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Volumn 271, Issue 1, 2016, Pages 141-155

Development of T-cell tolerance utilizes both cell-autonomous and cooperative presentation of self-antigen

Author keywords

Antigen presentation processing; Dendritic cells; Medullary thymic epithelial cells; T cells; Thymus; Tolerance suppression anergy

Indexed keywords

AUTOANTIGEN; AUTOIMMUNE REGULATOR PROTEIN; CYTOKINE; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84963533918     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12403     Document Type: Article
Times cited : (38)

References (140)
  • 1
    • 84901487911 scopus 로고    scopus 로고
    • Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)
    • Klein L, Kyewski B, Allen PM, Hogquist KA. Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see). Nat Rev Immunol 2014;14:377-391.
    • (2014) Nat Rev Immunol , vol.14 , pp. 377-391
    • Klein, L.1    Kyewski, B.2    Allen, P.M.3    Hogquist, K.A.4
  • 3
    • 84907308588 scopus 로고    scopus 로고
    • Revisiting thymic positive selection and the mature T cell repertoire for antigen
    • Vrisekoop N, Monteiro João P, Mandl Judith N, Germain Ronald N. Revisiting thymic positive selection and the mature T cell repertoire for antigen. Immunity 2014;41:181-190.
    • (2014) Immunity , vol.41 , pp. 181-190
    • Vrisekoop, N.1    Monteiro João, P.2    Mandl Judith, N.3    Germain Ronald, N.4
  • 4
    • 84862814979 scopus 로고    scopus 로고
    • Selection of regulatory T cells in the thymus
    • Hsieh CS, Lee HM, Lio CW. Selection of regulatory T cells in the thymus. Nat Rev Immunol 2012;12:157-167.
    • (2012) Nat Rev Immunol , vol.12 , pp. 157-167
    • Hsieh, C.S.1    Lee, H.M.2    Lio, C.W.3
  • 5
    • 82755198003 scopus 로고    scopus 로고
    • Regulatory T cell lineage commitment in the thymus
    • Klein L, Jovanovic K. Regulatory T cell lineage commitment in the thymus. Semin Immunol 2011;23:401-409.
    • (2011) Semin Immunol , vol.23 , pp. 401-409
    • Klein, L.1    Jovanovic, K.2
  • 6
    • 79954486763 scopus 로고    scopus 로고
    • Regulatory T cells and Foxp3
    • Rudensky AY. Regulatory T cells and Foxp3. Immunol Rev 2011;241:260-268.
    • (2011) Immunol Rev , vol.241 , pp. 260-268
    • Rudensky, A.Y.1
  • 7
    • 34547749066 scopus 로고    scopus 로고
    • Emerging challenges in regulatory T cell function and biology
    • Sakaguchi S, Powrie F. Emerging challenges in regulatory T cell function and biology. Science 2007;317:627-629.
    • (2007) Science , vol.317 , pp. 627-629
    • Sakaguchi, S.1    Powrie, F.2
  • 8
    • 67651177609 scopus 로고    scopus 로고
    • Dead man walking: how thymocytes scan the medulla
    • Klein L. Dead man walking: how thymocytes scan the medulla. Nat Immunol 2009;10:809-811.
    • (2009) Nat Immunol , vol.10 , pp. 809-811
    • Klein, L.1
  • 9
    • 67650507153 scopus 로고    scopus 로고
    • The thymic medulla: a unique microenvironment for intercellular self-antigen transfer
    • Koble C, Kyewski B. The thymic medulla: a unique microenvironment for intercellular self-antigen transfer. J Exp Med 2009;206:1505-1513.
    • (2009) J Exp Med , vol.206 , pp. 1505-1513
    • Koble, C.1    Kyewski, B.2
  • 11
    • 0035320679 scopus 로고    scopus 로고
    • + regulatory T cells induced by an agonist self-peptide
    • + regulatory T cells induced by an agonist self-peptide. Nat Immunol 2001;2:301-306.
    • (2001) Nat Immunol , vol.2 , pp. 301-306
    • Jordan, M.S.1
  • 13
    • 0032538918 scopus 로고    scopus 로고
    • + T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis
    • + T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J Exp Med 1998;188:1883-1894.
    • (1998) J Exp Med , vol.188 , pp. 1883-1894
    • Olivares-Villagómez, D.1    Wang, Y.2    Lafaille, J.J.3
  • 14
    • 0033136302 scopus 로고    scopus 로고
    • + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance
    • + naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J Immunol 1999;162:5317-5326.
    • (1999) J Immunol , vol.162 , pp. 5317-5326
    • Itoh, M.1
  • 16
    • 33645102841 scopus 로고    scopus 로고
    • An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
    • Hsieh C-S, Zheng Y, Liang Y, Fontenot JD, Rudensky AY. An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat Immunol 2006;7:401-410.
    • (2006) Nat Immunol , vol.7 , pp. 401-410
    • Hsieh, C.-S.1    Zheng, Y.2    Liang, Y.3    Fontenot, J.D.4    Rudensky, A.Y.5
  • 18
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran AE, et al. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J Exp Med 2011;208:1279-1289.
