodeling of the fungal secondary metabolome. Org. Biomol. Chem. 6, 1895-1897 (2008).
-
(2008)
Org. Biomol. Chem.
, vol.6
, pp. 1895-1897
-
-
Williams, R.B.1
Henrikson, J.C.2
Hoover, A.R.3
Lee, A.E.4
Cichewicz, R.H.5
-
96
-
-
58849110677
-
A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger
-
Henrikson, J. C., Hoover, A. R., Joyner, P. M. & Cichewicz, R. H. A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger. Org. Biomol. Chem. 7, 435-438 (2009).
-
(2009)
Org. Biomol. Chem.
, vol.7
, pp. 435-438
-
-
Henrikson, J.C.1
Hoover, A.R.2
Joyner, P.M.3
Cichewicz, R.H.4
-
97
-
-
84880028198
-
Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression
-
Asai, T. et al. Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression. Org. Lett. 15, 3346-3349 (2013).
-
(2013)
Org. Lett.
, vol.15
, pp. 3346-3349
-
-
Asai, T.1
-
98
-
-
77953005706
-
Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an Atlantic-Forest-soil-derived Penicillium citreonigrum
-
Wang, X. et al. Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an Atlantic-Forest-soil-derived Penicillium citreonigrum. J. Nat. Prod. 73, 942-948 (2010).
-
(2010)
J. Nat. Prod.
, vol.73
, pp. 942-948
-
-
Wang, X.1
-
99
-
-
33947308882
-
Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans
-
Bergmann, S. et al. Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat. Chem. Biol. 3, 213-217 (2007).
-
(2007)
Nat. Chem. Biol.
, vol.3
, pp. 213-217
-
-
Bergmann, S.1
-
100
-
-
34548206283
-
Identification and in vivo functional analysis by gene disruption of ctnA, an activator gene involved in citrinin biosynthesis in Monascus purpureus
-
Shimizu, T., Kinoshita, H. & Nihira, T. Identification and in vivo functional analysis by gene disruption of ctnA, an activator gene involved in citrinin biosynthesis in Monascus purpureus. Appl. Environ. Microbiol. 73, 5097-5103 (2007).
-
(2007)
Appl. Environ. Microbiol.
, vol.73
, pp. 5097-5103
-
-
Shimizu, T.1
Kinoshita, H.2
Nihira, T.3
-
101
-
-
68049088909
-
A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans
-
Chiang, Y. M. et al. A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans. J. Am. Chem. Soc. 131, 2965-2970 (2009).
-
(2009)
J. Am. Chem. Soc.
, vol.131
, pp. 2965-2970
-
-
Chiang, Y.M.1
-
102
-
-
0035977612
-
Isolation and structure elucidation of chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp
-
Duncan, S. J. et al. Isolation and structure elucidation of chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp. J. Am. Chem. Soc. 123, 554-560 (2001).
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 554-560
-
-
Duncan, S.J.1
-
103
-
-
79954997859
-
Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
-
Laureti, L. et al. Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens. Proc. Natl Acad. Sci. USA 108, 6258-6263 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 6258-6263
-
-
Laureti, L.1
-
104
-
-
56249143138
-
2-alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining
-
Corre, C., Song, L., O'Rourke, S., Chater, K. F. & Challis, G. L. 2-alkyl-4-hydroxymethylfuran-3-carboxylic acids, antibiotic production inducers discovered by Streptomyces coelicolor genome mining. Proc. Nat. Acad. Sci. USA 105, 17510-17515 (2008).
-
(2008)
Proc. Nat. Acad. Sci. USA
, vol.105
, pp. 17510-17515
-
-
Corre, C.1
Song, L.2
O'Rourke, S.3
Chater, K.F.4
Challis, G.L.5
-
105
-
-
79951642419
-
Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of kinamycins
-
Bunet, R. et al. Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of kinamycins. J. Bacteriol. 193, 1142-1153 (2011).
-
(2011)
J. Bacteriol.
, vol.193
, pp. 1142-1153
-
-
Bunet, R.1
-
106
-
-
84888617134
-
Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster
-
Sidda, J. D. et al. Discovery of a family of γ-aminobutyrate ureas via rational derepression of a silent bacterial gene cluster. Chem. Sci. 5, 86-89 (2014).
-
(2014)
Chem. Sci.
, vol.5
, pp. 86-89
-
-
Sidda, J.D.1
-
107
-
-
79952593656
-
Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis
-
Biggins, J. B., Gleber, C. D. & Brady, S. F. Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis. Org. Lett. 13, 1536-1539 (2011).
