Macrodiolide formation by the thioesterase of a modular polyketide synthase

Angewandte Chemie - International Edition

Volumn 54, Issue 17, 2015, Pages 5232-5235

  Zhou, Yongjun ^a   Prediger, Patrícia ^b   Dias, Luiz Carlos ^b   Murphy, Annabel C ^a   Leadlay, Peter F ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

biosynthesis; diolides; elaiophylin; polyketide synthase; thioesterase

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; CHEMICAL REACTIONS; PLANTS (BOTANY);

ASSEMBLY LINE; DIOLIDES; ELAIOPHYLIN; MACRODIOLIDE; NATURAL SUBSTRATES; POLYKETIDE SYNTHASES; RING FORMATION; THIOESTERASES;

KETONES;

ANTIINFECTIVE AGENT; ELAIOPHYLIN; MACROLIDE; POLYKETIDE SYNTHASE; RECOMBINANT PROTEIN; THIOL ESTER HYDROLASE;

ACYLATION; BIOSYNTHESIS; CHEMISTRY; CYCLIZATION; GENETICS; METABOLISM;

ACYLATION; ANTI-BACTERIAL AGENTS; CYCLIZATION; MACROLIDES; POLYKETIDE SYNTHASES; RECOMBINANT PROTEINS; THIOLESTER HYDROLASES;

EID: 84924208708     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201500401     Document Type: Article

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