    • (2011) J Exp Med , vol.208 , pp. 1279-1289
    • Moran, A.E.1
  • 19
    • 65749120321 scopus 로고    scopus 로고
    • Intraclonal competition limits the fate determination of regulatory T cells in the thymus
    • Bautista JL, et al. Intraclonal competition limits the fate determination of regulatory T cells in the thymus. Nat Immunol 2009;10:610-617.
    • (2009) Nat Immunol , vol.10 , pp. 610-617
    • Bautista, J.L.1
  • 20
    • 84874745221 scopus 로고    scopus 로고
    • Aire-dependent thymic development of tumor-associated regulatory T cells
    • Malchow S, et al. Aire-dependent thymic development of tumor-associated regulatory T cells. Science 2013;339:1219-1224.
    • (2013) Science , vol.339 , pp. 1219-1224
    • Malchow, S.1
  • 21
    • 84866524744 scopus 로고    scopus 로고
    • A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self
    • Lee H-M, Bautista Jhoanne L, Scott-Browne J, Mohan James F, Hsieh C-S. A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self. Immunity 2012;37:475-486.
    • (2012) Immunity , vol.37 , pp. 475-486
    • Lee, H.-M.1    Bautista Jhoanne, L.2    Scott-Browne, J.3    Mohan James, F.4    Hsieh, C.-S.5
  • 22
    • 84944879331 scopus 로고    scopus 로고
    • T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex
    • Beringer DX, et al. T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex. Nat Immunol 2015;16:1153-1161.
    • (2015) Nat Immunol , vol.16 , pp. 1153-1161
    • Beringer, D.X.1
  • 23
    • 84923355616 scopus 로고    scopus 로고
    • + T cells with identical antigen receptors
    • + T cells with identical antigen receptors. Nat Commun 2014;5:5061.
    • (2014) Nat Commun , vol.5 , pp. 5061
    • Wojciech, L.1
  • 24
    • 84945124349 scopus 로고    scopus 로고
    • Regulatory and T effector cells have overlapping low to high ranges in TCR affinities for self during demyelinating disease
    • Hood JD, Zarnitsyna VI, Zhu C, Evavold BD. Regulatory and T effector cells have overlapping low to high ranges in TCR affinities for self during demyelinating disease. J Immunol 2015;195:4162-4170.
    • (2015) J Immunol , vol.195 , pp. 4162-4170
    • Hood, J.D.1    Zarnitsyna, V.I.2    Zhu, C.3    Evavold, B.D.4
  • 25
    • 77958134780 scopus 로고    scopus 로고
    • + regulatory T lymphocytes in myelin oligodendrocyte glycoprotein-induced experimental allergic encephalomyelitis
    • + regulatory T lymphocytes in myelin oligodendrocyte glycoprotein-induced experimental allergic encephalomyelitis. J Immunol 2010;185:3895-3904.
    • (2010) J Immunol , vol.185 , pp. 3895-3904
    • Nguyen, P.1
  • 26
    • 71749113619 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. Immunity 2009;31:909-920.
    • (2009) Immunity , vol.31 , pp. 909-920
    • Liu, X.1
  • 27
    • 37849009964 scopus 로고    scopus 로고
    • A two-step process for thymic regulatory T cell development
    • Lio C-WJ, Hsieh C-S. A two-step process for thymic regulatory T cell development. Immunity 2008;28:100-111.
    • (2008) Immunity , vol.28 , pp. 100-111
    • Lio, C.-W.1    Hsieh, C.-S.2
  • 28
    • 82155170171 scopus 로고    scopus 로고
    • B7/CD28 in central tolerance: costimulation promotes maturation of regulatory T cell precursors and prevents their clonal deletion
    • Hinterberger M, Wirnsberger G, Klein L. B7/CD28 in central tolerance: costimulation promotes maturation of regulatory T cell precursors and prevents their clonal deletion. Front Immunol 2011;2:30.
    • (2011) Front Immunol , vol.2 , pp. 30
    • Hinterberger, M.1    Wirnsberger, G.2    Klein, L.3
  • 29
    • 37849008688 scopus 로고    scopus 로고
    • Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire
    • Burchill MA, et al. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 2008;28:112-121.
    • (2008) Immunity , vol.28 , pp. 112-121
    • Burchill, M.A.1
  • 30
    • 0348223787 scopus 로고    scopus 로고
    • + regulatory T cells by TGF-β induction of transcription factor Foxp3
    • + regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med 2003;198:1875-1886.
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1
  • 31
    • 33748448717 scopus 로고    scopus 로고
    • Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    • Li MO, Sanjabi S, Flavell Richard A. Transforming growth factor-β controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity 2006;25:455-471.
    • (2006) Immunity , vol.25 , pp. 455-471
    • Li, M.O.1    Sanjabi, S.2    Flavell Richard, A.3
  • 33
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 2005;6:1142-1151.
    • (2005) Nat Immunol , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 36
    • 84879601640 scopus 로고    scopus 로고
    • Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals
    • Tai X, et al. Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals. Immunity 2013;38:1116-1128.
    • (2013) Immunity , vol.38 , pp. 1116-1128
    • Tai, X.1
  • 37
    • 13944260538 scopus 로고    scopus 로고
    • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    • Tai X, Cowan M, Feigenbaum L, Singer A. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat Immunol 2005;6:152-162.