-
(2011)
Org. Lett.
, vol.13
, pp. 1536-1539
-
-
Biggins, J.B.1
Gleber, C.D.2
Brady, S.F.3
-
108
-
-
77957709176
-
Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant
-
Ishida, K., Lincke, T., Behnken, S. & Hertweck, C. Induced biosynthesis of cryptic polyketide metabolites in a Burkholderia thailandensis quorum sensing mutant. J. Am. Chem. Soc. 132, 13966-13968 (2010).
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 13966-13968
-
-
Ishida, K.1
Lincke, T.2
Behnken, S.3
Hertweck, C.4
-
109
-
-
84921496414
-
Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection
-
Guo, F. et al. Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection. Metab. Eng. 28, 134-142 (2015).
-
(2015)
Metab. Eng.
, vol.28
, pp. 134-142
-
-
Guo, F.1
-
110
-
-
84868515764
-
Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species
-
Franke, J., Ishida, K. & Hertweck, C. Genomics-driven discovery of burkholderic acid, a noncanonical, cryptic polyketide from human pathogenic Burkholderia species. Angew. Chem. Int. Ed. Engl. 51, 11611-11615 (2012).
-
(2012)
Angew. Chem. Int. Ed. Engl.
, vol.51
, pp. 11611-11615
-
-
Franke, J.1
Ishida, K.2
Hertweck, C.3
-
111
-
-
84897952067
-
Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074
-
Olano, C. et al. Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074. Microb. Biotechnol. 7, 242-256 (2014).
-
(2014)
Microb. Biotechnol.
, vol.7
, pp. 242-256
-
-
Olano, C.1
-
112
-
-
0021336760
-
Terferol, an inhibitor of cyclic adenosine-3, 5-monophosphate phosphodiesterase. II. Structure elucidation
-
Nakagawa, F. et al. Terferol, an inhibitor of cyclic adenosine-3, 5-monophosphate phosphodiesterase. II. Structure elucidation. J. Antibiot. 37, 10-12 (1984).
-
(1984)
J. Antibiot.
, vol.37
, pp. 10-12
-
-
Nakagawa, F.1
-
113
-
-
79951537655
-
Metabolites from the induced expression of cryptic single operons found in the genome of Burkholderia pseudomallei
-
Biggins, J. B., Liu, X., Feng, Z. & Brady, S. F. Metabolites from the induced expression of cryptic single operons found in the genome of Burkholderia pseudomallei. J. Am. Chem. Soc. 133, 1638-1641 (2011).
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 1638-1641
-
-
Biggins, J.B.1
Liu, X.2
Feng, Z.3
Brady, S.F.4
-
114
-
-
33646512641
-
Genome mining in Streptomyces coelicolor: Molecular cloning and characterization of a new sesquiterpene synthase
-
Lin, X., Hopson, R. & Cane, D. E. Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase. J. Am. Chem. Soc. 128, 6022-6023 (2006).
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 6022-6023
-
-
Lin, X.1
Hopson, R.2
Cane, D.E.3
-
115
-
-
77954303579
-
Genome mining in Streptomyces avermitilis: Cloning and characterization of SAV-76, the synthase for a new sesquiterpene, avermitilol
-
Chou, W. K. W. et al. Genome mining in Streptomyces avermitilis: cloning and characterization of SAV-76, the synthase for a new sesquiterpene, avermitilol. J. Am. Chem. Soc. 132, 8850-8851 (2010).
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 8850-8851
-
-
Chou, W.K.W.1
-
116
-
-
33751204753
-
Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic
-
McClerren, A. L. et al. Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc. Natl Acad. Sci. USA 103, 17243-17248 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 17243-17248
-
-
McClerren, A.L.1
-
117
-
-
84880075289
-
Phage P1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster
-
Jones, A. C. et al. Phage P1-derived artificial chromosomes facilitate heterologous expression of the FK506 gene cluster. PLoS ONE 8, e69319 (2013).
-
(2013)
PLoS ONE
, vol.8
, pp. e69319
-
-
Jones, A.C.1
-
118
-
-
84893456760
-
Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A
-
Yamanaka, K. et al. Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc. Natl Acad. Sci. USA 111, 1957-1962 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 1957-1962
-
-
Yamanaka, K.1
-
119
-
-
77954630177
-
Cloning large natural product gene clusters from the environment: Piecing environmental DNA gene clusters back together with TAR
-
Kim, J. H. et al. Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR. Biopolymers 93, 833-844 (2010).
