Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 29, 2013, Pages 11797-11802

  Owen, Jeremy G ^a,b   Reddy, Boojala Vijay B ^a,b   Ternei, Melinda A ^a,b   Charlop Powers, Zachary ^a,b   Calle, Paula Y ^a,b   Kim, Jeffrey H ^a,b   Brady, Sean F ^a,b  

^a Laboratory of Genetically Encoded Small Molecules   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Drug discovery; Nonribosomal peptide synthetase; Polyketide synthase; Secondary metabolite; Uncultured bacteria

Indexed keywords

ANTIBIOTIC AGENT; GLYCOPEPTIDE; LIPOPEPTIDE; NATURAL PRODUCT; THIOCORALINE;

ADENYLATION; AMPLICON; ARTICLE; CLONING; CONVERGENT EVOLUTION; DNA LIBRARY; DNA SEQUENCE; ECOSYSTEM; GENE CLUSTER; GENE MAPPING; GENETIC VARIABILITY; METAGENOME; METAGENOMICS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

DRUG DISCOVERY; NONRIBOSOMAL PEPTIDE SYNTHETASE; POLYKETIDE SYNTHASE; SECONDARY METABOLITE; UNCULTURED BACTERIA;

BASE SEQUENCE; BIOLOGICAL PRODUCTS; BIOSYNTHETIC PATHWAYS; CHROMOSOME MAPPING; DNA PRIMERS; DRUG DISCOVERY; GENE LIBRARY; GLYCOPEPTIDES; METAGENOME; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MULTIGENE FAMILY; SEQUENCE ANALYSIS, DNA; SOIL MICROBIOLOGY;

EID: 84880370987     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1222159110     Document Type: Article

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