    • (2005) Nat Immunol , vol.6 , pp. 152-162
    • Tai, X.1    Cowan, M.2    Feigenbaum, L.3    Singer, A.4
  • 38
    • 84929950085 scopus 로고    scopus 로고
    • Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition
    • Weist BM, Kurd N, Boussier J, Chan SW, Robey EA. Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition. Nat Immunol 2015;16:635-641.
    • (2015) Nat Immunol , vol.16 , pp. 635-641
    • Weist, B.M.1    Kurd, N.2    Boussier, J.3    Chan, S.W.4    Robey, E.A.5
  • 39
    • 2442496266 scopus 로고    scopus 로고
    • + T cells in vivo is rapid, transient, and influenced by TCR-specific competition
    • + T cells in vivo is rapid, transient, and influenced by TCR-specific competition. J Immunol 2004;172:6136-6143.
    • (2004) J Immunol , vol.172 , pp. 6136-6143
    • Sojka, D.K.1    Bruniquel, D.2    Schwartz, R.H.3    Singh, N.J.4
  • 40
    • 84929944502 scopus 로고    scopus 로고
    • Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors
    • Thiault N, et al. Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors. Nat Immunol 2015;16:628-634.
    • (2015) Nat Immunol , vol.16 , pp. 628-634
    • Thiault, N.1
  • 41
    • 84877742439 scopus 로고    scopus 로고
    • Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota
    • Cebula A, et al. Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota. Nature 2013;497:258-262.
    • (2013) Nature , vol.497 , pp. 258-262
    • Cebula, A.1
  • 42
    • 84907808308 scopus 로고    scopus 로고
    • Both retention and recirculation contribute to long-lived regulatory T-cell accumulation in the thymus
    • Yang E, Zou T, Leichner TM, Zhang SL, Kambayashi T. Both retention and recirculation contribute to long-lived regulatory T-cell accumulation in the thymus. Eur J Immunol 2014;44:2712-2720.
    • (2014) Eur J Immunol , vol.44 , pp. 2712-2720
    • Yang, E.1    Zou, T.2    Leichner, T.M.3    Zhang, S.L.4    Kambayashi, T.5
  • 43
    • 0141920662 scopus 로고    scopus 로고
    • + regulatory T cells
    • + regulatory T cells. J Immunol 2003;171:3348-3352.
    • (2003) J Immunol , vol.171 , pp. 3348-3352
    • Tang, Q.1
  • 44
    • 0033682056 scopus 로고    scopus 로고
    • + immunoregulatory T cells that control autoimmune diabetes
    • + immunoregulatory T cells that control autoimmune diabetes. Immunity 2000;12:431-440.
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1
  • 46
    • 84899475568 scopus 로고    scopus 로고
    • Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells
    • Mahmud SA, et al. Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nat Immunol 2014;15:473-481.
    • (2014) Nat Immunol , vol.15 , pp. 473-481
    • Mahmud, S.A.1
  • 47
    • 84904260731 scopus 로고    scopus 로고
    • Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation
    • Liu C, et al. Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation. J Immunol 2014;193:663-672.
    • (2014) J Immunol , vol.193 , pp. 663-672
    • Liu, C.1
  • 48
    • 84892741006 scopus 로고    scopus 로고
    • Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways
    • Williams JA, et al. Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways. J Immunol 2014;192:630-640.
    • (2014) J Immunol , vol.192 , pp. 630-640
    • Williams, J.A.1
  • 49
    • 84864819142 scopus 로고    scopus 로고
    • Abrogation of CD40-CD154 signaling impedes the homeostasis of thymic resident regulatory T cells by altering the levels of IL-2, but does not affect regulatory T cell development
    • Cuss SM, Green EA. Abrogation of CD40-CD154 signaling impedes the homeostasis of thymic resident regulatory T cells by altering the levels of IL-2, but does not affect regulatory T cell development. J Immunol 2012;189:1717-1725.
    • (2012) J Immunol , vol.189 , pp. 1717-1725
    • Cuss, S.M.1    Green, E.A.2
  • 50
    • 84937520585 scopus 로고    scopus 로고
    • Thymic B cells promote thymus-derived regulatory T cell development and proliferation
    • Lu F-T, et al. Thymic B cells promote thymus-derived regulatory T cell development and proliferation. J Autoimmun 2015;61:62-72.
    • (2015) J Autoimmun , vol.61 , pp. 62-72
    • Lu, F.-T.1
  • 51
    • 84878646386 scopus 로고    scopus 로고
    • + regulatory T cell development via the CD27-CD70 pathway
    • + regulatory T cell development via the CD27-CD70 pathway. J Exp Med 2013;210:715-728.
    • (2013) J Exp Med , vol.210 , pp. 715-728
    • Coquet, J.M.1
  • 52
    • 80052423824 scopus 로고    scopus 로고
    • Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance
    • Hubert F-X, et al. Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. Blood 2011;118:2462-2472.