-
(2010)
Biopolymers
, vol.93
, pp. 833-844
-
-
Kim, J.H.1
-
120
-
-
84907144112
-
Reconstructing fungal natural product biosynthetic pathways
-
Lazarus, C. M., Williams, K. & Bailey, A. M. Reconstructing fungal natural product biosynthetic pathways. Nat. Prod. Rep. 31, 1339-1347 (2014).
-
(2014)
Nat. Prod. Rep.
, vol.31
, pp. 1339-1347
-
-
Lazarus, C.M.1
Williams, K.2
Bailey, A.M.3
-
122
-
-
59649108349
-
DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways
-
Shao, Z., Zhao, H. & Zhao, H. DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways. Nucleic Acids Res. 37, e16 (2009).
-
(2009)
Nucleic Acids Res.
, vol.37
, pp. e16
-
-
Shao, Z.1
Zhao, H.2
Zhao, H.3
-
123
-
-
79952642503
-
Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler
-
Shao, Z., Luo, Y. & Zhao, H. Rapid characterization and engineering of natural product biosynthetic pathways via DNA assembler. Mol. Biosyst. 7, 1056-1059 (2011).
-
(2011)
Mol. Biosyst.
, vol.7
, pp. 1056-1059
-
-
Shao, Z.1
Luo, Y.2
Zhao, H.3
-
124
-
-
84890086658
-
Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster
-
Luo, Y. et al. Activation and characterization of a cryptic polycyclic tetramate macrolactam biosynthetic gene cluster. Nat. Commun. 4, 2894 (2013).
-
(2013)
Nat. Commun.
, vol.4
, pp. 2894
-
-
Luo, Y.1
-
125
-
-
84921517479
-
Functional optimization of gene clusters by combinatorial design and assembly
-
Smanski, M. J. et al. Functional optimization of gene clusters by combinatorial design and assembly. Nat. Biotechnol. 32, 1241-1249 (2014).
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 1241-1249
-
-
Smanski, M.J.1
-
126
-
-
84899632544
-
Synthetic biology tools for bioprospecting of natural products in eukaryotes
-
Unkles, S. E., Valiante, V., Mattern, Derek, J. & Brakhage, A. A. Synthetic biology tools for bioprospecting of natural products in eukaryotes. Chem. Biol. 21, 502-508 (2014).
-
(2014)
Chem. Biol.
, vol.21
, pp. 502-508
-
-
Unkles, S.E.1
Valiante, V.2
Mattern Derek, J.3
Brakhage, A.A.4
-
127
-
-
84900852249
-
Yeast synthetic biology platform generates novel chemical structures as scaffolds for drug discovery
-
Klein, J. et al. Yeast synthetic biology platform generates novel chemical structures as scaffolds for drug discovery. ACS Synthet. Biol. 3, 314-323 (2014).
-
(2014)
ACS Synthet. Biol.
, vol.3
, pp. 314-323
-
-
Klein, J.1
-
128
-
-
84900859146
-
Secondary metabolomics: The impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products
-
Krug, D. & Müller, R. Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products. Nat. Prod. Rep. 31, 768-783 (2014).
-
(2014)
Nat. Prod. Rep.
, vol.31
, pp. 768-783
-
-
Krug, D.1
Müller, R.2
-
129
-
-
84874956949
-
Natural product isolation-how to get from biological material to pure compounds
-
Bucar, F., Wube, A. & Schmid, M. Natural product isolation-how to get from biological material to pure compounds. Nat. Prod. Rep. 30, 525-545 (2013).
-
(2013)
Nat. Prod. Rep.
, vol.30
, pp. 525-545
-
-
Bucar, F.1
Wube, A.2
Schmid, M.3
-
130
-
-
84874999469
-
Using NMR to identify and characterize natural products
-
Breton, R. C. & Reynolds, W. F. Using NMR to identify and characterize natural products. Nat. Prod. Rep. 30, 501-524 (2013).
-
(2013)
Nat. Prod. Rep.
, vol.30
, pp. 501-524
-
-
Breton, R.C.1
Reynolds, W.F.2
-
131
-
-
84880370987
-
Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products
-
Owen, J. G. et al. Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products. Proc. Natl Acad. Sci. USA 110, 11797-11802 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 11797-11802
-
-
Owen, J.G.1
-
132
-
-
84870714378
-
Tetarimycin A an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters
-
Kallifidas, D., Kang, H. S. & Brady, S. F. Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters. J. Am. Chem. Soc. 134, 19552-19555 (2012).