    • (2011) Blood , vol.118 , pp. 2462-2472
    • Hubert, F.-X.1
  • 53
    • 84861212351 scopus 로고    scopus 로고
    • Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection
    • Taniguchi RT, et al. Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci USA 2012;109:7847-7852.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 7847-7852
    • Taniguchi, R.T.1
  • 54
    • 7244227645 scopus 로고    scopus 로고
    • Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation
    • Gallegos AM, Bevan MJ. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med 2004;200:1039-1049.
    • (2004) J Exp Med , vol.200 , pp. 1039-1049
    • Gallegos, A.M.1    Bevan, M.J.2
  • 55
    • 79251572366 scopus 로고    scopus 로고
    • + conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins
    • + conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins. J Immunol 2011;186:1421-1431.
    • (2011) J Immunol , vol.186 , pp. 1421-1431
    • Atibalentja, D.F.1    Murphy, K.M.2    Unanue, E.R.3
  • 56
    • 58149376454 scopus 로고    scopus 로고
    • Dendritic cells in the thymus contribute to T-regulatory cell induction
    • Proietto AI, et al. Dendritic cells in the thymus contribute to T-regulatory cell induction. Proc Natl Acad Sci USA 2008;105:19869-19874.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19869-19874
    • Proietto, A.I.1
  • 58
    • 58149154739 scopus 로고    scopus 로고
    • Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
    • McCaughtry TM, Baldwin TA, Wilken MS, Hogquist KA. Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J Exp Med 2008;205:2575-2584.
    • (2008) J Exp Med , vol.205 , pp. 2575-2584
    • McCaughtry, T.M.1    Baldwin, T.A.2    Wilken, M.S.3    Hogquist, K.A.4
  • 59
    • 84875257845 scopus 로고    scopus 로고
    • Murine thymic selection quantified using a unique method to capture deleted T cells
    • Stritesky GL, et al. Murine thymic selection quantified using a unique method to capture deleted T cells. Proc Natl Acad Sci USA 2013;110:4679-4684.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 4679-4684
    • Stritesky, G.L.1
  • 62
    • 34248598295 scopus 로고    scopus 로고
    • + medullary thymic epithelial cells
    • + medullary thymic epithelial cells. Nat Immunol 2007;8:351-358.
    • (2007) Nat Immunol , vol.8 , pp. 351-358
    • Aschenbrenner, K.1
  • 63
    • 51349101423 scopus 로고    scopus 로고
    • + thymocytes control mature medullary thymic epithelial cell cellularity
    • + thymocytes control mature medullary thymic epithelial cell cellularity. Immunity 2008;29:451-463.
    • (2008) Immunity , vol.29 , pp. 451-463
    • Irla, M.1
  • 64
    • 76249088374 scopus 로고    scopus 로고
    • Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction
    • Atibalentja DF, Byersdorfer CA, Unanue ER. Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction. J Immunol 2009;183:7909-7918.
    • (2009) J Immunol , vol.183 , pp. 7909-7918
    • Atibalentja, D.F.1    Byersdorfer, C.A.2    Unanue, E.R.3
  • 65
    • 0034857910 scopus 로고    scopus 로고
    • Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance
    • Klein L, Roettinger B, Kyewski B. Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance. Eur J Immunol 2001;31:2476-2486.
    • (2001) Eur J Immunol , vol.31 , pp. 2476-2486
    • Klein, L.1    Roettinger, B.2    Kyewski, B.3
  • 66
    • 52149099867 scopus 로고    scopus 로고
    • Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
    • Nedjic J, Aichinger M, Emmerich J, Mizushima N, Klein L. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature 2008;455:396-400.
    • (2008) Nature , vol.455 , pp. 396-400
    • Nedjic, J.1    Aichinger, M.2    Emmerich, J.3    Mizushima, N.4    Klein, L.5
  • 67
    • 84874565064 scopus 로고    scopus 로고
    • Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance
    • Aichinger M, Wu C, Nedjic J, Klein L. Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance. J Exp Med 2013;210:287-300.
    • (2013) J Exp Med , vol.210 , pp. 287-300
    • Aichinger, M.1    Wu, C.2    Nedjic, J.3    Klein, L.4
  • 68
    • 12844275079 scopus 로고    scopus 로고
    • Endogenous MHC class II processing of a viral nuclear antigen after autophagy
    • Paludan C, et al. Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science 2005;307:593-596.
    • (2005) Science , vol.307 , pp. 593-596
    • Paludan, C.1
  • 69
    • 67349269904 scopus 로고    scopus 로고
    • Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection
    • English L, et al. Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. Nat Immunol 2009;10:480-487.
    • (2009) Nat Immunol , vol.10 , pp. 480-487
    • English, L.1
  • 70
    • 76949091325 scopus 로고    scopus 로고
    • In vivo requirement for Atg5 in antigen presentation by dendritic cells
    • Lee HK, et al. In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity 2010;32:227-239.
    • (2010) Immunity , vol.32 , pp. 227-239
    • Lee, H.K.1
  • 71
    • 20344361954 scopus 로고    scopus 로고
    • Autophagy promotes MHC class II presentation of peptides from intracellular source proteins
    • Dengjel J, et al. Autophagy promotes MHC class II presentation of peptides from intracellular source proteins. Proc Natl Acad Sci USA 2005;102:7922-7927.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 7922-7927
    • Dengjel, J.1
  • 72
    • 33846224369 scopus 로고    scopus 로고
    • Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes
    • Schmid D, Pypaert M, Münz C. Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes. Immunity 2007;26:79-92.
    • (2007) Immunity , vol.26 , pp. 79-92
    • Schmid, D.1    Pypaert, M.2    Münz, C.3
  • 73
    • 84862490479 scopus 로고    scopus 로고
    • Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model
    • Sukseree S, et al. Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model. PLoS ONE 2012;7:e38933.
    • (2012) PLoS ONE , vol.7 , pp. e38933
    • Sukseree, S.1
  • 74
    • 55249109400 scopus 로고    scopus 로고
    • Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens
    • Zhao Z, et al. Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe 2008;4:458-469.
    • (2008) Cell Host Microbe , vol.4 , pp. 458-469
    • Zhao, Z.1
  • 75
    • 84921529601 scopus 로고    scopus 로고
    • Atg7 enhances host defense against infection via downregulation of superoxide but upregulation of nitric oxide
    • Li X, Ye Y, Zhou X, Huang C, Wu M. Atg7 enhances host defense against infection via downregulation of superoxide but upregulation of nitric oxide. J Immunol 2015;194:1112-1121.
    • (2015) J Immunol , vol.194 , pp. 1112-1121
    • Li, X.1    Ye, Y.2    Zhou, X.3    Huang, C.4    Wu, M.5
  • 77
    • 84903196141 scopus 로고    scopus 로고
    • The diabetes susceptibility gene Clec16a regulates mitophagy
    • Soleimanpour Scott A, et al. The diabetes susceptibility gene Clec16a regulates mitophagy. Cell 2014;157:1577-1590.
    • (2014) Cell , vol.157 , pp. 1577-1590
    • Soleimanpour Scott, A.1
  • 78
    • 84982179066 scopus 로고    scopus 로고
    • Diabetes susceptibility genes Pdx1 and Clec16a function in a pathway regulating mitophagy in β-cells
    • Soleimanpour SA, et al. Diabetes susceptibility genes Pdx1 and Clec16a function in a pathway regulating mitophagy in β-cells. Diabetes 2015;64:3475-3484.
    • (2015) Diabetes , vol.64 , pp. 3475-3484
    • Soleimanpour, S.A.1
  • 79
    • 84929712572 scopus 로고    scopus 로고
    • The autoimmunity-associated gene CLEC16A modulates thymic epithelial cell autophagy and alters T cell selection
    • Schuster C, et al. The autoimmunity-associated gene CLEC16A modulates thymic epithelial cell autophagy and alters T cell selection. Immunity 2015;42:942-952.
    • (2015) Immunity , vol.42 , pp. 942-952
    • Schuster, C.1
  • 80
    • 80054746235 scopus 로고    scopus 로고
    • Understanding type 1 diabetes through genetics: advances and prospects
    • Polychronakos C, Li Q. Understanding type 1 diabetes through genetics: advances and prospects. Nat Rev Genet 2011;12:781-792.
    • (2011) Nat Rev Genet , vol.12 , pp. 781-792
    • Polychronakos, C.1    Li, Q.2
  • 81
    • 63449108301 scopus 로고    scopus 로고
    • Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity
    • Ohnmacht C, et al. Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med 2009;206:549-559.
    • (2009) J Exp Med , vol.206 , pp. 549-559
    • Ohnmacht, C.1
  • 82
    • 50149099154 scopus 로고    scopus 로고
    • + T cells in the thymic cortex
    • + T cells in the thymic cortex. Proc Natl Acad Sci USA 2008;105:11903-11908.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 11903-11908
    • Liston, A.1
  • 84
    • 77958124293 scopus 로고    scopus 로고
    • Cutting edge: hematopoietic-derived APCs select regulatory T cells in thymus
    • Román E, Shino H, Qin FX-F, Liu YJ. Cutting edge: hematopoietic-derived APCs select regulatory T cells in thymus. J Immunol 2010;185:3819-3823.
    • (2010) J Immunol , vol.185 , pp. 3819-3823
    • Román, E.1    Shino, H.2    Qin, F.-F.3    Liu, Y.J.4
  • 85
    • 70349230989 scopus 로고    scopus 로고
    • + conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner
    • + conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner. J Immunol 2009;183:3053-3063.
    • (2009) J Immunol , vol.183 , pp. 3053-3063
    • Baba, T.1    Nakamoto, Y.2    Mukaida, N.3
  • 86
    • 84879688223 scopus 로고    scopus 로고
    • MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells
    • Oh J, et al. MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells. J Exp Med 2013;210:1069-1077.
    • (2013) J Exp Med , vol.210 , pp. 1069-1077
    • Oh, J.1
  • 87
    • 84907982768 scopus 로고    scopus 로고
    • Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus
    • Perry JSA, et al. Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus. Immunity 2014;41:414-426.
    • (2014) Immunity , vol.41 , pp. 414-426
    • Perry, J.S.A.1
  • 90
    • 73149115486 scopus 로고    scopus 로고
    • Aire's partners in the molecular control of immunological tolerance
    • Abramson J, Giraud M, Benoist C, Mathis D. Aire's partners in the molecular control of immunological tolerance. Cell 2010;140:123-135.