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 19552-19555
-
-
Kallifidas, D.1
Kang, H.S.2
Brady, S.F.3
-
133
-
-
84889261817
-
Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment
-
Chang, F. Y., Ternei, M. A., Calle, P. Y. & Brady, S. F. Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment. J. Am. Chem. Soc. 135, 17906-17912 (2013).
-
(2013)
J. Am. Chem. Soc.
, vol.135
, pp. 17906-17912
-
-
Chang, F.Y.1
Ternei, M.A.2
Calle, P.Y.3
Brady, S.F.4
-
134
-
-
84893581440
-
Microbiology: A talented genus
-
Jaspars, M. & Challis, G. L. Microbiology: a talented genus. Nature 506, 38-39 (2014).
-
(2014)
Nature
, vol.506
, pp. 38-39
-
-
Jaspars, M.1
Challis, G.L.2
-
135
-
-
33845903833
-
Drugs for bad bugs: Confronting the challenges of antibacterial discovery
-
Payne, D. J., Gwynn, M. N., Holmes, D. J. & Pompliano, D. L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6, 29-40 (2007).
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 29-40
-
-
Payne, D.J.1
Gwynn, M.N.2
Holmes, D.J.3
Pompliano, D.L.4
-
136
-
-
33847381100
-
A decade of fragment-based drug design: Strategic advances and lessons learned
-
Hajduk, P. J. & Greer, J. A decade of fragment-based drug design: strategic advances and lessons learned. Nat. Rev. Drug Discov. 6, 211-219 (2007).
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 211-219
-
-
Hajduk, P.J.1
Greer, J.2
-
137
-
-
69249202590
-
The biosynthetic logic of polyketide diversity
-
Hertweck, C. The biosynthetic logic of polyketide diversity. Angew. Chem. Int. Ed. Engl. 48, 4688-4716 (2009).
-
(2009)
Angew. Chem. Int. Ed. Engl.
, vol.48
, pp. 4688-4716
-
-
Hertweck, C.1
-
138
-
-
77954675603
-
Biosynthesis of polyketides by trans-AT polyketide synthases
-
Piel, J. Biosynthesis of polyketides by trans-AT polyketide synthases. Nat. Prod. Rep. 27, 996-1047 (2010).
-
(2010)
Nat. Prod. Rep.
, vol.27
, pp. 996-1047
-
-
Piel, J.1
-
139
-
-
84870918230
-
Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature
-
Arnison, P. G. et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat. Prod. Rep. 30, 108-160 (2013).
-
(2013)
Nat. Prod. Rep.
, vol.30
, pp. 108-160
-
-
Arnison, P.G.1
-
140
-
-
77951294519
-
Nonribosomal peptide synthetases: Structures and dynamics
-
Strieker, M., Tanovic, A. & Marahiel, M. A. Nonribosomal peptide synthetases: structures and dynamics. Curr. Opin. Struct. Biol. 20, 234-240 (2010).
-
(2010)
Curr. Opin. Struct. Biol.
, vol.20
, pp. 234-240
-
-
Strieker, M.1
Tanovic, A.2
Marahiel, M.A.3
-
141
-
-
70350643410
-
The long-overlooked enzymology of a nonribosomal-peptide synthetase independent pathway for virulence-conferring siderophore biosynthesis
-
Oves-Costales, D., Kadi, N. & Challis, G. L. The long-overlooked enzymology of a nonribosomal-peptide synthetase independent pathway for virulence-conferring siderophore biosynthesis. Chem. Commun. 2009, 6530-6541 (2009).
-
(2009)
Chem. Commun.
, vol.2009
, pp. 6530-6541
-
-
Oves-Costales, D.1
Kadi, N.2
Challis, G.L.3
-
142
-
-
84871576542
-
Terpenoid synthase structures: A so far incomplete view of complex catalysis
-
Gao, Y., Honzatko, R. B. & Peters, R. J. Terpenoid synthase structures: a so far incomplete view of complex catalysis. Nat. Prod. Rep. 29, 1153-1175 (2012).
-
(2012)
Nat. Prod. Rep.
, vol.29
, pp. 1153-1175
-
-
Gao, Y.1
Honzatko, R.B.2
Peters, R.J.3
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