    • (2010) Cell , vol.140 , pp. 123-135
    • Abramson, J.1    Giraud, M.2    Benoist, C.3    Mathis, D.4
  • 92
    • 84939600854 scopus 로고    scopus 로고
    • Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells
    • Brennecke P, et al. Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells. Nat Immunol 2015;16:933-941.
    • (2015) Nat Immunol , vol.16 , pp. 933-941
    • Brennecke, P.1
  • 93
    • 84939622896 scopus 로고    scopus 로고
    • Aire controls gene expression in the thymic epithelium with ordered stochasticity
    • Meredith M, Zemmour D, Mathis D, Benoist C. Aire controls gene expression in the thymic epithelium with ordered stochasticity. Nat Immunol 2015;16:942-949.
    • (2015) Nat Immunol , vol.16 , pp. 942-949
    • Meredith, M.1    Zemmour, D.2    Mathis, D.3    Benoist, C.4
  • 94
    • 84946214324 scopus 로고    scopus 로고
    • Fezf2 orchestrates a thymic program of self-antigen expression for immune tolerance
    • Takaba H, et al. Fezf2 orchestrates a thymic program of self-antigen expression for immune tolerance. Cell 2015;163:975-987.
    • (2015) Cell , vol.163 , pp. 975-987
    • Takaba, H.1
  • 95
    • 84904069469 scopus 로고    scopus 로고
    • Fez family transcription factors: controlling neurogenesis and cell fate in the developing mammalian nervous system
    • Eckler MJ, Chen B. Fez family transcription factors: controlling neurogenesis and cell fate in the developing mammalian nervous system. BioEssays 2014;36:788-797.
    • (2014) BioEssays , vol.36 , pp. 788-797
    • Eckler, M.J.1    Chen, B.2
  • 99
    • 79953238006 scopus 로고    scopus 로고
    • + T-cell activation after viral infection
    • + T-cell activation after viral infection. Nature 2011;471:629-632.
    • (2011) Nature , vol.471 , pp. 629-632
    • Wakim, L.M.1    Bevan, M.J.2
  • 100
    • 0032540474 scopus 로고    scopus 로고
    • Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus
    • Nakagawa T, et al. Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science 1998;280:450-453.
    • (1998) Science , vol.280 , pp. 450-453
    • Nakagawa, T.1
  • 101
    • 12444288446 scopus 로고    scopus 로고
    • Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo
    • Beers C, Burich A, Kleijmeer MJ, Griffith JM, Wong P, Rudensky AY. Cathepsin S controls MHC class II-mediated antigen presentation by epithelial cells in vivo. J Immunol 2005;174:1205-1212.
    • (2005) J Immunol , vol.174 , pp. 1205-1212
    • Beers, C.1    Burich, A.2    Kleijmeer, M.J.3    Griffith, J.M.4    Wong, P.5    Rudensky, A.Y.6
  • 102
    • 0038651151 scopus 로고    scopus 로고
    • Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs
    • Bania J, et al. Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs. Proc Natl Acad Sci USA 2003;100:6664-6669.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6664-6669
    • Bania, J.1
  • 103
    • 84861192687 scopus 로고    scopus 로고
    • Cathepsin S dominates autoantigen processing in human thymic dendritic cells
    • Stoeckle C, et al. Cathepsin S dominates autoantigen processing in human thymic dendritic cells. J Autoimmun 2012;38:332-343.
    • (2012) J Autoimmun , vol.38 , pp. 332-343
    • Stoeckle, C.1
  • 104
    • 84887571639 scopus 로고    scopus 로고
    • The central role of antigen presentation in islets of Langerhans in autoimmune diabetes
    • Calderon B, Carrero JA, Unanue ER. The central role of antigen presentation in islets of Langerhans in autoimmune diabetes. Curr Opin Immunol 2014;26:32-40.
    • (2014) Curr Opin Immunol , vol.26 , pp. 32-40
    • Calderon, B.1    Carrero, J.A.2    Unanue, E.R.3
  • 105
    • 33644845679 scopus 로고    scopus 로고
    • Journey through the thymus: stromal guides for T-cell development and selection
    • Takahama Y. Journey through the thymus: stromal guides for T-cell development and selection. Nat Rev Immunol 2006;6:127-135.
    • (2006) Nat Rev Immunol , vol.6 , pp. 127-135
    • Takahama, Y.1
  • 106
    • 79951715831 scopus 로고    scopus 로고
    • Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
    • Lei Y, et al. Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med 2011;208:383-394.
    • (2011) J Exp Med , vol.208 , pp. 383-394
    • Lei, Y.1
  • 107
    • 84922400370 scopus 로고    scopus 로고
    • Thymic CCL2 influences induction of T-cell tolerance
    • Cédile O, et al. Thymic CCL2 influences induction of T-cell tolerance. J Autoimmun 2014;55:73-85.
    • (2014) J Autoimmun , vol.55 , pp. 73-85
    • Cédile, O.1
  • 108
    • 84858786391 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance
    • Hadeiba H, et al. Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance. Immunity 2012;36:438-450.
    • (2012) Immunity , vol.36 , pp. 438-450
    • Hadeiba, H.1
  • 109
    • 33847350111 scopus 로고    scopus 로고
    • Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation
    • Gillard GO, Dooley J, Erickson M, Peltonen L, Farr AG. Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation. J Immunol 2007;178:3007-3015.
    • (2007) J Immunol , vol.178 , pp. 3007-3015
    • Gillard, G.O.1    Dooley, J.2    Erickson, M.3    Peltonen, L.4    Farr, A.G.5
  • 110
    • 77952302980 scopus 로고    scopus 로고
    • Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation
    • Nishikawa Y, et al. Biphasic Aire expression in early embryos and in medullary thymic epithelial cells before end-stage terminal differentiation. J Exp Med 2010;207:963-971.
    • (2010) J Exp Med , vol.207 , pp. 963-971
    • Nishikawa, Y.1
  • 111
    • 58149316251 scopus 로고    scopus 로고
    • Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance
    • Yano M, et al. Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. J Exp Med 2008;205:2827-2838.
    • (2008) J Exp Med , vol.205 , pp. 2827-2838
    • Yano, M.1
  • 112
    • 84897508383 scopus 로고    scopus 로고
    • Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program
    • Nishikawa Y, et al. Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program. J Immunol 2014;192:2585-2592.
    • (2014) J Immunol , vol.192 , pp. 2585-2592
    • Nishikawa, Y.1
  • 113
    • 35748941369 scopus 로고    scopus 로고
    • Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
    • Gray D, Abramson J, Benoist C, Mathis D. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med 2007;204:2521-2528.
    • (2007) J Exp Med , vol.204 , pp. 2521-2528
    • Gray, D.1    Abramson, J.2    Benoist, C.3    Mathis, D.4
  • 114
    • 84885854982 scopus 로고    scopus 로고
    • Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population
    • Metzger Todd C, et al. Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population. Cell Rep 2013;5:166-179.
    • (2013) Cell Rep , vol.5 , pp. 166-179
    • Metzger Todd, C.1
  • 115
    • 67549104034 scopus 로고    scopus 로고
    • Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity
    • Guerau-de-Arellano M, Martinic M, Benoist C, Mathis D. Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity. J Exp Med 2009;206:1245-1252.
    • (2009) J Exp Med , vol.206 , pp. 1245-1252
    • Guerau-de-Arellano, M.1    Martinic, M.2    Benoist, C.3    Mathis, D.4
  • 116
    • 84928581675 scopus 로고    scopus 로고
    • Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
    • Yang S, Fujikado N, Kolodin D, Benoist C, Mathis D. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance. Science 2015;348:589-594.
    • (2015) Science , vol.348 , pp. 589-594
    • Yang, S.1    Fujikado, N.2    Kolodin, D.3    Benoist, C.4    Mathis, D.5
  • 117
    • 59649118664 scopus 로고    scopus 로고
    • Antigen-specific peripheral shaping of the natural regulatory T cell population
    • Lathrop SK, Santacruz NA, Pham D, Luo J, Hsieh C-S. Antigen-specific peripheral shaping of the natural regulatory T cell population. J Exp Med 2008;205:3105-3117.
    • (2008) J Exp Med , vol.205 , pp. 3105-3117
    • Lathrop, S.K.1    Santacruz, N.A.2    Pham, D.3    Luo, J.4    Hsieh, C.-S.5
  • 119
    • 22144444873 scopus 로고    scopus 로고
    • Heterogeneity of thymic dendritic cells
    • Wu L, Shortman K. Heterogeneity of thymic dendritic cells. Semin Immunol 2005;17:304-312.
    • (2005) Semin Immunol , vol.17 , pp. 304-312
    • Wu, L.1    Shortman, K.2
  • 120
    • 63449133991 scopus 로고    scopus 로고
    • Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus
    • Li J, Park J, Foss D, Goldschneider I. Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymus. J Exp Med 2009;206:607-622.
    • (2009) J Exp Med , vol.206 , pp. 607-622
    • Li, J.1    Park, J.2    Foss, D.3    Goldschneider, I.4
  • 122
    • 84949557845 scopus 로고    scopus 로고
    • The role of dendritic cells in central tolerance
    • Oh J, Shin J-S. The role of dendritic cells in central tolerance. Immune Netw 2015;15:111-120.
    • (2015) Immune Netw , vol.15 , pp. 111-120
    • Oh, J.1    Shin, J.-S.2
  • 123
    • 34547525608 scopus 로고    scopus 로고
    • CCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestine
    • Wendland M, et al. CCR9 is a homing receptor for plasmacytoid dendritic cells to the small intestine. Proc Natl Acad Sci USA 2007;104:6347-6352.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6347-6352
    • Wendland, M.1
  • 125
    • 84883172356 scopus 로고    scopus 로고
    • Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens
    • Satpathy AT, et al. Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nat Immunol 2013;14:937-948.
    • (2013) Nat Immunol , vol.14 , pp. 937-948
    • Satpathy, A.T.1
  • 126
    • 84885447087 scopus 로고    scopus 로고
    • Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism
    • Welty NE, Staley C, Ghilardi N, Sadowsky MJ, Igyártó BZ, Kaplan DH. Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism. J Exp Med 2013;210:2011-2024.
    • (2013) J Exp Med , vol.210 , pp. 2011-2024
    • Welty, N.E.1    Staley, C.2    Ghilardi, N.3    Sadowsky, M.J.4    Igyártó, B.Z.5    Kaplan, D.H.6
  • 128
    • 84874207519 scopus 로고    scopus 로고
    • Expression of XCR1 characterizes the Batf3-dependent lineage of dendritic cells capable of antigen cross-presentation
    • Bachem A, et al. Expression of XCR1 characterizes the Batf3-dependent lineage of dendritic cells capable of antigen cross-presentation. Front Immunol 2012;3:214.
    • (2012) Front Immunol , vol.3 , pp. 214
    • Bachem, A.1
  • 129
    • 56249122238 scopus 로고    scopus 로고
    • Distinct functional capacities of mouse thymic and splenic dendritic cell populations
    • Proietto AI, Lahoud MH, Wu L. Distinct functional capacities of mouse thymic and splenic dendritic cell populations. Immunol Cell Biol 2008;86:700-708.
    • (2008) Immunol Cell Biol , vol.86 , pp. 700-708
    • Proietto, A.I.1    Lahoud, M.H.2    Wu, L.3
  • 130
    • 56449097442 scopus 로고    scopus 로고
    • + dendritic cells in cytotoxic T cell immunity
    • + dendritic cells in cytotoxic T cell immunity. Science 2008;322:1097-1100.
    • (2008) Science , vol.322 , pp. 1097-1100
    • Hildner, K.1
  • 131
    • 51349099789 scopus 로고    scopus 로고
    • Antigen-presentation properties of plasmacytoid dendritic cells
    • Villadangos JA, Young L. Antigen-presentation properties of plasmacytoid dendritic cells. Immunity 2008;29:352-361.
    • (2008) Immunity , vol.29 , pp. 352-361
    • Villadangos, J.A.1    Young, L.2
  • 132
    • 84857793524 scopus 로고    scopus 로고
    • Decisions about dendritic cells: past, present, and future
    • Steinman RM. Decisions about dendritic cells: past, present, and future. Annu Rev Immunol 2012;30:1-22.
    • (2012) Annu Rev Immunol , vol.30 , pp. 1-22
    • Steinman, R.M.1
  • 133
    • 67649844269 scopus 로고    scopus 로고
    • Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control
    • Wirnsberger G, Mair F, Klein L. Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control. Proc Natl Acad Sci USA 2009;106:10278-10283.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 10278-10283
    • Wirnsberger, G.1    Mair, F.2    Klein, L.3
  • 135
    • 58149097584 scopus 로고    scopus 로고
    • The who, how and where of antigen presentation to B cells
    • Batista FD, Harwood NE. The who, how and where of antigen presentation to B cells. Nat Rev Immunol 2009;9:15-27.
    • (2009) Nat Rev Immunol , vol.9 , pp. 15-27
    • Batista, F.D.1    Harwood, N.E.2
  • 136
    • 84885801968 scopus 로고    scopus 로고
    • Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection
    • Perera J, Meng L, Meng F, Huang H. Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection. Proc Natl Acad Sci USA 2013;110:17011-17016.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 17011-17016
    • Perera, J.1    Meng, L.2    Meng, F.3    Huang, H.4
  • 137
    • 84937631527 scopus 로고    scopus 로고
    • Thymic B cells are licensed to present self antigens for central T cell tolerance induction
    • Yamano T, et al. Thymic B cells are licensed to present self antigens for central T cell tolerance induction. Immunity 2015;42:1048-1061.
    • (2015) Immunity , vol.42 , pp. 1048-1061
    • Yamano, T.1
  • 138
    • 84928764413 scopus 로고    scopus 로고
    • + regulatory B cells in immune homeostasis
    • + regulatory B cells in immune homeostasis. J Leuk Biol 2015;97:547-556.
    • (2015) J Leuk Biol , vol.97 , pp. 547-556
    • Xing, C.1
  • 139
    • 84912573148 scopus 로고    scopus 로고
    • T cell-B cell thymic cross-talk: maintenance and function of thymic B cells requires cognate CD40-CD40 ligand interaction
    • Fujihara C, Williams JA, Watanabe M, Jeon H, Sharrow SO, Hodes RJ. T cell-B cell thymic cross-talk: maintenance and function of thymic B cells requires cognate CD40-CD40 ligand interaction. J Immunol 2014;193:5534-5544.
    • (2014) J Immunol , vol.193 , pp. 5534-5544
    • Fujihara, C.1    Williams, J.A.2    Watanabe, M.3    Jeon, H.4    Sharrow, S.O.5    Hodes, R.J.6
  • 140
    • 84903625200 scopus 로고    scopus 로고
    • A role for intrathymic B cells in the generation of natural regulatory T cells
    • Walters SN, Webster KE, Daley S, Grey ST. A role for intrathymic B cells in the generation of natural regulatory T cells. J Immunol 2014;193:170-176.
    • (2014) J Immunol , vol.193 , pp. 170-176
    • Walters, S.N.1    Webster, K.E.2    Daley, S.3    Grey, S.T.4


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